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Mutiara Medika: Jurnal Kedokteran dan Kesehatan
Published by Universitas Muhammadiyah Yogyakarta
ISSN : 14118033     EISSN : 26140101     DOI : 10.18196/mm
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Mutiara Medika Fakultas Kedokteran dan Ilmu Kesehatan (MMJKK) Universitas Muhammadiyah Yogyakarta is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from basic sciences, clinical, and community or public health research to integrate researches in all aspects of human health.
Arjuna Subject : -
Articles 934 Documents
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In vitro Cytotoxicity Evaluation of Dandelion Root Ethanol Extract on PANC-1 Cell Line Aras, Aliye İrem; Arslan, Emine; Özçay, Büşra
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 24, No 1 (2024): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v24i1.20917

Abstract

A challenging diagnosis is the outcome of pancreatic cancer's aggressivity and malignant character. This type of cancer is mostly detected in the metastatic stage. Current treatment options have various side effects, result in the survival rates and quality of life of patients are extremely decreased. Dandelion (Taraxacum officinale (L.) Weber ex F.H. Wigg.)  is one of the natural products that has the potential to be therapeutic against a wide range of diseases. This study aimed to evaluate the potential of ethanol extract of dandelion root (DRE) as an alternative anticancer agent. Based on this purpose, milk-rich dandelion roots were collected, cut into small pieces, and then extracted using Soxhlet in the presence of 70% ethanol. The cytotoxic effect of the DRE at certain doses (10, 5, and 2.5 mg/mL) was determined by the Microtetrazolium (MTT) assay for 24, 48, and 72 hours, and half-maximal inhibitory concentration (IC)50 values for these incubation periods were found to be 10 mg/mL, 6.80 mg/mL and 6 mg/mL (p0.001), respectively. As a result, DRE may reduce cell viability when applied to aggressive pancreatic cancer cells and may have the potential to be an alternative anticancer agent. This potential can be clarified with further studies.
The Correlation between Protein, Iron, and Vitamin C Intake with Hemoglobin Levels in Pregnant Women Sitorus, Elisabeth Prihana Rotua; Handayani, Septi; Balyas, Abi Bakring; Widayati, Ratna; Fatmaria, Fatmaria; Permatasari, Silvani
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 24, No 1 (2024): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v24i1.17311

Abstract

Hemoglobin is an important component of the human body. It aims to transport oxygen and carbon dioxide. Anemia during pregnancy often occurs in the second trimester. Pregnant women tend to be vulnerable to malnutrition since their nutritional needs will increase to satisfy the needs of both the mother and the fetus. Protein intake plays a crucial role in the transportation of iron in the body. Meanwhile, vitamin C serves as a promoter of iron absorption. This research aims to determine and analyze the correlation between protein, iron, and vitamin C intake and hemoglobin levels in pregnant women at Kayon Public Health Center, Jekan Raya District. This research used an analytic observational method with a cross-sectional approach and a purposive sampling technique. Bivariate analysis was also applied by using the Spearman test. The latter results obtain a p-value of 0.748 between protein intake and hemoglobin level; a p-value of 0.222 between vitamin C intake and hemoglobin level; and a p-value of 0.050 between iron intake and hemoglobin level. There was a correlation between iron intake and hemoglobin level, yet there was no correlation between protein and vitamin C intake with hemoglobin level.
Knowledge Level of Medical Students Regarding Clinical Manifestasions of Autism Spectrum Disorder Ichsanino, Muhammad Reyhan; Eka Pratiwi, Sari; Fitrianingrum, Lit
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 24, No 2 (2024): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v24i2.20620

Abstract

Autism Spectrum Disorder (ASD) is a group of brain development disorders characterized by stereotyped behavior and deficits in communication and social interaction. Cases of autism in Indonesia increased by as many as 6,900 cases per year. The increase in prevalence is due to the excellent knowledge and awareness among medical students and the broad possible criteria for making a diagnosis. Therefore, this study aims to describe the knowledge level of medical students regarding the clinical manifestations of ASD. This quantitative study used a descriptive design with a total sampling method. The target population of this study was all Tanjungpura University Medical Students. The sample population selected for this study was active Tanjungpura University Medical Students, Class of 2017 and 2018, who were then filtered using inclusion and exclusion criteria. As many as 178 participants filled out a questionnaire, and the data were subsequently analyzed utilizing a statistical program with a descriptive statistical test. Knowledge was divided into three categories of levels, namely good (76-100%), fair (56-75%), and poor (≤55%). The results revealed that the knowledge level of ASD clinical manifestation of the medical students was 77% good, 11% fair, and 12% poor.
Risk Factors of Breast Cancer in Patients at Dr. Doris Sylvanus Hospital, Palangka Raya Mutriqah, Dian Ana; Kania, Nia; Panghiyangani, Roselina; Husaini, Husaini
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 24, No 1 (2024): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v24i1.19067

Abstract

Breast cancer ranks first in contributes to cancer deaths in Indonesia. This study aims to analyze the relationship between menarche age, level of knowledge, and history of the use of control birth pills and the incidence of breast cancer. This study employed a case-control design. Inclusion criteria for the case group were women, 20–50 years, breast cancer patients, junior high education level, and married. The subjects excluded respondents who used contraception. The data comes from questioner and medical record. There were 27 respondents each for the case and control group. The result showed a major age range of 31–40 years (63.0%). The education level was dominated by junior high school (40.7%). The chi-square test showed a correlation between the age of menarche (p = 0.01) OR 5.50 (95% CI: 1.604 -18.864), and knowledge (p = 0.00) OR value of 8.31 (95% CI: 2.437-28.354) with breast cancer, but no correlation between history of use of pills contraception with breast cancer (p = 0.74). The dominant risk factor for breast cancer in patients at Dr. Doris Sylvanus Hospital was the level of knowledge. Increasing knowledge about cancer is important in preventing breast cancer in women, especially in Palangkaraya.
Knowledge Analysis of Postnatal Mother about Essential Newborn Care with Incidence of Postpartum Blues: A Cross-Sectional Study Ambarsarie, Riry; Prima, Indah; Sudjatmoko, Andri
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 24, No 1 (2024): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v24i1.19830

Abstract

Stress in the postpartum period can cause anxiety, fatigue, and decreased self-care associated with an increased risk of postpartum depression. In Indonesia, the incidence of postpartum blues is between 50-70%. This study assessed knowledge of essential newborn care among postnatal mothers and identified the incidence rate of postpartum blues. This cross-sectional study was conducted in Bengkulu city. Respondents of this research were 57 mothers who met the criteria included in the 2 weeks postpartum in Public Health Facilities. Mother’s knowledge was measured by Essential Newborn Care Questionnaire. The symptoms of postpartum blues were measured by the Edinburg Postnatal Depression Scale (EPDS). The contingency coefficient shows a relationship between mother’s knowledge about essential newborn care and the incidence of postpartum blues (p = 0.002; r = 0.380). The multiple logistic regression proved that knowledge is the main risk factor of postpartum blues (p 0.007; OR 6.039). The results of this study indicate that there is a significant relationship between maternal knowledge about essential newborn care and postpartum blues with a weak relationship. Those with poor knowledge, who are 6.039 times more risky than those with good knowledge, should be targeted for newborn care education.
Correlation between Blood Vitamin D Levels and Lipid Profiles in Post-Ischemic Stroke Patients Jaeri, Santoso; Retnaningsih, Retnaningsih; Husni, Amin; Maharani, Nani; Anjani, Gemala
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 24, No 2 (2024): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v24i2.22202

Abstract

Dyslipidemia and vitamin D deficiency are the predisposing factors for stroke. It is also established that vitamin D contributes to cholesterol metabolisms. Unfortunately, there is no evidence regarding the correlation between blood vitamin D levels and lipid profiles in patients with post-ischemic stroke. Herewith, the authors determine the correlation between blood vitamin D levels and lipid profiles among patients with post-ischemic stroke. A cross-sectional approach among 40 patients with post-ischemic stroke was obtained consecutively. Demographic characteristics, as well as the history of other diseases and 24 24-hour recall diet, were recorded. Then, the measurement of blood vitamin D levels and lipid profiles, such as total, LDL, HDL cholesterol, and triglyceride levels, were performed. Their correlations were determined using the Spearman correlation test. Among 40 subjects, no significant correlation was revealed between blood vitamin D levels and the serum total, LDL, HDL cholesterol, and triglycerides levels (p=0.898, 0.560, 0.361, and 0.622 respectively, and r=0.021, -0.095, 0.080, and 0.080 respectively). To summarize, there is no significant correlation between blood vitamin D levels and all lipid profiles in patients with post-ischemic stroke.
The Association between Religious Activities Participation and Physical Function in Indonesian Elderly Ekadinata, Nopryan; Imamah, Nur Fithriyanti; Nurhidayati, Evi
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 24, No 2 (2024): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v24i2.19185

Abstract

Physical function difficulty is a big concern in the elderly globally. Previous studies highlighted the inconclusive findings regarding the elderly's religious involvement and physical function disability. Furthermore, spiritual study is still scarce in Asian settings. The study examined the association between religious involvement (majelis taklim) and physical disability. This cross-sectional observational study harnessed the fifth wave of the Indonesian Family Life Survey (IFLS). Katz Index was used to measure the occurrence of physical disability. Participants aged ≥ 60 years were involved (n = 1799), and 18% reported having a physical function disability. Binomial logistic regression showed that in the unadjusted model, participation in majelis taklim (OR = 0.86, p 0.01) and involvement in the religious program (OR = 0.72, p0.05) were significantly associated with having no physical disability. Meanwhile, the lower frequency of participation in majelis taklim was significant with physical disability in the adjusted model (OR = 0.89; 95%, p0.05).  Participation in religious activities was associated with a lower probability of having a physical function disability in the elderly. The result of the study can be a potential consideration for caregivers, health workers, and policymakers to maximize the religiosity involvement program for reducing the risk of physical disability among the elderly.
The Level of Depression in Third Trimester Pregnancy, With and Without Anemia Primada, Lyla Fitrania; Wardani, Natalia Dewi; Pramono, M. Besari Adi
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 24, No 1 (2024): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v24i1.18655

Abstract

Anemia is a health problem worldwide, especially in pregnancy, as it can cause depression. Antenatal depression can cause impaired fetal growth and development, bleeding and abortion, prematurity, low birth weight babies, and postpartum depression. This research aims to determine the difference in levels of depression between anemia and non-anemia in the third trimester of pregnancy. It is an observational study with a cross-sectional design. The samples were 75 last-trimester pregnant women who did antenatal care in Diponegoro National and Amino Gondohutomo Hospital, and also Halmahera and Ngesrep Health Center in Semarang and willling to be respondents selected using a purposive sampling method. Data collection used a validated Edinburgh Postnatal Depression Scale (EPDS) questionnaire with a Content Validity Index (CVI) of 1.00 and a reliability of 0.706. Mann Whitney and Kruskal Wallis were utilized to analyze data. There were 38 respondents with anemia and 37 respondents without anemia. The 12 respondents (31.6%) with anemia had a risk of depression, and 13 respondents (35.1%) without anemia had a risk of depression. There was no significant difference in the level of depression in the third trimester of pregnancy with and without anemia (P0,05). 
Correlation Between Blood Pressure at Emergency Room and Mortality in Acute Non-Hemorrhagic Stroke Azzahra, Puteri Aulia; Wahyuliati, Tri
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 24, No 2 (2024): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v24i2.21140

Abstract

According to data from the World Stroke Organization (WSO), the annual incidence of stroke is around 13.7 million new cases, with an estimated 5.5 million deaths among those impacted. Stroke caused by complications of hypertension causes 51% of the 9.4 million deaths worldwide. The neurological severity of stroke patients is associated with a decrease in systolic blood pressure of 10 mmHg for every value below 150 mmHg. The purpose of this study is to examine the correlation between blood pressure levels and mortality in acute non-hemorrhagic stroke patients. This study uses cross-sectional research methods to conduct observational research. The study included a total of 60 patients with acute non-hemorrhagic strokes who were admitted to PKU Muhammadiyah Gamping Hospital. The patients were all over the age of 50 and met the specified inclusion and exclusion criteria. Data analysis using univariate tests and Spearman's bivariate tests. The results showed that there is no significant correlation between blood pressure at hospital admission and mortality in non-hemorrhagic stroke patients, as evidenced by a p-value of 0.5. The conclusion is that there is no meaningful correlation between blood pressure on admission to the hospital and mortality in patients with acute non-hemorrhagic strokes.
The Cytotoxicity of Agaro-Oligosaccharides and Neoagaro-Oligosaccharides on Macrophage Cells Pratitis, Visi Endah; Puspitasari, Pinki Anggrahini; Hanbal, Mayland Muhammad; Tsabitah, Khansa; Juliadmi, Dian; Saksono, Budi; Wijayanti, Nastiti
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 24, No 2 (2024): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v24i2.21059

Abstract

Agarose is a polysaccharide from red algae. Enzymatic hydrolysis of agarose can produce Agaro-Oligosaccharidess (AOS) and Neoagaro-Oligosaccharidess (NAOS). Different times of enzymatic hydrolysis can produce different types of AOS and NAOS based on their degree of polymerization (DPs). This study aims to examine the cytotoxicity of AOS and NAOS with different hydrolysis times on the macrophage cell line RAW 264.7. The parameters used were the percentage of cell viability and IC50 value. The cytotoxicity test using MTT assay and One-way ANOVA were used as statistical tests. The results showed that AOS-0 at a concentration below 125 µg/mL was not toxic and showed moderate toxicity up to a high concentration of 1000 µg/mL, while AOS hydrolyzed for 24 h (AOS-24) was not toxic to RAW 264.7 cells at all concentrations tested. The different results were shown in all NAOS samples, which were highly toxic to RAW 264.7 cells in the 125 to 1000 µg/mL, indicating that it was concentration dependent. The results showed that different hydrolysis times caused differences in the structure of AOS and NAOS compounds and influenced the toxicity level. Research development for further studies on antioxidants and anti-inflammatory needs more attention to the sample type and hydrolysis time.

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