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Medical Sains : Jurnal Ilmiah Kefarmasian
Published by Universitas Muhammadiyah Ahmad Dahlan Cirebon
ISSN : 25482114     EISSN : 25412027     DOI : https://doi.org/10.37874/ms
Core Subject : Health,
Medicine & Pharmacology
The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy covering the fields of formulation, pharmacology, communication pharmacy, A natural chemical chemistry, pharmacognomy and other health sciences which is a means for lecturers and researchers in the health sector to share knowledge and establish cooperation in implementing the Tri Dharma of Higher Education. Purpose and Scope The objective of the publication of the Medical Science journal is to publish articles in the field of pharmacy and other health as well as application of pharmaceutical . Based on this, the editorial board of Medical Sains invites lecturers and researchers to contribute to submit research articles related to the following themes: 1. Pharmaceutical formulation technology 2. Pharmacology 3. Community pharmacy 4. Clinical Pharmacy 5. Natural material chemistry 6. Pharmacognosy 7. Pharmaceutical Analysis and Medicinal Chemistry . All papers submitted to medical science journals will be examined by peer review partners who are tailored to their respective fields.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 25 Documents
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Search results for , issue "Vol 9 No 3 (2024)" : 25 Documents clear
DEVELOPMENT OF SUNSCREEN PRODUCTS CONTAINING Stichopus hermanii Semper, 1868 Widyowati, Ulfi; Genatrika, Erza; Djalil, Asmiyenti Djaliasrin
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1138

Abstract

Prolonged radiation from UV sunlight has been known to be responsible for skin damage. Sunscreen has been used to limit sun exposure. Sunscreen with natural ingredients has the potential to be developed along with the issue of side effects of synthetic ingredients. This study aimed to develop a zooceuticals sunscreen cream containing a Stichopus hermanii Semper, 1868 extracts. The sunscreen creams were formulated with various ingredients of extract include 0.05 (F1), 0.1 (F2), and 0.2 (F3) %, respectively. The in vitro sun protection factor, organoleptic properties, homogeneity, pH, viscosity, spreadability, and adhesion of the creams were evaluated. F3 met the requirements of physical properties. The extract show sun-protective efficacy with SPF value of 2.11 (F1), 3.09 (F2), and 3.46 (F3). Sunscreen containing 0.2% of Stichopus herrmanni extract is the most preferred formulation with minimal protection category.  Keywords: Sea Cucumber, Stichopus hermanii Semper, 1868, Sunscreen.
REVIEW: THE RELATIONSHIP BETWEEN KNOWLEDGE AND MEDICATION ADHERENCE IN TYPE 2 DIABETES PATIENTS Puspitasari, Neneng Eva; Wahyuningsih, Sri
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1175

Abstract

Diabetes mellitus poses a major threat to human health, as evidenced by the increasing prevalence of diabetes, and the number of cases of diabetes in Indonesia is anticipated to rise from 10.7 million in 2019 to 13.7 million by 2030.The lack of public knowledge and compliance with treatment has caused the incidence of the disease to increase every year. This Review aimed to determine the relationship between knowledge of medication compliance in patients with type 2 diabetes mellitus. The primary data methods obtained were national and international journals using search engines such as Google Scholar, PubMed, and Science Direct, as well as other search engines with the Narrative Review pattern.  The search result of the publications obtained 769 articles; 40 articles screened full text based on the results of the screening that received 18 articles that met the inclusion criteria and were used as a review. The analysis of data writing in this article is mostly based on cross-sectional study approaches. Surveys were conducted within a three-month period. The results showed that knowledge had a significant relationship with drug consistency (p-value value = 0, 000 < 0.05). Knowledge is very much related to the medication compliance of each individual; the higher a person's knowledge, the better the attitude of compliance with diabetes drug consumption. Keywords: Compliance, Knowledge, Type 2 Diabetes, Narrative Review.
NARRATIVE REVIEW: INCIDENCE, CAUSES AND INTERVENTION STRATEGIES OF MEDICATION ERRORS TO IMPROVE CHEMOTHERAPY SERVICES IN HOSPITALS Nurliyani, Hani; Alfian, Sofa Dewi; Rahayu, Cherry; Pradipta, Ivan Surya
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1180

Abstract

Medication errors (MEs) are medication errors that have the potential to harm patients during treatment or care. Cancer care is a complex and interconnected system and many errors can be catastrophic. ME in antineoplastic drugs have the potential to cause permanent injury and even death. Evaluation measures of ME incidence in Indonesia are still not optimally carried out, thus leading to the need for a good understanding of the potential ME incidence, especially in cancer patient care. A good understanding of the incidence of medication errors will encourage preventive efforts against the potential occurrence of ME. This narrative review aims to provide information related to the incidence of ME in the Chemotherapy department at the hospital, the causative factors, and the handling and prevention efforts. Scientific information searches were conducted on the PubMed and Google Scholar databases for the period 2012-2022. The results showed that the incidence of ME mostly occurred in the prescription phase, namely in the form of dosage errors (45–59.3%), incomplete prescriptions (43–45.5%), drug frequency errors (30.4%), and     errors in patient name, age, and diagnosis data (22.5%). Several aspects contributing to the occurrence of ME were identified, including work procedures, staff, organizational systems, and staff understanding of medication regimens. This study concluded that there is a need to regulate and evaluate several aspects, including work procedures, availability of auxiliary systems, and increasing the capacity of human resources involved. This may prevent the occurrence of ME.
RELATIONSHIP OF OHA’S TREATMENT RATIONALITY WITH THERAPY TARGETS ACHIEVEMENT IN TYPE II DIABETES MELLITUS PATIENTS Rizky, Wardhiana Agung; Annisaa, Eva; Dini, Intan Rahmania Eka
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1188

Abstract

Diabetes mellitus (DM) is the most common condition in Central Java. Irrational use of drugs can cause various problems, including increased disease morbidity and mortality rates, wasted health costs, and the emergence of undesirable effects. Therefore, this study was necessary to assess the rationality of the treatment. The aim was to describe the rationality of OHAs treatment and to achieve therapy targets, and to understand the relationship between OHA treatment rationality and therapy target achievement in patients with type 2 diabetes mellitus at primary health care in Wirosari District, Grobogan Regency. An analytical observational study used a cross-sectional design, purposive sampling, and chi-square test to establish relationships between variables. The rationale for treating OHAs in patients with type 2 diabetes mellitus at primary health care in Wirosari District, Grobogan Regency, is 47.67% rational and 52.33% irrational. Among the samples, 26.7% reached the therapeutic target, whereas 73.3% did not. The rationality of treating OHAs and achieving therapeutic targets was interconnected (p=0.014).  Keywords: HbA1C, rational treatment, therapeutic target, type 2 diabetes mellitus
OPTIMIZATION OF pH VALUE AND GEL VISCOSITY IN PORANG TUBER CAPSULE SHELL FORMULATION Maulana, Riza; Muhtadi; Suhendi, Andi; Prasetya, Farid Adi; Harimurti, Sabtanti; Hamzah, Hasyrul
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1212

Abstract

The porang tuber contains glucomannan compounds that can expand into a gel so that it has the potential to be used as the main ingredient of capsule shells. This research aims to optimize the pH and viscosity values that can affect the consistency of the capsule shell produced. The method used in the manufacture of capsule shells is the dipping pen method, while the optimization method carried out is trial and error by making 3 formulas by combining glycerin and PEG 400. The results obtained by the gel mass formed by the glycerin-PEG 400 gelling agent have a viscosity value of 586.67 dPas and a pH value of 6.02 can provide a gel mass that is easy to mold capsule shells and obtain capsule shells with elastic characters.  The results indicate optimal viscosity and pH values to obtain a gel mass that is easy to mold capsule shells with good organoleptic characteristics. Keywords:  Glucomannan, pH, viscosity, capsule shell.
REVIEW: THE RELATIONSHIP OF DRUGS INFORMATION SERVICES TO CHRONIC PATIENT LOYALTY Noviani, Lusy; Suharyani, Ine; Yohana
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1229

Abstract

Patient loyalty is one of the most important factors in drug therapy to achieve successful disease treatment. We conducted a literature review to examine the relationship between drug information services and chronic patient loyalty in pharmacies. The method used was a systematic examination of related studies and articles, using a qualitative approach. The first screening included 50 articles and excluded 9 articles, the second screening excluded 30 articles, and the final articles used in this review were 11 articles. The results showed that drug information services had a positive effect on patient loyalty through the mediation of patient satisfaction. The factors that influence drug information services include the type of drug information, competence of the pharmacist, interpersonal communication, and service time. The factors that influence patient loyalty include trust, commitment, customer value, and switching costs. Keywords: Drug information service, patient loyalty, patient satisfaction, service quality, pharmaceutical service quality, customer satisfaction.
FORMULATION AND EVALUATION OF SACHA INCHI OIL LIP BALM PREPARATIONS WITH CONCENTRATION VARIATIONS OF CERA ALBA AND LANOLIN AS LIP BALM Putri, Chintiana Nindya; Latifah, Fadzil; Zahro, Honest Fatimatuz
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1265

Abstract

Lip balm is used on lips that require protection, such as when humidity is low, to prevent the evaporation of water and epithelial cells on the lip mucosa. The active substance used in making this lip balm is Sancha inchi oil, which is a cold-pressed oil from the seeds of Plukenetia volubilista. This oil contains omega 3 (40–50%) and omega 6 (30–40%), as well as lower oleic acid (10%) than olive oil. Natural antioxidants, including tocopherols and polyphenols, have also been found in Sacha Inchi oil. Sacha inchi oil has a fatty acid ratio and phytochemical composition, it can be used as a cosmetic ingredient as an emollient and skin protector. An experimental laboratory method was used for this study. The research was carried out by preparing lip balm from various ingredients containing the active ingredient Sacha inchi oil (Plukenetia volubilis L) at a concentration of 15%, as well as varying concentrations of cera alba (range 5-25%) and lanolin (range 2-10%) as bases and additional ingredients for preparations, whose optimization had been determined using the simplex lattice design method. The aim of this study was to identify the lip balm formulation from Sacha inchi oil and identify the effect of changes in the concentration of cera alba and lanolin based on the results of the preparation evaluation. The results of this test show that sacha inchi oil can be used as an active lip-moisturizing agent in lip balm preparations ...
RISK FACTORS FOR DUPLICATION OF NSAIDs WITHOUT GASTROPROTECTIVE IN ONE OF THE HOSPITALS IN INDONESIA Nurmesa, Adi; Jannah, Wardatul; Rachman, Abu; Wahyudi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1271

Abstract

The use of dual NSAIDs without gastroprotective is one of the drug related problems that often occurs in hospitals, the purpose of giving dual NSAIDs is to increase the effectiveness of pain relief in reducing pain in patients. However, the use of dual NSAIDs without gastroprotective increases the risk of side effects on the gastrointestinal tract, kidneys, and cardiovascular system. This study aimed to examine the risk factors for duplication of NSAID therapy without gastroprotective in the outpatient pharmacy unit at a type C hospital in Banyuasin district. This analytical study used a cross-sectional research design to determine the influence of risk factors on the incidence of duplication of NSAIDs therapy without gastroprotective in the outpatient polyclinic. Data were analyzed using Pearson Chi Square analysis. The results of the bivariate analysis showed that older age, polypharmacy, and multipathology were factors associated with the incidence of NSAID duplication in outpatients with p values (OR) of 0.047 (1.101), 0.025 (2.63), 0.025 (2.63), and 0.025 (2.63), respectively. Keywords: Therapeutic duplications, Ibuprofen, Diclofenac, Gastroprotective agent
BIOEQUIVALENCE STUDY OF GENERIC SALBUTAMOL TABLETS WITH LOGO AND BRANDED GENERIC Rahmawati, Dewi; Rohmah, Atina Wahdatar; Meliana A J, Marthy; Ambari, Yani; Ningsih, Arista Wahyu; Aristia, Bella Fevi; Klau, Ivan Charles Seran
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1284

Abstract

Salbutamol is a medication that stimulates beta receptors, particularly beta agonists, which are widely used as a remedy for sudden asthma attacks and those triggered by physical exercise due to its potent and rapid bronchodilating properties. These medications are known as short-acting beta-agonists (SABA). The purpose of this study was to examine in detail the significant differences in dissolution and absorption rates associated with the active ingredient in two pharmaceutically equivalent drug products, and to compare them to determine their bioequivalence. The research methodology involved experimental studies using a quantitative approach, including tests of physical quality, content determination, and dissolution testing. The results of the physical quality test for the uniformity of salbutamol tablet sizes showed that generic branded tablets, brand A, brand C, and brand D had a thickness of 0.10 cm ± 0 and a diameter of 0.50 cm ± 0, brand B had a thickness of 0.20 cm ± 0 and a diameter of 0.60 cm ± 0, and brand E had a thickness of 0.10 cm ± 0 and a diameter of 0.40 cm ± 0. The weight uniformity test results indicated that none of the generic branded tablets, brand B, or brand D deviated from columns A (7.5%) and B (15%), whereas none of the tablets from brands A, C, or E deviated from columns A (10%) and B (20%) ...
FORMULATION AND ANTIOXIDANT ACTIVITY EMULGEL SENGGANI LEAF (Melastoma malabathricum L.) WATER FRACTIONS WITH VARIATIONS OF GELLING AGENT USING DPPH METHOD Sultan, Andi Rizka Walyanda; Ropiqa, Meri; Apridamayanti, Pratiwi; Anastasia, Desy Siska
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1289

Abstract

The senggani plant is reported to have antioxidant activity owing to its flavonoid content, which is a free radical scavenger. The water fraction of senggani leaves needs to be prepared for use, one of which is the emulgel. An important additional ingredient in emulgels is the gelling agent, and the most commonly used is carbopol 940. This study aimed to determine the formulation of emulgel preparations with the most stable variation in carbopol 940 and to test the antioxidant activity of water fraction emulgel preparations from senggani leaves (Melastoma malabatricum L.). The preparations were made by varying the concentrations of Carbopol 940 to 0.5% (F1), 1.25% (F2), and 2% (F3). Physical stability evaluations included organoleptic, homogeneity, pH, spreadability, adhesive power, viscosity, and antioxidant tests for 28 days. The results of the research showed that the emulgel that tested the physical stability of emulgel preparations with each concentration produced the best emulgel, F3 with an emulgel concentration of 2%, with a pH of 5.32-5.19, spreadability of 4.47-5.53 cm, adhesive power of 31. 21 -25.64 seconds, and viscosity of 47520-34853 cP. The IC50 value of the emulgel preparation is 17870.83-14851.28 ppm, with statistical test results of sig. (p-value) > 0.05, which means that storage has no effect on the emulgel preparation. The conclusion of this research is the best concentration of Carbopol as gelling agent of emulgel is 2% with the antioxidant activity is very weak Keywords:  emulgel; senggani leaf water fraction; carbopol 940; IC­50

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