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INDONESIA
Jurnal Kesehatan Andalas
Published by Universitas Andalas
ISSN : 23017406     EISSN : 26151138     DOI : -
Core Subject : Health,
Health Professions
Jurnal Kesehatan Andalas merupakan Jurnal yang diterbitkan oleh Fakultas Kedokteran Universitas Andalas.
Arjuna Subject : -
Articles 1,294 Documents
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Hubungan Tingkat Stres dengan Sindrom Pramenstruasi pada Mahasiswi Fakultas Kedokteran Angkatan 2021 Universitas Tarumanagara Fadhilah, Windy Hazmi; Herdiman, Julia
Jurnal Kesehatan Andalas Vol. 11 No. 3 (2022): Online November 2022
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v11i3.2086

Abstract

Premenstrual syndrome (PMS) is physical and non-physical symptoms experienced by women of the reproductive age two to fourteen days before menstruation. One of the factors can cause PMS is stress. Objective: To determined the correlation between stress and premenstrual syndrome among year 2021 Faculty of Medicine students at University of Tarumanagara. Methods: This research was an observational analytic study with a cross-sectional research design. The stress variable was measured using the Depression Anxiety Stress Scales-21 (DASS-21) questionnaire and the premenstrual syndrome variable was measured based on prospective questionnaire by the American College of Obstetricians and Gynecologists (ACOG). The number of respondents obtained was 138 and the chi-square test was analyzed as a hypothesis test. Results: There were 56 (62,2%) respondents classified as having stress and experienced PMS, while 15 (31,3%) respondents not having stress experienced PMS. The 34 (37,8%) respondents were classified as being stressed but not experiencing PMS, and 33 (68,8%) respondents were not stressed and not experiencing PMS. The affective and somatic symptoms most often experienced irritability (77,54%) and joint or muscle pain (49,28%). There was a significant relationship between stress and premenstrual syndrome with p-value = 0,001 (p-value <0,05). Conclusion: There is a statistically significant relationship between stress and PMS (p<0,05). Affective symptoms were felt more than the somatic ones.Keywords: DASS-21, diagnostic criteria of PMS, premenstrual syndrome, stress
Effect of Human Bone Marrow Mesenchymal Stem Cells on Burn Healing in Granulation Tissue Formation in Diabetic Rats Revilla, Gusti; Saputra, Deddy; Nurhasanah, Dini
Jurnal Kesehatan Andalas Vol. 11 No. 3 (2022): Online November 2022
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v11i3.2089

Abstract

Burns with diabetes mellitus can interfere with the wound-healing process. Mesenchymal stem cells have been studied to accelerate the healing of burns, one of which originates from the bone marrow. Objective: To determined the effect of human bone marrow mesenchymal stem cells (hBM-MSCs) on burn wound healing in granulation tissue formation in Diabetes Mellitus rats. Methods: This study was an experimental study with a post-test-only control group design, using 30 rats divided into two groups, the control group Phosphate Buffer Saline (PBS) and the treatment group (hBM-MSCs). Mice were induced by alloxan to cause hyperglycemia. Burns are made using a heated plate. Tissue collection was carried out after the termination of the experimental animals on the 3rd, 7th and 14th days and then histological preparations were made to assess the formation of granulation tissue. Data were analyzed using the two-way ANOVA test. Results: There was an increase in the number of macrophages, fibroblasts and new blood vessels after being given hBM-MSCs. On day 14 neutrophils and lymphocytes on day 3, there was no increase. Statistical analysis showed a significant increase in lymphocytes, macrophages, fibroblasts and new blood vessels. Conclusion: Human bone marrow mesenchymal stem cells can increase the formation of granulation tissue by increasing the number of macrophages, fibroblasts and new blood vessels in diabetic rats.Keywords: burn wound,  diabetic rat, human bone marrow mesenchymal stem cells, granulation tissue
Faktor yang Berhubungan dengan Kecelakaan Kerja pada Pekerja Bengkel Las di Distrik Abepura Kota Jayapura Mudasir, Aisyah; Medyati, Novita; Irjayanti, Apriyana
Jurnal Kesehatan Andalas Vol. 11 No. 3 (2022): Online November 2022
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v11i3.2094

Abstract

The welding industry is part of the informal sector industry whose work is associated with many hazards and risks that can increase the number of work accidents. With the increasing cases of work accidents, it is necessary to look for the causes or things that influence them so that prevention and mitigation efforts can be carried out. Objective: To determined the factors associated with work accidents among welding workshop workers in the Abepura District, Jayapura City. Methods: This research was conducted in an analytic observational manner with a cross-sectional design. The location of this research was carried out at welding workshops in the Abepura District, totaling 12 workshops. The sample of this research is 41 workers selected by purposive sampling technique. Data were analyzed using univariate and bivariate with a chi-square test. Results: The study showed that there was no relationship between age p = 0.671 (p>0.05) and education p = 1.000 (p>0.05) with the incidence of work accidents among welders. There was a relationship between years of service p = 0.033 (p<0.05), knowledge p=0.001 (p<0.05), and unsafe actions p=0.027 (p<0.05) with occupational accidents in welders. Conclusion: There is a relationship between years of service, knowledge, and unsafe actions with work accidents.Keywords:  welding workshop,  work accidents, worker 
Pengaruh Art Therapy terhadap Kualitas Hidup Anak Kanker yang Menjalani Kemoterapi Hasni, Hidayatul; Andika, Mira; Syahid, Armein
Jurnal Kesehatan Andalas Vol. 11 No. 3 (2022): Online November 2022
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v11i3.2099

Abstract

Continuous chemotherapy causes side effects in children, one of which affects the quality of life of children. The quality of life of children with cancer can be improved by providing complementary and alternative therapies, one of which is art therapy. Objective: To determine art therapy's effect on the quality of life of cancer children undergoing chemotherapy. Methods: The design of this study was a quasi-experimental one-group pre-test post-test on 30 children with cancer who underwent chemotherapy. The art therapy in this study was coloring activities. Quality of life assessed using PedsQoL instruments (Pediatric‘s Quality of Life) Generic 4.0. Data analysis used the Mann-Whitney test. Results: The average age of children with cancer was ten, and more than half (53.3%) were male. Most of them were diagnosed with Acute Leukemia Limfoblastic and more than half (73.3%) were diagnosed more than six months. There was a difference in the quality of life of children with cancer before and after being given art therapy with a p-value = 0.000 (<0.05). Art therapy affected the quality of life of cancer children undergoing chemotherapy with a p-value of 0.000 (<0.05). Conclusion: Art therapy can improve the quality of life of cancer children undergoing chemotherapy. Keywords:  art therapy, chemotherapy, children with cancer, quality of life
Efektivitas Penggunaan Platelet-Rich Plasma (PRP) dalam Proses Penyembuhan Tulang pada Model Hewan Coba: Systematic Review Noverial, Noverial; Putri, Biomechy Oktomalio
Jurnal Kesehatan Andalas Vol. 11 No. 3 (2022): Online November 2022
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v11i3.2129

Abstract

Bone injury causes thus, reduced productivity and death in the sufferer. Alternative treatment research was developed to speed up the bone healing process, including autologous treatments such as Platelet-Rich Plasma (PRP). Objective: To assessed the effectiveness of PRP use in the bone healing process on studies with experimental animal models. Methods: This study was a systematic review research whose article searches through the databases such as PubMed, ScienceDirect and ProQuest on English-language articles published from 2012-2022. The keywords used were ((bone healing OR fracture healing OR bone defect) AND (platelet rich plasma OR prp) AND (animal models)). Results: PRP was effective in accelerating bone regeneration in every experimental animal model in the early phases of healing, but not all studies have significant differences between groups that used PRP and those who did not. Conclusion: PRP has a positive impact in increasing bone mineral density, but the effectiveness of using PRP may vary from study result to study result, depending on the characteristics of the experimental animal model used in the study and the accuracy of concentration in the administration of PRP.Keywords: animal models, bone healing, platelet-rich plasma
Efek Pemakaian Hormone Replacement Therapy (HRT): Systematic Review Putri, Biomechy Oktomalio; Noverial, Noverial
Jurnal Kesehatan Andalas Vol. 12 No. 1 (2023): Online March 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i1.2131

Abstract

Menopausal women have a risk of suffering from several diseases due to decreased levels of the hormone estrogen in the body. One effort to reduce this risk is to use Hormone Replacement Therapy (HRT). Objective: To analyzed  the effect of HRT use on postmenopausal women.Methods: This research was a systematic review by searching articles in the PubMed electronic journal with keywords used [“Premenopausal women” OR “Postmenopausal women”, OR “Menopause”] AND  [“Hormone Replacement Therapy” OR “Menopausal Hormone Therapy”] AND [“Increased risk disease” OR “Decreased risk disease”]. Results: There were nine studies analyzed; six studies discussed the use of HRT having a positive effect in reducing the risk of several diseases, and as many as five studies discussed the use of HRT having a negative effect, namely, it could increase the risk of several diseases. The studies discussing the factors that influence the effect of HRT use are one study discussing how to use HRT, three studies discussing the type of HRT used, two studies discussing when to start using HRT, and three studies discussing the duration of using HRT which has a significant relationship to the effect resulting from HRT use. Conclusion: The use of HRT in postmenopausal women has negative and positive effects. This effect can be influenced by how HRT is used, the type of HRT used, when HRT was started, and the duration of using HRT.Keywords:  duration of use, how to use, HRT, type, time to start using
Pengaruh Pemberian Mesenchymal Stem Cells Wharton's Jelly terhadap Ekspresi Gen Sirtuin 1 pada Tikus Model Alzheimer Aizah, Havina Nurul; Yanis, Amel; Ali, Hirowati; Tofrizal, Tofrizal; Ilmiawati, Cimi; Arisanty, Dessy
Jurnal Kesehatan Andalas Vol. 12 No. 1 (2023): Online March 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i1.2140

Abstract

Mesenchymal Stem Cells Wharton's Jelly (MSC-WJ) has become a new hope for Alzheimer's disease due to its capability to suppress Amyloid-beta (Aβ) plaques formation. It is found that people with Alzheimer's disease have a lower expression of Sirtuin-1 because of the oxidative stress that was produced by Aβ plaques. Objective: To observe the Sirtuin-1 gene in Alzheimer's disease rat models that AlCl3 was inducing after being given MSC-WJ. Methods: This was an experimental study with a post-test-only control group design, including three groups with a total sample of 18 samples of Alzheimer RNA rat models. Group-1without AlCl3 and MSC-WJ; Group-2 with AlCl3; Group-3 AlCl3 and MSC-WJ. Mean value of the Sirtuin-1 gene was obtained by the Image-J application using a semiquantitative method which was then tested using the One Way ANOVA test. The study was significant if the p-value < 0,05. Results: This study found that the mean ± standard error value of the Sirtuin-1 gene in three groups were 0.18±0.04; 0.16±0.03; and 0.36±0.06 respectively. The statistical test showed a significant difference between the three groups (p = 0.014). Conclusion: There was an increased Sirtuin 1 gene expression in Alzheimer’s rat Model after being given Mesenchymal Stem Cells Wharton’s Jelly.Keywords:  Alzheimer, MSC-WJ, Sirtuin-1
Pengaruh Pemberian Mesenchymal Stem Cells Wharton’s Jelly terhadap Ekspresi Gen PPAR-γ pada Tikus Alzheimer Putri, Nabila Priscilla; Ali, Hirowati; Tofrizal, Tofrizal; Darwin, Eryati; Susanti, Restu; Hasmiwati, Hasmiwati
Jurnal Kesehatan Andalas Vol. 12 No. 2 (2023): Online July 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i2.2142

Abstract

The increased production of beta-amyloid marks Alzheimer's disease. PPAR-γ shows involvement in Alzheimer's disease. PPAR-γ Gene is suspected to reduce beta-amyloid plaques and reduce inflammation and oxidative stress in Alzheimer's disease. Mesenchymal Stem Cells Wharton's Jelly (MSC-WJ) is expected to increase the PPAR-γ Gene expression. Objective:  To observed the PPAR-γ Gene expression in Alzheimer's Mice. Methods: The mice are induced using AlCl3 and were given MSC-WJ. This study was an experimental study with a post-test-only control group design on 18 samples of RNA from Alzheimer's mice that were divided into 3 groups. Negative control group (K-), positive control group (K+), and experimented group (P). The mean of PPAR-γ gene expression was obtained by comparing the PPAR-γ gene with the GAPDH gene. This study used semiquantitative methods using ImageJ. Data analysis was used with the Kruskal-Wallis test. It is significant if the value is <0,05. Results: The mean ratio of PPAR-γ gene expression that was obtained in K-, K+, and P were 0.12, 0.06, and 0.08, respectively. There were significant differences between each group, with a p-value of 0,023 (p<0,05). Conclusion: Giving MSC-WJ could increase the PPAR-γ gene expression. Further study using real-time PCR is highly needed to increase the MSC-WJ treatment in patients with Alzheimer's disease.Keywords:  Alzheimer disease, MSC-WJ, PPAR- γ
Korelasi Status Nutrisi dengan Tingkat Kadar Hemoglobin Darah pada Anak Usia Sekolah Dasar Markidam di Desa Cilame Kabupaten Bandung Oktorina, Lenny; Hakim, Fadhli Dharmansyach; Buntoro, Josep Dharmadi; Berbudi, Afiat; Ewangga, Bayu
Jurnal Kesehatan Andalas Vol. 12 No. 1 (2023): Online March 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i1.2154

Abstract

Malnutrition has many adverse effects, including a decrease in hemoglobin levels, or known as anemia. Malnutrition caused by nutritional deficiencies can affect the decrease in hemoglobin levels or anemia. Objective: To determined the correlation between nutritional status and hemoglobin levels in Markidam elementary school-age children in Cilame Village Methods: This cross-sectional study uses primary data from research subjects who have agreed. The number of subject research that has been taken was 143 respondents. Anthropometric examinations using weight scales and microtoise were then carried out in a plotting process to determine the nutritional status of respondents. The hemoglobin level was used as a rapid diagnostic test tool with the Easytouch brand type GCHB. Spearman test to find out the results of this research hypothesis. Results:  Hemoglobin levels did not have a significant correlation with nutritional status. This could be seen from the significance value (p-value) of 0,172, where this value is greater than 0,05. Conclusion: There is no correlation between nutritional status and hemoglobin level at the age of elementary school children.Keywords: anemia, hemoglobin, nutritional status
Hubungan antara Rasio Neutrofil Terhadap Limfosit Preterapi dengan Angka Harapan Hidup Pasien Karsinoma Nasofaring di RSUD Abdoel Wahab Sjahranie Tahun 2018 Aulia, Nabiella Hasti; Irawiraman, Hadi; Susanti, Eva
Jurnal Kesehatan Andalas Vol. 12 No. 1 (2023): Online March 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i1.2155

Abstract

Nasopharyngeal carcinoma is a malignancy that originates from the epithelial tissues lining the nasopharynx and is considered one of the most common malignant cancers which cause mortality in Indonesia. Neutrophils and lymphocytes are the first lines to provide body immunity against foreign substances. Neutrophil-to-Lymphocyte Ratio (NLR) is a prognostic factor in various malignancies. Objective: To investigated the correlation between pre-therapy Neutrophil-to-Lymphocyte Ratio (NLR) and survival rate among patients with nasopharyngeal carcinoma at Abdoel Wahab Sjahranie Regional Public Hospital in 2018. Methods: The Neutrophil-to-Lymphocyte Ratio (NLR) data were obtained from outpatient medical records at Abdoel Wahab Sjahranie Regional Public Hospital in 2018. In addition, the data on mortality status were collected based on the information after directly contacting the patients. A purposive sampling technique was used to collect the data. Thirty-three data of patient medical records were obtained and analyzed using Kaplan-Meier survival analysis with a significant p-value of <0.05. Results: The analysis result showed p-value of 0.495. Conclusion: There is no correlation between pre-therapy Neutrophil-to-Lymphocyte Ratio (NLR) and survival rate among patients with nasopharyngeal carcinoma.Keywords:  nasopharyngeal carcinoma, neutrophil-to-lymphocyte ratio, survival rate

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