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Althea Medical Journal
Published by Universitas Padjadjaran
ISSN : -     EISSN : 23374330     DOI : 10.15850/amj
Core Subject : Health,
Medicine & Pharmacology
Althea Medical Journal (AMJ) is a peer reviewed electronic scientific publication journal which is published every 3 months (March, June, September, and December). Althea Medical Journal publishes articles related to research in biomedical sciences, clinical medicine, family-community medicine, and public health.
Arjuna Subject : -
Articles 1,068 Documents
 100   101   102   103   104 
Factors Affecting Breast Milk Substitute in Pidie Jaya, Aceh, Indonesia Fazira, Frisca; Arisanti, Nita; Gurnida, Dida; Susiarno, Hadi; Azis, Muhammad Alamsyah; Rusmil, Kusnandi
Althea Medical Journal Vol 11, No 2 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n2.3060

Abstract

Background: Breast milk is the first, main, and best natural food for babies. Breast milk contains various nutrients needed in the process of growth and development of babies. Breastfeeding is a health behavior carried out by mothers. This study aimed to analyze the factors that influence the provision of breast milk substitutes.Methods: This was a quantitative study, using a cross-sectional design. Data collection was carried out from July to August 2022 on 71 mothers who had babies aged up to 6 months at the Bandar Baru Public Health Center, Pidie Jaya, Aceh, Indonesia. Consecutive sampling technique was used. The variables studied included behavior intentions, social support, accessibility of information, personal autonomy, and situational action. Chi-square was used to assess the relationship between independent variables and the dependent variables.Results: Most mothers were aged 20–35 years (70.4%), had junior high school education (78.9%), were unemployed (76.1%), and most did not provide breast milk substitutes (70.4%). Mothers who provided breast milk substitutes was significantly associated with the mother’s intention to give breast milk (p=0.002) and environmental conditions/situations for action (p=0.001). Mothers with low intentions tended to substitute breastmilk (53.8%). Furthermore, the situation of action influenced mothers to provide breast milk substitutes (48.6%).Conclusion: Factors that influence mothers to provide breast milk substitutes are low intention and environmental conditions/situations to act. Therefore, education for mothers to give exclusive breast milk is encouraged. 
Patients Satisfaction with the Chronic Disease Management Program in Indonesia Using the Importance-Performance Matrix Kusumawardana, Ramza Aurum; Sunjaya, Deni Kurniadi; Gondodiputro, Sharon; Raksanagara, Ardini Saptaningsih; Ardisasmita, Mulya Nurmansyah; Widjajakusuma, Anggraini
Althea Medical Journal Vol 11, No 1 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n1.2780

Abstract

Background: Indonesia still has a high prevalence of hypertension and diabetes mellitus. On the other hand, essential health services were disrupted during the COVID-19 pandemic. Hence, the quality of service still needs to be prioritized. The government also obliges the government-owned primary healthcare facilities (Pusat Kesehatan Masyarakat, Puskesmas) to conduct customer satisfaction surveys to evaluate service quality. This study was conducted to analyze patients’ satisfaction with the chronic disease management program (Program Pengelolaan Penyakit Kronis, Prolanis) provided by Puskesmas in Bogor City.Methods: Quantitative research with a survey approach using the CSI-29 questionnaire was conducted from October to November 2021 on 104 Prolanis participants from 6 Puskesmas in Bogor City, West Java, Indonesia. The variables were 9 dimensions of satisfaction based on the CSI-29 questionnaire. Data was transformed using the Rasch model and analyzed using the Importance-Performance Matrix (IPM).Results: Of the 104 participants, there were 78 (75%) were satisfied with the Prolanis services provided by the Puskesmas. The IPM analysis showed that the dimensions of requirements, procedures, costs, type of service products, and attitudes of health workers had low expectations and perceived performance level.Conclusions: Most of the Prolanis participants were satisfied with the Prolanis services provided by the Puskesmas in Bogor City.
Knowledge, Attitudes, and Healthy Feeding Behavior of Mothers on the Nutritional Status of Elementary School Students Liemen, Sherin Felicia; Kurniawan, Felicia; Djaya, Nanny
Althea Medical Journal Vol 10, No 4 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n4.3062

Abstract

Background: Some children aged 6-9 years have started to enter the pre-pubertal rapid growth period. Therefore, the need for nutritious food has begun to increase significantly. The role of mothers in providing food is very much needed. This study aimed to discover the relationship between knowledge, attitudes, and behavior of mothers in healthy feeding on the nutritional status of children.Methods: This study was a cross-sectional study conducted in July–August 2019. The sample was mothers and their children who were in grades I to III of public and private elementary schools in Penjaringan, Jakarta. The total sampling method was conducted, and data collected included age, gender, height, weight, and mother’s knowledge, attitudes and behavior in healthy feeding Data was analyzed using Chi-square. The nutritional status of the students was calculated using the 2010 anthropometric standards of the Ministry of Health.Results: Of the 348 mothers included, there were 310 mothers (89.1%) with high level of knowledge, 86.5% of mothers had a positive attitude, and 75.3% had good behavior in healthy feeding. The nutritional status of the children was predominantly normal (46.2%) and overweight (34.8%). There was a significant relationship between maternal behavior in giving healthy food and children nutritional status (p=0.046).Conclusions: There is a significant relationship between the mother's behavior in offering healthy food and the children nutritional status. Therefore, parents should pay more attention to behavior in providing healthy food to children.
Characteristics and Clinical Outcomes of COVID-19 Patients with Hyperglycemia: Retrospective Cohort Study from a COVID-19 Referral Hospital, Bandung, Indonesia Permana, Hikmat; Ikhsanawati, Annisa; Susandi, Evan; Soetedjo, Nanny Natalia Mulyani; Alisjahbana, Bachti
Althea Medical Journal Vol 10, No 4 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n4.3111

Abstract

Background: COVID-19 often causes severe complications in patients with metabolic disorders such as diabetes mellitus. Conversely, inflammation caused by infection may also trigger insulin resistance, resulting in hyperglycemia and is related to the disease severity. This study aimed to describe the characteristics and clinical outcomes of COVID-19 patients with hyperglycemia at one of the COVID-19 referral hospitals in Bandung, Indonesia.Methods: This retrospective cohort study used secondary data from medical records of COVID-19 patients admitted to Dr. Hasan Sadikin General Hospital Bandung, Indonesia from March 2020 to March 2021. This study included all patients with confirmed COVID-19, aged >18 years, and had at least one blood glucose test at admission. Patients were grouped based on three possible types of hyperglycemia, namely diabetes mellitus, reactive hyperglycemia, and steroid-induced hyperglycemia; then their characteristics and disease outcomes were compared. Results: This study identified 1,114 patients’ medical records and included 1,013 data in the analysis. Hyperglycemia occurred in 45.1% of COVID-19 patients. The most common hyperglycemia types were diabetes mellitus (55.7%), reactive hyperglycemia (37.4%), and steroid-induced hyperglycemia (7%). The steroid-induced hyperglycemia group had similar characteristics as the diabetes group. The reactive hyperglycemia group exhibited a metabolic syndrome pattern resembling pre-diabetic conditions. The highest rates of severe disease and mortality were seen in the steroid-induced hyperglycemia group, followed by the diabetes group.Conclusions: There is an elevated prevalence of hyperglycemia in COVID-19 patients with diabetes. The steroid-induced hyperglycemia group has the most unfavorable outcomes. These observations emphasize the importance of identifying hyperglycemic conditions to improve management and outcomes.
Spatial Autocorrelation of Dengue and Its Relationship with Population Density in South Kalimantan, Indonesia Norjanah, Norjanah; Ridha, Muhammad Rasyid
Althea Medical Journal Vol 11, No 2 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n2.3190

Abstract

Background: Dengue is a viral infection transmitted to humans through the bite of Aedes aegypti and Ae. Albopictus mosquitoes. Demographic factors that may influence the development and prevalence of dengue cases include variations in population density, community characteristics, and economic and social demographics. This study aimed to determine the distribution, spatial autocorrelation, and relationship between population density and dengue.Methods: Secondary data analysis was conducted in Hulu Sungai Selatan District, South Kalimantan, Indonesia. Data on dengue cases, population density for each sub-district, and base maps were collected to and then be used as analysis material. Spatial autocorrelation was analyzed using the Moran's index and Local Spatial Autocorrelation Index (LISA), then the correlation of population density with dengue was carried out using linear regression.Result: Spatial Autocorrelation had positive autocorrelation and clustered spatial patterns in 2017 and 2018; whereas in 2019-2021 was negative and the spatial pattern was spread. There was a decrease in cases from high to low (HL) in Kandangan District in 2021, which was previously high to high (HH) in 2017-2019. There was a correlation between population density and dengue (R-value=0.448) with a moderate category.Conclusion: Dengue cases are more widespread in Kandangan. The spatial autocorrelation of dengue that occurs between sub-districts in Hulu Sunga Selatan District is due to sub-district location in the city center. There is a correlation between dengue and population density. Therefore, controlling dengue should be prioritized in the city center area first to break the chain of dengue transmission between sub-district in Hulu Sunga Selatan District. 
Effect of Yoga on Anxiety Levels among Medical Students During COVID-19 Pandemic Prameswari, Yovita Rinda; Amita, Angela Shinta Dewi; Gracia, Isadora; Lilis, Lilis
Althea Medical Journal Vol 11, No 2 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n2.3173

Abstract

Background: The COVID-19 pandemic became one of the factors that caused anxiety among medical students. Anxiety needs to be managed before it develops into a disorder. Yoga as a complementary therapy can reduce anxiety. This study aimed to determine the effectiveness of yoga on anxiety levels among medical students.Methods: This was a quasi-experimental study conducted in February–September 2022 and participated by medical students at the Atma Jaya Catholic University of Indonesia experienced anxiety. Participants were divided into two groups; an intervention group and a control group. Anxiety levels were measured using the Depression Anxiety Stress Scale 42 (DASS-42) questionnaire. The intervention provided was the Atma Jaya Yoga Intervention Studies (AJYOGIS) procedure for nine weeks. Yoga practice was performed online via Zoom and offline on campus. The Shapiro-Wilk test  was used to test data distribution, Paired Sample T-Test and Wilcoxon Signed-Rank test to observe changes within groups. The changes between groups were analyzed using Unpaired Sample T-Test and Mann-Whitney test. A p-value of <0.05 was considered statistically significant.Results: Of the 36 medical students participated, the anxiety level of most participants was in the moderate category (41.7%).  There was a significant decrease in anxiety scores in the intervention and control group after practicing yoga (p<0.05). However, there was no significant change in the anxiety category in the control group (p=0.231).Conclusion: Yoga can reduce anxiety levels, especially during the COVID-19 pandemic. Further detailed analysis with a larger sample size is needed to strengthen these findings.
Correlation between Gibbus and Neurological Status in Patients with Tuberculous Spondylitis and its impact after Operative Intervention Egypti, Lubna; Rahim, Agus Hadian; Ganiem, Ahmad Rizal; Ramdan, Ahmad; Dian, Sofiati
Althea Medical Journal Vol 11, No 1 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n1.2991

Abstract

Background: Tuberculous (TB) spondylitis is a chronic infectious disease associated with Mycobacterium tuberculosis that affects the spine. This disease is a challenging disease to treat due to its serious complications and high morbidity rate. Neurological deficits and spinal deformities that can occur along with gibbus are some of the most common complications. Early diagnosis and treatment are essential to cure this disease, with the administration of anti-TB drugs and operative intervention. This study aimed to analyze the correlation between gibbus and neurological status as well as the impact of operative intervention on the degree of gibbus and neurological status.Methods: This was an observational-analytic study with a cross-sectional design on 32 medical records of TB spondylitis patients who underwent operative intervention from January 2018 to December 2021 at Dr. Hasan Sadikin General Hospital. Gibbus determined by x-ray analysis and neurological status determined by the American Spinal Injury Association (ASIA) impairment scale (AIS) were examined before and after the intervention. The sample was chosen based on consecutive sampling. All data collected was tested using Spearman's correlative analysis, paired t-test, and Wilcoxon sign-rank test with a p-value <0.05 considered statistically significant.Results: There was a significant correlation between gibbus and neurological status-AIS (r=-0.708; p<0.05); and a significant positive impact of operative intervention on the degree of gibbus (p<0.05) and neurological status-AIS (p<0.05).Conclusion: There is a correlation between gibbus and neurological status-AIS. In addition, operative intervention also has a significant positive impact on the degree of gibbus and AIS, resulting in good clinical and radiological outcomes.
Expression of HMGB1 and NF-κB in Fetal Membranes of Premature Rupture of Membranes Sudiarta, Ketut Edy; Khan, Joan; Aldinasyah, Monicha Zalzabilla; Garianto, Efyluk; Budiarti, Retno
Althea Medical Journal Vol 10, No 4 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n4.2911

Abstract

Background: Inflammation, either sterile or infection-related, may lead to premature rupture of membranes (PROM). The non-histone nuclear proteins, high mobility group box-1 (HMGB1), and nuclear factor kappa-B (NF-κB) transcription factors have been extensively investigated in many disorders involving inflammatory reactions. This study aimed to determine the expression of HMGB1 and NF-κB in fetal membranes of PROM compared with non-PROM.Methods: This study was an analytical observational study with a case-control design, performed from November 2021 to January 2022, including 40 fetal membrane samples (20 PROM and 20 non-PROM), which were obtained from pregnant women treated in the emergency unit of a hospital in Surabaya from August to November 2019 using the non-probability sampling method. The HMGB1 and NF-κB expressions were examined using the immunohistochemical method and further viewed under a light microscope (400x magnification), then assessed by Image-J software. The values were then compared between PROM and non-PROM, and analyzed using the Mann-Whitney U test.Results: There was a significant difference (p<0.001) in the expression of HMGB1 and NF-κB in PROM and non-PROM for HMGB1 45.86± 14.21% vs. 8.50± 5.66% expression/mm2; and NF-κB 33.47±5.45% vs. 7.29±4.90% expression/mm2, respectively.Conclusions: PROM groups have significantly higher expression of HMGB1 and NF-κB s, indicating their higher activity and contribution to PROM.
Var Gene Encoding Duffy-Binding Like (DBL) 1α- Plasmodium Falciparum Erythrocyte Membrane Protein 1 (PfEMP1) as Diagnostic Marker and Clinical Predictor Candidates for Falciparum Malaria Dewi, Rosita; Sulistyaningsih, Erma; Aprilia, Annisa Nadya; Kusuma, Irawan Fajar; Sillehu, Sahrir
Althea Medical Journal Vol 11, No 4 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n4.2396

Abstract

Background: The pathogenesis of severe malaria involves the antigenic protein Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1), encoded by the var gene. One of the important domains in PfEMP1 is Duffy Binding Like 1α (DBL1α). To diagnose malaria, microscopic examination has low sensitivity and specificity, therefore, the development of molecular-based methods is needed. This study aimed to determine the potential of DBL1α-PfEMP1 as a diagnostic marker and clinical predictor for falciparum malaria.Methods: An exploratory descriptive study was conducted in 2019 on malaria patients at the Tiakur public health center, Southwest Maluku, Indonesia. Blood samples of patients infected with Plasmodium falciparum malaria were collected on filter paper for DNA isolation. Amplification by polymerase chain reaction (PCR) method used primers αAF [5'-GCA CG(A/C) AGT TTT GC-3'] and αBR [5'-GCC CAT TC(G/C) TCG AAC CA-3'] with cycles of denaturation 95oC 1-minute, annealing 42oC 1-minute, elongation 60oC 1-minute. PCR products were electrophoresed using 1% agarose gel. Amplicons were sequenced directly and analyzed using nucleotide BLAST-NCBI. Results: All patients showed mild malaria symptoms. PCR amplification yielded bands of 370 bp in all samples and 600 bp in 8 out of 10 samples, and 1 sample had a different pattern. Sequencing results confirmed that the amplicon was DBL1α, a var gene that had similarities to sequences from other regions.Conclusion: Positive amplification and sequencing results confirm the sensitivity of DBL1α-PfEMP1 as a diagnostic marker. The sequence variability of PCR product implies the presence of DBL1α variations, indicating a correlation with clinical outcomes and making it a clinical predictor.
Rationality of Empirical Antibiotic Usage among Digestive Surgery Inpatients at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia: Gyssens Criteria Analysis Yunivita, Vycke; Assyifa, Nanda; Yarman, Indra Prasetya; Bashari, Muhammad Hasan; Satriasih, Tulus
Althea Medical Journal Vol 11, No 3 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n3.3299

Abstract

Background: Many empirical antibiotics are prescribed unnecessarily, contributing to the rise in the incidence of antibiotic resistance. Preventing infection of surgical sites is one of the most frequent purposes of empirical antibiotic usage. Therefore, this study aimed to analyze the rationality of empirical antibiotic usage among digestive surgery inpatients based on the Gyssens criteria and clinical features outcomes.Methods: A descriptive method was used with a cross-sectional design. Data was collected from medical records of patients underwent digestive surgery and had received empirical antibiotic therapy post-surgery from July to September 2021 at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. Subsequently, the data was analyzed using the Gyssens method to qualitatively assess the rationality of antibiotic use based on specific criteria, classified from rational (category 0) to various levels of irrational use (categories I-VI). Clinical outcomes were evaluated by assessing leukocyte count, clinical symptoms of fever, and the appearance of surgical site infection before and after administration of empirical antibiotics.Results: In total, 70 empirical antibiotic prescriptions were obtained from 42 patients, with only 40% of patients using rational antibiotics, whereas 60% of antibiotics were used inappropriately (category I-VI). Clinical evaluation showed no fever, edema, or erythema and reduced leukocytosis and exudate/pus post-therapy.Conclusions: Inappropriate empirical antibiotic prescription for digestive surgery inpatients at Dr. Hasan Sadikin General Hospital based on the Gyssens criteria is high. Nonetheless, clinical outcomes showed improvements in infection-related parameters. These results emphasize the importance of stricter adherence to antibiotic stewardship and regular evaluation of empirical antibiotic practices to optimize usage and patient outcomes.

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