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Pharmascience
Published by Universitas Lambung Mangkurat
ISSN : 23555386     EISSN : 24609560     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal Pharmascience memuat naskah hasil penelitian dan artikel review bidang kefarmasian. Naskah dapat berasal dari mahasiswa, dosen, peneliti, dan lembaga riset. Setiap naskah yang diterima redaksi Jurnal Pharmascience akan ditelaah oleh Mitra Bebestari dan Anggota Redaksi. Jurnal Pharmascience terbit 2 (dua) kali dalam setahun yaitu Februari dan Oktober. Redaksi menerima pemesanan Jurnal Pharmascience untuk berlangganan atau pembelian setiap terbitan.
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Articles 360 Documents
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In Vitro Study of Antibacterial Activity of Patindis Leaf Extract (Urophyllum arboreum) and Microneedle Acne Patch against Propionibacterium acnes and Staphylococcus aureus Izma, Hayatun; Setiawan, Deni; Buih, Putri Helena Junjung; Muslimawati, Khoirunnisa; Azizah, Naila; Ajmi, Mahfuzatul
Journal of Pharmascience Vol 13, No 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.24008

Abstract

Acne vulgaris is a cutaneous disorder associated with Propionibacterium acnes and Staphylococcus aureus. This study investigated the antibacterial activity of patindis leaf extract (Urophyllum arboreum) and its microneedle acne patch against both bacteria. The extract was prepared from dried simplicia by maceration using 96% ethanol. Phytochemical screening was conducted using test-tube methods. Antibacterial testing included determination of inhibition zone diameter using the well-diffusion method, as well as the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Clindamycin 1% was used as a positive control, while 20% DMSO and microneedle patches without extract served as negative controls. The U. arboreum leaf extract contained flavonoids, alkaloids, saponins, condensed tannins and terpenoids. At concentrations of 1.25%, 2.5%, and 5%, the extract produced inhibition zones of 12.368, 14.693, 18.403 mm against P. acnes and 14.523, 17.408, 18.840 mm against S. aureus, respectively. The MIC and MBC values against both bacteria were 0.625%. The microneedle acne patch formulations produced inhibition zones of 9.196 mm (F1), 10.140 mm (F2), and 10.713 mm (F3) against P. acnes, but showed no activity against S. aureus. These results indicate that the microneedle acne patch containing U. arboreum leaf extract has potential as an alternative topical antibacterial agent.
Integrative Study on the Binding Energy Calculation: Molecular Docking and Molecular Mechanics with Generalized Born Surface Area Targeting Acetylcholinesterase Putranto, Ignasius Widya Parahita; Wiranata, Bonifacius Ivan; Istyastono, Enade Perdana; Riswanto, Florentinus Dika Octa
Journal of Pharmascience Vol 13, No 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.24094

Abstract

Alzheimer's disease (AD) imposes a significant global financial burden. Previous studies have reported that acetylcholinesterase (AChE) activity is strongly associated with AD, making it a key target in therapeutic research. Molecular docking and computational techniques are increasingly used to study these associations, yet a surge in publications has led to a departure from strictly designed paradigms. This study evaluates the accuracy of the Gibbs free energy of binding (ΔG) from molecular docking scores, Molecular Mechanics/Generalized Born Surface Area (MM/GBSA), and local Vina scores. The Spearman rank test was applied to compare ΔG predictions and the in vitro results from our previous study. The correlation coefficient for molecular docking was -0.491, the MM/GBSA correlation coefficient calculated at the best molecular docking pose was -0.309, the MM/GBSA correlation coefficient calculated at the last 5 nanoseconds (ns) snapshots was 0.164, and the correlation coefficient of the Vina local score calculated at the last 5 ns snapshots was 0.273. Our findings indicate that the ΔG prediction from the Vina local score for the last 5 ns shows the strongest correlation with in vitro results.
Antibiotics Without Prescription: Factors Affecting Sales and Purchases in the South Banjarbaru District Fitriah, Rahmayanti; Jannah, Ramilah Audini Miftahul; Hidayati, Rahmi
Journal of Pharmascience Vol 13, No 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.22237

Abstract

Antibiotics are drugs used to treat bacterial infections and should only be obtained with a doctor’s prescription. However, many people in Indonesia acquire them without one, and regulations are not fully enforced across regions. This study aimed to identify factors influencing the sale and purchase of non-prescription antibiotics. A quantitative approach was used, employing purposive sampling for sales factors and proportional random sampling for purchase factors, with data collected via questionnaires. Data were analyzed using univariate (frequency distribution), bivariate (Kendall’s tau test), and factor analysis methods. Results showed that antibiotic sales without prescriptions were at a moderate level (50%), while purchases were at a low level (65.3%). There was no significant relationship between antibiotic sales and purchases without prescriptions in South Banjarbaru District. The factors that most influence sales are integrity, financial, legal and critical sense, as well as external pressure, while the factors that influence purchasing are integrity, financial,  ease of access, knowledge, and recommendations/information from others.
Evaluation of Extraction Methods on the Antioxidant Potential of Balik Angin Leaves Ethanol Extract (Alphitonia incana (Roxb.) Teijsm. & Binn. ex Kurz) Sayakti, Putri Indah; Ramadhan, Hafiz; Forestryana, Dyera; Susiani, Eka Fitri; Aprillinia, Nadya; Khairany, Nadhia; Awwaliyah, Wardah Izzatul; Dewi, Winda Ameilia; Syifa, Nur
Journal of Pharmascience Vol 13, No 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.24662

Abstract

Alphitonia incana, also known locally as balik angin, is an endemic natural antioxidant plant of Borneo. The objective of the present work was to compare the effectiveness of maceration and Soxhlet extraction of balik angin leaves with respect to antioxidant activity and phenolic–flavonoid content. Ethanolic extracts were prepared using both extraction methods, and the phenolic-flavonoid content was quantified spectrophotometrically. Antioxidant performance was assessed through DPPH, CUPRAC, and FRAP assays. The findings revealed that the Soxhlet-derived extract contained higher concentrations of phenolic-flavonoid compounds than those produced by maceration. In addition, the Soxhlet-derived extract demonstrated stronger antioxidant activity, as evidenced by lower IC₅₀ and EC₅₀ values in the DPPH (10.872 ppm) and CUPRAC (6.578 ppm) assays compared with the macerated extract (IC₅₀ 13.127 ppm; EC₅₀ 14.034 ppm) and was classified as a very strong antioxidant. The FRAP assay further supported these results, with ferric reducing power values of 1,484.1 mg AAE/g extract for the Soxhlet-derived extract and 1,295.8 mg AAE/g extract for the macerated sample. Overall, the study concludes that Soxhlet extraction is more effective than maceration in enhancing the antioxidant potential of balik angin leaf, a result that is closely associated with their elevated phenolic and flavonoid content.
Determination of Total Phenolic and Caffeine Content and Their Correlation with Antioxidant Activity in Local Coffee Brews from South Kalimantan Wathan, Nashrul; Azmira, Naura; Anaini, Nurul Khasanah; Yahya, Nur Aulia; Lestari, Dhian Ririn; Joharman, Joharman; Fadlilaturrahmah, Fadlilaturrahmah
Journal of Pharmascience Vol 13, No 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.22576

Abstract

Coffee brews are widely consumed beverages known to contain bioactive compounds such as phenolic compounds and caffeine that provide health benefits, including antioxidant activity. The objective of this research is to evaluate the antioxidant activity, total phenolic content, and caffeine content of coffee brews made from local coffee beans of South Kalimantan, demonstrating their potential as functional beverages with health promoting properties. The local coffee beans used in this study originated from Pengaron, Aranio, Mataraman and Bati-Bati. The research included sample identification, beverage formulation, antioxidant activity assay using the DPPH method, and analysis of total phenolic and caffeine content using UV-Vis spectrophotometry. The results showed that the antioxidant activity, as indicated by IC₅₀ values, was lowest in coffee from Pengaron (202.962 ± 0.89 ppm), followed by Aranio (166.716 ± 0.358 ppm), Mataraman (150.043 ± 0.345 ppm), and the strongest in Bati-Bati (113.242 ± 0.122 ppm). The total phenolic content ranged from 58.327 ± 0.017 mg GAE/mL in Pengaron, 83.993 ± 0.017 in Aranio, 104.536 ± 0.032 in Mataraman, to 108.646 ± 0.042 in Bati-Bati. Caffeine levels were 123.876 ± 0.331, 139.340 ± 0.238, 175.495 ± 0.715, and 131.833 ± 0.620 mg/serving, respectively. The findings reveal a strong positive relationship between total phenolic content and antioxidant activity, while caffeine content did not consistently align with antioxidant performance. These findings support the significant role of phenolic compounds in determining the antioxidant potential of South Kalimantan’s local coffee beverages. The highest antioxidant activity and phenolic content were observed in coffee beverages made from Coffea liberica beans originating from Bati-Bati, suggesting its superior potential as a functional beverage with health benefits.
OPTIMASI DAN UJI AKTIFITAS ANTIOKSIDAN FORMULA TONER MINYAK DAUN SIRIH HIJAU (Piper betle L.) Agistia, Nesa; Iskandar, Benni; Nofriyanti, Nofriyanti
Journal of Pharmascience Vol 13, No 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.23886

Abstract

Paparan radikal bebas dapat menyebabkan kerusakan pada kulit. Minyak daun sirih hijau memiliki aktifitas antioksidan dan dapat diformulasikan menjadi sediaan toner namun pada formula sebelumnya dihasilkan toner yang keruh. Penelitian ini bertujuan untuk memperoleh formula optimum toner dan mengetahui aktivitas antioksidan. Metode pada optimasi menggunakan desain faktorial dengan dua faktor yaitu konsentrasi tween 80 dan PEG 400. Penentuan formula optimum toner menggunakan Design Expert 13. Formula optimum toner minyak daun sirih hijau menunjukkan hasil formula terbaik tween 80 (10%) dan PEG 400 (5%) dengan prediksi pH 5,66 dan persen transmitan 99%. Pengujian prediksi dan hasil uji dibandingkan dengan One Sample T-Test menunjukkan hasil yang tidak berbeda signifikan dengan nilai signifikansi > 0,05. Formula optimum toner yang dihasilkan memiliki sifat fisik yang baik, ditunjukkan dengan nilai pH 5,69 yang sesuai dengan pH kulit dan persen transmitan 99,2%. Toner minyak daun sirih hijau menunjukkan aktivitas sebagai antioksidan yang sangat kuat dengan nilai IC50 sebesar 43,29 µg/mL, ukuran partikel 12,2 nm. Dapat disimpulkan bahwa komposisi formula optimum toner menghasilkan sediaan toner yang memiliki sifat fisik yang baik dan aktivitas antioksidan sangat kuat.
Predicted Factors Related to Medication Compliance and Blood Pressure in Hypertension Patients Baroroh, Faridah; Faridah, Imaniar Noor; Sari, Andriana; Dewi, Yosi Pratama
Journal of Pharmascience Vol 13, No 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.22750

Abstract

Nonadherence to antihypertensive medication is a key factor contributing to treatment-resistant hypertension. The main goal of hypertension treatment is to reduce morbidity and mortality by effectively lowering blood pressure. This study aimed to identify the factors influencing medication adherence and blood pressure regulation in patients with hypertension. This research utilized a retrospective cohort design. Data were gathered using the MARS questionnaire and patient medical records. The study sample consisted of hypertensive outpatients from five community health centers in the Special Region of Yogyakarta, Indonesia. Data analysis was performed using the Chi-square test. A total of 410 respondents met the inclusion criteria, with the majority being female (75.7%), 67.8% of patients adhered to their medication regimen, while 49.5% had controlled blood pressure. Difficulty remembering to take medication (p=0.010) and difficulty taking medication (p=0.049) were significantly associated with non-adherence. Age (p=0.001) and medication adherence (p=0.037) were also significantly associated with blood pressure control. The study's conclusion showed that adherence to taking medication and age are highly correlated to controlled blood pressure in hypertensive patients. Moreover, several factors related to compliance need to be identified to increase patient compliance and therapy outcomes for outpatient hypertension patients at the health center.
In silico Evaluation of Quercetin and Apigenin from Litsea angulata as Potential Dual Binders of DPP-4 and SUR1 Arfan, Aulia Rhamadani; Akbar, Nabila Hadiah; Fakih, Taufik Muhammad; Ghifari, Tegar Asandra; Wisesa, Sulthan Waliid Anggara
Journal of Pharmascience Vol 13, No 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.24835

Abstract

Litsea angulata leaves have traditionally been used for diabetes management; however, the molecular mechanisms underlying their antidiabetic activity remain poorly understood. This study aimed to evaluate the interaction potential of two major flavonoids from L. angulata, quercetin and apigenin, against two protein targets associated with type 2 diabetes mellitus: dipeptidyl peptidase-4 (DPP-4, PDB ID: 1X70) and sulfonylurea receptor 1 (SUR1, PDB ID: 5YKG). Ligand structures were optimized using density functional theory at the B3LYP/6-31G level, followed by molecular docking simulations using AutoDock Vina. Sitagliptin and glibenclamide were used as reference ligands for DPP-4 and SUR1, respectively. The docking results showed that quercetin and apigenin exhibited moderate binding affinities toward DPP-4 (–8.0 and –7.5 kcal/mol), interacting with key residues including Arg125 and Tyr547. In contrast, both flavonoids demonstrated stronger predicted binding energies toward SUR1 (–9.1 and –9.0 kcal/mol) compared with glibenclamide (–8.8 kcal/mol), although the interactions occurred at residues different from the primary functional binding site. The protein–ligand interactions were mainly stabilized by π–π stacking and van der Waals interactions rather than strong hydrogen bonds. Additional in silico analysis indicated that both compounds possess favorable physicochemical and pharmacokinetic properties based on ADME prediction, while toxicity assessment suggested relatively acceptable safety profiles. These findings indicate that quercetin and apigenin may serve as promising flavonoid scaffolds for the development of antidiabetic agents targeting multiple proteins involved in glucose regulation. Further experimental studies are required to validate their pharmacological activity and clarify their mechanisms of action.
Effectiveness Probiotics as Anti-Aging for Facial Skin: A Systematic Review Putri, Putu Adinda Novyta Arsha; Sutema, Ida Ayu Manik Partha; Hita, I Putu Gede Adi Purwa; Widowati, I Gusti Ayu Rai
Journal of Pharmascience Vol 13, No 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.22558

Abstract

Premature skin aging is increasingly prevalent among individuals in their mid-20s to 30s, influenced by genetic, lifestyle, and environmental factors. Probiotics have emerged as a promising natural intervention to address this issue. This systematic review aimed to evaluate the effectiveness of oral and topical probiotics in preventing and managing signs of premature skin aging. A systematic search of PubMed and Scopus was conducted for Randomized Controlled Trials (RCTs) published between 2020 and 2025, using PICO-based inclusion and exclusion criteria. Methodological quality was assessed with the JBI checklist. Of 202 articles screened, eight RCTs were included. Results showed that oral probiotics improved skin quality by enhancing collagen production (24%), hydration (18%), and antioxidant activity, while topical probiotics reduced wrinkles (22%) and increased skin density (15%). In conclusion, oral and topical probiotics represent effective dual strategies for combating premature skin aging, though further studies are needed to optimize strain-specific formulations.
Acute Oral Toxicity of Methanolic Extracts from the Fruit and Leaf of Parijoto (Medinilla speciosa Blume) in Mice Muti, Annisa Farida; Maulana, Refian Ariesta Eka; Pradana, Dhigna Luthfiyani Citra; Rahmi, Eldiza Puji
Journal of Pharmascience Vol 13, No 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.24762

Abstract

Medinilla speciosa Blume, or parijoto, contains flavonoids, saponins, alkaloids, and tannins with pharmacological potential. However, information regarding its safety profile, particularly acute toxicity data, is still very limited, so research is needed to evaluate its safety level. This study aims to evaluate the acute oral toxicity of M. speciosa leaf and fruit extracts in ddY mice. This study used a true experimental design. M. speciosa leaf and fruit extracts were obtained by ultrasonic-assisted extraction with methanol as a solvent. The acute oral toxicity test was conducted with a fixed-dose method at a single dose of 2000 mg/kgBW. Parameters observed for 14 days included mortality, clinical symptoms of toxicity, body weight changes, relative organ weights, and histopathological analysis of the liver and kidneys. The findings indicated an absence of fatalities across all treatment groups. The LD50 values for both extracts were determined to exceed 2000 mg/kgBW, categorising the fruit and leaf extracts as mildly toxic (category 5). Mild toxic symptoms were only observed in the treatment group receiving the fruit extract. Histopathological analysis of the liver and kidneys revealed mild cellular changes that were not statistically significant. Therefore, a single oral administration of M. speciosa fruit and leaf extracts at doses up to 2000 mg/kgBW is relatively safe.

Page 36 of 36 | Total Record : 360

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