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INDONESIA
Berkala Kedokteran
Published by Universitas Lambung Mangkurat
ISSN : 14120550     EISSN : 25485660     DOI : http://dx.doi.org/10.20527
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Berkala Kedokteran is a journal contains scientific articles from original research and literature review in medical and health scope. It is published twice in a year, on February and September.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 491 Documents
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Combination of Modified Rhomboid Flap and Full-Thickness Skin Grafts (FTSG) for Scalp Defects Caused by Infiltrative Basal Cell Carcinoma (BCC): A Case Report Mayun, Komang Abdi Baskara; Irawan, Hendry
Berkala Kedokteran Vol 21, No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v21i2.24408

Abstract

Basal cell carcinoma (BCC) is the most common form of malignancy and its prevalence is increasing. BCCs have a low fatality rate but can cause severe morbidity, mainly through local damage. Full-thickness skin grafts (FTSGs) is a classic approach of reconstructing skin defects that have been utilised for wide defects. Objective of this study is to report an experience in treating BCC with wide excision and reconstruction using modified rhomboid flap and FTSG in Udayana University Hospital. A 75 years old female came with a complaint of lump in the head in the last 6 months ago. It was originally the size of a marble and progressively increasing. Physical examination showed a visible mass measuring 9x5 cm on the right temporoparietal region. The patient was diagnosed with BCC on the right temporoparietal region. It was planned for wide excision and reconstruction using modified rhomboid flap and FTSG. The donor site of the skin graft was harvested from the right inguinal. After underwent these procedures, a post-operative histopathological examination was conducted. The result showed BCC with infiltrative subtype. After one month, the reconstruction was acceptable and there was no sign of cancer recurrence. The flap and graft were in good and viable condition and there were no signs of inflammatory response. Combining modified rhomboid flap and FTSG gave numerous advantages for handling skin defects, especially in terms of healing process which shows better aesthetic and functional outcome, greater coverage, and less secondary contraction. These benefits can be seen in this case.
Relationship between Interleukin 6 and Estradiol Levels in Obese and Adult Men Dwipayana, I Made Pande; Semadi, I Made Siswadi; Nugraha, Ida Bagus Aditya; Gotera, Wira; Saraswati, Made Ratna; Suastika, Ketut; Saraswati, Putu Ayu Indah
Berkala Kedokteran Vol 21, No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v21i2.24498

Abstract

Obesity is a chronic disease characterized by a pathophysiological process that causes an increase in adipose tissue mass, leading to an increased risk of morbidity and mortality. Currently, there are many conditions that allow the interaction between environmental factors and genes that lead to various metabolic disease complications, such as diabetes mellitus and heart attack. Health workers are at the forefront of managing obesity and its associated complications. The study was conducted at Ngoerah Hospital from March to October 2024. The target population in this study were adult male medical personnel with and without obesity, working at Ngurah Hospital. The inclusion criteria in this study: male health workers in the environment at Ngoerah Hospital aged 18-45 years and willing to participate in the study by signing informed consent. Exclusion criteria in this study were all male health workers with infectious or inflammatory diseases, and or suffering from malignancies or a history of chemotherapy, and or with the use of hormonal therapy. The sample size of the study was 64 subjects. Data analysis included descriptive statistics, a normality test using the Kolmogorov-Smirnov test, a comparison test using the Mann-Whitney U test, and a correlation test using the Spearman rank correlation. This study was approved by the Research Ethics Commission, approval number 1697/UN14.2.2.VII.14/LT/2024. The results of this study found that IL-6 and estradiol levels in the obese group were higher than the non-obese group, however, the differences were not statistically significant. This may be attributed to the relatively young age of the subjects and the absence of significant inflammation in the early stages of obesity. There was no significant correlation between IL-6 and estradiol in all subjects, obese and non-obese groups.
Characteristics of Congenital Fetal Abnormalities in Ulin General Hospital Banjarmasin, South Kalimantan Sabaruddin, Hermin; Ahyadi, Robyanoor; Abimanyu, Bambang; Widhiati, Ruth; Hariadi, Hariadi; Sauqi, Hardyan; Aqmal, Hendri
Berkala Kedokteran Vol 21, No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v21i2.24989

Abstract

Congenital abnormalities are the leading cause of infant mortality and a significant contributor to child and adult morbidity. This study aims to analyze the characteristics and outcomes of fetuses with congenital abnormalities in a tertiary hospital. This study aims to determine the characteristics, influencing factors and a clearer picture of the prevalence and types of congenital abnormalities that occur at Ulin Banjarmasin Regional Hospital. This descriptive-retrospective study used secondary data from medical records collected between January 2022 and December 2024. A total of 85 congenital abnormalities were recorded over three years, with maternal ages ranging from 20 to 35 years, covering 58 (68.24%) cases. The majority of the mothers came from Tabalong Regency, South Kalimantan Province (n=19, 22.35%). Gestational age in the third trimester (>28 weeks) was found in 72 women (81.71%). The majority of respondents were multigravida (n=57, 67.06%). Caesarean section was the most common method of delivery (n=65, 76.47%). There were 51 respondents who had no history of congenital disease in the family (60.00%). The majority of respondents did not consume alcohol and smoke (n=79, 92.94% and n=75, 88.24%). Regarding folic acid consumption, 56 respondents (65.88%) did not consume it. The most common type of congenital disorder found was related to the nervous system with the largest proportion of 21 babies.
Determination of Flavonoid Levels and Anti-Inflammatory Activity of Lime Root Extract (Citrus aurantifolia) by Granuloma Pouch Method Mukti, Yusuf Anggoro; Rohama, Rohama; Jannah, Ghina Raudhatul; Rizantha, M. Iqbal; Daud, Muhammad Alfian
Berkala Kedokteran Vol 21, No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v21i2.24410

Abstract

Non-communicable diseases (NCDs) are still the leading cause of death at the global level. In Indonesia, NCDs contribute 71% of the total mortality rate. One of the causes of non-communicable diseases is the occurrence of oxidative stress in the body which is a condition of imbalance between free radical compounds and antioxidants. One of the sources of free radical formation in the body is when the inflammatory process occurs. Lime is used by the Indonesian people as a seasoning for cooking or empirically as an appetite enhancer, antipyretic and antibacterial. Research states that  lime root extract has very strong antioxidant activity with an IC50 value of 24.81 ppm and positively contains alkaloids, flavonoids, saponins and tannins. Flavonoids are thought to act as antioxidants and anti-inflammatory through their ability to donate hydrogen atoms and the ability to bind prostaglandins, COX-1 and COX-2 and lipooxygenase enzymes. The very strong antioxidant activity and the presence of flavonoids contained make lime root have the potential as an anti-inflammatory. Determination of flavonoid levels of lime root extract using UV-Vis spectrophotometry method with quercetin as a comparison and testing of anti-inflammatory activity of lime root extract using the Granuloma Pouch  method using mouse test animals. The results showed that the total flavonoid level was 36.8 mg QE (Quersetin Equialen)/g or 3.68%. And itexerts an anti-inflammatory effect through its ability to reduce the volume of exudate, lower the total exudate leukocytes, and lower the number of neutrophils in the exudate, most notably at a concentration of lime root extract of 20%.
Tube-Test of Antibiofilm Activity of Yellow Root Extract (Fibraurea tinctoria Lour.) Against Bacteria Causing Impetigo Budiarti, Lia Yulia; Dewi, Arisanty; Fahmi, Yafi; Biworo, Agung
Berkala Kedokteran Vol 21, No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v21i2.24506

Abstract

Impetigo is a contagious superficial bacterial skin infection that commonly occurs in children. The main causative agents are Staphylococcus aureus (S. aureus) and Streptococcus pyogenes (S. pyogenes). Both types of bacteria are capable of forming biofilms, making them resistant to antimicrobial agents. Antimicrobial agents that affect the survival of biofilm-forming bacteria are not only derived from synthetic drugs but also from phytochemical compounds. The antibiofilm effect can be assessed through a tube-test. Fibraurea tinctoria Lour (F. tinctoria), known as yellow root, contains various antibacterial compounds and has the potential as an antibiofilm agent. This experimental study aims to evaluate the ability of F. tinctoria root extract as an antibiofilm against S. aureus and S. pyogenes as the causative agents of impetigo in vitro. The study design used a post-test only with control group design with a tube-test method. The antibiofilm effect of F. tinctoria root extract at concentrations of 3.125%-50% and a 0.5% ampicillin control were tested on standard ATCC isolates of S. aureus and S. pyogenes. The observed parameters were the Minimum Biofilm Inhibitory Concentration (MBIC) and Mean Gray Value (MGV). The result showed F. tinctoria extract inhibited the biofilm formation of the tested bacteria. The antibiofilm activity was significantly influenced by extract concentration (P > 0.05). The MBIC value of the extract was found at a concentration of 12.5%, with MGV against S. aureus ranging from 130.303-157.3833 and 131.9767-160.1833 against S. pyogenes. In conclusion, F. tinctoria root extract demonstrates antibiofilm effects in vitro against the two tested bacteria that cause impetigo.
Conservative Management of Placental Abruption Wicaksono, Muhammad Adhitya; Ahyadi, Robyanoor; Abimanyu, Bambang; Widhiati, Ruth; Sabaruddin, Hermin
Berkala Kedokteran Vol 21, No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v21i2.25133

Abstract

Placental abruption is a severe obstetric complication. This case involves a 43-year-old woman with chronic hypertension, severe preeclampsia, and IUGR at 26-27 weeks gestation. Underweight (BMI 18.1), she presented with suspected placental abruption, oligohydramnios, and fetal growth restriction. This study highlights the importance of early detection and a multidisciplinary approach in improving outcomes. The patient received conservative treatment, including magnesium sulfate, corticosteroids, antihypertensives, and nutritional support. Despite maternal stability, fetal IUGR, and hypoxia led to an emergency cesarean at 33-34 weeks. A 1055g baby girl was delivered with Apgar scores of 6, 7, and 8. Placental examination revealed retroplacental hemorrhage and calcification. This case emphasizes the importance of early diagnosis, intensive monitoring, and timely intervention in high-risk pregnancies with placental abruption and severe preeclampsia. A multidisciplinary approach is essential to improve maternal and neonatal prognosis.
Risk Factors for Hypertension Incidence in the Riverbank Communities of Banjarmasin City Heriyani, Farida; Zein, Siti Habibah; Nursantari, Widya; Skripsiana, Nika Sterina
Berkala Kedokteran Vol 21, No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v21i2.24494

Abstract

Hypertension is a serious medical condition and a leading cause of death worldwide, including in Indonesia. South Kalimantan ranks second for the highest number of hypertension cases Indonesia. Banjarmasin City, particularly its riverbank areas, has unique environmental and socioeconomic conditions that may influence the health status of its residents, including the incidence of hypertension. This study aims to describe the risk factors for hypertension incidence among communities living along the riverbanks of Banjarmasin City, South Kalimantan. This descriptive study involved 70 respondents diagnosed with hypertension from three areas of Puskesmas (Community Health Center) in Banjarmasin City. The results of the study showed several risk factors for hypertension found among the respondents, including age ≥ 40 years (84.29%), female gender (65.71%), Banjar ethnicity (71.43%), high school or equivalent education level (64.29%), knowledge (50%), unemployed status (62.86%), family history of hypertension (68.57%), high salt consumption habits (65.71%), insufficient rest (42.86%), smoking habits (22.86%), low physical activity (62.86%), and obesity (31.43%). These findings indicate that the majority of respondents possessed a combination of both modifiable and non-modifiable risk factors. Therefore, early detection for non-modifiable risk groups and targeted health education and promotion efforts are essential to encourage lifestyle changes and prevent hypertension in the riverbank communities of Banjarmasin City.
Correlation Analysis of Mortality and Length of Stay in Sepsis Cases Among Heart Failure Patients with Low Ejection Fraction at Dr. Saiful Anwar General Hospital, East Java, Indonesia Sakti, Pradhika Perdana; Anjarwani, Setyasih; Rohman, Mohammad Saifur; Prasetya, Indra; Tjahjono, Cholid Tri
Berkala Kedokteran Vol 21, No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v21i2.24597

Abstract

In Indonesia, heart failure (HF) prevalence reaches 5%, contributing to over 1.8 million annual hospitalizations, accompanied by a 29% readmission rate and a 30-day mortality rate of 17%. The burden of infectious diseases, notably sepsis, further complicates the clinical landscape. Patients with sepsis residing in tropical regions often exhibit mortality rates surpassing global averages. Sepsis-associated coagulopathy (SAC) serves as a significant complication in this context. This study investigates the correlation between SAC, indicated by international normalized ratio (INR) levels, and outcomes in patients with heart failure with reduced ejection fraction (HFrEF) who develop sepsis. Utilizing a retrospective cohort approach, we analyzed medical records from Saiful Anwar Regional General Hospital, Malang, East Java, involving adult HFrEF patients who underwent INR testing. Purposive sampling was applied. Statistical analyses, including the Mann-Whitney Test, Kaplan-Meier Analysis, Log-Rank Test, Cox Proportional Hazards Regression, and Multiple Linear Regression, were conducted employing SPSS software. Results revealed a mean survival of 7.69 days in the Non-SAC group compared to 6.78 days in the SAC group, though the difference was not statistically significant (p=0.080). Notably, additional clinical complications predominantly influenced survival outcomes. This study elucidates that elevated INR levels, indicative of SAC, correlate with increased mortality and decreased survival in HFrEF patients with sepsis. Furthermore, the exacerbating effect of clinical complications on mortality highlights the imperative for early SAC detection and management of cardiovascular implications to enhance patient prognosis.
Exploring the Link Between Severe Preeclampsia and Asymptomatic Urinary Tract Infections in the Third Trimester: A Cross-Sectional Study Abimanyu, Bambang; Budinurdjaja, Pribakti; Radam, M. Robyanoor Ahyadi; Putri, Ruth Widhiati Raharjo; Sauqi, Hardyan; Sabaruddin, Hermin; Vamela, Agatha
Berkala Kedokteran Vol 21, No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v21i2.25138

Abstract

Urinary tract infection (UTI) is prevalent in women between 16 and 35 years old. UTI occurs in 2%-7% of pregnant women and affects the inflammatory process, which damages the vascular endothelium by decreasing nitric oxide (NO). This condition is evident in pregnant women with preeclampsia. This research aims to determine the relationship between urinary tract infections and preeclampsia in the third trimester of pregnancy in the delivery room at Ulin Regional Hospital Banjarmasin from January to December 2023. This study's design was cross-sectional observational using secondary data, including patient registers and medical record data. The sample included those who came in with labor, not labor and post-partum conditions for any causes and third-trimester pregnant patients diagnosed with UTI and Severe Preeclampsia in the delivery room of Ulin Regional Hospital, Banjarmasin and use chi-square test for each category. The 119 total pregnant patients with UTI in the third trimester arriving in the delivery room, 73 of them were diagnosed with preeclampsia. Most of them were under 35 yo. A total of 48 patients had multigravida status in all cases of UTI in preeclampsia in the third trimester of pregnancy. The chi-square analysis of the relationship and preeclampsia in pregnant women in the third trimester with p-value of 0.000, and the Odds ratio value was 4.4. Third-trimester pregnant women who suffer from urinary tract infections are 4.4 times more likely to experience preeclampsia.
Use of Natural Ingredients on the banks of the Lulut River as Self-medication and Potential for Pharmaceutical Product Development Melviani, Melviani; Noval, Noval
Berkala Kedokteran Vol 21, No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v21i2.24496

Abstract

Since ancient times, the people of the Banjar Tribe of South Kalimantan have used medicinal plants as a treatment for all kinds of diseases. However, over time, the forest area has been used as shifting cultivation, rubber plantations and oil palm plantations. This has resulted in a decrease in the number of plants in the forest, including medicinal plants. Apart from that, minimal information about types of medicinal plants in the community can also reduce public awareness of the use of medicinal plants as herbal medicines. This has resulted in concerns about the loss of use of medicinal plants from the forest in the future. So it is necessary to encourage the community to increase the role of traditional medicine. The aim of this research is to determine the use of natural ingredients as medicine in riverbank communities as well as efforts to develop the potential of medicinal plant products in the community as pharmaceutical preparations. The research method uses an observational research design with a cross-sectional approach and cluster sampling technique. This research involved 100 respondents from Sungai Lulut, South Kalimantan. The majority of respondents were women (76%) from the Banjar tribe (98%). The use of natural ingredients as traditional medicine, such as soursop leaves, which are the most commonly used, are often boiled and drunk to treat cancer, fever and diarrhea. The majority of respondents chose trees as the type of natural material used, especially the leaves. Information about traditional medicine was mostly obtained from the surrounding environment, while knowledge about the contents of natural ingredients, storage methods, and taboos or use was not generally known to respondents. for the development of pharmaceutical preparations which are most preferred in the form of tablets, capsules and pills.

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