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Pharmascience
Published by Universitas Lambung Mangkurat
ISSN : 23555386     EISSN : 24609560     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal Pharmascience memuat naskah hasil penelitian dan artikel review bidang kefarmasian. Naskah dapat berasal dari mahasiswa, dosen, peneliti, dan lembaga riset. Setiap naskah yang diterima redaksi Jurnal Pharmascience akan ditelaah oleh Mitra Bebestari dan Anggota Redaksi. Jurnal Pharmascience terbit 2 (dua) kali dalam setahun yaitu Februari dan Oktober. Redaksi menerima pemesanan Jurnal Pharmascience untuk berlangganan atau pembelian setiap terbitan.
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Articles 340 Documents
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Pengaruh Metode Pengeringan Terhadap Kadar Flavonoid Ekstrak Etanolik Kulit Buah Alpukat (Persea americana Mill.) dengan Spektrofotometri UV-VIS Novia Ariani; Siska Musiam; Rakhmadhan Niah; Dwi Rizki Febrianti
Jurnal Pharmascience Vol 9, No 1 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i1.10864

Abstract

Buah alpukat (Persea americana Mill.) merupakan salah satu tanaman yang memiliki khasiat sebagai obat. Bagian yang sering dimanfaatkan adalah daging buah sedangkan kulit buah belum banyak dimanfaatkan. Kulit buah alpukat berpotensi untuk dikembangkan sebagai antioksidan dengan kandungan senyawa aktif flavonoid. Proses pengolahan simplisia sangat penting terutama pada tahap pengeringan. Tahap pengeringan bertujuan untuk memperoleh simplisia yang tidak mudah rusak selama penyimpanan dalam waktu lama dan menjamin kandungan senyawa aktif yang memiliki khasiat obat. Penelitian ini bertujuan untuk mengetahui pengaruh metode pengeringan terhadap kadar flavonoid ekstrak kulit buah alpukat. Jenis penelitian ini eksperimental. Teknik pengambilan sampel adalah Random Sampling. Metode pengeringan yang digunakan dengan penjemuran dengan sinar matahari dan menggunakan oven. Ekstraksi dilakukan dengan metode maserasi menggunakan pelarut etanol 96%. Metode analisis senyawa dilakukan dengan spektrofotometer Uv-Visible. Perbandingan dua metode pengeringan dianalisis dengan statistik Independent T-Test. Hasil penelitian menunjukkan Kadar flavonoid kulit buah alpukat yang dikeringkan dengan oven sebesar 13,14% sedangkan yang dikeringkan dengan sinar matahari ditutup kain hitam sebesar 5,58%. Dari hasil kadar dapat disimpulkan bahwa metode pengeringan kulit buah alpukat dengan oven lebih efektif dalam menghasilkan ekstrak yang memiliki kandungan kadar flavonoid Kata Kunci: Flavonoid, Metode Pengeringan, Persea americana Mill., Spektrofotometri  Avocado (Persea americana Mill.) is a plant that has medicinal properties. The part that is often used is the flesh of the fruit, while the skin of the fruit has not been widely used. Avocado skin has which the potential to be developed as an antioxidant with the active compound being flavonoids. The processing of raw materials is very important, especially at the drying stage. The drying stage aims to obtain raw materials that is not easily damaged during long storage and ensures the content of active compounds that have medicinal properties. This study aims to determine the effect of the drying method on flavonoid levels of avocado peel extract. This type of research is experimental. The sampling technique was random sampling. Methods of the drying used is in the sun drying and using an oven. Extraction was carried out by maceration method using ethanol 96% solvent. The method of compound analysis was carried out with a Uv-Visible spectrophotometer. The comparison of the two drying methods was analyzed using the Independent T-Test statistic. The results showed that the flavonoid content of oven-dried avocado peels was 13.14%, while those dried in the sun covered with a black cloth were 5.58%. From the results, it can be concluded that the oven-drying method of avocado peel is more effective in producing extracts that contain higher levels of flavonoids than the sun drying method.
Standarisasi dan Aktivitas Tabir Surya Ekstrak Etanol Daun Kakao (Theobroma cacao L.) Maria Ulfah; Sri Mulyati; Nurma Yunita
Jurnal Pharmascience Vol 9, No 1 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i1.11385

Abstract

Senyawa kimia dalam tanaman tidak dapat dijamin selalu konstan dan aman, sehingga diperlukan standarisasi, selain itu senyawa flavonoid dan fenolik diduga berpotensi sebagai tabir surya melindungi kulit dari radiasi sinar UV. Penelitian ini bertujuan menetapkan standarisasi dan aktivitas tabir surya ekstrak etanol daun kakao. Daun kakao diekstraksi menggunakan Microwave Assisted Extraction dengan etanol 70%. Hasil ekstrak diuji parameter spesifik meliputi identitas, organoleptik, kadar senyawa larut air dan etanol, skrining fitokimia, kadar flavonoid dan fenolik total, serta diuji parameter non spesifik meliputi susut pengeringan, kadar air, kadar abu total dan abu tak larut asam serta cemaran logam. Hasil dianalisis deskriptif dibandingkan dengan standar. Aktivitas tabir surya diuji dengan spektrofotometri λ 290-320 nm, nilai SPF dihitung dengan persamaan Mansur. Hasil organoleptic ekstrak kental berwarna coklat, rasa pahit, berbau coklat mengandung alkaloid, flavonoid, saponin, fenolik serta memiliki kadar flavonoid total 9,777±0,170 mgRE/gr ekstrak, fenolik total 45,321±1,220 mgGAE/gr ekstrak dan memenuhi parameter spesifik dan non spesifik meliputi senyawa larut air 21,024±0,574%, larut etanol 18,316±1,593%, susut pengeringan 15,08±0,148%, kadar air 17,16±0,261%, kadar abu total 2,342±0,015%, abu tak larut asam 0,789±0,036%, logam Pb <0,622 mg/kg, Cd <0,022 mg/kg, As 0,025 mg/kg serta memiliki nilai SPF konsentrasi 700 µg/mL sebesar 17,95±0,084 yang termasuk dalam kategori proteksi ultra. Kata Kunci: Parameter Spesifik, Parameter Non Spesifik, SPF Chemical compounds in plants cannot be guaranteed to always be constant and safe, so standardization is needed, besides flavonoid and phenolic compounds are suspected to have the potential as sunscreens to protect the skin from UV radiation. This study aims to establish the standardization and activity of cocoa leaf ethanol extract sunscreens. Cocoa leaves are extracted using Microwave Assisted Extraction with 70% ethanol. The results of the extract were tested for specific parameters including identity, organoleptic, levels of water soluble compounds and ethanol, phytochemical screening, total flavonoid and phenolic levels, as well as tested nonspecific parameters including drying shrinkage, moisture content, total ash content and acid insoluble ash and metal spruce. The results were analyzed descriptively compared to the standard. The activity of the sunscreen is tested with a spectrophototometry of λ 290-320 nm, the SPF value is calculated by the Mansur equation. Organoleptic results of brown thick extract, bitter taste, smelling of chocolate contains alkaloids, flavonoids, saponins, phenolics and has a total flavonoid content of 9,777±0.170 mgRE/gr extract, phenolics total 45,321±1,220 mgGAE/gr extract and meet specific and non-specific parameters including water soluble compounds 21,024±0.574%, ethanol soluble 18,316±1,593%, drying shrink 15.08±0.148%, water content 17.16±0.261%, total ash content 2,342±0.015%, acid insoluble ash 0.789±0.036%, Pb metal <0.622 mg/kg, Cd <0.022 mg/kg, As 0.025 mg/kg and has a concentration value of 700 μg/mL of 17.95±0.084 which belongs to the category of ultra protection.
Optimasi Preparasi Sampel untuk Penetapan Kadar Protein Ekstrak Cacing Tanah (Lumbricus rubellus) Ahmad Fauzi; Wahyu Utami; Denny Vitasari; Arifah Sri Wahyuni
Jurnal Pharmascience Vol 9, No 1 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i1.12961

Abstract

Demam tifoid merupakan salah satu penyakit yang menjangkit masyarakat Indonesia dengan 500 kasus per 100.000 penduduk dengan angka kematian mencapai 5%. Pengobatan utama demam tifoid adalah menggunakan berbagai macam antibiotik. Namun masyarakat Indonesia cenderung lebih memilih pengobatan alternatif atau tradisional. Salah satu obat tradisional demam tifoid adalah ekstrak cacing (Lumbricus rubellus) yang mempunyai kandungan protein sampai 71%. Kandungan protein sangat tergantung pada proses produksinya. Untuk itu diperlukan metode preparasi dan analisis untuk menentukan kadar protein yang bisa digunakan untuk menjamin mutu produk ekstrak cacing. Metode preparasi yang optimum  adalah dengan pemanasan pada temperatur 50°C selama 5 menit kemudian dianalisis kadar proteinnya dengan metode Lowry menggunakan spektrofotometer UV-Vis pada panjang gelombang 650,8 nm. Metode linier, akurat dan teliti dengan batas deteksi sebesar 0,18 mg/mL dan batas kuantifikasi sebesar 0,58 mg/mL. Kata Kunci: Protein, Cacing Tanah, Spektrofotometri, Metode Lowry  Typhoid fever is a disease that affects Indonesian people with 500 cases per 100,000 population with a mortality rate of 5%. The main treatment for typhoid fever is the use of various antibiotics. However, Indonesian people prefer to use alternative or traditional medicine. One of the traditional medicines for typhoid fever is earthworm (Lumbricus rubellus) extract which has a protein content of up to 71%. Protein content is highly dependent on the production process. For this reason, preparation and analysis methods are needed to determine protein levels that can be used to guarantee the quality of the worm extract products. The optimum preparation method is by heating at 50°C for 5 minutes and then the protein is analyzed using the Lowry's method using a UV-Vis spectrophotometer at wavelength of 650.8 nm. The method is linear, accurat and presice with  detection limit of 0.18 mg/mL and quantification limit of 0.58 mg/mL.
Identifikasi Gugus Fungsi Fraksi Etil Asetat dan Fraksi n-Heksan Hylocereus polyrhizus (F.A.C.Weber) Britton & Rose Sri Wahdaningsih; Fajar Nugraha; Hadi Kurniawan; Anis Marselia; Dian Novita Sari
Jurnal Pharmascience Vol 9, No 1 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i1.11192

Abstract

Buah naga merah diketahui memiliki manfaat pada daging maupun kulit buahnya. Kulit buah naga merah yang sering dibuang sebagai limbah ternyata memiliki aktivitas antioksidan yang lebih banyak daripada daging buahnya. Penelitian ini bertujuan untuk mengidentifikasi gugus fungsi yang ada pada fraksi etil asetat dan n-heksan kulit buah naga merah. Analisis gugus fungsi dilakukan dengan menggunakan alat spektrofotometer FTIR dengan metode pelet KBr. Hasil yang diperoleh bersifat kualitatif yaitu berupa spektrum inframerah. Hasil identifikasi gugus fungsi dari fraksi etil asetat kulit buah naga merah adalah gugus fungsi O–H, C–H alkana, C=O, C–O, dan C–H aromatik. Hasil identifikasi gugus fungsi dari fraksi n-heksan kulit buah naga merah adalah gugus fungsi O-H , C-H alkana, C-H alkena, C-O, dan C=O. Senyawa yang terkandung pada fraksi etil asetat kulit buah naga merah adalah fenolik, flavonoid, terpenoid, steroid, dan alkaloid. Senyawa yang terkandung pada fraksi n-heksan kulit buah naga merah adalah flavonoid, terpenoid, dan steroid. Kata Kunci: Kulit Buah Naga Merah, Fraksinasi, Spektrum, Fourier Transform Infrared  Red dragon fruit is known have benefits in the flesh and peel of the fruit. The peel of the red dragon fruit, which is often disposed of as waste, has more antioxidant activity than its flesh. This study aimed to identify the functional groups in the ethyl acetate and n-hexane fractions of red dragon fruit peel. Functional group analysis was done by using FTIR spectrophotometer with KBr pellet method. The results obtained were qualitative in the form of an infrared spectrum. The results of the identification of functional groups from the ethyl acetate fraction of red dragon fruit peel were O–H, C–H alkanes, C=O, C–O, and C–H aromatics functional groups. The results of the identification of functional groups from the n-hexane fraction of red dragon fruit peel were O-H, C-H alkanes, C-H alkenes, C-O, and C=O functional groups. The compounds that contained in the ethyl acetate fraction of red dragon fruit peel are phenolics, flavonoids, terpenoids, steroids, and alkaloids. The compounds that contained in the n-hexane fraction of red dragon fruit peel are flavonoids, terpenoids, and steroids.
Essential Oil and Ethanolic Extract of Curcuma Inhibits Mammae Tumors in Rats Induction by DMBA Akhmad Endang Zainal Hasan; Ekowati Handharyani; Sri Wahyuni
Jurnal Pharmascience Vol 9, No 1 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i1.13215

Abstract

Curcuminoids and xanthorizol are active components that may act as anticancer in the rhizome of Curcuma xanthorrhiza. The purpose of this study was to determine the content of the class of compounds in curcuma extract and essential oil using the phytochemical screening test method, the Folin-Ciocalteu method to determine the total phenolic content and the AlCl3 method for the total fentuconoid content. In addition, the activity of curcuma in inhibiting the influence of DMBA on the growth of breast cancer in rats was determined. Curcuma extract used is the result of extraction using 70% ethanol on an industrial scale. Total phenolic content and flavonoid extract of curcuma were determined by spectrophotometer. Inhibition testing of tumors formed due to DMBA induction was carried out by administering temulawak extract at doses of 35, 70, 140, 210 and 280 mg/kg body weight. Based on the phytochemical analysis, the ethanol extract of curcuma contained terpenoids, alkaloids, phenolic compounds and flavonoids. The results of the analysis of the ethanol extract of curcuma contained total phenols and flavonoids with concentrations of 42.96 mg GAE/g and 3.96 mg QE/g, respectively. The group that was given curcuma extract as the control group (p<0.05) had a significant difference. Based on the Mann-Whitney analysis, the third group with a dose of 140 mg/kg BW had the highest effect on tumor inhibition. The hope is that the development of curcuma extract into a standardized herbal medicine so that it can be used for the treatment of breast cancer can use the results of this research.
Uji Aktivitas Antibakteri Kombinasi Minyak Kelapa Murni dan Arang Aktif terhadap Streptococcus mutans Nurul Chusna; Muhammad Priyadi
Jurnal Pharmascience Vol 9, No 1 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i1.12704

Abstract

Streptococcus mutans merupakan bakteri penyebab masalah pada karies gigi. Penggunaan bahan alami dipercaya menjadi salah satu terapi infeksi yang dapat digunakan sebagai antibakteri. Beberapa penelitian menunjukkan adanya potensi bahan alami seperti minyak kelapa murni dan mineral arang aktif dapat mengobati karies gigi. Hal ini mendorong untuk mengetahui aktivitas antibakteri kombinasi antara minyak kelapa murni dan arang aktif terhadap S. mutans. Pengujian antibakteri dilakukan dengan metode difusi cakram dengan mengukur diameter zona hambat. Kelompok sampel uji terdiri dari kombinasi minyak kelapa murni : arang aktif (konsentrasi 10% v/v : 5% b/v, 5% v/v : 5% b/v, dan 5% v/v : 10% b/v) dan amoksisilin 30 µg sebagai kontrol positif. Hasil menunjukkan kombinasi minyak kelapa murni : arang aktif (10% v/v : 5%b/v, 5% v/v : 5% b/v, dan 5% v/v : 10% b/v) dan amoksisillin memiliki besaran zona hambat berturut-turut sebesar  8,50 mm; 6,90 mm; 6,90 mm dan 30,04 mm. Hasil uji penelitian yang dilakukan menunjukkan bahwa kombinasi antara minyak kelapa murni dan arang aktif memiliki aktivitas antibakteri yang lemah terhadap bakteri S. mutans. Selanjutnya, perlu dilakukan penelitian lanjutan aktivitas minyak kelapa murni maupun bahan-bahan alami lainnya pada penanganan infeksi gigi dan mulut. Kata Kunci: Antibakteri, Minyak Kelapa Murni, Arang Aktif, Karies Gigi, Streptococcus mutans   Streptococcus mutans is bacteria that causes problems in dental caries. The use of natural ingredients is believed to be one of the infection therapies that can be used as antibacteria. Several studies have shown the potential of natural ingredients such as virgin coconut oil and activated charcoal minerals to treat dental caries. It is encouraging to know the antibacterial activity of the combination of virgin coconut oil and activated charcoal against S. mutans. Antibacterial testing was carried out by disc diffusion method to know the diameter of the inhibition zone. The test sample group consisted of a combination of virgin coconut oil: activated charcoal (10% v/v : 5% w/v, 5% v/v : 5% w/v, and 5% v/v : 10% w/v ) and amoxicillin as a positive control. The results showed that the combination of virgin coconut oil: activated charcoal (10% v/v : 5% w/v, 5% v/v : 5% w/v, and 5% v/v : 10% w/v) and amoxicillin 30 µg had the size of the inhibition zone was 8.50 mm, 6.90mm, 6.90 mm and 30.04 mm, respectively. The results of the research conducted showed that the combination of virgin coconut oil and activated charcoal had weak antibacterial activity against S. mutans. Furthermore, it is necessary to conduct further research on the activity of virgin coconut oil and other natural ingredients in the treatment of dental and oral infections.
Analisis Hubungan Penggunaan Kontrasepsi Hormonal dengan Obesitas dan Hiperkolesterolemia di Puskesmas Pal III Pontianak Annisa Mutia Yusran; Nurmainah Nurmainah; Mohamad Andrie
Jurnal Pharmascience Vol 9, No 1 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i1.11697

Abstract

Pengaturan kehamilan dapat dilakukan dengan menggunakan kontrasepsi. Kontrasepsi hormonal seperti pil dan suntik memiliki efek samping peningkatan berat badan dan kadar kolesterol. Tujuan penelitian ini adalah untuk menganalisis hubungan antara obesitas dan hiperkolesterolemia dengan penggunaan kontrasepsi hormonal pada akseptor di Puskesmas Pal III Pontianak. Metode yang digunakan merupakan penelitian observasional dengan rancangan penelitian potong lintang (cross sectional) yang bersifat analitik. Teknik pengambilan sampel ialah  purposive sampling dengan jumlah sampel yang memenuhi kriteria inklusi sebanyak 40 akseptor. Metode pengumpulan data menggunakan rekam medis akseptor pengguna kontrasepsi hormonal periode Januari-Juni 2020. Pengukuran kadar kolesterol pada akseptor dilakukan dengan menggunakan alat Easy Touch® GCU dengan pengambilan sampel sebanyak satu kali. Analisis data dilakukan dengan menggunakan analisis chi-square. Hasil analisis jenis kontrasepsi hormonal menunjukkan bahwa persentase akseptor pengguna kontrasepsi hormonal yang mengalami obesitas untuk pil KB sebanyak 17,5%, dan suntik sebanyak 32,5%. Persentase akseptor pengguna kontrasepsi hormonal yang mengalami hiperkolesterolemia untuk pil KB sebanyak 20%, dan suntik sebanyak 27,5%. Analisis statistik menunjukkan bahwa tidak terdapat hubungan yang bermakna antara obesitas (p value = 0,058) dan hiperkolesterolemia (p value = 0,342) dengan penggunaan kontrasepsi hormonal. Kesimpulan dari penelitian ini bahwa tidak ada hubungan antara jenis kontrasepsi hormonal dengan risiko obesitas dan hiperkolesterolemia. Kata Kunci: Kontrasepsi Hormonal, Risiko Obesitas, Risiko Hiperkolesterolemia  Pregnancy control can be done using contraception. Hormonal contraceptives such as pills and injections have side effects of increasing weight and cholesterol levels. The purpose of this study was to analyze the relationship between obesity and hypercholesterolemia with the use of hormonal contraceptives in acceptors at the Pal III Public Health Center Pontianak. The method used was an observational study with an analytic cross-sectional design. The sampling technique was purposive sampling with the number of samples that met the inclusion criteria as many as 40 acceptors. The data collection method used medical records of acceptors of hormonal contraceptive users for the period January-June 2020. Measurement of cholesterol levels in acceptors was carried out using the Easy Touch® GCU device by taking samples once. The analysis was carried out using chi-square analysis. The results of the analysis of types of hormonal contraception showed that the percentage of hormonal contraceptive users who were obese was 17.5% for family planning pills, and 32.5% for injections. There was no significant relationship between the use of hormonal contraception at Pal III Public Health Center Pontianak with the risk of obesity (p-value = 0.058) and hypercholesterolemia (p-value = 0.342). This study concludes that there is no relationship between the type of hormonal contraception with the risk of obesity and hypercholesterolemia.
Sitotoksisitas dan Selektivitas In Vitro Daun Benalu Cengkeh (Dendrophthoe pentandra L. Miq) terhadap Sel Kanker Serviks HeLa Susilowati Susilowati; Truly Dian Anggraini; Nurul Kotimah
Jurnal Pharmascience Vol 9, No 2 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i2.13514

Abstract

Kanker serviks merupakan salah satu jenis kanker dengan tingkat kejadian dan kematian yang tinggi. Bahan alam dapat dianggap sebagai pendekatan yang menjanjikan untuk pengendalian dan manajemen kanker. Benalu cengkeh adalah salah satu tanaman parasit yang telah diketahui mengandung komponen anti kanker. Kuersetin dalam benalu cengkeh diyakini sebagai senyawa yang bertanggung jawab sebagai agen antikanker. Penelitian ini bertujuan untuk menguji sitotoksisitas dan selektivitas daun benalu cengkeh terhadap sel HeLa. Ekstraksi menggunakan metode maserasi dengan etanol 70% dan uji sitotoksik dievaluasi dengan metode MTT (3 (4,5-Dimethillitiazol-2-il) -2,5 diphenyltetrazolium bromide) pada model sel kanker Serviks HeLa dan model sel normal sel Vero. Efek sitotoksisitas diperoleh dari nilai IC50 dan selektivitas dinilai dari indeks selektivitas. Ekstrak etanol daun benalu cengkeh menurunkan viabilitas sel HeLa dengan potensi sitotoksik moderat (IC50 sebesar 43,90 μg / mL) dan selektivitas yang tinggi (SI sebesar 13,34), menunjukkan ekstrak tersebut berpotensi untuk dikembangkan sebagai produk biofarmasi. Penelitian lebih lanjut diperlukan untuk memastikan potensi antikankernya secara in vivo dan untuk menjelaskan mekanisme kerjanya pada tingkat molekuler dan biokimiawi. Kata Kunci: Sitotoksik, Selektivitas, Dendrophthoe pentandra, Sel HeLa, Sel Vero, MTT  Cervical cancer is one of cancer type with a high incidence and mortality rate. Natural ingredients can be considered a promising approach to cancer control and management. Dendrophthoe pentandra is one of the parasite plants that has been known to contain anticancer component. Quercetin in Dendrophthoe pentandra is believed to be marker compound as an anticancer agent. The current study aims to detect cytotoxicity and selectivity of Dendrophthoe pentandra leaves against HeLa cell. The extraction using maceration method with 70% ethanol and cytotoxic test was evaluated by MTT (3 (4,5-Dimethillitiazol-2-il) -2,5 diphenyltetrazolium bromide). The cytotoxicity effect was obtained from IC50 values and selectivity was assessed from selectivity index (SI). The ethanol extract of Dendrophthoe pentandra leaves reduces the viability of HeLa cells with moderate cytotoxic (IC50 of 43,90 µg / mL) and high selectivity (SI by 13,34) compared to normal vero cells, indicating its potential for biopharmaceutical use. Further studies are needed to ascertain its efficacy in vivo and to elucidate its mechanism of action at molecular and biochemical levels.
Analisis Akar Penyebab Masalah dalam Meningkat-kan Overall Equipment Effectiveness (OEE) Mesin Pengisi Bedak ke Kaleng PT. Coronet Crown Yanuar Hadi Irawan; Agnes Nuniek Nuniek Winantari; Sagitha Devina
Jurnal Pharmascience Vol 9, No 2 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i2.12195

Abstract

Industri farmasi, seperti PT. Coronet Crown memperoleh tantangan dalam menghadapi masa pandemi covid-19 dimana produktivitas dan efisiensi mesin harus berjalan dengan baik untuk menghasilkan produk yang berkualitas, bermutu baik, dan kapasitas produksi yang maksimal dengan harga yang kompetitif. Bedak Herocyn® merupakan salah satu produk andalan PT. Coronetcrown dimana mengalami peningkatan permintaan pasar setiap tahunnya. Penelitian ini bertujuan untuk menghitung produktivitas dan efisiensi mesin pengisi bedak Herocyn® ke kaleng sehingga dapat mengidentifikasi permasalahan pada mesin dan menyelesaikannya dengan solusi yang tepat agar produktivitas bedak meningkat. Metode yang digunakan adalah dengan perhitungan overall equipment effectiveness (OEE) pada dua mesin pengisi bedak selama bulan Januari-Desember 2020 dengan mendapatkan data loading time, downtime, total product, ideal cycle time, operating time dan total defect. Hasil OEE digunakan untuk mengidentifikasi six big losses kemudian permasalahan diidentifikasi menggunakan diagram Pareto dan diagram sebab-akibat sehingga solusi yang tepat dapat ditentukan. Hasil penelitian, nilai OEE mesin filling powder I dan II berturut-turut adalah 75,5% dan 78,3%. Nilai OEE kedua mesin masih dibawah nilai ideal. Berdasarkan hasil diagram Pareto, kontribusi tertinggi tidak idealnya nilai OEE kedua mesin yaitu idling and minor stoppages losses, setelah dianalisa menggunakan diagram sebab-akibat akar masalahnya adalah ketidakseragamnya ketrampilan operator dan preventive maintenance yang kurang optimal. Kata Kunci: OEE, Herocyn®, Mesin Pengisi Bedak, Diagram Pareto, Diagram Sebab-Akibat Pharmacy Industry, like PT. Coronet Crown gains a challenge in facing the pandemic situation of COVID-19 where the machine productivity and efficiency must work well to produce good quality product and maximum product capacity with competitive cost. Herocyn® powder is one of the leading product in PT. Coronet Crown which gaining increased demands in every year. This study aims to calculate the powder filling machine productivity and efficiency to identify problems in the works of the machine to get the best solution. The methode used is the calculation of overall equipment effectiveness (OEE) of two powder filling machine in January-December 2020 periode by taking loading time, downtime, total product, ideal cycle time, operating time, and total defect datas. The result of OEE will be determined to identify six big losses which then the problem cause will be identified using pareto diagram and cause-effect diagram to find the best solution. The result of OEE of filling powder machine I and II are 75.5% and 78.3%. These results mean that the two machine are in below state of OEE ideal score. According to pareto diagram, the highest contribution of low OEE score is idling and minor stoppages losses and after being analyzed with cause-effect diagram, the cause problem is the non-uniformity of operator skill and non optimal preventive maintenance.
Penentuan Aktivitas Antioksidan Ekstrak Etanol Bunga Ceguk (Combretum Indicum L.) Tipe Membulat pada Beberapa Wilayah di Kalimantan Selatan Amalia Khairunnisa; Samsul Hadi; Sri Oktaviana Sari
Jurnal Pharmascience Vol 9, No 2 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i2.13859

Abstract

Tanaman ceguk (Combretum indicum L.) memiliki 2 variasi yaitu tipe membulat dan tipe memanjang dan berpotensi sebagai antioksidan. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan bunga ceguk tipe membulat pada beberapa wilayah di Kalimantan Selatan yakni di Kota Banjarbaru, Kabupaten Banjar dan Kabupaten Kotabaru. Penentuan aktivitas antioksidan baik secara kualitatif maupun kuantitatif dilakukan dengan menggunakan KLT dan Spektrofotometer UV-Vis. Ekstrak etanol bunga C. indicum tipe membulat dari Kota Banjarbaru, Kabupaten Banjar, dan Kabupaten Kotabaru secara kualitatif memiliki aktivitas antioksidan yang ditandai dengan adanya bercak kuning dengan latar belakang ungu pada plat KLT setelah penyemprotan reagen DPPH. Adapun nilai IC50 ekstrak etanol bunga C. indicum tipe membulat pada Kota Banjarbaru, Kabupaten Banjar, dan Kabupaten Kotabaru masing-masing sebesar 16,358 ppm, 28,445 ppm, dan 20,868 ppm dengan kategori sangat kuat. Berdasarkan hasil penelitian ini bunga C. indicum tipe membulat memiliki aktivitas antioksidan tertinggi pada wilayah  Kota Banjarbaru.Kata Kunci : Combretum indicum L, bunga ceguk, ekstrak, antioksidan Combretum indicum L. has 2 types, rounded and elongated , as an antioxidant activity. This study aims to determine the antioxidant activity of round-type flowers in several areas in South Kalimantan, such as in Banjarbaru City, Banjar Regency and Kotabaru. Determination of antioxidant activities, qualitatively and quantitatively, was carried out using TLC and UV-Vis Spectrophotometer. The qualitative test of ethanolic extract of round type C. indicum flowers from Banjarbaru City, Banjar Regency, and Kotabaru had antioxidant activity which was indicated by the presence of yellow spots on a purple background on the TLC plate after spraying DPPH reagent. The IC50 values for the ethanolic extract of C. indicum flower type in Banjarbaru City, Banjar Regency, and Kotabaru were 16.358 ppm, 28.445 ppm, and 20.868 ppm with a very strong category antioxidant. Based on the results of this study, the round type of C. indicum flowers had the highest antioxidant activity in the Banjarbaru City area.

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