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Althea Medical Journal
Published by Universitas Padjadjaran
ISSN : -     EISSN : 23374330     DOI : 10.15850/amj
Core Subject : Health,
Medicine & Pharmacology
Althea Medical Journal (AMJ) is a peer reviewed electronic scientific publication journal which is published every 3 months (March, June, September, and December). Althea Medical Journal publishes articles related to research in biomedical sciences, clinical medicine, family-community medicine, and public health.
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Articles 1,068 Documents
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Overview of Non-Pharmacological Treatment Option for Adolescent Girls with Dysmenorrhea in Cimahi, West Java, Indonesia Rahmani, Shofiatunisa Firdhausy; Anwar, Ruswana; Sasongko, Elsa Pudji Setiawati; Ritonga, Mulyanusa Amarullah; Arya, Insi Farisa Desy
Althea Medical Journal Vol 11, No 1 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n1.3064

Abstract

Background: Dysmenorrhea is a condition of pain during menstruation that may affect daily activities. The phenomenon of dysmenorrhea in West Java has reached 54,9%. When dysmenorrhea is not treated, it can decrease productivity at school. This study aimed to find out which therapy was more widely used, the reasons for using the therapy, and to identify changes in non-pharmacological therapy as seen from the visual analog scale (VAS) assessment.Methods: This research used quantitative data with a descriptive study conducted with a cross-sectional method, and the instrument used was a questionnaire. The study was conducted in July 2022 with a total sample of 457 participants, and 366 samples met the inclusion criteria. This data analysis used Statistical Package for Social Scientists (SPSS version 28) to identify changes before and after non-pharmacological therapy options and the frequency distribution of the data.Results: The non-pharmacological therapy option was preferred by students (n= 366), and the reasons students used this therapy were seen from various aspects. Rest was the most frequently chosen activity by students (n= 329). All students felt a change in the pain scale before and after using non-pharmacological therapy with the visual analog scale (VAS).Conclusion: Students in grades 1 and 2 of SMAN 1 Cimahi prefer non-pharmacological therapy with rest. They have various aspects of reasoning and feeling changed after using the therapy. There is a change in the pain scale after using non-pharmacological therapy.
Front Cover, Editorial Team, Table of Contents, and Back Cover back cover, front
Althea Medical Journal Vol 10, No 2 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Determinant of Hypertension among Adults in West Java, Indonesia: Analysis of National Basic Health Research Data 2018 Karlen, Jannatin; Berbudi, Afiat; Wahyudi, Kurnia
Althea Medical Journal Vol 10, No 4 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n4.2826

Abstract

Background: Hypertension is a serious health problem worldwide. Many studies on the determinants of hypertension have been done, however studies in West Java are still very minimal. This study aimed to determine the risk factors for hypertension among adults in West Java, Indonesia.Methods: This study used a cross-sectional method with a quantitative approach using secondary data from the National Basic Health Research 2018. The final number of individuals sampled was 46,186 people. Data analysis was performed using simple logistic regression and multiple logistic regression methods.Results: The mean age of the sample was 42.97 years (SD=15.37), and females were the predominant (52.95%). The majority of samples consumed sweet beverages (31.06%) and salty foods more than once a day (29.22%), did not smoke (59.17%), had a normal body mass index (BMI) (53.78 %), and had experienced gum disease and dental problems in the last year (56.75 %). Physical activity in metabolic equivalent task (MET) minute was 5,917.79. There was a significant positive association between age and hypertension, with an odds ratio (OR) of 1.06 and a 95% confidence interval (CI) of 1.05–1.06. Furthermore, the analysis found a significant negative correlation between physical activity and hypertension, with an OR of 0.999 and a 95% CI of 0.9999874–0.9999962.Conclusions: Hypertension is significantly associated with age, whereas physical exercise is negatively associated. Priority should be given to elderly individuals and people with a high BMI for interventions such as routine blood pressure monitoring and education.
Effect of the Dates Milkshake on the Duration of the First Stage of Labor Wahyuni, Elly; Baska, Dwie Yunita
Althea Medical Journal Vol 11, No 2 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n2.3177

Abstract

Background: Prolonged labor can occur due to malnutrition during the first stage of labor. During the labor process, women need foods rich in sugar, such as dates milkshake, to optimize uterine contractions. This study aimed to explore the effect of dates milkshake on the duration of the first stage of labor.Method: This study was a quasi-experiment conducted from August to November 2021 in Bengkulu City, Indonesia using a posttest-only design with nonequivalent groups. Participants included 34 primigravida and multigravida women who were then divided into intervention group who received dates milkshake and control group who received local fruit juice, each with 17 participants. Daily routine consumption and the partographs during labor were observed. The data obtained was analyzed using Mann Whitney and Cochran’s and Mantel-Haenszel.Results: The duration of labor in mothers given dates milkshake averaged 4.1 hours (± 0.697), ranging from 3 to 5 hours; meanwhile the control group averaged 7 hours (± 1.904), ranging from 5 to 11 hours. There was a significant difference in the duration of labor between mothers given dates milkshake and local fruit juice (p= 0.000, OR=4.0).Conclusions: Dates milkshake has an effect on shortening the duration of the first stage of labor. Dates milkshake can be used as a viable food choice for pregnant women to help maintain and increase maternal energy availability during childbirth.
Turmeric and Mangosteen Extract Modulate Autophagy Gene Expression in High-Fat Diet-Induced Rats Gunadi, Julia Windi; Jasaputra, Diana Krisanti; Pangestuti, Balqist Sriprobo; Wahyudianigsih, Roro; Lesmana, Ronny
Althea Medical Journal Vol 11, No 1 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n1.3148

Abstract

Background: High-fat diet (HFD) increases the risk of obesity, metabolic syndrome, coronary artery disease, and chronic kidney disease, resulting in lipotoxicity. Turmeric and mangosteen are two ingredients mostly used in Indonesian food, and are known for their antihyperlipidemic and antioxidant effects. The aim of this study was to explore the effect of turmeric and mangosteen on autophagy gene expression in HFD-induced kidneys in rats model.Methods: The study was an experimental study, including 25 male Wistar rats aged 8 weeks, divided into 5 groups with a completely randomized design; group with a standard diet as negative control group, the group with a high-fat diet as a positive control group, and the HFD groups with turmeric or mangosteen or fenofibrate. The study was conducted in Maranatha Biomedical Research Laboratory from January to November 2022. Autophagy gene expression (LC3, p62) was measured along with the histopathological scoring to observe necrosis, inflammation, and fat degeneration state. Data was analyzed using One Way ANOVA or Kruskal Wallis and post hoc Least Significant Difference or Mann Whitney.Results: There were significant differences in inflammation in groups treated with mangosteen (p=0.007); in fat degeneration in groups treated with mangosteen and fenofibrate (p=0.007). Furthermore, the LC3 gene expression was increased in all HFD groups as well as the p62 gene expression in group treated with turmeric (p=0.020) and fenofibrate (p=0.005).Conclusions: Mangosteen decreases inflammation and fat degeneration scoring, while turmeric  increases autophagy in the kidney of HFD induced Wistar rats.
Patient Satisfaction with National Health Insurance and Public Health Center Accreditation: Lessons Learnt from Majalengka Regency, Indonesia Ruhiyat, Yayat; Sunjaya, Deni Kurniadi; Gondodiputro, Sharon; Mutyara, Kuswandewi; Sujatmiko, Budi; Arisanti, Nita
Althea Medical Journal Vol 10, No 4 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n4.2743

Abstract

Background: Perceptions of patient satisfaction influence the quality of the public health center (Pusat Kesehatan Masyarakat, Puskesmas) services. This study aimed to determine the differences in the level of patient satisfaction with national health insurance and the accreditation status of Puskesmas.Methods: This quantitative analytical study using a cross-sectional method was conducted at four Puskesmas in Majalengka Regency from October to November 2021 using a purposive sampling technique. The instrument used was the community satisfaction instrument (IKM-29) questionnaire , with the variable measured being the level of satisfaction. Data was transformed into numerical form using Rasch modelling and analyzed using the Chi-Square, independent-t, and one-way ANOVA tests.Results: A total of 273 respondents consisted of insured (Jaminan Kesehatan Nasional, JKN) and non-insured (non-JKN) respondents, resulting in the satisfaction mean value between JKN and non-JKN patients of 2.50 and 2.51 (p-value= 0.926). Satisfaction at Puskesmas levels 1 (Dasar), 2 (Madya), 3 (Utama), and 4 (Paripurna) was 2.15, 2.23, 2.56, 3.03, respectively (p-value = 0.002), indicating an increase in the level of satisfaction at the Puskesmas accreditation level.Conclusion: There is no difference in satisfaction between respondents using JKN and non-JKN. However, there is an increase in satisfaction related to the Puskesmas accreditation level. It is recommended for each Puskesmas to maintain the same service to all patients and improve the quality of service, especially in service dimensions that are considered inferior. Additionally, it is necessary to review the minimum standard value for accreditation programs.
Curcuma longa L. Prevents Hepatotoxicity Induced Isoniazid and Rifampicin: An Experiment in Wistar Rats Model Rahman, Putri Halleyana; Dwiwina, Resti Gradia; Pratiwi, Yuni Susanti; Bashari, Muhammad Hasan
Althea Medical Journal Vol 11, No 2 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n2.3161

Abstract

Background: Hepatotoxicity induced by the combination of isoniazid (INH) and rifampicin (RIF) in the treatment of tuberculosis (TB) remains a major concern. Oxidative stress has a role in mechanism of hepatotoxicity. Curcuma longa L. has been widely used as a traditional medicine and has shown antioxidant activity. This study aimed to provide evidence of Curcuma longa L as protection against oxidative stress induced by isoniazid and rifampicin therapy.Methods: This was an experimental study on male Wistar rats weighing 150-200 grams, aged 8-10 weeks which were divided into a negative control group (K0), a positive control group with INH + RIF (K1), a treatment group with a dose of 2.2 gr/kg/day Curcuma longa L powder (K2), and treatment group with INH+RIF and additional 2.2 gr/kg/day turmeric rhizome powder (K2+). SGOT and SGPT were measured from blood plasma on the 28th day; then hepatic tissue was obtained to measure MDA levels and observed histologically. Statistical analysis was done using ANOVA and continued with Duncan procedure using SPSS ver. 27.Results: SGOT, SGPT, the highest average MDA level in the liver, and the highest mean necrotic cell count in the positive control group showed a significant difference (p<0.05). The treatment group had a smaller average number of necrotic cells than the positive control group with a significant difference (p <0.05).Conclusion: Curcuma longa L powder has been shown to prevent elevation in SGOT, SGPT, MDA of liver tissue and hepatocyte necrosis, indicating its potential in protecting the liver from oxidative stress.
Maternal Risk Factors among Pregnant Women with Miscarriage Sofia, Norlaila; Fadlyana, Eddy; Irianti, Setyorini; Krisnadi, Sofie; Susiarno, Hadi
Althea Medical Journal Vol 11, No 1 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n1.3037

Abstract

Background: Approximately, 4.1% of maternal deaths in Indonesia occur due to miscarriage. Miscarriage might be caused by various factors such as fetal, maternal, and external factors. Monitoring and early detection of maternal factors might prevent miscarriage.  This study aimed to analyze the influence of maternal factors on the incidence of miscarriage. Methods: This was an analytic observational study with a case-control design conducted in Banjar District, South Kalimantan in August–September 2022. Data was collected from the medical records of pregnant women who experienced miscarriage (n=60) and pregnant women who did not (n=120). Data was analyzed using the chi square test and logistic regression. The level of maternal risk factors for the incidence of miscarriage was determined from the odds ratio (OR) value at a 95% confidence interval.Results: The results revealed that parity (p=0.000; OR=2.2), nutritional status (p=0.000; OR=77.1), level of education (p=0.001; OR=3.5), and employment status (p=0.000; OR=8.1) had a significant effect on the incidence of miscarriage.Conclusion: Maternal factors such as parity, nutritional status, education level, and employment status influence on the incidence of miscarriage, therefore, it is essential to educate pregnant women on various factors related to miscarriage.
Clinical Symptoms and Treatment Outcomes of COVID-19 Patients with Stroke Daud, Oskar Yuda; Sinurat, Robert
Althea Medical Journal Vol 11, No 1 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n1.3120

Abstract

Background: COVID-19 patients who come to the emergency room often suffer from stroke. This study aimed to examine clinical symptoms and treatment outcomes of COVID-19 patients with stroke.Methods: This study was a retrospective study using secondary data from medical records of COVID-19 patients with stroke, hospitalized at the Universitas Kristen Indonesia Hospital, Jakarta, Indonesia for the period 2020–2022. Patients with PCR test positive for COVID-19 who had clinical symptoms of stroke, confirmed by  CT scan showing brain ischemic or hemorrhage were included. Data on gender, age, Glasgow coma scale (GCS), subtype of stroke, severity of COVID-19, and outcome were recorded and analyzed using paired t-test and the Spearman correlation.Results: Of the 49 patients included, 91.8% were over 45 years old and suffered from severe COVID-19. Men were slightly more (51.1%) than women and 93.9% of patients suffered from ischemic stroke. The GCS scores of 46.9% of patients decreased significantly during hospitalization (p=0.02). Most of patients (65.3%) had used non-rebreathing mask (NRM), 10.2% ventilators, and others used nasal cannulas. As many as 46.9% of patients died, 44.9% recovered with neurological deficits, and only 8.2% recovered completely. Interestingly, oxygen delivery devices were significantly correlated with outcome (p=0.00). Patients receiving the antiviral favipiravir had better outcomes compared with those taking remdesivir (p=0.021).Conclusion: The mortality rate for stroke patients with severe COVID-19 is high, and the outcome of patients using NRM or ventilator is worse than patients using nasal cannulas. The antiviral Favipiravir has better outcomes for stroke patients with severe COVID-19.
Association of Nuclear VDR Immunoexpression with Breslow’s Thickness in Acral Melanoma Sholihah, Fitria; Usman, Hermin Aminah; Dewayani, Birgitta Maria
Althea Medical Journal Vol 10, No 4 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n4.2801

Abstract

Background: Acral melanoma (AM) is a subtype of malignant melanoma (MM) that has a predilection for glabrous skin and is the most common type of melanoma among Asians. Depth of invasion is one of the prognostic factors in AM. VDR may have an association with depth of invasion in AM. However, reports from Asian patients are still lacking. The aim of this study was to explore the association between VDR immunoexpression and depth of invasion in AM patients in Bandung, Indonesia.Methods: This study was a retrospective cross-sectional study that analyzed the nuclear and cytoplasm VDR expression of melanoma cells and its association with Breslow’s thickness in patients with AM in Dr. Hasan Sadikin General Hospital Bandung. VDR immunostaining was performed on paraffin blocks. The Breslow thickness was measured using dot slide software. Chi square statistical analysis was done to determine the results.Results: Of the 30 patients, 73% had a Breslow thickness of >4 mm.  There was a significant inverse association between nuclear VDR immunoexpression and Breslow thickness of AM (p<0.001), but not for cytoplasmic VDR immunoexpression (p=0.914). Conclusion: Low nuclear VDR immunoexpression is associated with the depth of invasion in AM. Nuclear VDR immunoexpression possibly affect progression and should be considered before administration of vitamin D therapy in AM. 

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