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Medula
Published by Universitas Lampung
ISSN : -     EISSN : 97726154     DOI : -
Core Subject : Health, Science, Education,
Education Medicine & Pharmacology Neuroscience Public Health
Medical Profession Journal of Lampung didirkan pada tahun 2013. Medula hadir memenuhi kebutuhan publikasi jurnal bagi mahasiswa Fakultas Kedokteran, Dosen ataupun klinisi dan profesi lain dibidang kedokteran. Medula diterbitkan dengan frekuensi 4 kali dalam setahun yang tiap nomornya mencakup 30 jenis artikel ilmiah seperti artikel penelitian, laporan kasus, tinjauan pustaka dan lain-lain. Medula sudah memiliki nomor ISSN media cetak sejak tahun 2013
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 972 Documents
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Budaya Keselamatan Pasien Terhadap Keselamatan Pasien Rumah Sakit : Tinjauan Pustaka Hendri, Kevin; Anggileo Pramesona, Bayu; Ganda Ratna, Maya; Lisiswanti, Rika
Medula Vol 14 No 10 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1374

Abstract

Patient safety culture is an important aspect of healthcare that focuses on risk reduction and improved patient safety. Patient safety goals are efforts to prevent incidents that can harm patients and health institutions that are designed to improve patient safety by reducing the risk of injury, error, or danger during the provision of health services. Patient safety goals have six points including correct patient identification, effective communication, safety of medications that must be watched out, ensuring the correct surgical site, correct procedures and correct patients, reducing the risk of infection due to health care and reducing the risk of patients falling. Factors that affect patient safety culture include communication, lifelong learning, working hours and occupational safety culture affecting patient safety. Things that greatly contribute to the patient safety culture include openness in communication (67.54%), cooperation in hospital units (67.48%), organizational learning and sustainable development (66.90%) and non-punitive responses in case of mistakes (65.07%).  The conclusion of this study is that all units have a role in patient safety. Patient safety culture and patient safety goals are very closely related to patient safety in hospitals. However, further research is needed related to other factors that affect patient safety culture, especially regarding family involvement in patient safety.
Eksplorasi Imunoterapi dan Terapi Gen dalam Pengobatan Tumor Otak: Literature Review Hana Muthi'a Putri; Windarti, Indri; Mayasari, Diana; Susianti, Susianti
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1378

Abstract

Brain tumors are a significant neurological disorder with a high mortality rate, especially in cases of glioblastoma, which is highly aggressive and difficult to treat. Conventional treatment methods, such as surgery, radiation therapy, and chemotherapy, are often not effective enough, particularly in advanced stages. This study aims to explore two innovative approaches, namely immunotherapy and gene therapy, as alternative treatments for brain tumors. Immunotherapy works by enhancing the immune system's ability to fight cancer cells through methods such as checkpoint inhibitors, cancer vaccines, and CAR-T therapy. However, the success of immunotherapy is often hindered by the blood-brain barrier (BBB), which limits the delivery of therapy to the brain. On the other hand, gene therapy offers a solution by modifying genetic material, either to repair damaged genes or to directly destroy cancer cells. Approaches such as the use of oncolytic viruses, CRISPR technology, and nanoparticles have shown promising results in preclinical research and early clinical trials, particularly for glioblastoma. The combination of immunotherapy and gene therapy opens new opportunities to enhance treatment effectiveness by strengthening the immune response and targeting tumors more specifically. However, challenges remain, including treatment resistance, side effects, and limitations in brain delivery methods. Further research is needed to ensure the safety, efficacy, and widespread application of this combination therapy. Immunotherapy and gene therapy have great potential as breakthroughs in the future treatment of brain tumors. Relevant literature, including articles and journals from both national and international sources, were gathered through online searches in various databases, such as Google Scholar, PubMed, and NCBI, and used to compile this article.
Faktor-Faktor yang Memengaruhi Perfoma Atlet Prestasi Olahraga Permainan Bola Kecil Farhati, Soraya; Berawi, Khairun Nisa; Daulay, Suryani Agustina; Kurniawan, Candra
Medula Vol 14 No 10 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1379

Abstract

Small ball game sports are a category of sports that involve small-sized balls and bats. Examples of these sports include badminton, rounders, baseball, softball, tennis, and others. Indonesia has not yet achieved notable achievements in small ball game sports. To improve performance and achieve better results, athletes must maintain optimal performance levels. It is crucial to identify and optimize all factors affecting the performance of small ball game athletes to help them reach their full potential. Optimal physical condition is the most essential factor for athletes. Physical fitness can be improved through the right combination of frequency, intensity, duration, and types of exercise. Another factor that affects athletic performance is nutrition, including macronutrients such as carbohydrates, proteins, and fats, as well as micronutrients like vitamins and minerals. Athletes have different nutritional needs compared to non-athletes. Furthermore, nutritional requirements vary across different sports disciplines and are highly individualized. Psychological factors also significantly affect an athlete's performance. An athlete's psychological state greatly influences their concentration during competitions and plays a crucial role in their ability to perform at their best. Key psychological aspects to consider include discipline, motivation, self-confidence, and personality. To achieve optimal performance, athletes require physical training, nutritional monitoring, and psychological support.
Central Obesity as a Risk Factor for Low Back Pain Putri, Reny Arienta; Setiorini, Anggi; Mayasari, Diana; Mustofa, Syazili
Medula Vol 14 No 11 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i11.1380

Abstract

Central obesity, or abdominal obesity, is a condition marked by excessive fat accumulation around internal organs, leading to a variety of health complications such as cardiovascular disease, type 2 diabetes, and musculoskeletal disorders, including low back pain (LBP). Central obesity is defined by increased waist circumference, with values greater than 80 cm in women and 90 cm in men. The condition is primarily influenced by factors such as physical inactivity, poor eating habits, and aging. The relationship between central obesity and LBP is supported by studies indicating that abdominal fat increases mechanical load on the lumbar spine, contributing to disc degeneration and pain. Additionally, adipose tissue secretes pro-inflammatory cytokines that exacerbate inflammation and pain sensitization in the spine, leading to LBP. Obesity-related complications, such as muscle weakness and sleep disturbances, can further reduce quality of life. Preventive measures for LBP include physical exercise, weight reduction, and posture correction. Effective treatment options range from pharmacological therapies to physical rehabilitation and alternative medicine approaches. Understanding the link between central obesity and LBP is critical in developing preventive strategies and improving the management of this common condition.
Manuver Epley dan Brandt-Daroff Dalam Penatalaksanaan Benign Paroxysmal Positional Vertigo (BPPV) Hafidah, Hazima Hasna; Marcellia, Selvi; Apriliana, Ety
Medula Vol 14 No 10 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1383

Abstract

Benign Paroxysmal Positional Vertigo (BPPV) is the most common cause of vertigo with a case prevalence of 1.6% globally. It is characterized by recurrent episodes of vertigo due to changes in head position. BPPV disease is caused by the transfer of otoconia to the semicircular canal, stimulating the vestibulocochlear nerve resulting in symptoms of vertigo, nystagmus, and becoming more sensitive to head movement. The impact is significant on the physical, psychological, and quality of life aspects of the patient. This literature review discusses the mechanism, effectiveness, and success rate of Epley and Brandt-Daroff maneuvers. Data were obtained from relevant literature with data sources coming from Pubmed, NCBI, and Google Scholar.  The results of the literature review showed that the Epley maneuver has high effectiveness with a cure rate of up to 92% within one week and a significant reduction in sequelae, especially in the modified Epley maneuver. In addition, the Brandt-Daroff maneuver proved to be effective for self-treatment at home with gradual improvement of vertigo symptoms. Both methods have advantages, such as the flexibility of the Brandt-Daroff maneuver and quick results in the Epley maneuver, but have certain limitations in patients with comorbid conditions. The conclusion of this literature review shows that the Epley maneuver is the first choice in the treatment of BPPV due to its higher effectiveness, while the Brandt-Daroff maneuver can be used as an alternative.
Gambaran Budaya Keselamatan Pasien di Rumah Sakit: Tinjauan Pustaka Amallia, Rizka Dina; Pramesona, Bayu Anggileo; Setiawan, Gigih; Saftarina, Fitria
Medula Vol 14 No 10 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1389

Abstract

Patient safety culture is the key to providing high-quality and safe healthcare services. All healthcare providers, especially nurses, must be committed to creating and maintaining a strong patient safety culture. This research aims to gain a deep understanding of patient safety culture. The method used is a literature study taken from PubMed and Google Scholar databases published within the last 5 years and relevant to the topic. The selected articles are those that are fully available, focus on hospitals as the research site, and are written in Indonesian or English. The research shows that a good patient safety culture, characterized by leadership support, teamwork, open communication, and an effective incident reporting system, can improve the quality of healthcare and reduce risk of medical errors. However, many hospitals have not fully implemented a patient safety culture optimally. Some common challenges include low incident reporting rates, lack of leadership support, and a lack of a learning culture from mistakes. To address this problem, continuous efforts are needed to build a strong patient safety culture, such as increasing staff awareness, providing training, and creating safe environment for reporting errors.
Pengaruh Pemberian Ekstrak Etanol Buah Pare (Momordica Charantia L) Terhadap Gambaran Histopatolgi Arteri Koronaria Tikus Putih (Rattus Norvegicus) Jantan Galur Sprague Dawley Yang Diinduksikan Minyak Jelant Joni, Agnesia Priskila; Windarti, Indri; Oktarlina, Rasmi Zakiah; Susianti, Susianti
Medula Vol 14 No 10 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1392

Abstract

Coronary heart disease is one of the main causes of death in the world, with more than 17 million deaths every year due to heart and blood vessel diseases, with around 8.7 million of them caused by coronary heart disease and around 15 out of 1000 residents in Indonesia which is equivalent to around 2,78,064 people suffer from coronary heart disease. The high frequency of use of cooking oil means that cooking oil is often used repeatedly. Repeated use of cooking oil can cause damage to various body organs such as the liver, heart, kidneys and arteries. Exposure to free radicals and free fatty acids obtained from used cooking oil if it enters the body will result in oxidative stress. The atherosclerosis process is characterized by the change of k-LDL to Ox-LDL which triggers endothelial dysfunction and the formation of atherosclerotic plaque on the walls of blood vessels. The high fatty acid content in used cooking oil can easily stick to the walls of blood vessels, so that it will accumulate and form atherosclerotic plaque. One of the alternative antioxidants that comes from herbs is bitter melon (Momordica Charantia L). Bitter melon contains flavonoid compounds. Flavonoids are secondary metabolites which are antioxidants that can inhibit free radical activity and can prevent atherosclerosis. Antioxidant compounds can reduce atherosclerosis by inhibiting LDL metabolism in secondary atherosclerotic lesions to prevent LDL oxidation in these lesions.
Tekanan Darah Pada Atlet Al Ghifari, Ghaza Ahmad; Berawi, Khairun Nisa; Graharti, Risti; Kurniati, Intanri
Medula Vol 14 No 10 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1398

Abstract

Blood pressure in athletes is an important topic in exercise physiology studies, given its influence on performance and long-term health. In general, athletes exhibit lower blood pressure at rest compared to sedentary individuals, as a result of the body's adaptation to regular physical exercise. The purpose of this method is to analyze and collate knowledge relevant to the research topic. In this study, 12 articles from national and international journals published between 2015 and 2023 were used. The articles were obtained from databases such as PubMed and Google Scholar. The collected sources were then analyzed using the systematic literature review method. The result of this study is that blood pressure in athletes can be different compared to individuals who are not involved in intense physical activity, due to the body's adaptation to regular exercise. Blood pressure in athletes is influenced by a variety of factors, including sport type, training pattern, age, gender, as well as genetic and environmental factors. Understanding these blood pressure patterns is important for optimizing performance and maintaining cardiovascular health in athletes.
- Kanker Prostat, Diagnosis Dini, dan Faktor Prognostik di Indonesia : Tinjauan Literatur: Tinjauan Literatur Mochammadin, Rafly Abdullah; -, Intanri Kurniati; -, Ramadhana komala; Fitria Saftarina
Medula Vol 14 No 11 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i11.1399

Abstract

Prostate cancer is one of the most common types of cancer among men, with a significantly increasing prevalence worldwide, including Indonesia. Early diagnosis of prostate cancer is critical to improving patient survival, and PSA (Prostate-Specific Antigen) serves as a key biomarker in this process. Elevated PSA levels are often an early indicator of prostate cancer, although many men are unaware of the symptoms in the early stages, which can lead to a late diagnosis. Therefore, regular screening of PSA levels is highly recommended, especially for men over the age of 50 years. This study evaluated the role of PSA in the diagnosis of prostate cancer as well as prognostic factors affecting patient survival. Results showed that high PSA levels were associated with the likelihood of prostate cancer, and factors such as the number of metastatic lesions and the patient's general health condition had a significant influence on clinical outcomes. Education about the symptoms and risks of prostate cancer needs to be improved to encourage men to undergo regular health checks. With a better understanding of prostate cancer and an appropriate
Dampak Stres pada Kesehatan Qonita, Adzrok; Setiorini, Anggi; Ratna, Maya Ganda; Zuraida, Reni
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1404

Abstract

Stress is a bodily response to a stressor, which refers to any condition perceived as threatening or causing pressure. Stress can have both positive (eustress) and negative (distress) effects. Prolonged distress can affect various body systems through the activation of the Hypothalamus-Pituitary-Adrenal (HPA) axis and the Sympathetic-Adreno-Medullary (SAM) axis. Activation of these axes triggers the release of cortisol, epinephrine, and norepinephrine, leading to physiological and behavioral changes. Stress impacts multiple organ systems, including the cardiovascular, respiratory, gastrointestinal, hepatobiliary, urinary, reproductive, musculoskeletal, integumentary, sensory, and immune systems. It also affects sleep quality and mental health. In the cardiovascular system, stress can cause hypertension, atherosclerosis, and an increased risk of heart disease. In the respiratory system, stress worsens asthma and increases the risk of airway infections. In the gastrointestinal system, stress triggers digestive disorders, such as gastritis and peptic ulcers, due to increased stomach acid production and inflammatory mediators. Stress affects the hepatobiliary system by impairing liver function through increased inflammation. In the urinary system, stress can cause dysfunctions such as enuresis and increased urination frequency. In the reproductive system, stress can result in menstrual disorders in women and decreased testosterone levels in men. The musculoskeletal system can be affected by excessive muscle contractions, leading to pain and muscle fatigue. Stress impacts the integumentary system, triggering conditions such as acne, psoriasis, and alopecia areata. It can also cause sensory system disorders, affecting hearing, taste, and vision. In the immune system, stress suppresses immune responses, increasing susceptibility to infections and prolonging wound healing. Prolonged stress negatively impacts both physical and mental health, highlighting the importance of understanding the mechanisms through which stress affects the body to reduce the risk of serious health problems.

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