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Evaluasi Kejadian Efek Samping pada Pasien Rheumatoid Arthritis yang Menggunakan DMARDs di Rumah Sakit di Banjarmasin Valentina Meta Srikartika; Khoerul Anwar; Amalia Amalia
Jurnal Pharmascience Vol 8, No 2 (2021): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v8i2.11681

Rheumatoid Arthritis merupakan penyakit inflamasi kronis dengan pembengkakan, nyeri, dan kerusakan sendi. Obat yang digunakan pasien rheumatoid arthritis (RA) termasuk dalam Disease Modifying Anti-Rheumatoid Drugs (DMARDs) yang dilaporkan menyebabkan berbagai efek samping. Penelitian ini bertujuan untuk mengevaluasi kejadian efek samping dalam penggunaan DMARDs serta hubungan karakteristik pasien dan pola penggunaan DMARDs terhadap kejadian efek samping. Desain penelitian ini adalah cross sectional dengan pengambilan data secara retrospektive. Populasi penelitian adalah seluruh pasien RA yang memenuhi kriteria yang berobat rawat jalan di poli sub spesialis Rheumatology pada salah satu Rumah Sakit di Banjarmasin. Pasien RA yang mengalami efek samping pada penggunaan DMARDs berjumlah 45 pasien (80,36%). Efek samping yang terbanyak pada pasien RA ialah alopesia yaitu sebesar 26 kejadian (23,21%) serta yang terkecil ialah diare 6 kejadian (5,36%) dan retinopati sebesar 6 kejadian (5,36%). Terdapat hubungan bermakna antara jenis kelamin dengan kejadian alopesia (p-value = 0,004), jenis obat dengan kejadian diare (p-value = 0,003), dan lama pengobatan dengan kejadian ruam (p-value = 0,038). Berdasarkan penelitian dapat disimpulkan bahwa mayoritas pasien rawat jalan RA yang menggunakan DMARDs mengalami berbagai efek samping dan terdapat hubungan antara karakteristik dengan kejadian efek samping tertentu. Kata Kunci: Rheumatoid Arthritis (RA), Disease Modifying Anti-Rheumatoid Drugs (DMARDs), Efek samping, Karakteristik pasien, Alopesia, Diare, Retinopati Rheumatoid Arthritis (RA) is a chronic inflammatory-disease characterized by joint’s swelling, pain, and damage. The drug used to treat patients with RA is categorised as Disease Modifying Anti-Rheumatoid Drugs (DMARDs) that has been reported has various side-effects. This study aimed to evaluate the profile of side-effect DMARDs use and the relationship of patient characteristics and DMARDs use to the incidence of adverse events. This study used cross sectional study design with retrospective data collection. The population were all RA outpatients that met the criteria treated in the poly sub-specialist Rheumatology Hospital in Banjarmasin. RA patients experienced adverse events on the use of DMARDs were 45 patients (80,36%). Most adverse events in RA patients were alopecia 26 events (23,21%) and the smallest was diarrhea 6 events (5,36%) and retinopathy of 6 events (5,36%). There was significant relation between sex and alopecia occurrence (p-value = 0,004), drug type and diarrhea occurrence (p-value = 0,003), and duration of treatment and rash occurrence (p-value = 0,038). It can be concluded that the majority of RA outpatients who use DMARDs experienced various side-effects and there was significant relationship between patient characteristics and particular side-effects.

Pengaruh Brief Counseling Modifikasi 5A Terhadap Kepatuhan dan Kadar Gula Darah Pasien Diabetes Melitus Tipe II Di RSUD Sawerigading Kota Palopo Muhammad Ashar Muslimin; Antonius Adji Prayitno Setiadi; Yosi Irawati Wibowo
Jurnal Pharmascience Vol 8, No 2 (2021): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v8i2.11355

Diabetes melitus merupakan salah satu masalah kesehatan masyarakat yang penting baik secara nasional maupun internasional. Diabetes melitus dianggap penyakit kronis yang memerlukan penggunaan terapi jangka panjang. Kepatuhan pasien dibutuhkan untuk mencapai kebrhasilan terapi. Salah satu intervensi yang dapat dilakukan untuk meningkatkan kepatuhan sehingga gula darah dapat terkontrol adalah brief counseling modifikasi 5A. Brief counseling modifikasi 5A merupakan proses pemberian informasi dan edukasi secara singkat. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh brief counseling modifikasi 5A farmasis terhadap kepatuhan dan hasil terapi berupa kadar gula darah pasien (GDP) pasien diabetes mellitus (DM) tipe II rawat jalan RSUD Sawerigading Kota Palopo. Desain penelitian ini menggunakan desain eksperimental pre-posttest. Pengambilan sampel dilakukan selama periode 9 Juni – 20 September 2020 di depo farmasi rawat jalan RSUD Sawerigading Kota Palopo. Sebanyak 40 pasien yang diberikan brief counseling modifikasi 5A sebanyak 2 kali dan 40 pasien yang tidak diberikan perlakuan brief counseling modifikasi 5A. Pengukuran hasil kepatuhan dan GDP dilakukan setelah 2 kali intervensi. Hasil penelitian menunjukkan bahwa perlakuan brief counseling modifikasi 5A dapat meningkatkan kepatuhan pengobatan pasien DM tipe II di depo farmasi rawat jalan RSUD Sawerigading Kota Palopo serta menurunkan GDP (p = 0,001). Diharapkan penelitian ini dapat diterapkan sebagai terapi konseling secara periodik bagi penderita DM Tipe II di RSUD Sawerigading Kota Palopo. Kata kunci: brief counseling, DM, kepatuhan pasien, GDP. Diabetes melitus is one of the important public health problems both nationally and internationally. One of the interventions that can be done to improve compliance so that blood sugar can be controlled is the 5A modification brief counseling. Modified 5A Brief counseling is a process of providing brief information and education. Diabetes mellitus is considered a chronic disease that requires the use of long-therm therapy. Patients compiliance is needed to achieve therapeutic success. One of the interventions that can be done to improve compliance so that blood sugar can be controlled is the 5A modification brief counseling. Modified 5A brief counseling is a process of a providing brief information and education. The purpose of this study was to determine the effect of the modified 5A pharmacist brief counseling on compliance and therapeutic outcames in the form of blood sugar levels (GDP) of type II diabetes mellitus (DM) patients in outpatient Sawerigading Hospital Palopo City. The design of this study used a pre-posttest experimental design. Sampling was carried out during the period starting June 9 – September 2020 at the outpatient pharmacy depot at sawerigading hospital palopo city. A total of 40 patients were given 5A modification brief counseling twice and 40 patients were not given 5A modification brief counseling treatment. Measurement of compliance and GDP result was carried out after 2 interventions. The results showed that the 5A modification brief counseling treatment could improve treatment adherence of type II DM patients at the outpatient pharmacy depot at Sawerigading Hospital Palopo City and reduce GDP (p=0.001). It is hoped that this research can be applied as a periodic counseling therapy for patients with Type II DM at Sawerigading Hospital Palopo City.

Evaluasi Penggunaan Antibiotik pada Pasien Bedah Bersih Terkontaminasi di Rumah Sakit Bhayangkara Surabaya Nurul Akhirin Nisak; Rika Yulia; Ruddy Hartono; Fauna Herawati
Jurnal Pharmascience Vol 9, No 1 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i1.10107

Bedah bersih terkontaminasi merupakan prosedur bedah yang dilakukan pada traktus bilier, traktus urinarius, respiratorius dan digestif, reproduksi kecuali ovarium atapun operasi tanpa disertai kontaminasi yang nyata. Bedah bersih terkontaminasi memiliki potensi terjadinya infeksi sebesar 3-11% untuk mencegah dan mengatasi terjadinya infeksi diperlukan pemberian antibiotik. Penelitian ini bertujuan untuk mengevaluasi penggunaan antibiotik dalam satuan Defined Daily Dose (DDD)/100 patient-days pada pasien bedah bersih terkontaminasi di RS Bhayangkara Surabaya. Metode penelitian dilakukan secara retrospektif observasional pada pasien rawat inap bedah dalam periode 1 Januari-31 Desember 2020. Hasil penelitian didapatkan 40 data medis kesehatan pasien yang memenuhi kriteria inklusi dan eksklusi. Total nilai DDD/100 patient-days antibiotik profilaksis tertinggi adalah ceftriaxone 25 DDD/100 patient-days, sedangkan antibiotik terapi yang paling tinggi adalah amoxicillin 38,35 DDD/100 patient-days. Antibiotik yang termasuk dalam segmen DU 90% pada penggunaan antibiotik profilaksis adalah ceftriaxone, cefazolin, dan amoxicillin; sedangkan untuk antibiotik terapi adalah amoxicillin, ceftriaxone, metronidazole, dan cefadroxil. Kesimpulan dari penelitian ini adalah penggunaan antibiotik pada bedah bersih terkontaminasi tinggi dan jenis antibiotik yang paling banyak digunakan adalah antibiotik golongan sefalosporin generasi 3 (ceftriaxone) yang spektrum antibakterinya lebih luas daripada antibiotik golongan sefalosporin generasi 2 (cefazolin).Kata Kunci: DDD/100 patient-days, Bedah Bersih Terkontaminasi, AntibiotikClean-contaminated surgery is a surgical procedure performed on the biliary tract, urinary tract, respiratory and digestive tracts, reproduction except for the ovaries or surgery with no contamination encountered. This procedure has a potential infection in the range of 3-11%, therefore it is necessary to give antibiotics to prevent and treat the possibility of infections. This study was to evaluate the use of antibiotics using the Defined Daily Dose (DDD)/100 patient-days in clean-contaminated surgical patients at Bhayangkara Hospital Surabaya. Data was collected retrospectively observational in surgical inpatients from 1st January-31st December 2020. Total samples 40 met the inclusion and exclusion criteria. The highest total DDD prophylactic antibiotic value was ceftriaxone 25 DDD/100 patient-days. On the other hand, the highest therapeutic antibiotic was amoxicillin 38.35 DDD/100 patient-days. The antibiotics included in the 90% DU segment in the use of prophylactic antibiotics were ceftriaxone, cefazolin, and amoxicillin. Meanwhile, for therapeutic antibiotics, namely amoxicillin, ceftriaxone, metronidazole, and cefadroxil. The use of antibiotics in clean surgery is high and the type of antibiotic that is most widely used is the third generation cephalosporin antibiotic (ceftriaxone) whose antibacterial spectrum is wider than the second generation cephalosporin antibiotic (cefazolin).

Analisa Kepatuhan Minum Obat Antihipertensi pada Pasien Peserta Posyandu Lansia Kartini Surya Khatulistiwa Pontianak Syarifah Nurul Yanti Rizki Syahab Asseggaf; Ridha Ulfah
Jurnal Pharmascience Vol 9, No 1 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i1.11870

Hipertensi yang tidak terkontrol dapat menimbulkan komplikasi berupa aneurisma, gagal jantung, sindrom metabolik yang memicu diabetes, penyakit jantung, stroke, demensia, dan sebagainya. Penelitian ini bertujuan untuk mengetahui penggunaan obat antihipertensi pada peserta Posyandu Lansia Kartini Madu II. Penelitian ini merupakan penelitian analitik menggunakan data sekunder berupa rekam medis pasien dengan total sampel sebanyak 48. Data berupa usia, jenis kelamin, jenis, dosis dan frekuensi pemberian obat antihipertensi, serta kepatuhan terapi pasien yang diukur dengan Medication Possession Ratio (MPR). Hasil penelitian ini menunjukkan hampir semua responden berusia ≥56 tahun (lansia lanjut) yakni sebanyak 44 orang (91,7%). Mayoritas pasien adalah pasien dengan hipertensi tingkat 2 yakni 29 orang (60,41%). Obat antihipertensi yang digunakan adalah kaptopril sebanyak 37 orang (77,08%) dan amlodipine sebanyak 11 orang (22,92%). Mayoritas pasien tidak patuh terhadap terapi antihipertensi yakni sebanyak 30 orang (62,5%). Terdapat hubungan bermakna derajat hipertensi terhadap kepatuhan minum obat pasien (p=0,0,040). Tidak terdapat hubungan bermakna antara bermakna usia, jenis kelamin, jenis obat, dosis obat dan frekuensi pemberian obat terhadap kepatuhan minum obat pasien (p>0,05). Kata Kunci: Hipertensi, Obat Antihipertensi, Kepatuhan Terapi Pasien Uncontrolled hypertension can lead complications including aneurysms, metabolic syndrome that caused of diabetes, stroke, dementia, and etc. This study determined the use of antihypertensive drugs in the participants of Posyandu Kartini Madu II. This study was a analytic study using patient medical record as secondary data in a total sample of 48 patients. Data collected were age, gender, type of doses and frequency antihypertensive drugs, and patient compliance in treatment measured with Medication Possession Ratio (MPR). The result of this study showed that almost all of patiens were ≥56 years old (91.7%). Majority of patients were patients with hypertension grade II as many as 29 people (60.41%). The antihypertensive drugs used were captopril by 37 people (77.08%) and amlodipine by 11 people (22.92%). Majority of patients as many as 30 people were not compliant with medical treatment of antihypertensive drugs (62.5%). There was a significant relationship of patient’s medication compliance with the degree of hypertension (p=0.040). There was no significant relationship of patient’s medication compliance with age, sex, class, dose and frequency of admistrasion of antihypertensive drug (p>0.05).

Skrining Fitokimia, Formulasi, dan Uji Sifat Fisik Sediaan Foot Sanitizer Spray Minyak Atsiri Sereh Wangi (Cymbopogon citratrus sp.) Rifqi Ferry Balfas; Yuniarti Dewi Rahmawati
Jurnal Pharmascience Vol 9, No 1 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i1.11990

Kulit merupakan bagian permukaan tubuh yang paling luar yang sangat vital untuk menutupi dan melindungi organ di bawahnya dari gangguan fisik maupun kimiawi. Bau kaki disebabkan oleh keringat karena bagian yang tertutup lama dan menjadi masalah bagi sebagian manusia. Foot sanitizer spray merupakan sediaan topikal pembersih kaki yang dapat membunuh bakteri, ragi dan jamur. Kandungan sereh wangi yaitu minyak atsiri, saponin, polifenol dan flavonoid dan mempunyai aktivitas antibakteri Tujuan penelitian ini untuk analisis fitokimia minyak atsiri sereh wangi dan memformulasikan agar memiliki sifat fisik yang sesuai dan disukai responden. Metode yang digunakan yaitu destilasi uap dan hasilnya skirining fitokima, sediaan foot sanitizer spray minyak atsiri di uji fisik dan uji kesukaan. Hasil penelitian analisis fitokimia minyak atsiri sereh wangi yaitu hasil positif pada uji triterpenoid, tanin, flavonoid, dan saponin, sedangkan negatif pada uji alkaloid dan steroid. Uji fisik yang di dapatkan untuk uji pH 4,5-4,8 sehingga sesuai dengan pH kulit yaitu 4,5-6,5; uji viskositas 1,720 – 1,003; dan hasil cycling test serta uji stabilitas tidak adanya perubahan yang signifikan pada pengamatan organoleptis (warna, bau, bentuk, dan tekstur). Uji kesukaan yang dihasilkan untuk kontrol 6,67 %, formulasi 1 (F1) 10 %, F2 36,67 %, dan F3 46,67 %. Kata Kunci: Foot Sanitizer Spray, Kaki, Kulit, Sereh Wangi Skin is outermost part of the body's surface which is vital to cover and protect the underlying organs from physical and chemical disturbances. Foot odor is caused by sweat because the part is covered for long time and becomes problem for some people. Foot sanitizer spray is a topical foot cleaning preparation that can kills bacteria, yeast and fungi. Citronella’s compound contents are essential oil, saponin, polyphenol and flavonoid that has antibacterial activity. This research aimed to analyzed phytochemicals of citronella essential oil and to formulated it in order to had appropriate physical properties and being preferred by the respondents. Method that used was steam distillation and the results would analyzed for phytochemical screening, the preparation of citronella essential oil foot sanitizer spray was tested for physical and hedonic tests. The results of phytochemical analysis of citronella essential oil were positive for triterpenoids, tannins, flavonoids and saponins. Negative for alkaloids and steroids. Physical test that was obtained for pH 4.5-4.8 test, so that it was suitable with skin pH, namely 4.5-6.5. Viscosity test result were 1.720–1.003 and results of the cycling test and stability test showed no significant changes in organoleptic observations (color, smell, shape and texture). The resulting preference test for control is 6.67%, formulation 1 (F1) is 10%, F2 is 36.67 %, and F3 is 46.67 %.

Pengembangan Modul dan Desain Aplikasi Konseling Farmasi untuk Hipertensi Berbasis Android Herda Ariyani; Mukhaimy Gazali; Aziza Fitriah; Muhammad Anshari
Jurnal Pharmascience Vol 9, No 1 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i1.12899

Kasus Hipertensi di Kalimantan Selatan cenderung mengalami peningkatan setiap tahunnya. Resiko kardiovaskular dapat menjadi tinggi pada hipertensi dengan faktor resiko. Berdasarkan penelitian kami sebelumnya diketahui bahwa Brief counseling modifikasi 5A yang diberikan apoteker dapat meningkatkan perilaku pasien, kepatuhan dan hasil terapi. Saat ini belum ada pedoman konseling farmasi untuk hipertensi dalam bentuk aplikasi yang praktis di era digital. Tujuan dalam penelitian ini adalah (1) menghasilkan desain modul konseling farmasi, (2) mengetahui kevalidan dan kepraktisan dari modul tersebut, (3) menghasilkan desain protototype aplikasi konseling farmasi untuk hipertensi berbasis android. Penelitian ini menggunakan pendekatan yaitu tahap ke-1: Pembuatan systematic review untuk mengetahui konten/isi dan sistematika modul. Tahap ke-2 dilakukan uji kevalidan oleh 2 orang Doktor dan uji kepraktisan dari modul oleh 7 orang apoteker menggunakan angket. Tahap ke-3, pembuatan prototype aplikasi digital. Penelitian ini merupakan penelitian dan pengembangan (Research and Development) dengan model Four-D (4-D) yang terdiri dari empat tahap pengembangan, yaitu Define (pendefinisian), Design (desain), Develop (pengembangan), Desseminate (penyebaran). Hasil penelitian menunjukkan bahwa modul konseling yang dikembangkan memiliki kriteria valid di mana setiap butir pernyataan memiliki indek aiken lebih dari 0,8. Berdasarkan aspek kepraktisan berada di kategori sedang, namun nilainya hampir mendekati tinggi di mana dari seluruh butir pernyataan didapatkan nilai rata-rata 0,78. Dapat disimpulkan bahwa validitas modul ini pada kategori tinggi dan praktis digunakan oleh apoteker. Adapun aplikasi konseling farmasi untuk hipertensi terbagi atas dua aplikasi utama. Aplikasi pertama berbasis web untuk mengelola data pasien. Aplikasi kedua merupakan berbasis android untuk memudahkan konselor dalam melakukan analisis terhadap kondisi pasien. Kata Kunci: Asuhan Kefarmasian, Aplikasi Android, Brief Counseling, Hipertensi, Modul Hypertension cases in South Kalimantan tend to increase every year, Cardiovascular risk may be high in hypertension with risk factors. Based on our previous research, it is known that the 5A modified brief counseling given by pharmacists to hypertensive patients can improve patient behavior, compliance and therapeutic outcomes. Currently, there are no pharmaceutical counseling guidelines for hypertension in the form of practical applications in the digital era. The purpose of this research is (1) produce pharmaceutical counseling module design, (2) determine the validity and practicality of module pharmaceutical counseling, (3) generating design protototype pharmaceutical counseling application for android-based hypertension. This study uses the approach that is stage-1: Preparation a systematic review to determine the content / content and systematics modules. In the second stage, the validity test was performed by 2 doctors and the practicality test of the module was carried out by 7 pharmacists using a questionnaire. The third stage is making a digital application prototype. This study is a research and development (Research and Development) with the Four-D models (4-D), which consists of four stages of development, ie define (definition), Design (design), Develop (development), Desseminate (deployment). The results showed that the counseling module developed had valid criteria where each statement item had an index of more than 0.8. Based on practical aspects are in the medium category, but its value is almost nearing where the whole point statement obtained from an average value of 0.78. The conclusion from the validity of this module is in the high category and is used practically by pharmacists. The applications of pharmaceutical counseling for hypertension are divided into two main applications. The first web-based application to manage patient data. The second is an android-based application to facilitate counselors in the analysis of the condition of the patient.

Larvacide Activity of Bungur Plants (Lagerstroemia loudonii T. & B.) Fahrauk Faramayuda; Faizal Hermanto; Ari Sri Windyaswari; Soraya Riyanti; Viola Aditya Nurhayati
Jurnal Pharmascience Vol 9, No 1 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i1.9982

The prevalence of DHF, especially in Indonesia, is still high. Dengue Hemorrhagic Fever (DHF) is a disease transmitted by the Aedes aegypti species mosquito vector. Therefore, reducing the incidence of DHF requires efforts to break the chain of transmission by inhibiting the growth of the Aedes aegypti mosquito vector. One of the plants that can inhibit the growth of A. aegypti mosquito larvae is the bungur plant. This study aimed to determine the larvicidal activity of ethanol extract of leaves, bark, stems, and fruit of bungur (Lagerstroemia loudonii T. & B.) against A. aegypti larvae. Extraction process used maceration method with 96% ethanol solvent. Phytochemical screening results showed that the ethanol extract of bungur leaves and fruit contains alkaloids, flavonoids, saponins, quinones, tannins, polyphenols, monoterpenoids, and sesquiterpenoids as well as steroids and triterpenoids, whereas in the ethanol extract bungur bark and stems contains alkaloids, flavonoids, saponins, quinones, tannins, polyphenols, monoterpenoids, and sesquiterpenoids. LC50 values of ethanol extract of leaves, bark, stems, and bungur fruit were 374.64 ± 11.88 µg/mL, 396.70 ± 3.99 µg/mL, 425.80 ± 8.15 µg/mL, and 312.54 ± 2.24 µg/mL, consecutively. The results showed that the ethanol extract of the leaves, bark, stems, and fruit of bungur could inhibit the growth of A. aegypti larvae. Ethanol extract of bungur fruit has the best larvicidal activity compared to other test extracts.

Cost Effectiveness Analysis Antibiotik Profilaksis pada Pasien Apendisitis di RSUD Anutapura Palu Tahun 2018 Khusnul Diana; Muzna Muzna; Muhamad Rinaldhi Tandah; Arya Dibyo Adisaputra
Jurnal Pharmascience Vol 9, No 1 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i1.11005

Apendisitis adalah peradangan akibat infeksi pada apendiks yang mana memerlukan penanganan berupa pembedahan untuk mencegah komplikasi perlu dilakukannya apendiktomi atau pengangkatan apendiks. Apendiktomi merupakan operasi bersih kontaminasi dan termasuk dalam kategori tinggi untuk diberikan antibiotik profilaksis. Tujuan penelitian ini adalah untuk mengetahui manakah penggunaan antibiotik profilaksis yang paling cost-effective pada pasien apendisitis di RSUD Anutapura Palu. Jenis penelitian ini adalah penelitian deskriptif dengan pengambilan data secara retrospektif. Penelitian ini dilakukan untuk menganalisis efektivitas biaya (Cost-Effectiveness Analysis) antibiotik profilaksis pada pasien apendisitis dengan melihat parameter penurunan suhu tubuh. Subyek penelitian yaitu 69 pasien rawat inap yang memenuhi kriteria inklusi dan eksklusi. Hasil penelitian menunjukan terdapat pasien yang menggunakan terapi antibiotik tunggal sebanyak 35 pasien (50,72%), kombinasi 2 antibiotik 27 pasien (39,13%) dan kombinasi 3 antibiotik 7 pasien (10,14%). Rata-rata total biaya medis langsung penggunaan antibiotik tunggal Rp. 7.430.971, kombinasi 2 antibiotik Rp. 11.236.020, kombinasi 3 antibiotik Rp. 12.321.345. Berdasarkan perhitungan ACER, diperoleh antibiotik yang memiliki biaya rendah adalah antibiotik tunggal seftriakson dengan nilai Rp. 159.199/unit suhu. Kata Kunci: Apendisitis, Antibiotik Profilaksis, Apendiktomi, Cost-Efffectiveness Analysis, Direct Medical Cost Appendicitis is inflammation due to infection of the appendix which requires treatment in the form of surgery to prevent complications, it is necessary to do an appendectomy or removal of the appendix. Appendectomy is a clean operation of contamination and is included in the high category for prophylactic antibiotics. The purpose of this study was to determine which use of prophylactic antibiotics was the most cost-effective in appendicitis patients at Anutapura Hospital Palu. This type of research is descriptive research with retrospective data collection. This study was conducted to analyze the cost-effectiveness (Cost-Effectiveness Analysis) of prophylactic antibiotics in appendicitis patients by looking at the parameters of decreasing body temperature. The research subjects were 69 hospitalized patients who met the inclusion and exclusion criteria. The results showed that there were 35 patients (50.72%), a combination of 2 antibiotics (39.13%) and a combination of 3 antibiotics 7 patients (10.14%). The average total direct medical cost of using a single antibiotic is Rp. 7,430,971, a combination of 2 antibiotics Rp. 11,236,020, a combination of 3 antibiotics Rp. 12,321,345. Based on ACER calculations, the antibiotic that has a low cost is the single antibiotic ceftriaxone with a value of Rp. 159,199 /unit temperature.

Efektivitas Ekstrak Etanol Kulit Batang Pakan Banyu (Croton argyratus Blume) terhadap Kualitas dan Kuantitas Spermatozoa sebagai Antifertilitas Nurlely Nurlely; Anika Iktishad Aslama; Noor Cahaya; Valentina Meta Srikartika
Jurnal Pharmascience Vol 9, No 1 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i1.11397

Kulit batang pakan banyu (Croton argyratus Blume) secara empiris digunakan sebagai obat kontrasepsi tradisional. Penelitian ini bertujuan mengevaluasi pengaruh ekstrak etanol kulit batang pakan banyu terhadap perubahan kualitas dan kuantitas spermatozoa pada tikus putih (Rattus norvegicus) jantan. Desain penelitian ini menggunakan rancangan post test only control group design. Kulit batang pakan banyu dimaserasi menggunakan etanol 70%. Pada bagian kulit batang terdapat zat aktif steroid, saponin, tanin, dan alkaloid. Uji pengaruh gambaran mikroskopik terhadap kualitas dan kuantitas spermatozoa menggunakan dua puluh ekor tikus jantan dengan 4 kelompok perlakuan yang diberi perlakuan secara oral selama 15 hari yaitu Kontrol negatif (Na CMC 0,5%), dan kelompok perlakuan (ekstrak dosis 100 mg/kgBB, 200 mg/kgBB, 500 mg/kgBB). Setelah 15 hari hewan uji dinekropsi untuk mengamati jumlah spermatozoa menggunakan improved neubauer hemositometer, motilitas spermatozoa, viabilitas dan abnormalitas spermatozoa menggunakan eosin negrosin sebagai pewarna. One way ANOVA digunakan untuk menganalisa data kuantitatif yang didapatkan. Hasil penelitian menunjukkan bahwa dosis 100 mg/kgBB, 200 mg/kgBB, dan 500 mg/kgBB memberikan perbedaan bermakna terhadap kelompok kontrol negatif (p < 0,05). Berdasarkan hasil penelitian tersebut dapat disimpulkan bahwa dosis 100 mg/kgBB, 200 mg/kgBB, dan 500 mg/kgBB memberikan pengaruh terhadap perubahan motilitas, abnormalitas, viabilitas, dan jumlah spermatozoa. Kata Kunci: Pakan Banyu, Kontrasepsi Pria, Spermatozoa Stem Bark of pakan banyu (Croton argyratus Blume) empirically is used as a traditional contraception method. This study aimed to evaluate the effect of the ethanol extract of the pakan banyu stem bark to change in the quality and quantity of spermatozoa in albino male rats (Rattus norvegicus). This research is an experimental research with posttest only control group design. Pakan Banyu stem bark was macerated using 70% ethanol. The extract contained the active substances such as steroids, saponins, tannins, and alkaloids. This study used twenty male rats which were divided into 4 groups: negative control (CMC Na 0,5%), and treatment groups (extract dose of 100, 200 and 500 mg/kg body weight). The treatment was orally administered for 15 days. After 15 days, the testis was isolated to observe the number of spermatozoa using improved Neubauer hemocytometer, motility, viability and sperm abnormalities using eosin nigrosin. Quantitative data were analyzed using one-way ANOVA. The results showed that dose of 100, 200, and 500 mg/kg body weight possessed a significant difference to the negative control group (p <0.05). Thus, it can be conclude that ethanol extract of Pakan Banyu stem bark (C. argyratus Blume) possesses an effect in changing of motility, abnormality, viability, and number of spermatozoa.

Formulasi Fast Disintegrating Tablet Ekstrak Etanol Avicennia marina fructus dengan Metode Granulasi Basah Mia Fitriana; Muhammad Habibie; Abidzar Mirza; Rafli Al Anshari
Jurnal Pharmascience Vol 9, No 1 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i1.12853

Avicennia marina fructus mengandung kandungan senyawa berupa alkaloid, flavonoid, saponin, glikosida yang terbukti memiliki aktivitas antidiabetes. Prevalensi diabetes melitus semakin meningkat pada pasien geriatri. Pasien geriatri cenderung mengalami kesulitan menelan tablet konvensional sehingga perlu dibuat sediaan yang lebih cepat hancur seperti fast disintegrating tablet. Salah satu metode granulasi yang dapat digunakan untuk membuat fast disintegrating tablet adalah menggunakan metode granulasi basah. Penelitian ini bertujuan untuk Penelitian ini bertujuan untuk menentukan formula fast disintegrating tablet yang memilik sifat fisika yang baik.Ekstraksi dilakukan dengan metode maserasi. Tiga formula dibuat dengan memvariasikan bahan penghancur yakni explotab®. Serbuk sediaan dievaluasi laju alir, sudut diam dan bobot jenis benar. Sediaan tablet dilakukan evaluasi keseragaman bobot dan waktu hancur. Hasil menunjukkan bahwa ketiga formula memenuhi syarat pada evaluasi granul laju alir, sudut diam dan bobot jenis benar dan uji evaluasi keseragaman bobot tablet. Formula I dan III tidak memenuhi syarat uji waktu hancur tablet, sedangkan formula II memenuhi syarat waktu hancur fast disintegrating tablet yang baik. Kesimpulan dari penelitian ini adalah formula yang menghasilkan sifat fisik sediaan yang baik adalah formula II dengan komposisi ekstrak A. marina fructus 2,5%, explotab® 6%, magnesium stearat 2,5 %, aerosil 0,5%, talkum 0,5%, gelatin 0,1%, dan manitol 87,9%. Kata Kunci: Fast Disintegrating Tablet, Evaluasi, Diabetes Avicennia marina fructus contains compounds in the form of alkaloids, flavonoids, saponins, glycosides which are proven to have antidiabetic activity. The prevalence of diabetes mellitus has been increasing in geriatric patients. Geriatric patients tend to have difficulty swallowing conventional tablets, so it is necessary to make preparations that disintegrate more quickly, such as fast disintegrating tablets. One of the granulation methods that can be used to make fast disintegrating tablets is the wet granulation method. The purpose of this study was to determine the formula for fast disintegrating tablets that had good physical properties. Extraction was carried out by the maceration method. Three formulas were made by varying the disintegrator agent, namely explotab®. The granule preparations were evaluated for flow rate, angle of repose and the density. The tablet preparations were evaluated for weight uniformity and disintegration time. The results showed that the three formulas met the requirements for evaluating the granule flow rate, angle of repose and the density and the weight uniformity of tablet. Formula I and III did not meet the requirements for the disintegration time of tablets, while formula II met the requirements for a good disintegrating time for fast disintegrating tablets. The conclusion of this research was the formula that produced good physical properties of the preparation was formula II with a composition of 2.5% A. marina fructus extract, 6% explotab®, 2.5% magnesium stearate, 0.5% aerosil, 0.5% talc, 0.1% gelatin and 87.9% mannitol.

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Abstract

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Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Muhammad Ikhwan Rizki

Contact Email ikhwanrizki@unlam.ac.id

Phone -

Journal Mail Official jps@unlam.ac.id

Editorial Address -

Location Kota banjarmasin, Kalimantan selatan INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Muhammad Ikhwan Rizki

Contact Email
ikhwanrizki@unlam.ac.id

Phone
-

Journal Mail Official
jps@unlam.ac.id

Editorial Address
-

Location
Kota banjarmasin,

Kalimantan selatan

INDONESIA