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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 571 Documents
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Back Matter Vol. 56, No. 4 December (2020) Matter, Back
Folia Medica Indonesiana Vol. 56, No. 4
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The Effect of Time on Blood Types of ABO Systems on Saliva Spots of Cigarette Butts for Forensic Identification Purnadianti, Mely; MAR, Mieke Sylvia; Yudianto, Ahmad
Folia Medica Indonesiana Vol. 54, No. 4
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The identification process is not only carried out on the body of a victim of a crime, but identification can also be carried out on the evidence evidence found at the crime scene. The timing of a crime case and the time interval for collecting evidence of a crime is an obstacle in the process of identifying blood saliva on cigarette butts. Saliva will dry within an hour and forty minutes at room temperature and with the influence of various other factors saliva will dry in less than three hours. The purpose of this study was to determine the effect of the duration of temperature exposure on the protein levels of cigarette saliva in order to help the identification process of forensic blood groups. The time series design was used in this study where 18 filter cigarette butts were collected from 6 individuals who were subjected to research with blood types A, B and AB then incubated 1.3 and 6 hours. Examination of protein content was carried out using trizol reagent with UV spectrophotometer reading. The data was processed using non-parametric T-test statistics. There was a decrease in salivary levels in a predetermined time of 1, 3 and 6 hours. Cigarette butt saliva protein levels can still be detected within 1, 3 and 6 hours so that they can be used to help identify the forensic blood group from cigarette butt saliva.
Bacterial and Antibiogram Profile of Urinary Tract Infection Patients in a Tertiary Hospital, Surabaya, Indonesia Utami, Mahrumi Dewi Tri; Wahyunitisari, Manik Retno; Mardiana, Nunuk; Setiabudi, Rebekah Juniati
Folia Medica Indonesiana Vol. 58, No. 3
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Highlights: • Most urinary tract infections are caused by Gram-negative bacteria with E. coli being the most common bacteria. • Antibiotics with the highest susceptibility for Gram-negative bacteria were ertapenem, meropenem, amikacin, and imipenem. • Antibiotics with the highest susceptibility for Gram-positive bacteria mainly were susceptible to chloramphenicol,streptomycin, vancomycin, rifampin, tigecycline, teicoplanin, and ampicillin. Abstract: Urinary tract infection (UTI) is one of the most common bacterial infections. Inappropriate antibiotic use for UTI treatment may lead to antibiotic resistance. This study aimed to provide an updated bacterial and antibiogram profile from urine specimens of patients diagnosed with UTI. This study was a retrospective study using urine culture and antibiotic susceptibility test results obtained from Clinical Microbiology Laboratory in a tertiary general hospital in Surabaya, Indonesia for a two-month period patients. Most aged more than and/or equal to 59 years, in both sexes. Gram-negative bacteria, particularly , was being the most between June to July 2019. There were 215 patients with significant urine culture results of 54.4% from Escherichia coli female bacteria were carbapenem antibiotics and amikacin, while teicoplanin and vancomycin were some antibiotics susceptible to gramcommon bacteria that caused UTI, followed by K. pneumoniae. Some antibiotics with the highest susceptibility to gram-negative positive bacteria. This study result indicated that there was an urge to conduct local antibiogram profile investigation due to the low susceptibilities shown in recent empirical therapy recommendations, such as trimethoprim sulfamethoxazole, fluoroquinolone, nitrofurantoin, and fosfomycin.
Clinical Importance of Sarcopenia And How It Impacts Orthopaedic-Trauma Patients and The Surgical Outcomes Fauzi, Ahmad; Idrial, David; Asdi, Akbar Rizki Beni
Folia Medica Indonesiana Vol. 58, No. 4
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Highlights: • Sarcopenia can cause deleterious effects on patients. • The Asian Working Group for Sarcopenia (AWGS) and the European Working Group on Sarcopenia in Older People (EWGSOP) provide the most widely used criteria to diagnose sarcopenia. • Knowledge of sarcopenia should be a trigger for clinicians and surgeons to evaluate the treatment plan and anticipate the implications experienced by the patients. Abstract: Sarcopenia is a condition of low muscle strength, mass, and low physical performance that is affected by age (primary sarcopenia) and one or combination of systemic diseases, physical inactivity, and insufficient intake of energy (secondary sarcopenia). This condition affects one in ten healthy adults aged ≥60 years. There are two widely used criteria to diagnose sarcopenia, the Asian Working Group for Sarcopenia (AWGS) and the European Working Group on Sarcopenia in Older People (EWGSOP). These working groups created algorithms to facilitate the diagnosis. Establishing the diagnosis is crucial because it has deleterious impacts on patients, such as increasing risks of mortality, morbidity, falls, complications during and after surgery, disability, prolonged hospitalization, and fractures. Sarcopenia is considered an independent mortality risk. It is paramount for physicians to assess this condition before treating the patients because it can predict the risk and plan better treatment options to achieve better outcomes. Early assessment is crucial, even for surgeons. Sarcopenia also negatively impacts patients who had surgery. Up to 44% patients who underwent orthopedic trauma surgery had sarcopenia. The high percentage was affected by the increased risk of falls and fractures. On that account, this condition needs to be treated. The main treatments for this condition are exercise dan adequate nutrition intake. The recommended exercise as a first-line treatment is resistance or strength training. Overall, knowledge on sarcopenia can prepare clinicians and surgeons in anticipating the implications of sarcopenia.
Thrombocytopenia as a Clinical Biomarker of Retinopathy of Prematurity Sutyawan, I Wayan Eka; Surasmiati, Ni Made Ayu; Agrasidi, Putu Anindya; Dwianggita, Priscilla; Anggara, Stephanus Anggara
Folia Medica Indonesiana Vol. 59, No. 4
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Highlights: • This is the first systematic review investigating thrombocytopenia and its association with retinopathy of prematurity. • Thrombocytopenia can be a useful clinical biomarker in retinopathy of prematurity screening, considering the quick, affordable, and widespread availability of the examination. Abstract Retinopathy of prematurity (ROP) is the primary cause of childhood blindness. It arises from the underdevelopment of retinal blood vessels in premature infants. Platelets have a vital function in the regulation of angiogenesis. Thus, thrombocytopenia may contribute to the progression of ROP. The objective of this systematic study was to examine the relationship between thrombocytopenia and ROP. The PubMed and Cochrane Library databases were accessed to search for retrospective, case-control, and cross-sectional studies. This study adhered to the guidelines outlined by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The literature search resulted in nine records to be analyzed in our review. All the selected studies were conducted between 2017 and 2022. Seven studies reported that the prevalence of thrombocytopenia in infants with ROP ranged from 18.37% to 71%. The frequency of thrombocytopenia in preterm children without ROP was between 5.71% and 21%. Thrombocytopenia was identified as a risk factor for ROP in seven studies, with the odds ratio (OR) for thrombocytopenia ranging from 2.8 to 6.69. Thrombocytopenia in premature infants can potentially serve as a clinical biomarker in the screening of type 1 ROP. This finding suggests that thrombocytopenia may contribute to the pathophysiology of ROP. Further research is necessary to determine the critical threshold platelet count for thrombocytopenia in infants with ROP.
Primary Healthcare Providers' Knowledge on the Early Detection of Biliary Atresia Prihaningtyas, Rendi Aji; Setyoboedi, Bagus; Nesa, Ni Nyoman Metriani; Masturina, Melinda; Utomo, Martono Tri; Arief, Sjamsul
Folia Medica Indonesiana Vol. 60, No. 1
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Highlights: 1. An evaluation is necessary to verify that the knowledge of healthcare providers is sufficient for the early detection of biliary atresia. 2. It is crucial to promote education on prolonged jaundice to ensure early detection of biliary atresia in primary health facilities, as some primary healthcare providers have insufficient knowledge on the subject. Abstract Primary healthcare providers frequently fail to recognize biliary atresia because it closely mimics physiological jaundice. Early detection plays an important role in ensuring the optimal treatment of biliary atresia. Delays in referring to biliary atresia cases remain a problem around the world. The objective of this study was to analyze the knowledge of primary healthcare providers regarding prolonged jaundice as an early sign of biliary atresia. A cross-sectional study was conducted at primary healthcare centers using a self-administered questionnaire. The data were analyzed descriptively with the assistance of IBM SPSS Statistics for Windows, version 21.0 (IBM Corp., Armonk, N.Y., USA). A total of 271 respondents participated in this study, including midwives (63.8%), nurses (24.4%), and medical doctors (8.5%). This study found that 73.8% of the respondents agreed that infants with prolonged jaundice need to undergo a serum bilirubin level assessment. However, 40.2% of the respondents believed that pale stools and dark urine in yellow infants were symptoms of physiological jaundice. Concerning the definition of prolonged jaundice, 209 (77.1%) respondents provided a response indicating more than two weeks. A total of 137 (50.6%) respondents stated that biliary atresia is a disease that must be ruled out first in cases of prolonged jaundice. Nevertheless, 86 (31.7%) and 87 (32.1%) respondents also mentioned that breastfeeding jaundice and breast milk jaundice must be considered as potential causes to be investigated. These results indicated that primary healthcare providers still had limited knowledge regarding cholestasis. Education on prolonged jaundice in primary healthcare centers should be more improved to enhance the early detection of biliary atresia.
Estrous cycle and uterine weight of ovariectomized menopause female rat models after treatment with Leucaena leucocephala (Lam.) de Wit leaf extract Wiratmini, Ngurah Intan; Sukmaningsih, Anak Agung Sagung Alit; Setyawati, Iriani
Folia Medica Indonesiana Vol. 60, No. 2
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Highlights: 1. This study found that Leucaena leucocephala leaf ethanol extract has the ability to stimulate the growth of vaginal epithelial cells in ovariectomised rats. 2. Leucaena leucocephala leaf extract can be developed as a safe and cost-effective natural alternative for hormone replacement therapy in premenopausal women and livestock. Highlights: 1. This study found that Leucaena leucocephala leaf ethanol extract has the ability to stimulate the growth of vaginal epithelial cells in ovariectomised rats. 2. Leucaena leucocephala leaf extract can be developed as a safe and cost-effective natural alternative for hormone replacement therapy in premenopausal women and livestock. Abstract Hormone replacement therapy has adverse effects that may cause additional health problems, such as hot flashes, cancer, ischemic stroke, and death. Phytoestrogen is an alternative ingredient used for hormone replacement therapy with less risk. The Leucaena leucocephala (Lam.) de Wit plant is widely used as a medicinal ingredient and animal feed. This study aimed to determine the effect of Leucaena leucocephala leaf extract on the uterine weight and estrous cycle of ovariectomized rats. This research used a completely randomized control design, which included two treatment groups (P1 and P2) and two control groups (negative (K-) and positive (K+)) with six replications in each group (n=24). The negative control (K-) was given 2 mL of corn oil, while K+ received 0.1 mg/kg bw of 17β-estradiol. P1 and P2 were administered 250 and 300 mg/kg bw of Leucaena leucocephala leaf extract, respectively. The extract was administered daily by gavage for 30 days. Estrous cycle data were obtained on day 31 by previously collecting vaginal swabs twice a day for 15 days. After the rats were sacrificed under anesthesia using chloroform, they underwent surgery to remove the uterine organs for weight measurement. The data were analyzed for normality and homogeneity using the Shapiro-Wilk and Levene tests. The data distribution were not normal, so the Kruskal Wallis test was used to test the hypothesis. If there was a difference between controls and treatments, the analysis continued with the Mann-Whitney test (p<0.05). The controls and treatments exhibited a significant difference in the length of each phase and overall estrous cycle. The post hoc Duncan test revealed that the highest uterine weight was found in 17β-estradiol treated rat. It was significantly different with both extracts treated rats. Both extract effect on uterine weight were not significantly difference. In conclusion, administering Leucaena leucocephala leaf extract results in an increased uterine weight and a normal estrous cycle in ovariectomized rats.
Effects of edamame (glycine max) extracton post-prandial serum triglyceride in wistar rats Kamal, Imran H; Dewanti, Linda; Wironegoro, Rio
Folia Medica Indonesiana Vol. 52, No. 1
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Edamame (Glycine max) is a preparation of immature soybeans in the pod, which is high in calcium and dietary fiber, two elements described in previous studies that could alter the level of post-prandial serum triglyceride.The purpose of this research is to analyze the effect of edamame (Glycine max) extract on post-prandial serum triglyceride in rats after intragastric administration of palm oil.The materials used in this study are palm oil, edamame extract, and ether. The design of this study is experimental post-test study design, which is a design to measure the serum triglyceride level after meal with and without Glycine max. Triglyceride is measured on each subject two times on total, first one after consumption of meal without Glycine max and the second one after consumption of meal with Glycine max. There is a washout period of 1 week between two times the samples were taken. Both results are then compared in every subject.The level of 2-hour post-prandial serum triglyceride in rats after palm oil without intragastric edamame (Glycine max) extract administration and with intragastric edamame (Glycine max) extract administration showed no significant difference. In conclusion, edamame (Glycine max) extract had no effect on 2-hour post-prandial serum triglyceride after palm oil administration via intragastric tube.
Effect of Celery Extract on Fructose Induced Insulin Resistance Rattus norvegicus Sukarno, Devitya Angielevi; Mustika, Arifa; Rejeki, Purwo Sri
Folia Medica Indonesiana Vol. 56, No. 4
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Diabetes mellitus (DM) is one of the global health problems and in the top 4th ranks as the main cause of death in developing countries (IDF, 2015). The pathogenesis of type II DM involves abnormalities in insulin secretion and activity that leads to insulin resistance. This research aims to study the efficacy of celery (Apiumgraveolens) as a prevention of insulin resistance. In this study, the samples were 45 Wistar rats (Rattus norvegicus), male sex, aged 4-6 weeks, weight 150-175 grams,and had normal fasting blood glucose levels by tested before treatment. The experimental animals were divided into 5 groups, K1 was negative control group (insulin resistance by given 20% fructose 1,86 g/kg BW PO qDay);K2 was positive control group (those given 20% fructose 1,86 g/kg BW PO qDayand standard insulin resistance therapy metformin 500 mg/kg BW PO qDay); the K3 treatment group was given 20% fructose 1,86 g/kg BW PO qDay and celery extract 200 mg/kg BW PO qDay; the K4 treatment group was given fructose 20% 1,86 mg/kg BW PO qDay and celery extract 400 mg/kg BW PO qDay; and the K5 treatment group was given fructose 20% 1,86 mg/kg BW PO qDay and celery extract 600 mg/kg BW PO qDay. The treatment had been given every day for 60 days.Fasting blood glucose levels were measured using a Glucometer. Fasting blood insulin levels were measured using ELISA, HOMA-IR was calculated using a standardized formula, and GLUT4 protein expression was measured using immunohistochemistry. It the end of the intervention, there was a significant decreased in fasting blood glucose (FBG) in K4 group compared with K1 (p <0.05), insulin resistance in K1 was characterized by a higher HOMA-IR value compared to the therapy group, especially K4 and K5 (p <0.05). There was an increase in GLUT-4 expression on K4 and K5 compared with K1 (p <0.05). It can be concluded that celery extract has antihyperglycemia effect and furthermore it can prevent insulin resistance condition.
Characteristics of hellp syndrome in severe preeclampsia patients in dr. Soetomo hospital surabaya P, Warih Angesti; Ernawati, Ernawati; Susanti, Dwi
Folia Medica Indonesiana Vol. 51, No. 4
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Hemolysis, elevated liver enzyme, and low platelet count syndrome (HELLPs) is complication following severe preeclampsia which is one of the three leading causes of maternal mortality in Indonesia. The purpose of this study was to understand the prevalence, characteristics, and post-partum outcome of HELLPs patients who deliver in Dr. Soetomo Hospital in July 2012-June 2013. This study was observational-descriptive, cross sectional study. The population observed was the severe preeclampsia patients who deliver in Dr. Soetomo Hospital and have complete medical data in July 2012-June 2013. study subject taken by total sampling. HELLPs follow the 7% of severe preeclampsia patients. The maternal average age of HELLPs group was 30.2 (19-43), while in non-HELLPs was 30.8 (17-46). Most HELLPs patients were in the first and second pregnancy. The average of gestational age at labor in HELLPs was 33-34 weeks. Both in HELLPs and non-HELLPs most performed Cesarean Section delivery. No post-partum maternal mortality found in HELLPs, but 25% had stillbirth. The average of birth weight in HELLPs was 1994.4 g. First minute Apgar score >7 was 33.3% in HELLPs group. In conclusion, Most HELLPs patients were in the first and second pregnancy, while non-HELLPs were in first pregnancy. The average of gestational age at labor was lower in HELLPs group. Neonates mortality were higher in HELLPs group. The average of birth weight was lower in HELLPs group. First minute Apgar score > 7 was higher in non-HELLP group.

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