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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 571 Documents
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Fertilization of bovine oocytes vitrified pre- and post in vitro maturation Faizah, Zakiyatul; Darsini, Ninik; Hinting, Aucky
Folia Medica Indonesiana Vol. 52, No. 2
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The success rate of fertilization post save frozen oocytes is still very low, because the oocyte has distinctive features, namely the volume ratio and a lower surface to the limited penetration of water and cryoprotectants penetrate cells. Beside mature oocytes have a thread spindles are particularly vulnerable to the drop in temperature. Keep frozen oocytes is needed, especially in women who needed rescue fertility so their oosit can be fertilized. Maturation is done in TC 100 mL medium covered with mineral oil in a petri dish with a diameter of 36 mm. Oocyte vitrification begins with washing in PBS supplemented medium serum 20% for 1-2 minutes, followed by serum in the medium PBS + 20% + 10% ethylene glycol for 10-14 minutes. Then oocyte vitrification medium is transported in PBS + serum 20% + sucrose 0.5M ethylene glycol + 15% + 15% PROH for 25-30 seconds. Thawing oocytes is done by successive immersed in the media: 1). PBS + 20% serum + 0.5M sucrose, 2). PBS + 20% serum + 0.25M sucrose, and 3). PBS + 20% serum + 0.1 M sucrose. Insemination is done in rosset, and the number of fertilization was observed after 48 hours. Fertilization in the control group amounted to 42.97%, while the K1 and K2 there are no fertilization at all. The analysis showed that fertilization in the control and treatment groups significantly different at p <0.05 in both treatment groups K1 or K2 there are no fertilization at all. The conclusions of this study is there is no difference between the amount of fertilization of bovine oocytes were vitrified pre and post-maturation in vitro.
Front Matter Vol. 57 No. 1 March 2021 2021, Vol. 57 No. 1 March
Folia Medica Indonesiana Vol. 57, No. 1
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Back Matter Vol. 57 No. 1 March 2021 2021, Vol. 57 No. 1 March
Folia Medica Indonesiana Vol. 57, No. 1
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Back Matter Vol. 57 No. 3 September 2021 Matter, Back
Folia Medica Indonesiana Vol. 57, No. 3
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Efficacy of Live Attenuated Dengue Vaccines: CYD-TDV, TDV (TAK-003), and TV003/TV005 Hertanto, Yoseph Jeffry; Novita, Bernadette Dian
Folia Medica Indonesiana Vol. 57, No. 4
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Highlight: • Differences in the efficacy of CYD-TDV versus the other TAK-003 and TV003/TV005 were discussed. • One licensed dengue vaccine is CYD-TDV (Dengvaxia). Abstract: Dengue fever is the most common tropical disease, but there still remains no specific therapy that can overcome it. Special attention needs to be paid to this disease, because there were large increases in incidence in the last decade. As an effective preventive strategy, finding a new vaccine for dengue fever with higher potentiation and efficacy is highly necessary to stop dengue transmission especially in the endemic area. Vaccine triggers an immune response, so that it can create a robust immune response when infected. Nowadays, there is only one licensed dengue vaccine that is CYD-TDV (Dengvaxia). However, this vaccine still has many weaknesses, namely its dependency on the serostatus of the recipient. There are also other dengue vaccines that are in ongoing clinical testing and have promising results, TDV (TAK-003) and TV003/TV005. These three vaccines are live attenuated vaccines with various results. This review discussed differences in the efficacy of CYD-TDV against the other TAK-003 and TV003/TV005; considering the known and unknown various factors.
HOW RISK FACTORS SIGNIFICANTLY AFFECT THE INCIDENCE OF TYPE 2 DIABETES MELLITUS IN TARUS, KUPANG Harsa, I Made Subhawa; Masneno, Prisilia Christin Velisites; Setijowati, Eva Diah; Al Aska, Andra Agnez
Folia Medica Indonesiana Vol. 61, No. 1
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The incidence of type 2 diabetes mellitus (T2DM) is influenced by both unmodifiable factors, such as age, family history, education, and employment status, as well as modifiable factors, including obesity, diet, physical activity, and smoking habits. Researchers have recognized the necessity of research on risk factors for T2DM across various regions. However, the findings have been inconsistent. The absence of research on risk factors for T2DM in some regions has necessitated the conduct of studies in these areas, particularly in primary health care facilities such as Community Health Centers (\textit{Puskesmas}). This study aims to control the risk factors that contribute to the incidence of diabetes mellitus. This study is an observational study with a cross-sectional research approach. The study comprised a sample of 97 respondents who met the study inclusion and exclusion criteria selected from all residents of Kupang City domiciled in the working area of the Tarus Community Health Center, Kupang City. This study employed the Chi-square test to conduct the data analysis. This study revealed a correlation between age, family history, and exposure to cigarette smoke with the incidence of T2DM. However, the authors did not find any correlation between gender, physical activity, diet, and alcohol consumption and the incidence of diabetes mellitus. The study concluded that the primary factor associated with the incidence of diabetes mellitus was a family history of Type 2 diabetes mellitus (T2DM).
EVALUATION OF ANTIBACTERIAL ACTIVITY OF <i>Amaranthus spinosus</i> EXTRACT AGAINST <i>Streptococcus mutans</i>: AN IN-VITRO STUDY Nisa, Fakhrun; Warella, Juen Carla; Hursepuny, Valentine; Bension, Johan Bruyif; Rahma, Khairunnida
Folia Medica Indonesiana Vol. 61, No. 1
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Streptococcus mutans is a component of the normal oral flora that can become a primary pathogen, leading to dental caries and tooth decay. Tooth decay and dental caries are the most common oral health issues worldwide. Treatment of dental caries and tooth decay represents a crucial effort in addressing global health concerns. One alternative treatment the community used to treat dental caries and tooth decay is thorn spinach (Amaranthus spinosus). Thorn spinach leaves contain bioactive compounds with potential antibacterial properties, including flavonoids, tannins, saponins, and alkaloids. This study aimed to evaluate the antibacterial activity of thorn spinach leaf extract at concentrations of 10%, 20%, 40%, 80%, and 100% against S. mutans. This study employed a descriptive observational design, utilizing a laboratory-based experimental approach. The leaves were extracted using the maceration technique, employing methanol and ethyl acetate as the solvents. The results showed that these extracts can inhibit the growth of S. mutans. The inhibition zones were observed for the methanol extract at concentrations of 10% (6.84 ± 5.36), 20% (12.95 ± 0.85), 40% (8.45 ± 1.00), 80% (14.66 ± 4.17), and 100% (4.74 ± 2.88). For the ethyl acetate extract, the mean inhibition zones were at concentrations of 10% (0.08 ± 0.15), 20% (8.71 ± 4.04), 40% (11.99 ± 2.44), 80% (14.79 ± 5.13), and 100% (15.00 ± 3.09). These findings indicated that, among the two types of solvents utilized, ethyl acetate was more effective than methanol, demonstrating the highest inhibitory activity with moderate to strong inhibitory categories.
FACTORS ASSOCIATED WITH MEDICATION ADHERENCE AND SYSTOLIC AND DIASTOLIC BLOOD PRESSURE OF HYPERTENSIVE PATIENTS Ziddan, Hamka; Ardiana, Meity; Dewanti, Linda; Ratri, Anudya Kartika
Folia Medica Indonesiana Vol. 61, No. 1
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Uncontrolled hypertension can cause complications such as heart disease, brain disease, kidney disease, and other diseases. Medication adherence is a primary factor in controlling blood pressure (BP) in hypertensive patients. This study aims to provide an overview of the factors associated with medication adherence of hypertensive patients treated at Taman Public Health Center in Sidoarjo, Indonesia. This study used a cross-sectional approach involving hypertensive patients. This study employed consecutive sampling, with the number of samples comprised of patients undergoing outpatient care from January 2, 2023, to February 25, 2023, totaling 103 respondents. The study employed the Morisky Medication Adherence Scale 8-item (MMAS-8) questionnaire to evaluate medication adherence. Fifty-nine (57.3%) patients had poor adherence, and 83 (80.6%) patients had poor BP control. The significant factors associated with medication adherence were employment status (p = 0.021), drug regimen and prescription refill time (p = 0.001), and experiencing forgetfulness/negligence related to their medication (p = 0.011). Significant factors associated with systolic and diastolic BP are having health insurance (p = 0.030 and p = 0.006) and drug regimen-prescription refill time (p = 0.029 and p = 0.041). These factors can be used as considerations during policymaking to improve medication adherence and BP control of hypertensive patients.
ASSESSMENT AND IDENTIFICATION OF BACTERIA IN <i>SAGU LEMPENG</i> SOLD IN AMBON CITY, INDONESIA Taher, Dilya Maghfirah; Yunita, Melda; Taihuttu, Yuniasih Mulyani Jubeliene; Azizah, Siti Nur
Folia Medica Indonesiana Vol. 61, No. 1
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Maluku Province in Indonesia is known for its diverse traditional foods, including sagu lempeng, which is widely consumed across different social groups. However, poor hygiene during its preparation, packaging, and sale in traditional markets can serve as a medium for microbial contamination, posing potential health risks. In Ambon City, the capital of Maluku, no research had been conducted concerning the total plate count (TPC) analysis and identification of food-contaminating bacteria in sagu lempeng, which are crucial for ensuring its microbiological safety. Therefore, this study aimed to assess the microbiological quality of sagu lempeng according to Indonesian National Standards (INS 7388:2009) and to identify any presence of food-contaminating bacteria. This research employed a quantitative descriptive methodology with a true experimental laboratory approach. The samples used were sagu lempeng collected from three traditional markets in Ambon, Indonesia. The TPC analysis was conducted to estimate the number of bacterial colonies per gram of samples, while Gram staining and biochemical testing were carried out for macroscopic and microscopic bacterial identification. The results showed that the highest TPC was found in sagu lempeng from Waiheru Market at 8.1 × 105 CFU/g, while the lowest was from Mardika Market at 5.95 × 103 CFU/g. The identified bacteria included Klebsiella pneumoniae ssp. and Staphylococcus arlettae. Although bacterial contamination was detected, the TPC of sagu lempeng from all sampled markets remained under the maximum allowable limit set by Indonesian National Standards (1 × 106 CFU/g). In conclusion, sagu lempeng sold in traditional markets around Ambon complies with microbiological safety standards and is considered safe for consumption.
THE EFFECT OF MLC901 ON RED CELL DISTRIBUTION WIDTH (RDW) AS A PREDICTOR OF ACUTE ISCHEMIC STROKE OUTCOME IN ACUTE ISCHEMIC STROKE MODEL IN RATS Ilham, Muhammad Arya Rifqi; Hunaifi, Ilsa; Dirja, Bayu Tirta
Folia Medica Indonesiana Vol. 61, No. 1
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Stroke is the second leading cause of death globally, with ischemic stroke being the most prevalent type. Thrombolysis is the standard treatment for ischemic stroke; however, the rate of thrombolysis administration remains low. Therefore, neuroprotective therapies such as MLC901 are considered promising alternatives. The role of MLC901 in influencing red cell distribution width (RDW) during pathological ischemic stroke remains unclear. Hence, research on the effect of MLC901 on RDW is warranted. Male rats (n = 15) were divided into three groups: (1) acute ischemic stroke treated with MLC901 at a dose of 43.2 mg, (2) acute ischemic stroke treated with MLC901 at 21.6 mg, and (3) acute ischemic stroke treated with CMC-Na (positive control). Stroke was induced using the unilateral carotid artery occlusion (UCAO) method. RDW was measured before stroke induction and at 24 hours, 72 hours, and day 14. Neurological deficits were assessed using the foot fault score, and infarct volume was measured using ImageJ software. Following stroke induction, the positive control group had the highest mean RDW value, followed by the 21.6 mg and 43.2 mg MLC901 groups. However, there were no significant differences between the groups (p > 0.05). The positive control group exhibited greater neurological deficits compared to the MLC901 groups, with significant differences observed on days 7 and 14 (p < 0.05). Additionally, the positive control group had a significantly larger infarct volume than the MLC901 groups (p < 0.05). In conclusion, MLC901 did not affect RDW values but significantly reduced neurological deficits and infarct volume.

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