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Ahmad Shafwan S. Pulungan
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Program Studi Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Negeri Medan Jl. Willem Iskandar Psr V Medan Estate, Sumatera Utara
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JBIO: jurnal biosains (the journal of biosciences)
Published by Universitas Negeri Medan
ISSN : 24431230     EISSN : 24606804     DOI : https://doi.org/10.24114/jbio.v6i1
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology
Jurnal Biosains (JBIO) features works of exceptional significance, originality, and relevance in all areas of biological science, from molecules to ecosystems, (ie genetic, microbiology, ecology, biosystematic, biostatistic) including works at the interface of other disciplines, such as chemistry, medicine,physic and mathematics. We also welcome data-driven meta-research articles that evaluate and aim to improve the standards of research in the life sciences and beyond. Our audience is the international scientific community as well as educators, policy makers, patient advocacy groups, and interested members of the public around the world.
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 269 Documents
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PROCESSING AND EVALUATION OF TONIC HAIR EXTRACT OF SINGKONG LEAVES (Manihot esculenta Crantz): COMBINATION OF ROSE WATER SQUEEZED (Rossa sp) IN MALE RABBITS Sofia Rahmi Tambusai; Dian Ika Pebrina Meliala; Desi Damayanti
JBIO: jurnal biosains (the journal of biosciences) Vol 7, No 3 (2021): Jurnal Biosains
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v7i3.28368

Abstract

Hair growth cosmetics that make hair grow and stimulate hair growth due to baldness and hair loss are often called hair tonics. The alternative to natural ingredients used for hair tonic cosmetics as hair growth by rubbing then on the scalp, cassava leaves are used which can accelerate hair growth and reduce the occurrence of hair loss because the cassava leaves contain vitamin C and organic compounds, such as flavonoids, tannins, triterpenoids, and saponins. Hair tonic processing in this study used an experimental method by processing cassava leaves into extracts with a concentration of 5%; 7.5% and 10%, mixed with additional ingredients in the form of rose water juice, propylenglycol, nipagin, nipasol, BHT, menthol, and methyl paraben. These preparations were then tested on male rabbits weighing 1.5-2 kg, and Observed for four weeks. Processed hair tonic is given in an orderly manner in the specified part. Extracting hair used tweezers so that it can be observed. In the 20 plucked hairs, choosen the 10 longest strands of hair and measure them with a caliper. The period of hair removal is once a week. This research concluded that the processed hair tonic of cassava leaf extract, a combination of rose water juice, can be processed at a concentration of 5%; 7.5%, and 10%. The 10% concentration of hair tonic in the cassava leaf extract, the combination of the juice of rose water, resulted in a better hair length growth of 0.30 mm when compared to Natur's processing of 0.25 mm.
ACTIVITY OF JAVA ACID LEAF EXTRACT (Tamarandus indica L.) ON BLOOD GLUCOSE LEVELS OF RABBIT DRAIN INDUCED BY STREPTOZOTOCIN Bunga Rimta Barus; Sofia Rahmi
JBIO: jurnal biosains (the journal of biosciences) Vol 7, No 3 (2021): Jurnal Biosains
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v7i3.28579

Abstract

One of the plants commonly used as medicinal ingredients is tamarind leaf (Tamarindus indica L.). This plant belongs to the Leguminoceae family which has antidiabetic activity. This study aims to determine the antidiabetic activity of tamarind leaf capsule (Tamarindus indica L.) and determine the effective dose that acts as an anti-diabetic. This study used male white rabbits that had previously been induced with streptozotocin at a dose of 60 mg/kgBW. Rabbits were divided into five treatment groups, namely CMC-Na (negative control), glibenclamide 0.45 mg/kgBW (positive control) and tamarind leaf capsules at a dose of 50 mg/kgBW, 100 mg/kgBW and 200 mg/kgBW. The results obtained were analyzed by statistical test One way ANOVA and Tukey test. The results obtained that tamarind leaf capsules at a dose of 200 mg/kgBW have antidiabetic activity close to glibenclamide at a dose of 0.45 mg/kgBW. The results of the One Way ANOVA test obtained a significance value (p < 0.05) and when continued with the Tukey test, the results showed that tamarind leaf capsules at a dose of 100 mg/kgBW and a dose of 200 mg/kgBW had no significant difference in decreasing blood glucose levels. This means that both doses are effective as antidiabetic doses which are comparable to glibenclamide 0.45 mg/kgBW.
MANUFACTURE OF ACTIVE CARBON TABLETS FROM SALACCA (SALACCA ZALACCA) SEEDS AS ANTI-DIARY TREATMENT Christica Ilsanna Surbakti; Bunga Rimta Barus
JBIO: jurnal biosains (the journal of biosciences) Vol 8, No 1 (2022): JBIO: jurnal biosains (the journal of biosciences)
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v8i1.32356

Abstract

Salak seeds (Salacca zalacca) used to be considered as waste that is not useful and just thrown away. Now with advances in technology, some of the by-products of salak seeds can be processed into more economical products such as activated carbon which can be used as a treatment for diarrhea because it acts as an adsorbent. The method used to make activated carbon tablets is the wet granulation method with 2 kinds of formulas. The physical properties of the tablets were tested, including weight uniformity, hardness, friability and tablet disintegration time. Pharmacological testing on this activated carbon tablet which is used for the treatment of diarrhea will be tested on rats given orally and observed for 3 days.and the maximum result is the addition of 250 mg of activated carbon where the weight of the feces is reduced by up to 30%
pH, WATER AND FAT CONTENT ANALYSIS OF INTEGRATED FORMULATION OF HERBS AND SPICES IN TYPICAL SIMALUNGUN “TINUKTUK” Marini Damanik; Risti Rosmiati; Tyas Permatasari; Syarifah Ayuni; Tia Aulia Surbakti
JBIO: jurnal biosains (the journal of biosciences) Vol 8, No 1 (2022): JBIO: jurnal biosains (the journal of biosciences)
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v8i1.33534

Abstract

The use of spices and herbs is a functional food product that is believed to be efficacious for health and can increase the body's immunity or is usually called an immunomodulator. Tinuktuk has very good properties for the health of the body. By warming the body and also counteracting free radicals with antioxidant activity. This study aims to determine the optimization of the dose of the main components of red ginger and black pepper to produce Tinuktuk with high nutritional value by preparing with an oven. The process in this method uses the percentage of the ratio variation of 70:30, 60:40, 50:50, 40:60, and 30:70. Then, the quality of the tinuktuk was tested, namely: the pH, moisture and fat content. The oven method showed that the pH values from the ratio of 70:30, 60:40, 50:50, 40:60, and 30:70 were 6.15, 6.25, 6.25, 6.25, 6,3, respectively. Beside, for the water content was 56.61%, 54.68%, 54.065%, 49.395%, 45.265% and fat content was 15.52%, 18.35%, 15.46%, 19.39%, 16.50%.@font-face {font-family:"Cambria Math"; panose-1:2 4 5 3 5 4 6 3 2 4; mso-font-charset:0; mso-generic-font-family:roman; mso-font-pitch:variable; mso-font-signature:-536869121 1107305727 33554432 0 415 0;}@font-face {font-family:Rosarivo; panose-1:2 11 6 4 2 2 2 2 2 4; mso-font-charset:0; mso-generic-font-family:auto; mso-font-pitch:auto; mso-font-signature:0 0 0 0 0 0;}p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-unhide:no; mso-style-qformat:yes; mso-style-parent:""; margin:0cm; text-align:justify; line-height:115%; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman",serif; mso-fareast-font-family:"Times New Roman"; mso-ansi-language:IN; mso-fareast-language:EN-ID;}.MsoChpDefault {mso-style-type:export-only; mso-default-props:yes; mso-ansi-language:IN; mso-fareast-language:EN-ID;}.MsoPapDefault {mso-style-type:export-only; text-align:justify; line-height:115%;}div.WordSection1 {page:WordSection1;}
EFFECTS OF PHYSICAL ACTIVITY Fast Interval Training AND PROVISION OF MELINJO SKIN EXTRACT (Gnetum gnemon) ON EXPRESSION OF URAT1 TRANSPORTER, GLUT9 AND SGLT2 IN HYPERURICEMIA INSULIN RESISTANCE Armansyah Maulana Harahap; Yetty Machrina
JBIO: jurnal biosains (the journal of biosciences) Vol 8, No 1 (2022): JBIO: jurnal biosains (the journal of biosciences)
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v8i1.29105

Abstract

Observational studies and randomised controlled studies suggest Increased prevalence of hyperuricemia is a decrease in physical activity and high consumption of purines. Disruption of urate reabsorption causes changes in the main functions of transporter proteins in the proximal tubule membrane. One of them is the intake of URAT1 and efflux by GLUT9 and also for the expression of SGLT2. Insulin resistance causes disturbances in glucose uptake in (SGLT2) and urate. The mechanism of glucose uptake can be mediated by exercise and effect of melinjo skin extract. A Technical Expert Panel (TEP) of 2 medical specialist and expertise of disorder the urinary system performed the review using the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) model. The TEP planned a research on PubMed selecting “Hyperuricemia” as MeSH (Medical Subject Headings) term adding to PubMed Search Builder the terms “Exercise” and “Melinjo skin extract”. TEP is considered for eligibility articles published within the last 10 years, including original research, in particular in vitro studies, and animal and clinical studies in English. Results: Of the 90 identified studies, TEP included 15 studies, 8 animals, and 4 clinical studies and 3 Review. Conclusion: Our scoping review describes and summarizes the important role of exercise and the effect of melinjo peel extract in modulating uric acid levels, Insulin resistance and up-and-down regulation of urate transportersKeyword: Hyperuricemia, URAT1, GLUT9, SGLT2, Exercise
THE IDENTIFICATION OF ANTIBACTERIAL COMPOUNDS IN CLOVE STEM EXTRACT (Syzygium aromaticum) AND ITS EFFECTIVENESS IN INHIBITING THE GROWTH OF Escherichia coli Yunita Diyah Safitri; Ana Amalia; Fatimah Fatimah; Afidatul Muadifah
JBIO: jurnal biosains (the journal of biosciences) Vol 8, No 1 (2022): JBIO: jurnal biosains (the journal of biosciences)
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v8i1.28089

Abstract

Clove plants usage in daily life is very diverse, such as kitchen spices, mixtures of various drinks, and medicines. Clove is a spice plant that contains clove oil which is known as an antibacterial agent. The clove stem has a fairly high clove oil content, but this is not widely known by the public. Clove oil is known to have the ability as a fungicide, bactericide, insecticide, and nematicide. The purpose of this study is to identify antibacterial compounds and the effectiveness of clove stem extract on the growth of Escherichia coli. We used GCMS (Gas Chromatography Mass Spectrometry) analysis to identification antibacterial compounds. Antibacterial activity test using paper disc method by measuring the diameter of the inhibition zone formed from clove stem extract at doses of 30%, 50%, and 70% against Escherichia coli. The results of the study were analyzed using ANOVA with significance (p<0.05). The identification of the active compound showed 13 kinds of compounds were found with the dominant compound was alpha-pinene. The results of the antibacterial test showed the antibacterial activity of clove stem extract at doses of 30%, 50% and 70% with inhibition zones formed 12 mm, 12.7 mm, and 14.1 mm respectively. 
Coliform AND Escherichia coli TESTS IN THE AIR OF THE WELLS OF THE VILLAGE SIDO MAKMUR KUALA DISTRICT LANGKAT DISTRICT Wulandari Wulandari; Mhd Yusuf Nasution; Hudson Sidabutar; Ahmad Shafwan S Pulungan
JBIO: jurnal biosains (the journal of biosciences) Vol 8, No 1 (2022): JBIO: jurnal biosains (the journal of biosciences)
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v8i1.18755

Abstract

Dug well water is a source of clean water that is used by 99.39% of the residents of Sido Makmur Village, Kuala District, Langkat District to meet their daily needs. The majority of people who have cow pens around dug wells trigger the importance of conducting microbiological water quality research, given the existence of dug wells that are very vulnerable to cow manure contamination. Therefore the research sample was taken based on the distance of the dug well with a cattle pen that is less than 5 meters. Five samples from Inpres Hamlet, Petak Dua Hamlet, Handayani Hamlet, Sidorejo Hamlet and Mandailing Hamlet were tested using the Most Probable Number (MPN) method in the North Sumatra Province Health Laboratory, to determine the presence of Coliform and Escherichia coli through the estimation test, assertion test , and test the completeness and coloring of grams. Then a biochemical reaction test is performed to confirm the presence of Escherichia coli. The results showed that all dug well water samples with sample codes ASG 01, ASG 02, ASG 03, ASG 04 and ASG 05 were positively polluted by Coliform through assertion tests with total Coliform exceeding the 80% threshold and below the threshold of 20% based on Minister of Health Regulation No. 416 / MENKES / PER / IX / 1990 concerning Requirements and Supervision of Water Quality. Then there is also the content of Escherichia coli in the five samples which exceeds the established threshold, the positive results of E.coli have also been strengthened through the results of gram staining and biochemical reaction tests. Therefore the dug well water samples tested are not feasible or do not meet the microbiological quality requirements for clean water.
Suspension Stability Ethanol Extract Of Frankincense Gum (Styrax Benzoin) Nora Susanti; Yosia Gopas Oetama Manik; Jamalum Purba
JBIO: jurnal biosains (the journal of biosciences) Vol 8, No 2 (2022): JBIO: jurnal biosains (the journal of biosciences)
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v8i2.33622

Abstract

Sap is a very important commodity in the industrial pharmacy, perfumes and medicines contain abundant active compounds of frankincense making resin widely used. Extraction and solvation processes play an important role in the production of stable frankincense extract. One of the widely used preparations is suspension, which is an active compound that does not dissolve in water to become soluble. The purpose of this study was to determine the manufacture of a suspension of frankincense gum extract as an active pharmaceutical ingredient. The method used was precipitation using cosolvent, surfactant and agitation process at 1500 rpm at a temperature of 40oC. Various comparisons were analyzed for phytochemical screening, viscosity and pH. in the most stable formula to be tested, the size of the suspension particles found that frankincense extract was soluble in distilled water with an average particle size is 4.80205 μm. .
GCMS ANALYSIS OF BIOACTIVE COMPOUNDS OF CHINESE BEAT LEAVES (Peperromia pellucida) WITH EXTRACTION APPLICATION USING SOXHLET ATION METHOD Armansyah Maulana Harahap; Nila Zusmita Wasni; Indra Priawan M
JBIO: jurnal biosains (the journal of biosciences) Vol 8, No 3 (2022): JBIO: jurnal biosains (the journal of biosciences)
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v8i3.33512

Abstract

Chinese betel leaf (Perperomia pellucida) is generally widely used as a medicinal plant. Many people use Chinese betel leaf as a traditional medicine based on natural ingredients which are believed to be able to treat various diseases with fewer side effects than synthetic drugs. In general, China betel leaf has several secondary metabolites, generally flavonoids, steroids, alkaloids and terpenoids. However, in testing for secondary metabolites, there is still no clear description of the plant parts taken. So this study aims to determine the secondary metabolites in the young leaves of Chinese betel (Peperromia pellucida) by gas chromatography. The results obtained based on the GCMS analysis contained 18 secondary metabolites. Phytol, 2,3-BIS (4-(CA RBOXYMETHYL) PHENYL) BENZO [B] FURAN, and 6-ALLYL-4,5 -DIMETHOXY- 1,3-BENZOD IOXOLE are the 3 highest bioactive com pounds based on the percentage of content.
ANTIOXIDANT POTENTIAL OF RED AND WHITE CABBAGE: A COMPARISON Huyen-Trang Thi Tran; Khairiza Lubis; Hau Van Doan; Thach N Ho; Kieu-Tien T Nguyen
JBIO: jurnal biosains (the journal of biosciences) Vol 8, No 2 (2022): JBIO: jurnal biosains (the journal of biosciences)
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v8i2.36656

Abstract

This study aimed to compare the antioxidant activity of white cabbage (B. oleracea var. capita f. alba) and red cabbage (B. oleracea var. capita f. rubra) in vitro. Dried cabbages were extracted by Soxhlet extraction using chloroform as solvent. The extracts were screened for phytochemicals followed by the antioxidant capacity measurement through free radical scavenging activity (DPPH and ABTS). The results showed that red cabbage extract (RCE) significantly had stronger antioxidant activity than white cabbage (WCE) (P<0,05). The IC50 values of RCE were 350,80 ± 5,27 µg/ml (DPPH) and 87,03 ± 1,92 µg/ml (ABTS) while these of WCE were 613,75 ± 8,76 µg/ml and 114,57± 0,41 µg/ml, respectively. Moreover, a higher level of phytoconstituents was found in RCE based on thin-layer chromatography analysis. These findings support that red cabbage has higher antioxidant activity than white cabbage which may be correlated with its phytoconstituents concentration.

Page 19 of 27 | Total Record : 269

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