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Fakultas Kedokteran Universitas Brawijaya Gedung Graha Medika Lt. 1, Ruang 104
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Kota malang,
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INDONESIA
Jurnal Kedokteran Brawijaya
Published by Universitas Brawijaya
ISSN : 02169347     EISSN : 23380772     DOI : http://dx.doi.org/10.21776/ub.jkb
Core Subject : Health,
Medicine & Pharmacology
JKB contains articles from research that focus on basic medicine, clinical medicine, epidemiology, and preventive medicine (social medicine).
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 822 Documents
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Remained Insect's Body Part in the Corneal Stroma: A Rare Case Report Abdillah, Fauzi; Widyanto, Ilham Aditya; Ariany, Dessira Rizka Tri
Jurnal Kedokteran Brawijaya Vol. 33 No. 3 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.03.12

Abstract

Corneal foreign bodies are the second most common cornea disease after corneal abrasion. The causes of foreign bodies in the cornea vary, most often due to lack of eye protection. Patients with foreign bodies in the cornea usually complain pain, a lump in the eyes, visual acuity deficit, watery eyes, red eyes, sticky eyes, and photophobia. Rapid and effective treatment is needed to avoid the risk of worsening the patient's condition and decreasing vision or even permanent blindness. In this case, we report a 41-year-old male who suffered an eye injury due to insect's body parts remaining in the corneal stroma while riding a motorbike. Foreign body extraction, eye irrigation, topical and systemic antibiotics and steroids, topical cycloplegic are the various treatment modalities for better result. Further examination could be done to find out the chemical elements of insect's toxin so that more adequate therapies can be given. 
Human-induced Pluripotent Stem Cell Potential for Schizophrenia Therapy: A Literature Review Kusumadewi, Andrian Fajar; Adi, Winengku Basuki
Jurnal Kedokteran Brawijaya Vol. 33 No. 3 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.03.6

Abstract

Schizophrenia is a severe and chronic mental disorder characterized by a neurodegenerative process. Currently, there has been no cure for schizophrenia. However, a newer significant potential for modeling and curing schizophrenia has been recognized in human-induced pluripotent stem cells (HiPSCs), which are obtained from adult somatic cell reprogramming. This study aimed to assess the potential of HiPSCs in schizophrenia by reviewing relevant scientific journals published in reputable databases such as Springer, Elsevier, Science Direct, Nature, and Pubmed, in the last 10 years. Research findings indicate that stem cells can help determine the effectiveness of antipsychotics and repair damaged neuronal cells in certain areas of the brain by transplanting programmed stem cells. The proliferative ability of neuronal cells in schizophrenia tends to decline, affecting their physiological neurogenesis. HiPSCs have the potential to return the neuronal function in schizophrenia, offering new hope in psychiatry. 
Mohs Micrographic Surgery for Morpheaform Type Basal Cell Carcinoma: A Case Report Larasaty, Nanda Shaskia; Widiatmoko, Arif; Retnani, Diah Prabawati
Jurnal Kedokteran Brawijaya Vol. 33 No. 3 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.03.9

Abstract

Morpheaform basal cell carcinoma (BCC) is an infiltrative and destructive type of BCC with a high recurrence, necessitating effective and minimally invasive management. Mohs Micrographic Surgery (MMS) is a treatment option for BCC with high conservation results of the entire tumor wall with minimal removal of surrounding healthy tissue, and the lowest recurrence rate compared to other treatment options.  In this study, we report a 48-year-old woman with dark spots on the left cheek area that had enlarged over the past year. Dermatological examinations showed hyperpigmentation patches with indistinct borders, irregular edges, and telangiectasis. Fine Needle Aspiration Biopsy (FNAB) confirmed BCC, and the patient underwent Mohs Micrographic Surgery (MMS) for tumor removal. The post-procedural follow-up showed a good outcome.
Self-Care Management Education Using a Pocketbook on Illness Perception Improvement in Psoriasis Patients Fatma, Endah Panca Lydia; Sari, Dewi Purnama; Rohmadani, Dewi; Windarwati , Heni Dwi; Susanto, Akhiyan Hadi
Jurnal Kedokteran Brawijaya Vol. 33 No. 3 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.03.5

Abstract

Psoriasis is an autoimmune disease affecting the integumentary and organ systems. It impacts daily activities and degrades self-esteem. Meanwhile, there is a minimum amount of literature about self-care management education for Psoriasis. Pocketbooks can be used as an alternate learning tool for self-care management by making them more portable among patients. The aims are to foster a positive perception of illness and self-determination regarding Psoriasis. This study evaluated the effectiveness of providing self-care management education using a pocketbook on the illness perception of Psoriasis. The research employed a mixed-methods design, combining quasi-experimental and qualitative approaches. The study involves 30 participants diagnosed with Psoriasis. Participants are divided into two groups: a control and an intervention group. The Brief Illness Perception Questionnaire (B-IPQ) was utilized to assess the participants' perceptions of their illness before and after the intervention. A paired t-test was used to compare pre-test and post-test scores within each group. A two-sample t-test was employed to compare the mean differences between the control and intervention groups. The significance level was set at a p-value of 0.05. The interview data were transcribed verbatim using thematic analysis. The study indicates a difference in the illness perception of patients between control and intervention groups with a significance value of 0.000. Patients report that understanding triggers and management strategies allow for better health. Pocketbook is a practical education approach improving illness perceptions of Psoriasis. Recognizing triggers and adopting management techniques, patients are able to take steps to deal with flare-ups and improve their well-being.
Depression Levels and CD4 Counts in HIV Patients at Dr. Saiful Anwar General Hospital Malang Budiarti, Niniek; Patra Utama, Haniel; Agustin Purwantiningrum, Danik; Dwiastuti Wisnu Putri, Winarni Dian
Jurnal Kedokteran Brawijaya Vol. 33 No. 3 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.03.2

Abstract

Untreated depression in HIV patients is associated with lower CD4 cell counts attributed to the excessive HPA axis activity, which leads to increased cortisol secretion. This can accelerate the progression of HIV through shifting cytokine production from Th1 to Th2, which triggers CD4 cell destruction and stimulates HIV replication. This study aimed to determine the relationship between depression levels and CD4 counts in HIV patients at Dr. Saiful Anwar General Hospital Malang. This study used a quantitative method with an analytical observational study design and a cross-sectional approach. A total of 30 participants were selected through purposive sampling. The Beck Depression Inventory-II (BDI-II) questionnaire was used to evaluate the participants' depression levels. Six participants were identified with moderate depression, while 24 participants exhibited either no depression or minimal depression. The Spearman's Rank Correlation Coefficient test showed p=0.183, p>0.05, with a correlation coefficient of -0.250, indicating no significant relationship between the depression levels and CD4 cell count in HIV patients at Dr. Saiful Anwar General Hospital Malang. Nevertheless, among the study subjects with moderate depression (6 participants), low CD4 counts (≤345cells/mm3) were observed, suggesting a tendency for depression levels to be associated with CD4 count.
Aminophylline Induced Blood Pressure Decrease in Patients with Acute Phase Non-Hemorrhagic Stroke and Chronic Obstrutive Pulmonary Disease (COPD) Sahil Haikal, Sayyid Muhammad; Dirgantara Putra, Aryo
Jurnal Kedokteran Brawijaya Vol. 33 No. 3 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.03.13

Abstract

Stroke and Chronic Obstrutive Pulmonary Disease (COPD) are two diseases that have high mortality and disability rates in the world. Smoking is one of the risk factors that cause these two diseases. The occurrence of Non-Hemorrhagic Stroke (NHS) and COPD simultaneously in one patient will cause a poor prognosis and more comprehensive treatment. In addition, there are no therapeutic guidelines for these two diseases if they occur together. This case report reports a case of NHS and COPD in a 64-year-old man who received aminophylline therapy. The patient experienced hypotension on the second day of treatment induced by aminophylline administration. Discontinuation of aminophylline therapy in the patient and administration of other supportive therapies for NHS and COPD showed improvements in blood pressure and other medical conditions related to the patient's disease on the sixth day of treatment. A decrease in blood pressure by >15% in the acute phase of NHS is a quite dangerous condition because it causes a lack of collateral blood flow which results in a lack of blood flow in the penumbra area. Administration of aminophylline has the effect of lowering blood pressure because it increases the release of catecholamines that stimulate beta adrenergic to reduce vascular resistance. Aminophylline should be given >48 hours after the attack to prevent the expansion of cerebral infarction and recurrent NHS attacks and strict monitoring is required when administering COPD therapy accompanied by NHS in relation to the effects caused by the administration of this therapy.
Hormonal vs. Non-Hormonal Contraceptives for Women in Relation to Cervical Cancer: A Systematic Review Rusfandi, Annisa Adhania; Agung Indrawan, I Wayan
Jurnal Kedokteran Brawijaya Vol. 33 No. 3 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.03.7

Abstract

Recent global statistics indicate approximately 527,624 new cases of cervical cancer and 265,672 deaths annually. Additionally, recent research has identified a correlation between cervical cancer incidence and the use of hormonal or non-hormonal contraceptives. This systematic review aims to investigate this correlation. Articles meeting inclusion criteria from Google Scholar and PubMed within the last five years were searched. Eight eligible studies were included: six on hormonal contraceptives and two on non-hormonal contraceptives. The review findings suggest that the use of both non-hormonal and hormonal contraceptives increases the risk of cervical cancer. Non-hormonal contraception was associated with a slightly elevated risk, while hormonal contraceptives, especially oral contraceptive tablets used over an extended period, showed a clear link to increased cervical cancer risk.
Association between Clinical Pathway for Cesarean Section and Length of Stay in Dr. Saiful Anwar Regional Hospital Malang Rusfandi, Annisa Adhania; Agung Indrawan, I Wayan
Jurnal Kedokteran Brawijaya Vol. 33 No. 3 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.03.4

Abstract

Cesarean section (C-section) is one of the main medical procedures performed at Dr. Saiful Anwar Regional Hospital in Malang. Implementing a clinical pathway (CP) as a standard of evidence-based care can influence the length of hospital stay for patients. This study aims to analyze the relationship between CP implementation and the length of hospital stay for C-section patients at Dr. Saiful Anwar Regional Hospital. The analysis was based on data from CP forms and patient medical records. The lowest CP implementation score in this study was 89.86%. A correlation test across all samples (n=97) revealed a significant relationship between CP implementation and length of stay (correlation coefficient: 0.246, p=0.008). Dividing the samples into four groups based on the most frequent diagnosis categories (placenta previa, PROM (Premature Rupture of Membranes), preeclampsia, and placenta accreta) showed significant differences in the length of stay between patients with PROM and those with preeclampsia (p=0.0001) and placenta accreta (p=0.002). The CP implementation rate for all C-section patients was above 80% and was significantly correlated with the length of hospital stay. In the future, CPs specifically designed for different C-section indications may be developed to accommodate various patient conditions.
Optimizing Burn Injury Care: A Comparative Network Meta-Analysis of Skin Grafts' Efficacy Del Rosario Puling, Imke Maria; Pramana Giri, Nyoman Deva; Almadita, Teresa; Limantara, Jane; Arviansyah, Arviansyah
Jurnal Kedokteran Brawijaya Vol. 33 No. 3 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.03.8

Abstract

Burn injuries, causing approximately 180,000 deaths. Skin grafting serves as a cornerstone intervention in burn injury management. This study aimed to evaluate the efficacy of different types of skin grafts in promoting the healing process of burn injuries. The outcomes of the study were the reepithelialization time and repigmentation rate of skin graft. Quality appraisal was done using ROBINS-I and the Newcastle Ottawa Scale, while network and single arm meta-analysis were conducted using R-Studio. A literature search across 6 databases resulted in the selection of 7 articles. Quality assessment categorized 6 studies as low- and 1 as moderate-risk of bias studies. The device facilitated autologous skin cell increase in reepithelialization rate (OR=5.21; 95% CI=0.24-114.41), followed by autologous skin cell and synthetic graft (OR=0.47; 95% CI=0.04-5.98), topical agent (OR=0.30; 95% CI=0.06-1.47), and Xenograft (OR=0.09; 95% CI=0.00-4.89). Furthermore, the single-arm meta-analysis showed an overall repigmentation rate of 61.49%, with xenograft displaying the highest repigmentation rate (87.50%), followed by synthetic graft (70.32%), and autologous skin cell (37.54%). Xenografts have proven effective in promoting burn wound healing. Nevertheless, the outstanding efficacy and minimal repigmentation of device-facilitated autologous skin cell transplantation highlight its potential in clinical practice.
Analysis of Factors for Incomplete Informed Consent at Medical Record Installation of Bangil Regional General Hospital in 2021 Mahbubah, Mahbubah; Roosalina, Arma; Holipah, Holipah
Jurnal Kedokteran Brawijaya Vol. 32 Supplement 1 (2022)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2022.032.01.7s

Abstract

All medical procedures on patients must be initiated by completing the informed consent. According to the hospital's minimum service standard, the completeness of informed consent filling is 100%, but the achievement of informed consent completeness at Bangil Regional General Hospital is still 37%. This study analyzed the causative factors of incomplete informed consent at Bangil General Hospital. The data analysis method used was descriptive. Data collection techniques were document studies and focus group discussions (FGD). Document studies were conducted on 100 informed consent documents, and FGD was done with 17 people consisting of 7 physicians-in-charge and 10 installation heads. The results of the FGD were analyzed using a fishbone diagram and revealed a list of problems that caused incomplete informed consent at Bangil General Hospital; then, scoring was carried out to determine the three main factors driving the problem of incomplete informed consent at the hospital. The three main factors for incomplete informed consent were the absence of a flow or policy guide for filling out, the unavailability of informed consent documents in outpatient installations, and the absence of a person in charge of the room for filling out informed consent.

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