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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 571 Documents
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IMPACT OF MICROPLASTICS CONTAMINATED FOOD AND BEVERAGES ON REPRODUCTIVE AND MENTAL HEALTH Titilayo, Lala Opeyemi; Funmilayo, Adisa Ayomide; Motunrayo, Adelowo Joy; Eniola, Oladapo Jesutomi; Adeola, Oyekanmi Bolape; Gbenga, Lala Olusegun; Olanike, Afolabi Opeyemi; Adenike, Ajayeoba Titilayo; Elizabeth, Morakinyo Adetoun; Kolawole, Oladipo Elijah; Obukohwo, Oyowvi Mega; Adenike, Oyedepo Temitope
Folia Medica Indonesiana Vol. 61, No. 1
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Microplastics, defined as plastic particles smaller than 5 mm, have emerged as a global environmental pollutant resulting from widespread plastic waste. Increasing concerns have been raised regarding their potential contamination of food and beverages, which may pose health risks to humans. This review aimed to evaluate current literature focusing on potential reproductive and mental health risks associated with the consumption of microplastic-contaminated food and beverages. A comprehensive literature search was conducted using multiple databases and Boolean operators to identify peer-reviewed English-language articles published within the past thirteen years. The review included studies that addressed microplastics in food and beverages, their health impacts particularly on reproductive and mental health and the techniques used for their detection and quantification. Studies not addressing these specific topics, non-English publications, and those published before the year 2000 were excluded. Evidence suggests that microplastics can enter the food chain through various routes, including ingestion by marine organisms, contamination during food processing, and leaching from plastic packaging. Consequently, microplastics have been detected in a wide range of food products, such as seafood, table salt, honey, and bottled water. Exposure to microplastics has been associated with endocrine disruption, alterations in gut microbiota, and neurobehavioral effects, potentially contributing to anxiety and depression through mechanisms involving oxidative stress, apoptosis, and inflammatory responses. Furthermore, microplastics may act as vectors for harmful additives and chemical contaminants, posing long-term health risks. Although current levels of exposure are generally low, the potential for cumulative effects underscores the need for further research to better understand associated risks and to develop effective mitigation strategies. As a precautionary measure, reducing the intake of processed and packaged foods in favor of fresh alternatives may help minimize microplastic exposure.
ANALYSIS OF TRANSCRIPTS AND CARDIAC MYOSIN-BINDING PROTEIN WITH VARIANTS OF UNCERTAIN SIGNIFICANCE IN CARDIOMYOCYTES Guterres, Egas Manuel; Guterres, Luis Manuel
Folia Medica Indonesiana Vol. 61, No. 1
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Mutations in the myosin-binding protein C (MYBPC3) gene, particularly variants of uncertain significance (VUS), are associated with cardiomyopathies. This systematic review aims to analyze the impact of VUS mutations in MYBPC3 on transcripts and proteins in cardiomyocytes. A comprehensive literature search across multiple databases (i.e., PubMed, Google Scholar, and ScienceDirect) identified relevant studies focusing on the effects of these mutations on transcript and protein levels. Additionally, exclusion criteria were applied, and studies were excluded if they did not focus on cases analyzing transcript levels and MYBPC3 protein behavior in cardiomyocytes harboring VUS mutations. A total of fifteen studies published between 2015 and 2023 were selected after undergoing rigorous screening and quality assessment processes. Data extraction and quality assessment were conducted using standardized tools. This review highlights the diverse impacts of VUS mutations on MYBPC3 transcript expression and protein function, utilizing common methodologies such as next-generation sequencing (NGS), quantitative polymerase chain reaction (qPCR), western blotting, and immunofluorescence. VUS mutations can lead to altered transcript levels and disruptions in protein localization and stability, contributing to the pathogenesis of cardiomyopathies. This study underscores the need for further functional studies to gain a deeper understanding of the role of MYBPC3 VUS mutations in cardiac pathology and to enhance their clinical interpretation.
A NETWORK META-ANALYSIS: EFFICACY AND SAFETY OF ROTATIONAL ATHERECTOMY, ORBITAL ATHERECTOMY, AND INTRAVASCULAR LITHOTRIPSY COMPARISONS FOR NODULAR CORONARY LESIONS IN PERCUTANEOUS CORONARY INTERVENTION Handayani, Riana; Oktaviono, Yudi Her; Suryawan, I Gde Rurus; Susilo, Hendri; Aziz, Karimah Khitami; Erwan, Nabila Erina
Folia Medica Indonesiana Vol. 61, No. 1
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Abstract

Percutaneous Coronary Intervention (PCI) has continued to evolve since its introduction in 1977. Currently, 12% of all PCI procedures for coronary artery stenosis involve Calcified Nodules (CN). CN is defined as nodular calcification that protrudes into the lumen of the coronary artery. In this era, improving the feasibility and success of PCI is essential through the use of advanced techniques, innovative approaches, and specialized devices in coronary interventions. These techniques include Rotational Atherectomy (RA), Orbital Atherectomy (OA), and Intravascular Lithotripsy (IVL). Comparisons of RA, OA, and IVL are still being extensively studied in terms of their effectiveness and safety in treating complex lesions such as CN. Given the high costs of these devices, this Network Meta-Analysis (NMA) was conducted to evaluate and compare the efficacy and safety of RA, OA, and IVL based on recent studies. The primary analysis in this study was performed using MetaInsight V6.1.1, presenting odds ratios (OR) based on a Bayesian Network Meta-Analysis and ranking the interventions according to the Surface Under the Cumulative Ranking Curve (SUCRA). The primary outcomes assessed were efficacy and safety. Efficacy was defined as the procedural success rate, and safety as the overall safety rate of each procedure. Secondary outcomes included periprocedural complications (dissection, perforation, slow flow/no-reflow, cardiac tamponade, and device failure), as well as the incidence of major adverse cardiovascular events (MACE) within 30 days. The analysis revealed a statistically significant difference in efficacy between IVL and RA, favoring IVL (OR 2.66, 95% CrI: 1.27, 6.16). However, no statistically significant differences were observed in other primary or secondary outcomes among RA, OA, and IVL. Based on SUCRA rankings, OA was the most effective in preventing MACE, while RA showed the lowest risk of periprocedural complications. Nevertheless, this network meta-analysis has several limitations due to the uncertainty of the available data. Further research, including randomized controlled trials (RCTs) or larger cohort studies with direct comparisons of all three techniques (closed-loop designs), is warranted to validate these findings.
THE EFFECT OF ASTAXANTHIN ON TUMOR NECROSIS FACTOR ALPHA (TNF-<i>α</i>) AND INTERLEUKIN 10 (IL-10) EXPRESSION IN UV-B-INDUCED RATS MODEL Rahman, Akhmad Setyo; Budhy, Theresia Indah; Nugraha, Jusak; Fadhilah, Nur Lailatul
Folia Medica Indonesiana Vol. 61, No. 1
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Abstract

The skin, the largest organ in the human body, serves as a protective barrier against external factors. Exposure to UV-B radiation accounts for approximately 90% of skin damage, leading to aging characterized by dryness and wrinkles. Proper nutrition has been associated with skin repair and delayed aging. Astaxanthin, known for its pharmacological properties including anti-cancer, anti-diabetic, anti-inflammatory, and antioxidant activities has garnered attention for its ability to improve damaged skin when administered as a daily supplement. This study investigated the roles of TNF-α and IL-10 as inflammatory markers in skin damage and repair, which remain underexplored. A true experimental randomized posttest-only control group design was employed using 24 male white rats divided into four groups: (1) normal group (N), untreated rats; (2) control group (C), rats administered with olive oil (5 ml/kg BW); (3) treatment group 1 (P1), rats exposed to UV-B and administered with olive oil (5 ml/kg BW); and (4) treatment group 2 (P2), rats exposed to UV-B and administered with astaxanthin (10 mg/kg BW) combined with olive oil (5 ml/kg BW). ANOVA and Games-Howell post-hoc tests revealed significant differences (p < 0.05) among groups, except between the control (C) and normal (N) groups. Astaxanthin (10 mg/kg BW) demonstrated both curative and protective effects by reducing TNF-α expression (pro-inflammatory) and increasing IL-10 expression (anti-inflammatory) in UV-B-induced rats. These findings highlight astaxanthin’s potential as a therapeutic agent for UV-B-induced skin damage.
ALLOPLASTIC IMPLANTS FOR RHINOPLASTY: A SYSTEMATIC REVIEW AND META-ANALYSIS OF CLINICAL OUTCOMES AND COMPLICATIONS Cikita, Rafeni Bunga; Nataadmaja, Beta Subakti
Folia Medica Indonesiana Vol. 61, No. 1
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Alloplastic implants emphasize the importance of a comprehensive understanding of both clinical and histological aspects, which are attributed to enhancing patient satisfaction and surgical success rates. The study aims to assess the viability of different implant materials and their related risks over time. A systematic literature search was conducted across multiple databases, including PubMed, Cochrane, and EBSCOhost, to identify 79 records. After eliminating duplicates and applying specific inclusion and exclusion criteria, four new studies were included for evaluation, focusing on postoperative outcomes related to alloplastic implants in rhinoplasty. Late-onset inflammation in non-healthy capsules required removal and showed histological damage. One study also found increased infection rates in soft implants and aesthetic adjustment concerns with firm implants. Other research reported Medpor implants’ long-term durability, but malposition and infection. Silicone implants had a 10% infection rate and 30% displacement rate, while Medpor(R) had contracture and contour difficulties. Overall, complications vary based on implant type and patient factors. The review emphasizes the importance of using the right implant materials and surgical methods to reduce problems. It advocates for further research into alternative materials and personalized approaches to enhance patient outcomes in rhinoplasty procedures.
DETECTION OF SEROTYPES AND KNOCKDOWN-RESISTANCE MUTATIONS IN DENGUE AND OTHER FLAVIVIRUS SAMPLES COLLECTED FROM MENGARE ISLAND, INDONESIA Dwiyanti, Tasya Amalia; Sucipto, Teguh Hari; Suhandarini, Khoirunnisa; Fathiarachman, Azizia Kanya; Nastiti, Helena Putri; Putri, Anika Rahma; Fauziyah, Shifa; Widiyanti, Prihartini; Hariyono, Hariyono; Rehman, Saifur
Folia Medica Indonesiana Vol. 61, No. 1
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Dengue fever, caused by the dengue virus (DENV), poses a significant public health challenge, particularly in tropical regions. This study aimed to detect flavivirus presence, DENV serotypes, and knockdown-resistance (kdr) mutations in mosquito samples collected from Mengare Island, Gresik, Indonesia. A cross-sectional experimental design was employed, utilizing reverse transcription polymerase chain reaction (RT-PCR) for flavivirus detection and serotyping, as well as for identifying kdr mutations. Ribonucleic acid (RNA) extraction was performed using the Quick-RNA™ Miniprep Plus Kit (Zymo Research, Irvine, CA, USA), followed by RT-PCR with specific primers for DENV serotypes 1–4 and kdr mutations (V1016G and F1534C). Six adult female Aedes albopictus mosquitoes were analyzed in this study. The results revealed no evidence of flavivirus infection or DENV serotypes in the mosquito samples, as no complementary deoxyribonucleic acid (cDNA) bands corresponding to expected base pair sizes were observed on the agarose gels. Similarly, the analysis of kdr mutations showed that all samples were homozygous wildtype, with no mutations detected at the V1016G or F1534C loci. In conclusion, these findings suggest the absence of active dengue virus transmission or notable insecticide resistance in the studied mosquito population from Mengare Island. This study highlights the importance of continuous monitoring of flavivirus presence and resistance mutations. The variability in kdr mutation frequencies across regions underscores the need for sustained surveillance and effective control measures to mitigate potential outbreaks in high-risk areas such as Mengare Island.
DOUBLE BURDEN STRESS IN WOMEN AND THE ROLE OF PSYCHO-RELIGIOUS WORSHIP IN ALLEVIATING IT Putra, Fahmi Mandala; Ismah, Zata; Syahfitri, Rizky Indah; Nasution, Citra Cahyati; Putri, Az-zahra Atika; Amirah, Fitria; Helmi, Tri Amelia Rahmitha
Folia Medica Indonesiana Vol. 61, No. 1
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It has been recognized that women are twice as likely to experience depression compared to men. In addition to biological vulnerability, there is also a combined effect of bearing the burden of household responsibilities while contributing financially through employment. One coping strategy that helps women endure these challenges is meditation, which in Islam includes the practice of dhikr (remembrance of God). This study aims to analyze the phenomenon of double burden stress in women and how psychoreligious practices can help reduce stress levels. The study employed a prospective cohort design, tracking the respondents' dhikr habits over a 21-day period. On the final day, general stress levels and stress related to their professional roles were measured. The study involved 69 women participants aged 17 and above, comprising housewives as well as women who held dual roles as both teachers and students. Stress levels were assessed using the DASS-42 instrument. Respondents recorded the number of times they missed the istighfar recitation at specific times of the day on a control card. Findings indicated that women who are mothers and simultaneously hold dual roles as teachers and students are more vulnerable to stress. Further correlation tests revealed that missing istighfar after the Fajr prayer, before the Asr prayer, and after the Isha prayer was associated with increased stress levels. The predictive model showed that collectively missing istighfar at these three times (after Fajr, throughout daily activities, and the total missed times) significantly increased the likelihood of stress among women. The study concludes that women who have dual roles as mothers and teachers or students are the most vulnerable group to stress. Moreover, the more frequently istighfar is neglected at the recommended times, the higher the stress levels experienced by women.
EFFECT OF LOW INTENSITY AEROBIC EXERCISE ON VO2PEAK OF WOMEN WITH BREAST CANCER UNDERGOING CHEMOTHERAPY Novayanti, Etta; Wardhani, Indrayuni Lukitra; Narasinta, Inggar; Suprabawati, Desak Gede Agung; Pratiwi, Niken; Soebadi, Ratna Daryanti
Folia Medica Indonesiana Vol. 61, No. 1
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Breast cancer treatments, particularly chemotherapy, have been associated with significant declines in cardiopulmonary fitness, a key determinant of functional independence and survival. VO2peak, a marker of cardiopulmonary function, is often reduced in patients undergoing chemotherapy, increasing morbidity risks. Researchers have proposed exercise interventions to mitigate these effects. However, most studies focused on moderate-to-high-intensity regimens, with limited data on the efficacy of low-intensity aerobic exercise. This study aimed to explore the impact of low-intensity cycle ergometer aerobic exercise on VO2peak in women undergoing chemotherapy for breast cancer. A randomized controlled trial with twenty participants randomly assigned to an intervention group (n = 10, low-intensity aerobic exercise twice per week for 8 weeks) or a control group (n = 10, usual care). VO2peak was estimated using the 30-Second Sit-to-Stand (30STS) test. Statistical analysis was performed using paired and independent t-tests, with effect size (Cohen’s d) calculated to assess clinical significance. The intervention group demonstrated a significant increase in VO2peak (Δ= +1.93 mL/kg/min, p < 0.001), while the control group showed a non-significant change (Δ= +0.25 mL/kg/min, p = 0.31). Between-group analysis suggested a significant difference in favour of the intervention (p = 0.02, Cohen’s d = –2.56), indicating a large effect size.
HOSPITAL LENGTH OF STAY IN SEPSIS PATIENTS ACROSS AGE, COMORBIDITY, AND INVASIVE DEVICE USE CATEGORIES Sutanto, Heri; Izzati, Alif Nurul; Mustika, Syifa
Folia Medica Indonesiana Vol. 61, No. 1
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Sepsis is a life-threatening condition caused by a dysregulated response of the body to infection. Sepsis is closely associated with high costs and prolonged length of hospitalization. The purpose of this study was to determine the correlation between sepsis risk factors and length of hospitalization for sepsis patients at Dr. Saiful Anwar Malang General Hospital. This study used a retrospective cohort approach with a sample size of 56 medical records. The study used inclusion criteria for sample selection. The analysis results in a p-value of 0.976 and an r-value of 0.004; the findings demonstrated a correlation between patient age and length of hospitalization. A p-value of 0.634 and an r-value of --0.065 indicated a correlation between comorbidities and length of hospitalization. The p-value was 0.101, and the r-value was 0.222, indicating a correlation with the use of intrusive devices. This result suggests that the length of hospitalization for sepsis patients at Dr. Saiful Anwar General Hospital in Malang was not significantly correlated with sepsis risk factors, including age, comorbidities, and the use of invasive devices. Therefore, it is also necessary to examine the admission diagnosis, the SOFA score, and the quantity and duration of invasive device use.
EXPLORING THE CORRELATION BETWEEN PUPIL DISTANCE AND MYOPIA PREVALENCE: AN OBSERVATIONAL BIOANTHROPOLOGY STUDY IN SURABAYA Kinasih, Anggitha Hayuning; Aditya, Dwi Martha Nur; Wicaksono, Y Adhimas Setyo
Folia Medica Indonesiana Vol. 61, No. 1
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Bioanthropology integrates biological and cultural perspectives, thereby enhancing our understanding of human health across populations. Myopia is a significant refractive error affecting potentially 2.5 billion people globally by the end of the decade. Bioanthropological theories suggest that pupil diameter and distance contribute to axial elongation and the progression of myopia. Nevertheless, current literature lacks empirical validation through rigorous hypothesis testing, highlighting a gap in comprehension. The research explores the relationship between pupil distance and the incidence of myopia via empirical assessments in Surabaya. An observational cross-sectional study was conducted, which involved pupil distance measurements and eye refraction assessments. Inclusion criteria required participants to provide informed consent, while those with other specific refractive disorders were excluded. The research utilized a Pupillary Distance Meter for precise measurement of the pupil distance. In addition, the refractive index was assessed using standard ocular instruments, including the Snellen Chart, Trial Lens, Trial Frame, and Occluder tool sets. The research employed a non-probability sampling method with a consecutive design. The sample size was determined using the formula for proportion estimation. The data was analyzed using the Chi-Square (CI = 95%) statistical method. The study comprised 298 individuals as participants, of which 229 were from the adult population (124 emmetropic and 105 myopic), and 69 individuals were from the elderly population (47 emmetropic and 22 myopic). Based on gender, the sample consisted of 117 males (113 emmetropic; 4 myopic) and 181 females (58 emmetropic; 123 myopic). The study statistically discovered that there was no significant association between pupil distance and myopia prevalence, with a p-value <0.05 (0.933), indicating a lack of correlation. The empirical data analysis indicates no evidence linking pupil distance to myopia incidence. The incongruence between the empirical findings of the study and the theoretical construct suggests an indirect association via axial elongation, an association that requires further inquiry.

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