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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 571 Documents
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Risk Factors of Body Mass Index (BMI), Age of Menarche, Parity and Hormonal Contraception of Genu Osteoarthritis in Female Patients Alisiya, Alisiya; Sulistiawati, Sulistiawati; Kurniawati, Patricia Maria; Wardhani, RR Indrayuni Lukitra
Folia Medica Indonesiana Vol. 57, No. 2
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Osteoarthritis (OA) is a degenerative disease related to joint cartilage and commonly occurs in the knee joint. The 2013 National Survey recorded the prevalence of joint diseases in East Java was 26.9%. OA affected more women than men due to the estrogen and caused disabilities in many women. This study aimed to find the relationship between Body Mass Index (BMI), age of menarche, parity, and the use of hormonal contraceptives against OA in genu at Universitas Airlangga Hospital, Surabaya. This was an analytic observational study with a case-control approach. Data collection was carried out through a short interview using a questionnaire. The sample size was calculated using a formula and found that the study required 42 patients with OA in the case group and 42 patients without OA in the control group. The case group was dominated by patients with 56-60 years old age (62.1%), BMI 23-24.9 kg/m2 (58.7%), menarche age 12-13 years (53.6%), multiparous (52.6%), having contraception pill usage history (62.3%) particularly using combination pills (60.5%) with a mean duration of use > 1 year (56.8%). There was a relationship between BMI and type of hormonal contraceptive used against genu OA in female patients at Universitas Airlangga Hospital Surabaya.
Antioxidant Activities and Potential Wound Healing Effects of Meniran (Phyllanthus niruri) Extract Gel Arif, Julio; Nasution, Ali Napiah; Nasution, Sri Wahyuni; Widowati, Wahyu; Dewi, Nindia Salsabila Mia; Kusuma, Hanna Sari Widya
Folia Medica Indonesiana Vol. 60, No. 1
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Abstract

Highlights: 1. This study analyzed the potential of Meniran extract gel for wound healing therapy, a plant-based medicine that has not been thoroughly researched in the context of promoting a healthy lifestyle. 2. The analysis found that Meniran extract gel has antioxidant properties that can be used for wound treatment to improve human health. Abstract Research on the use of medicinal plants to treat numerous diseases has been widely conducted. However, for chronic wound healing, the availability of medicinal plants for treatment remains rare. Gels containing active plant-based compounds may provide a solution. Phyllanthus niruri, known as "meniran" in Indonesian, is a medicinal plant used traditionally to cure various diseases. This study aimed to examine the antioxidant activities of Meniran extract gel, potentially for wound healing. Meniran was extracted using 70% methanol and formulated into a gel. The Meniran gel was composed of three formulations: 3%, 4%, and 5% sodium carboxymethylcellulose (CMC-Na) supplemented with 5% Meniran extract. The quality of the gel was assessed based on homogeneity, spreadability, pH, and viscosity. This study utilized 2,2"²-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays to evaluate the antioxidant activity of Meniran gel at seven different concentrations through its scavenging capacities. The results were calculated to determine the median inhibitory concentration (IC50). Analysis of variance (ANOVA) and post-hoc Tukey's honestly significant difference (HSD) were used for statistical analysis (p < 0.05). The three Meniran gel formulations showed good quality with spreadability ranging from 5.37 to 5.59 cm, pH levels from 5.90 to 6.03, and viscosity from 9.080 to 9.230 cps. Higher gel concentrations led to an increase in the free radical DPPH- and ABTS-scavenging activities. The highest DPPH and ABTS assays were found at 1,000 μg/mL with IC50 values of 69.72 μg/mL and 20.15 μg/mL, respectively. In conclusion, Meniran gel formulas exhibit good standards and have antioxidant properties suitable for wound healing therapy.
HbA1c and Pulsatility Index in Middle Cerebral Artery of Patients with Acute Thrombotic Stroke Bintan, Rio Tasti Surpa Rahmat; Setyowati, Sita; Adrianto, Yudhi
Folia Medica Indonesiana Vol. 60, No. 2
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Abstract

Highlights: 1. The findings of this study indicate that clinicians should remain vigilant, as effective glycemic control, reflected by optimal HbA1c levels, does not necessarily correlate with favorable distal cerebrovascular resistance, as measured by pulsatility index (PI). 2. This study recommends that patients with acute thrombotic stroke undergo a comprehensive examination to ensure an accurate diagnosis and appropriate treatment. Abstract Stroke is the second leading cause of death and disability in the world. Diabetes mellitus is a risk factor for stroke with an increase in blood viscosity associated with hyperglycemia, and HbA1c is a well-established biomarker primarily used for the long-term monitoring of glycemic control in patients with diabetes mellitus. The Pulsatility index (PI) parameter of Trans Cranial Doppler (TCD) can measure blood vessel resistance. This study was to prove the correlation between HbA1c and PI in Middle Cerebral Artery (MCA) of acute thrombotic stroke patients. A cross-sectional study was conducted to thrombotic stroke patients treated at the neurological ward of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia from March 2019 to April 2020 who met the inclusion and exclusion criteria. Data were obtained from medical records. Statistical analysis was performed using Spearman test for numerical data and Chi-square for categorical data with a significant value of p <0.05. There were 32 subjects who met the inclusion and exclusion criteria. A total of 24 subjects (75%) were males and 8 (25%) females with a mean age of 56.41±13.22 years. PI MCA results were abnormal in 14 subjects (43.75%) with an average of 1.8±0.97 and PI MCA was normal in 18 subjects (56.25%) with an average of 0.87±0.15. The average HbA1c was 6.55±1.9%. There was no statistically significant association observed between HbA1c and PI in MCA examination (r=0.07; p=0.73). In conclusion, the findings of this study indicate the lack of correlation between pulsatility index and HbA1c in patients with acute ischemic stroke. This underscores the importance of comprehensive cerebrovascular evaluation regardless of HbA1c status.
Glut-1 is a promising target for atp depletion on diabetic energy deficiency syndrome Purwanto, Bambang; Harjanto, Harjanto; Asnar, Elyana
Folia Medica Indonesiana Vol. 53, No. 3
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Abstract

Diabetes is a metabolic syndrome which characterized with insulin insensitivity, lack of GLUT-4 membrane presentation and ATP deficiency. ATP is needed for substrate phosphorylation, signalling pathways, protein translation and cellular survival. Since GLUT-1 was discovered as alternative glucose transporter on muscle membrane, some studies started to investigate it more. This study aimed to investigate GLUT-1 presentation on diabetes muscle membrane of rat model in time. Diabetes was obtained from a 50 mg/kg B.W of streptozotocin intra peritoneal injection on rat. We found that GLUT-1 presentation increased significantly in time of diabetic stages. It correlated negatively with GLUT-4 presentation and mortality. Eccentric downhill running on diabetic rat model improved GLUT-1 presentation and blood glucose level. It was promising for diabetes management therapy at the future.
Cross-Cultural Adaptation of Indonesian Version of Activities-Specific Balance Confidence Scale for Elderly in Surabaya Nuruzzaman, Andi; Satyawati, Rwahita; Wulan, Sri Mardjiati Mei
Folia Medica Indonesiana Vol. 56, No. 4
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Falling is a major health problem and is also a major cause of morbidity and mortality in the elderly. The more serious consequences of falling on the elderly are the increased risk of injury and fear of falling. Activities-Specific Balance Confidence (ABC) scale is one of the assessment instruments for fear of falling. This instrument is used to assess balance confidence in various ambulation activities. The purpose of this study was to carry out the process of adaptation of the cross cultural ABC English questionnaire to ABC Indonesian. This study was a cross sectional study with participants of five elderly members of the Posyandu Lansia who were in accordance with the inclusion and exclusion criteria. The output is the correlation between the score of ABC English with ABC Indonesian and the score of ABC Indonesian with ABC English Back Translation which are tested at different times. All the question score in the ABC English questionnaire correlated with ABC Indonesian, as well as the Indonesian Language ABC correlated with ABC English back translation, have a significant correlation (r> 0.3). The conclusion of this study is that the ABC English has a close meaning with the ABC Indonesian and the ABC Indonesian has a close meaning with the ABC English back translation. The validity and reliability of the Indonesian version of ABC questionnaire is needed to obtain a valid and reliable questionnaire.
Relationship between High Sensitivity-C Reactive Protein Level and Impaired Cognitive Function in HIV Patients Kurniawati, Rachmi; Sugianto, Paulus
Folia Medica Indonesiana Vol. 57, No. 1
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Human Immunodeficiency Virus (HIV) infection was one of the most serious health challenges in the world. The Ministry of Health of the Republic of Indonesia reports the number of HIV cases in Indonesia as of June 2019 as many as 349,882. At present, although antiretroviral combination therapy has been found, the prevalence of neurocognitive disorders in the form of HIV-associated neurocognitive disorders (HAND) reaches 50% of HIV patients. This study aimed to determine the relationship between high sensitivity-C Reactive Protein (hs-CRP) level and cognitive impairment assessed using MoCA-INA score in HIV patients at the UPIPI Dr. Soetomo Academic Hospital Surabaya. This cross-sectional study used consecutive sampling that fulfilled inclusion and exclusion criteria. The cognitive function of the subjects was examined by MoCA-INA score and blood samples were collected for measuring hs-CRP level. Of 100 subjects, 41 had abnormal MoCA-INA score and 59 had normal score. The number of subjects with high level of hs-CRP (>= 5) who had abnormal and normal MoCA-INA score were 22 (53,7%) and 6 (10,2%) respectively. This result was significantly difference with p = 0,0001, RO = 28,072 (95% CI, 5,470-144,052). Therefore, there was a significant relationship between hs-CRP level and cognitive function, where a subject with a high hs-CRP level was more likely to have impaired cognitive function.
Case report: arteriovenous malformation in foot. Surgical management combined with scleroting agent Rustina, Lusi; MT, Ivan Joalsen
Folia Medica Indonesiana Vol. 53, No. 3
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Abstract

Diagnosis and management of arteriovenous malformation (AVM) requires a multidisciplinary approach and includes the knowledge of the pathophysiology of the blood vessels. The incidence of vascular anomalies is rare, and they are mainly localized in the head or upper extremity. There are studies on AVM with dermatological manifestations. However, studies involving manifestations in foot are rare. The goal of this report is to provide diagnosis and treatment case of an 19 year-old boy with arterio-venous malformation of the foot. A 19-year-old Indonesian male presented with a chief complaint of a painful mass on his plantar medial right foot that had been present since his birth and had increased in size. Physical examination revealed a large plantar medial mass, with size ± 8 x 5 cm, slightly mobile, bluish, soft, and non-compressible. The mass was pulsatile on palpation and no bruit. The working diagnosis of this patient was AVM. MRI showed there was a punctat or nidus, granular hyperintense in the middle and pedis with a draining vein, and the mass was laying from subcutaneous and extended into muscular layer. Surgical management was performed. Excision of AVM in subcutaneous part was combined with injection of polidocanol 1% in muscular side. Tissue pathology results revealed AVM with no evidence of malignancy. Evaluation wounds after 2 days of operation: there was no bleeding, no signs of infection, pain was reduced. Four weeks after surgery, the patient slowly could bear his full weight on his foot, and the mass and local pain were totally reduced. Length of stay in hospitals was 4 days. This report described an unusual localization of an arteriovenous malformation. Arteriovenous malformation in foot is a challenging malformation that can be successfully managed with excision and sclerosing agents.
Effect of Adaptive Exercise on Body Temperature in Children with Motoric Disorder Mulyadi, Soffil Yudha; Rejeki, Purwo Sri; Tinduh, Darmayanti; Sari, Gadis Meinar; Prasetya, Rizka Eka
Folia Medica Indonesiana Vol. 56, No. 2
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Abstract

Motoric disorder in child increased every year, especially cerebral palsy. Children with motoric disorder which is majority experiencing long immobilization results in their general condition declining. One of this declining appears on body temperature in child, even lead to hypothermia. A simple exercise which applicatively performed at home can be a simple solution to maintain general condition, especially body temperature. The purpose of this study was to determine effect of adaptive exercise on body temperature change in children with motoric disorder. This study was an experimental study of one group pre and posttest. A total of 31 children (11 girls and 20 boys) aged 2-10 years old performed adaptive exercise consist of warming up 5 minutes, core movement 25 minutes, cooling down 5 minutes. Data were analyzed by paired T test. Body temperature in pretest was 36.12 ± 0.53oC, and body temperature in posttest was 36.63 ± 0.6oC, with p = 0.00. Adaptive exercise can increase body temperature but still in normal range.
Respirable Dust Levels, Years of Service, and Pulmonary Physiological Disorders in Marble Home Industry Workers Alia, Siti Arum; Widajati, Noeroel; Martiana, Tri; Sari, Firda Qurba; Tualeka, Abdul Rohim
Folia Medica Indonesiana Vol. 58, No. 2
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Abstract

Highlights: • The strength of the relationship between respiratory dust levels and pulmonary function disorders could not be obtained. • The weakness level of correlation between years of service and pulmonary function disorders. Abstract: Environmental dust in the workplace exposes the workers as they are breathing. The dust is inhaled into the respiratory tract and causes occupational diseases in the form of pulmonary function disorders. Workers in the marble industry are also prone to dust exposure. This study aimed to analyze the correlation between years of service, respiratory dust levels, and pulmonary function disorders in marble home industry workers in Tulungagung Regency, Indonesia. This study was a descriptive observational study with data from a cross-sectional technique. The population was 18 workers taken as respondents. The independent variables in this study were years of service and the level of respirable dust, while the dependent variable was the pulmonary function disorders experienced by the workers. The data were analyzed using the Correlation Contingency test. There was a close correlation between years of service and pulmonary function disorders by 0.196, indicating that the relationship between those variables was weak. The strength of the relationship between respiratory dust levels and pulmonary function disorders could not be obtained because the constant results met the threshold value. The correlation between years of service and pulmonary function disorders was weak, and the relationship between respiratory dust level and pulmonary function disorders could not be obtained.
Mean Differences of Total Cholesterol Levels among Vegetarians and Non-Vegetarians at Maha Vihara Maitreya Duta Palembang, Indonesia Nudhar, Lathifah; Subandrate, Subandrate; Susilawati, Susilawati; Oswari, Liniyanti
Folia Medica Indonesiana Vol. 56, No. 3
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Abstract

Total cholesterol level is one of the risk factor of cardiovascular disease. The proportion rate of hypercholesterolemia in Indonesia remains high, numbering around one third of (35,9%) Indonesians. Hypercholesterolemia is a modifiable risk factor, one of early measures that can be taken to prevent hypercholesterolemia is nutritional intervention. A dietary pattern high in plant sources and lower fat consumption has been recommended by several health organisation for prevention of hypercholesterolemia. This study was intended to determine mean difference of cholesterol level between vegetarian and nonvegetarian in Maha Vihara Maitreya Duta Palembang. This was an observational analytical study with cross-sectional design. A total of 173 subjects at Maha Vihara Maitreya Duta Palembang was included which consist of 80 Vegetarian and 93 Nonvegetarian. Measurement of total cholesterol level was done using rapid diagnostic test (RDT) Autocheck® Multi Monitoring System and parametric Independent T Test was chosen as method of statistical analysis. p <0.001 indicates significant differences of total cholesterol level between vegetarian (172,51± 39,05 mg/dL ) and nonvegetarian (228,67±68,07 mg/dL) groups. The mean differences of total cholesterol of vegetarian group is 56,16 mg/dl lower than non vegetarian groups. A significant differences exist in total cholesterol level between vegetarian and non vegetarian group at Maha Vihara Maitreya Duta Palembang. Vegetarian groups has lower total cholesterol level compared to nonvegetarian.

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