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Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Published by Universitas Katolik Widya Mandala Surabaya
ISSN : 23388404     EISSN : 26572311     DOI : https://doi.org/10.33508/jfst
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Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) is published twice a year in March and October, containing research articles, review and short communication in the pharmacy science field, including medicinal chemistry, analytical chemistry, biological pharmacy, pharmaceutical sciences, and clinical pharmacy researches; the practice of pharmacy in industry, clinic and community, such as pharmacies, distributors and pharmacy education.
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Articles 172 Documents
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Olaparib As Therapy For Metastatic-Castration Resistant Prostate Cancer : Systematic Review And Meta Analysis Putra Gunawan, I Made Rian; Herawati, Fauna; Kirtishanti, Aguslina
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 11 No. 1 (2024): February
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v11i1.5284

Abstract

Prostate cancer is the second most prevalent cancer in men with approximately 1.4 million men worldwide. The main therapy for prostate cancer is androgen deprivation therapy (ADT), but patients who have received ADT may experience a condition of castration resistant prostate cancer (CRPC). More than 84% of patients have metastasized when diagnosed with CRPC (mCRPC) and median survival about 36 months. The Food & Drugs Association (FDA) has approved a new therapy for mCRPC patients, an example is olaparib. The purpose of this systematic review and meta analysis is to assess effectiveness (overall survival) and safety of olaparib in mCRPC. This research is using randomized control trial’s (RCT) article. The literature search process was carried out using the PubMed database. The quality of inclusion was assessed using the Critical Appraisal Skill Program (CASP) checklist and journal reputation. The results of the meta-analysis on the effectiveness of olaparib has showed that there was no significant difference in the patient's overall survival rate (RR=0. 81; 95% CI=0.58-1.13). The results of the meta analysis on the safety level of olaparib has showed a significant difference, seen from the side effects such as anemia (RR=3.47; 95% CI=2.59-4.65), nausea (RR=2.05; 95% CI=1.62-2.60) and fatigue (RR=1.32; 95% CI=1.10-1.59). The conclusion is olaparib as mCRPC therapy does not show significant effectiveness in improving overall survival in mCRPC. In addition, the low safety level of olaparib in mCRPC patients were seen from side effects such as anemia, nausea and fatigue
Perbedaan Kombinasi Konsentrasi Bahan Pengikat Pati Garut (Maranta Arundinaceae. L) Dan Pati Talas (Colocasia Esculanta L. Scoot) Terhadap Karakteristik Fisik Sediaan Tablet Hisap Ekstrak Jahe Merah (Zingiber Officinale Var. Rubrum) Devi, Sisca; Baiti, Hilma Nur
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 11 No. 2 (2024): October
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v11i2.5290

Abstract

Red ginger contains gingerol which is used as a throat lozenge. One of the dosage forms used in developing the use of red ginger is lozenges. Making lozenges requires additional ingredients in the form of a binder which can be obtained from starch. Arrowroot starch and taro starch contain amylose and amylopectin which have the ability to adhere. The combination of the use of arrowroot starch and taro starch binders has an impact on the characteristics of the lozenges produced. This research aims to determine the differences in the combination of using concentrations of binding agents, namely arrowroot starch and taro starch, on the physical characteristics of red ginger extract lozenges.This research is an experimental study with the independent variable being the combination of concentrations of arrowroot starch and taro starch (100:0); (50:50); (0:100). Testing of the physical characteristics of red ginger extract lozenges included organoleptic and tablet dimensions, weight uniformity, tablet hardness and friability and disintegration time. Analysis of normally distributed and homogeneous data using One-Way Anova at a confidence level of 95% followed by Post Hoc testing. The Kruskal-Wallis test is used for data that is not normally and homogeneously distributed followed by the Mann Whitney test.The test results showed that the combination of concentrations of arrowroot starch and taro starch binders had an effect on the physical characteristics, namely tablet hardness and brittleness and tablet disintegration time (p<0.05).
Efektivitas Terapi Tocilizumab Terhadap Mortalitas Pasien COVID-19 Derajat Berat di Rumah Sakit “X” Surabaya: studi observasional Djunaidy, Vania Denise; Parwitha, Ida Ayu Andri; Dinillah, Intan Sari Yati; Prawesti, Galuh Nawang; Lestyaningtyas, Nika
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 11 No. 1 (2024): February
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v11i1.5378

Abstract

Tocilizumab merupakan agen inhibitor IL-6 yang direkomendasikan untuk terapi pasien COVID-19 derajat berat hingga kritis. Beberapa penelitian menunjukan hasil yang bervariasi terkait waktu pemberian tocilizumab yang optimal. Peningkatan kadar sitokin yang terjadi pada fase awal COVID-19 memunculkan hipotesis bahwa pemberian tocilizumab lebih awal dapat menurunkan resiko mortalitas pasien. Penelitian ini bertujuan untuk mengetahui efektivitas pemberian tocilizumab dalam waktu 72 jam setelah dirawat di rumah sakit dalam menurunkan angka mortalitas pasien COVID-19 derajat berat yang dirawat di rumah sakit X di Surabaya. Desain penelitian yang digunakan adalah observasional retrospektif pada pasien COVID-19 derajat berat. Subyek dipilih dengan menyamakan karakteristik demografi menggunakan metode propensity score matching untuk kelompok kontrol. Analisis hasil luaran mortalitas dianalisis menggunakan multivariable logistic regression. Sebanyak 98 pasien COVID-19 derajat berat diikutsertakan dalam penelitian, 49 subyek (50%) mendapatkan terapi tocilizumab dan 49 subyek tidak mendapatkan tocilizumab. Dari 49 subyek yang mendapat terapi tocilizumab, sebanyak 30 subyek mendapatkan terapi tocilizumab dalam waktu 72 jam setelah masuk rumah sakit. Hasil penelitian menunjukkan bahwa pemberian tocilizumab dapat menurunkan angka mortalitas yang tidak signifikan (aOR: 0,79; 95% CI: 0,305 - 2,049; p: 0,629). Penurunan angka mortalitas yang lebih besar teramati pada subyek yang mendapatkan tocilizumab lebih awal (aOR: 0,77; 95% CI: 0,42 – 1,85). Pemberian tocilizumab dalam waktu 72 jam pada pasien COVID-19 derajat berat dapat menurunkan resiko mortalitas yang tidak signifikan.
Review Artikel: Keragaman Actinomycetes Laut Indonesia Sebagai Sumber Senyawa Antibiotik Baru Pasmawati
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 11 No. 2 (2024): October
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v11i2.5468

Abstract

Infeksi mikroba patogen merupakan penyebab penyakit paling umum dalam dunia medis. Hasil studi menunjukkan bahwa adanya infeksi bakteri merupakan salah satu hambatan dalam proses penyembuhan yang sering ditemukan dalam perawatan pasien dengan Luka Kaki Diabetes. Salah satu upaya pencegahan pada penyakit infeksi yang disebabkan oleh mikroba patogen adalah menggunakan antimikrobial seperti antibiotik. Review artikel ini dilakukan dengan melakukan kajian literatur ilmiah melalui pencarian literatur menggunakan database Google Scholar, PudMed, dan Science Direct dengan kata kunci “marine”, “Actinomycetes”, “Actinobacteria”, “Antimicrobial”, “Indonesia”. Penelitian ini dilakukan untuk mendapatkan informasi mengenai keragaman dan strain Actinomycetes laut Indonesia yang menghasilkan senyawa metabolit sekunder sebagai antimikroba. Data menunjukkan bahwa terdapat keragaman Actinomycetes laut Indonesia yang tersebar hampir diseluruh wilayah Indonesia. Sampel yang diisolasi diperoleh dari berbagai sampel seperti sedimen, tanah rhizosfer mangrove, lumpur, juga ditemukan berasosiasi dengan rumput laut, lamun, alga merah, timun laut, invertebrata, dan spons. Actinomycetes laut Indonesia yang ditemukan didominasi oleh genus Streptomyces, Micromonospora, Nocardiopsis, dan Micrococcus. Actinomycetes laut lainnya yaitu tergolong ke dalam genus Pseudonocardia, Dermacoccus, Nocardiopsis, Verrucosispora, Kytococcus, Corynebacterium, Brachybacterium, Pseudonocardia, Virgibacillus, Labrenzia, dan Halomonas. Actinomycetes laut tersebut dilaporkan menghasilkan senyawa metabolit sekunder yang memiliki aktivitas antimikroba sehingga sangat berpotensi sebagai sumber senyawa antibiotik baru.
Literature Review: Bioactivity and Drug Formulation of Tapak Dara (Catharanthus roseus) Fadhli, Haiyul; Fadillah, Ma’isyatul; Hazimah, Hazimah; Fitriah, Dina
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 11 No. 2 (2024): October
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v11i2.5696

Abstract

Tapak dara (Catharanthus roseus), also known as Madagascar periwinkle or Vinca, is a tropical plant native to Madagascar and has been widely distributed throughout the world, including in Indonesia. This review article looks at bioactivities and drug formulations using different parts of the Catharanthus roseus plant. Literature sources and data were collected through Google Scholar and Google Books on the topic of formulations and pharmacological activities of Catharanthus roseus, published from 2014 to 2024. This review describes various studies showing the potential of Catharanthus roseus plants in various bioactivities such as antioxidants, anticancer, analgesic, antihyperglycemic, antibacterial, wound healing, anti-inflammatory, hepatoprotective, antihyperlipidemic, and antidiabetic properties. Besides bioactivity aspects, this review also covers formulations involving Catharanthus roseus, including the development of various products such as extracts, ointments, creams, gels, emulgels, and nano emulsions for medical purposes. In conclusion, this article provides an in-depth insight into the bioactivity of the Catharanthus roseus plant and its potential in drug formulations.  
Pengaruh Suhu dan Waktu Penyeduhan Dalam Variasi Jenis Teh Terhadap Kadar Flavonoid Total Menggunakan Spektrofotometri UV-Vis Taufiq, Mawaddah; Yuniarto , Prayoga F.; Sukmawati , Datin An Nisa; Kadir , Mujtahid bin Abd
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 12 No. 1 (2025): March
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v12i1.5805

Abstract

Tea derived from the tea plant (Camellia sinensis) is a plant that consists of many types and is spread in various countries. In tea leaves, the flavonoid content varies. This is caused by several factors: tea plant variety, leaf age, leaf picking method, planting location, temperature, and processing. Based on the habits of people in Indonesia who brew tea with hot water at a temperature of 700C or 1000C in this study, the flavonoid content in each type of tea was extracted using several variations in temperature and brewing time which aims to determine the maximum level of flavonoid content in tea variations. Determination of flavonoid levels in tea that has been extracted will be determined using uv-vis spectrophotometry. The results of this study show that the initial temperature and brewing time affect the total flavonoid content of various types of tea. Flavonoid levels in green tea, oolong tea, black tea, and pu-erh tea have the highest levels at a temperature of 1000C within 10 minutes with green tea levels at 9,80 mg/g, oolong tea 7,02 mg/g, black tea 4,22 mg/g and pu-erh tea 2,61 mg/g. While white tea has the highest level at 1000C in 5 minutes with the highest level of white tea at 3,76 mg/g.
Hubungan Pengetahuan Dan Persepsi Masyarakat Terhadap Minat Beli Sediaan Sirup Di Apotek Terkait Isu Cemaran Etilen Glikol Dan Dietilen Glikol Ramdani, Debby Valenia Azzahra
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 11 No. 2 (2024): October
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v11i2.5813

Abstract

Obat adalah bahan yang dimanfaatkan untuk mengobati penyakit, mengidentifikasi penyakit, mengurangi rasa nyeri serta sakit, dan menyembuhkan berbagai organ tubuh. Jumlah kandungan Etilen Glikol (EG) dan Dietilen Glikol dalam sirup obat yang melampaui kadar yang diperbolehkan telah mengkontaminasi sirup obat yang beredar di Indonesia dan meningkatkan risiko gagal ginjal yang akut dikalangan anak-anak. Dengan pendekatan deskriptif secara kuantitatif, penelitian ini memiliki tujuan untuk menganalisis minat beli masyarakat terhadap sediaan sirup berdasarkan tingkat pengetahuan dan persepsi masyarakat. Dalam penelitian ini, IBM SPSS versi 25 digunakan untuk menganalisis data yang sudah ada dengan sampel purposif sebanyak 60 sampel. Analisis regresi berganda dilakukan terhadap data. Hasil penelitian menunjukkan bahwa Nilai thitung pengetahuan = 2,087 dan persepsi = 2,301 dengan nilai ttabel 2,002 sedangkan nilai Fhitung 5,846 dengan nilai Ftabel 3,16. Dengan demikian, penelitian menunjukkan hasil bahwa pengetahuan dan persepsi masyarakat terhadap masalah kontaminasi etilen glikol dan dietilen glikol secara parsial dan simultan mempengaruhi minat beli sediaan sirup obat di Apotek. Medicines are substances that are used to treat diseases, identify diseases, reduce pain and illness, and heal various organs of the body. The amount of Ethylene Glycol (EG) and Diethylene Glycol content of medicinal syrups that exceeding the allowed levels has contaminated the medicinal syrups circulating in Indonesia and increased the risk of acute kidney failure among children. With a quantitative and descriptive approach, this study aims to analyse public buying interest in syrup preparations based on the level of public knowledge and perception. In this study, IBM SPSS version 25 was used to analyse existing data with a purposive sample of 60 samples. The analysis of multiplication regressions was applied to this data. The study results show that tcount value of knowledge = 2.087 and perception = 2.301 with ttable value of 2.002 while Fcount value is 5.846 with Ftable value of 3.16. The study showed that people's knowledge and perceptions about ethylene glycol and diethylene glycol contamination problems partially and simultaneously affect the interest in buying medicinal syrup preparations at the pharmacy.
Analisa BKO Prednison, Paracetamol, Deksametason, Meloksikam dan Piroksikam dalam Sediaan Obat Tradisional Diana; Setiawan, Henry Kurnia; Ramadhani, Rizky Pratama; Nayotama, Brian; Bimantara, Shandy Aditya
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 11 No. 2 (2024): October
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v11i2.5839

Abstract

AbstrakPenambahan bahan kimia obat ke dalam sediaan obat tradisional masih sering ditemukan. Praktek ini dilarang oleh undang-undang di Indonesia dan dapat menimbulkan efek berbahaya bagi penggunanya. Unsur kesengajaan yang melatarbelakangi hal tersebut, membuat aspek pengawasan sediaan dan penindakan menjadi faktor yang krusial dalam penanganannya. Analisa keberadaan BKO dalam sediaan obat tradisional membutuhkan metode yang handal serta mampu mendeteksi keberadaan beragam BKO yang mungkin ditambahkan ke dalam sediaan. Dalam penelitian ini keberadaan BKO Prednison, Paracetamol, Deksametason, Meloksikam dan Piroksikam dideteksi menggunakan kromatografi lapis tipis-densitometri. Eluasi dilakukan menggunakan kloroform:metanol (9:1) pada fase diam silika yang diamati di λ 240 nm dan 246 nm. Lempeng kemudian dianalisa menggunakan TLC-scanner (densitometri) untuk mendapatkan luas area dibawah puncak untuk masing-masing analit. Metode ini mampu mendeteksi keberadaan BKO dengan konsentrasi 6,5 ppm (Prednison), 3,0 ppm (Paracetamol), 1,8 ppm (Deksametason), 6,0 ppm (Meloksikam), 8,0 ppm (Piroksikam) dalam larutan uji. Metode tervalidasi untuk menganalisa 5 pengotor kimia yang umum dijumpai pada sediaan obat tradisional. Analisis dapat dilakukan secara simultan menggunakan metode sederhana, sehingga sesuai untuk melakukan skrining pengotor yang terdapat dalam obat tradisional. AbstractMisuse of drugs (BKO) in traditional medicinal preparation is still often found. This practice is prohibited by Indonesia’s law and can harm users. Malfeasance behind this problem makes law enforcement and control a crucial factor in handling it. Analysis of BKO requires a reliable method that detects the presence of various BKOs that may be added to the preparation. In this study, Prednisone, Paracetamol, Dexamethasone, Meloxicam, and Piroxicam were detected using thin-layer chromatography–densitometry. Elution was carried out using chloroform:methanol (9:1) on silica stationary phase observed at 240 nm and 246 nm. Plates then analyzed using tlc-scanner (densitometry) to acquire area under curve of each analyte. The method is capable of detecting the presence of BKO with concentration of 6,5 ppm (Prednisone), 3,0 ppm (Paracetamol), 1,8 ppm (Dexamethasone), 5,9 ppm (Meloxicam), 8,0 ppm (Piroxicam) in test solution. The proposed validated method is capable to analyze 5 common chemical impurities often found in traditional drug preparation. Analysis can be done simultaneously using simple method hence it is suitable to used as a tool to screen impurities in traditional medicine.
Efektifitas dan Keamanan Terapi Sodium Glucose Co-transporter 2 (SGLT2) Inhibitor pada Gagal Jantung: Narrative Literatur Review Diniah, Melisa Nur; Suharjono, Suharjono
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 12 No. 1 (2025): March
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v12i1.5866

Abstract

Heart Failure (HF) is a clinical syndrome due to structural or functional defects in the myocardium causing impaired ventricular filling or ejection of blood. HF is currently divided into 3 types namely HFrEF, HFpEF, and HFmEF. In the last 5 years, treatment in HF patients has been updated to be able to use SGLT 2 inhibitor therapy. Initially, SGLT2 inhibitors were a therapy given to patients with type 2 diabetes mellitus. This recommendation was given because SGLT2 inhibitors can reduce the risk of cardiovascular death and reduce the incidence of repeated hospitalizations in HF patients. The safety of SGLT2 inhibitor administration is also reported to not cause serious side effects.
Penetapan Kadar Flavonoid Total berbagai Variasi Pelarut Pada Ekstrak Beras Hitam (Oryza Sativa L.Indica) Dengan Metode Spektrofotometri UV-Vis Mahbub, Khafid; Novitasari , Novitasari
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 12 No. 1 (2025): March
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v12i1.5967

Abstract

Black rice (Oryza sativa L. Indica) is known to have a high anthocyanin compound content, and is included in the flavonoid compound group. The flavonoid content in an extract can be taken using an appropriate solvent. This shows that quality control is needed for the quality of the simplicia and the type of solvent, so that it can obtain quality secondary metabolites. The reason for this study was to determine the effect of 96% ethanol, methanol and acetone solvents on the flavonoid content of black rice extract. Black rice extract was analyzed qualitatively and the amount of flavonoid content. Quantitative testing of the amount of flavonoids used the UV-Vis spectrophotometry method. The results were analyzed using the One Way Anova strategy with a confidence level of 95%. The results showed that 96% ethanol, methanol and acetone extracts of black rice contained flavonoids, alkaloids, tannins, saponins and terpenoids. Theresults of the overall flavonoid test using the UV-Vis spectrophotometry strategyfrom 96% ethanol, methanol and acetone extracts of black rice were 8.6355 mg QE / g, respectively; 8.3713 mg QE/g and 22.4559 mg QE/g. The results of the Tukey One Way Annova test showed that the difference in solvent types had a significant effect on the flavonoid content of black rice extract with a significance value of 0.000 (p<0.05). Acetone solvents were effective in extracting flavonoid compounds compared to  methanol and 96% ethanol solvents

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