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Medical Sains : Jurnal Ilmiah Kefarmasian
Published by Universitas Muhammadiyah Ahmad Dahlan Cirebon
ISSN : 25482114     EISSN : 25412027     DOI : https://doi.org/10.37874/ms
Core Subject : Health,
Medicine & Pharmacology
The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy covering the fields of formulation, pharmacology, communication pharmacy, A natural chemical chemistry, pharmacognomy and other health sciences which is a means for lecturers and researchers in the health sector to share knowledge and establish cooperation in implementing the Tri Dharma of Higher Education. Purpose and Scope The objective of the publication of the Medical Science journal is to publish articles in the field of pharmacy and other health as well as application of pharmaceutical . Based on this, the editorial board of Medical Sains invites lecturers and researchers to contribute to submit research articles related to the following themes: 1. Pharmaceutical formulation technology 2. Pharmacology 3. Community pharmacy 4. Clinical Pharmacy 5. Natural material chemistry 6. Pharmacognosy 7. Pharmaceutical Analysis and Medicinal Chemistry . All papers submitted to medical science journals will be examined by peer review partners who are tailored to their respective fields.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 523 Documents
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ANALYSIS OF NaOCl CONTENT OF HAND & BODY LOTION AND FACE WASH CREAM BY IODOMETRIC TITRATION METHOD Jeli Marlita; Yuyun Febriani; Risma Hayatun Nufus; Muhlisun Azim; Baiq Maylinda Gemantari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1242

Abstract

Cosmetics are needed by the public, such as hand and body lotions and face brightening creams, and there are many misuses of hazardous chemicals in cosmetics, including lotions and face brightening creams. Sodium hypochlorite, a  hazardous chemical, can cause skin damage, such as irritation, rash, hypersensitivity, and burns. The purpose of this study was to determine the presence of sodium hypochlorite compounds and sodium hypochlorite in hand and body lotion cosmetics and face brightening cream. The method used in this research was qualitative analysis with color reaction and quantitative analysis with iodometric titration. The results qualitatively showed that color changes occurred in all samples. NaOCl concentration in hand and body lotion at 0.2% concentration showed an average NaOCl concentration of 3.263 % ± 0.25 and face brightening cream concentration at an average concentration of 10 mg showed NaOCl levels of 88.933 % ± 7.57. Based on this, it was concluded that in the samples of hand and body lotion and face brightening cream, sodium hypochlorite compounds with different levels. Therefore, these samples could have side effects and toxicity in their usefulness as cosmetics. Keywords: Hand & body lotion, face brightening cream, sodium hypochlorite (NaOCl), iodometric titration
REVIEW ARTICLE: NANOHERBAL AS A NATURAL SOLUTION FOR BACTERIAL DIARRHEA PROBLEMS Embas Saraswati, Dewa Ayu; Jafar, Garnadi; Sulaeman, Agus; Mulyani, Yani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1248

Abstract

Diarrhea is a global health problem that is often caused by bacterial infections, including Escherichia coli and Staphylococcus aureus. The use of conventional antibiotics in treating diarrhea often faces challenges, such as drug resistance and adverse side effects. As an alternative, current research interest is focused on the use of nanoparticles from herbal ingredients as potential antibacterial agents in the treatment of diarrhea. This review article aims to present the latest developments in the use of herbal nanoparticles as an anti-bacterial therapy for diarrhea. The literature search method was carried out via PubMed, Science Direct, and Google Scholar using relevant keywords. Selected articles must meet inclusion criteria, such as originality, language, period, and availability of full text. After the selection process, articles that meet the criteria will be reviewed to identify findings related to the use of herbal nanoparticles in treating diarrhea. Data analysis was conducted to compare the findings of each article and draw appropriate conclusions. Therefore, this review article aims to provide a comprehensive understanding of the potential use of nanoparticles from herbal ingredients as an effective and safe solution to treat diarrhea problems, while also highlighting interesting research possibilities to be carried out in the future. effectiveness and bioavailability in the treatment of diarrhea. By increasing absorption and penetration into bacterial cells, this therapy can serve as an effective and sustainable antibacterial agent ...
DETECTION OF WHITE RICE ADULTERANTS IN LAMPUNG ROBUSTA COFFEE EXTRACT USING FT-IR METHOD BY FINGERPRINT ANALYSIS AND PRINCIPAL COMPONENT ANALYSIS Ivan Andriansyah; Liling Dwi Ambaga; Reza Pratama; Fauzan Zein Muttaqin
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1254

Abstract

Lampung Province has 3 areas that produce coffee: West Lampung, Tanggamus, and Waykanan, which can produce 51,484 tons of coffee annually. The high demand for coffee and limited harvest are some factors that cause the addition of adulterants to coffee products such as corn, soybeans, rye, coffee beans, and rice. This study aims to detect rice adulterants in Lampung robusta coffee using the FTIR spectrophotometric method combined with chemometric analysis using the PCA (Principal Component Analysis) method. FTIR spectrophotometric method combined with chemometric analysis using PCA (Principal Component Analysis) method. The PCA method was validated using the cross-validation method. Samples were taken from 3 Lampung coffees on the market. The extraction process was carried out on Lampung coffee and Lampung rice from 3 regions using 96% ethanol. After concentrating, the coffee and rice extracts were measured using FTIR and read in the 4000-650 cm-1 wave number range. Different wave number curves were obtained between coffee and rice. A pre-processing chemometric analysis was performed, which resulted in the classification of Robusta coffee and rice using PC1 and PC2 (50% and 24%). The results of PCA analysis showed that PC1 and PC2 in the three Lampung coffee samples, samples A and C, did not contain adulterants, while sample B was suspected of containing white rice.  Keywords: Alduteran, FTIR, Chemometrics, PCA, Lampung Robusta Coffee.
POTENTIAL ANTIOXIDANT ACTIVITY OF SURUHAN LEAF AND STEM EXTRACT (Peperomia pellucida L. Kunth) USING THE DPPH METHOD AND DETERMINATION OF PHENOLIC AND FLAVONOID LEVELS Sodik, Jajang Japar; Budiana, Wempi; Roni, Asep; Wahyudin
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1264

Abstract

Antioxidants are compounds that are capable of neutralizing free radicals. One plant with potential antioxidant properties is Peperomia pellucida. Objective: This study aimed to determine the antioxidant activity, total phenolic content, and total flavonoid content of extracts of the leaves and stems of Peperomia pellucida. Methods: Antioxidant activity was tested using the DPPH method, while the total phenolic and flavonoid contents were measured using UV-Vis spectrophotometry. Extraction was performed via reflux using three different solvents: n-hexane, ethyl acetate, and ethanol. Results: The highest antioxidant activity was found in the ethanol extract of the leaves, with an IC50 value of 36.85 µg/mL, and in the stems, with an IC50 value of 71.28 µg/mL. The highest total phenolic content in the ethanol extract of the leaves was 14.46 mg GAE/g and that in the stems was 12.82 mg GAE/g. The highest total flavonoid content in the ethanol extract of the leaves was 12.12 mg QE/g and that in the stems was 10.49 mg QE/g. Conclusion: The results indicated that the ethanol extract of Peperomia pellucida leaves exhibited very strong antioxidant activity. Keywords: antioxidants, DPPH, phenolic, flavonoids, suruhan Plants
SYNTHESIS OF CHALCONE AND PYRAZOLINE DERIVATIVES WITH ACETOPHENONE AND VERATRALDEHYDE AS PRECURSORS Fatmayanti, Baiq Risma; Habibie, Ahmad; Dhey, Anselmania Kartini
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1274

Abstract

Chalcones and pyrazolines are heterocyclic compounds with promising biological and pharmaceutical activities. Chalcone and pyrazoline can be found in different sources, such as natural and synthetic compounds. This study aimed to explore the synthesis of chalcone and pyrazoline derivatives with acetophenone and veratraldehyde as precursors. Chalcone was successfully synthesized through the Claissen-Schmidt reaction between acetophenone and veratraldehyde at room temperature 25-30 ºC and mediated by KOH as a base catalyst for 20 hours. The corresponding substituted pyrazoline derivative was also successfully synthesized through a cyclocondensation reaction between the synthesized chalcone and phenylhydrazine as starting materials under reflux conditions at temperatures of 75-80 ºC for 4 hours. The Chalcone A derivative compound obtained was (E)-3-(3,4-dimethoxy phenyl)-1-phenyl prop-2-en-1-one (Chalcone A). The Pyrazoline A derivative compound was obtained as pyrazole compound 5-(3,4-dimethoxy phenyl)-1,3-diphenyl-4,5-dihydro-1H-pyrazole (pyrazoline A). Chalcone A and Pyrazoline A obtained as yellowish and brownish-orange powders in 14.89 % and 66.57 % yields, respectively. The chastities of Chalcone A and Pyrazoline A was 98.55 % and 88.54 %, respectively. A qualitative identification for both synthesized compounds was performed using normal-phase thin-layer chromatography which revealed the Rf value for Chalcone A and Pyrazoline A was 0.43 (in mobile phase ethyl acetate:n-hexane 3:1 v/v) and 0.55 (in mobile phase DCM:n-hexane 3:1 v/v), respectively. Moreover, the elucidation structure of synthesized compounds using FTIR and GC-MS instruments revealed the structure of synthesized Chalcone A and Pyrazoline A agrees with the theoretical structure of Chalcone A and Pyrazoline A. Keywords: Synthesis, Chalcone, Pyrazoline, Acetophenone, Veratraldehyde
IN SILICO IDENTIFICATION OF BREADFRUIT PLAN COMPOUNDS (Artocarpus atilis) AGAINST ANGIOTENSIN-CONVERTING ENZYME 2 AS A CANDIDATE MODEL OF COVID-19 INHIBITORS Fauzi, Muhammad; Soemarie, Yulistia Budianti; Hasniah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1275

Abstract

The spread of COVID-19 has continued to grow rapidly worldwide. This disease is characterized by the presence of severe respiratory syndrome disorders in humans. The ACE2 receptor is the gateway for the COVID-19 virus to target cells, where it is expressed in airway epithelial and vascular endothelial cells. Breadfruit (Artocarpus altilis) contains active flavonoids. Flavonoid derivatives found in breadfruit include artonin-E, cycloaltilisin-7, cycloaltilisin, isocyclomorusin, cyclomorusin, cyclomulberrin, isocyclomulberrin, cyclocommunal, morusin, quercetin and artocarpin. This study aimed to determine the flavonoid derivative of breadfruit (Artocarpus altilis), which has the most effective potential against the ACE2 receptor, as a candidate inhibitor of the COVID-19 virus in silico. The results showed that of the eleven flavonoid derivatives of breadfruit (Artocarpus altilis) tested, 3 compounds gave the lowest binding affinity value, namely cycloaltilisin -8.79 kcal/mol, cyclomulberrin -8.95 kcal/mol, and artocarpin -9.30. kcal/mol compared to Chloroquine -7.67 kcal/mol and Hydroxychloroquine -7.22 kcal/mol. The predicted results of the Lipinski Rule of Five showed that the 3 compounds and the comparison drug met the Ro5 rule. The compounds cycloaltilisin, cyclomulberin, and artocarpine have antiviral activity, as indicated by the Pa value in the range of 0.5<Pa<0.7. Cycloaltilisin, cyclomulberin and artocarpine are the most effective compounds to be developed as candidates for COVID-19 inhibitors. Keywords: Breadfruit, ACE-2, Covid-19, In Silico
ANALYSIS OF FACTORS AFFECTING THE QUALITY OF LIFE OF PROLANIS PATIENT WITH TYPE 2 DIABETES MELLITUS Handayani, Dian; Salsabila, Jihan; Versita, Riana; Pranata, Meki
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1277

Abstract

Diabetes mellitus is an infectious disease characterized by hyperglycemia due to abnormalities in insulin secretion action or both. The goals of diabetes mellitus therapy include reducing symptoms and complications, reducing mortality, and improving the quality of life of patients with diabetes mellitus. This study aimed to provide an overview of the quality of life and the correlation between the characteristics of respondents and the quality of life of patients with type 2 diabetes mellitus who received oral antidiabetics. This study used observational analytics with a cross sectional design of 84 respondents. Patients' quality of life was measured using the Diabetes Quality of Life Clinical Trial Questionnaire (DQLCTQ). Data analysis was performed using an Independent Sample T-test. The results of this study showed that the quality of life of patients with type 2 diabetes mellitus was classified as good (56%) and there were significant differences between the two groups in the domains of health pressure, personal satisfaction, and trial effects on the DQLCTQ questionnaire; there were significant differences in BMI, duration of DM, and treatment type on the quality of life of prolanis patients with type 2 diabetes mellitus.  Keywords: type 2 diabetes mellitus, quality of life, DQLCTQ
ANTIBACTERIAL ACTIVITY TEST OF TEA TREE AND LEMON OIL COMBINATION AND ITS FORMULATION IN CREAM PREPARATION Sulistiorini Indriaty; Rima Yulia Senja; Deni Firmansyah; Nur Rahmi Hidayati; Nina Karlina; Muhammad Yani Zam Zam; Dhea Aulia Ramadhani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1278

Abstract

Tea tree oil contains hydrocarbon compounds, namely terpenes, especially monoterpenes, sesquiterpenes, and alcohols. Terpinen-4-ol is the main component of tea tree oil, which has antimicrobial activity. Lemon oil is useful as an antibacterial because it contains flavonoids that prevent attacks from pathogenic bacteria. This study aims to determine whether tea tree and lemon oil have antibacterial activity against Propionibacterium acnes bacteria and can be formulated into cream preparations. The antibacterial activity test of the combination of tea tree oil and lemon oil in the 1: 1, 1: 2, and 2: 1 ratio was carried out in vitro against Propionibacterium acnes bacteria by disc diffusion method and using virile gel as a positive control. The cream stability test is replicated using the cycling test method with organoleptic test parameters, homogeneity, pH, dispersion, cream type testing, viscosity, and flow properties. The stability test results with the cycling test method showed good stability results, including organoleptic tests, homogeneity, spreadability, pH, emulsion type, viscosity, and flow properties. The combination of tea tree and lemon essential oils in a 1:1, 1:2, 2:1 ratio has antibacterial activity against Propionibacterium acnes bacteria with inhibition zones diameter ±1,23 cm, ±1,12 cm, and ±1,12 cm and control has ±1,53 cm. Combining tea tree and lemon essential oil in a 1:1, 1:2, and 2:1 ratio has antibacterial activity against Propionibacterium acnes bacteria and can be formulated into cream preparations. Keywords: tea tree oil, lemon oil, antibacterial, Propionibacterium acnes, cream.
DEVELOPMENT OF SUNSCREEN PRODUCTS CONTAINING Stichopus hermanii Semper, 1868 Widyowati, Ulfi; Genatrika, Erza; Djalil, Asmiyenti Djaliasrin
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1138

Abstract

Prolonged radiation from UV sunlight has been known to be responsible for skin damage. Sunscreen has been used to limit sun exposure. Sunscreen with natural ingredients has the potential to be developed along with the issue of side effects of synthetic ingredients. This study aimed to develop a zooceuticals sunscreen cream containing a Stichopus hermanii Semper, 1868 extracts. The sunscreen creams were formulated with various ingredients of extract include 0.05 (F1), 0.1 (F2), and 0.2 (F3) %, respectively. The in vitro sun protection factor, organoleptic properties, homogeneity, pH, viscosity, spreadability, and adhesion of the creams were evaluated. F3 met the requirements of physical properties. The extract show sun-protective efficacy with SPF value of 2.11 (F1), 3.09 (F2), and 3.46 (F3). Sunscreen containing 0.2% of Stichopus herrmanni extract is the most preferred formulation with minimal protection category.  Keywords: Sea Cucumber, Stichopus hermanii Semper, 1868, Sunscreen.
REVIEW: THE RELATIONSHIP BETWEEN KNOWLEDGE AND MEDICATION ADHERENCE IN TYPE 2 DIABETES PATIENTS Puspitasari, Neneng Eva; Wahyuningsih, Sri
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1175

Abstract

Diabetes mellitus poses a major threat to human health, as evidenced by the increasing prevalence of diabetes, and the number of cases of diabetes in Indonesia is anticipated to rise from 10.7 million in 2019 to 13.7 million by 2030.The lack of public knowledge and compliance with treatment has caused the incidence of the disease to increase every year. This Review aimed to determine the relationship between knowledge of medication compliance in patients with type 2 diabetes mellitus. The primary data methods obtained were national and international journals using search engines such as Google Scholar, PubMed, and Science Direct, as well as other search engines with the Narrative Review pattern.  The search result of the publications obtained 769 articles; 40 articles screened full text based on the results of the screening that received 18 articles that met the inclusion criteria and were used as a review. The analysis of data writing in this article is mostly based on cross-sectional study approaches. Surveys were conducted within a three-month period. The results showed that knowledge had a significant relationship with drug consistency (p-value value = 0, 000 < 0.05). Knowledge is very much related to the medication compliance of each individual; the higher a person's knowledge, the better the attitude of compliance with diabetes drug consumption. Keywords: Compliance, Knowledge, Type 2 Diabetes, Narrative Review.

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