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Trisnia, Putu Ayunda
Universitar Warmadewa
Religion Agriculture, Biological Sciences & Forestry Arts Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Library & Information Science Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Efficacy of high-dose methylprednisolone and cyclophosphamide in childhood-onset systemic lupus erythematosus Putu Ayunda Trisnia; Ketut Dewi KUmara Wati; Komang Ayu Witarini; Ida Bagus Ramajaya Sutawan; Hendra Santoso
Paediatrica Indonesiana Vol 60 No 3 (2020): May 2020
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (208.304 KB) | DOI: 10.14238/pi60.3.2020.117-24

Abstract

Background Systemic lupus erythematosus (SLE) is a chronic, multisystem, autoimmune disease. Untreated SLE often become progressive and lead to increased risk of mortality. Corticosteroid and cyclophosphamide remain the treatment of choice for severe SLE. Disease activity assessed with SLE Daily Activity Index (SLEDAI). Objective To compare the disease activity of childhood-onset severe SLE at the time of diagnosis, after completion of high dose methylprednisolone, and after three month of cyclophosphamide by using SLEDAI. Methods This study was conducted in the Division of Pediatric Allergy and Immunology, Department of Child Health, Udayana University/Sanglah Hospital, Denpasar, Bali. Subjects were SLE patient aged 0-18 years who had severe clinical manifestations. Subject received therapy combination of high dose methylprednisolone and cyclophosphamide every 2 weeks for six doses. SLEDAI score was assessed at the time of diagnosis, after completion of high dose methylprednisolone, and after three month of cyclophosphamide. Results During the study period, 51 children were diagnosed as SLE. Twenty-one subjects were included for analysis. Median SLEDAI score at the time of diagnosis was 23 (range 13-39). SLEDAI score after three months of cyclophosphamide was decreased to 2 (range 0-14). Post hoc analysis with Wilcoxon signed-rank test showed the improvement of SLEDAI score at the time of diagnosis and after three months of cyclophosphamide was statistically significant (Z=-4.016, P<0.0001). Conclusion SLEDAI score reduced after completion of high-dose methylprednisolone and three month of cyclophosphamide therapy.
First Aid Training for Elementary School Teachers at SD Genta Saraswati Gianyar Anak Agung Sri Agung Aryastuti; Desak Putu Citra Udiyani; Putu Ayunda Trisnia; Asri Lestarini
ABDIMAS: Jurnal Pengabdian Masyarakat Vol. 7 No. 4 (2024): ABDIMAS UMTAS: Jurnal Pengabdian Kepada Masyarakat
Publisher : LPPM Universitas Muhammadiyah Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35568/abdimas.v7i4.5200

Abstract

SD Genta Saraswati is a private elementary school located in the center of Gianyar City. Based on initial interviews, it was stated that teachers encountered many student conditions that required immediate treatment, such as sprains, wounds, stomach aches, fevers, nosebleeds, and other conditions. For this condition, teachers have provided simple treatment, but there is still minimal understanding and skills in providing first aid for children's accidents at school. The aim of this community service activity is to empower partners in providing first aid for children's accidents at school. The method of implementing the program is carried out through socialization, training, assistance with first aid equipment, mentoring, and evaluation of activity results by fully involving partners. This program involved 16 participants, consisting of teachers and staff at SD Genta Saraswati. After delivering the program, participants' knowledge increased, which can be seen from the increase in the average pre-test score from 6.56 to 9.06 (p<0.05). After carrying out practical training in providing basic life support and first aid in accidents, it was also seen that the participants were able to practice how to provide first aid in accidents that occurred at school. By carrying out this activity, it is hoped that teachers and staff at SD Genta Saraswati will be able to provide first aid independently for accidents or illnesses that occur at school.  
PENDAMPINGAN KELUARGA IBU HAMIL DI DESA SELULUNG KECAMATAN KINTAMANI EKAYANTI, NI WAYAN SRI; TRISNIA, PUTU AYUNDA
Jurnal Abdi Mahosada Vol. 3 No. 1 (2025): Jurnal Pengabdian Kepada Masyarakat 2025
Publisher : STIKES Advaita Medika Tabanan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54107/abdimahosada.v3i1.338

Abstract

Ibu hamil memerlukan kebutuhan asupan gizi yang semakin meningkat seiring dengan bertambahnya usia kehamilan. Kekurangan asupan gizi pada saat hamil akan berdampak terhadap kesehatan ibu dan janin misalnya terjadi berat bayi lahir rendah yang merupakan salah satu faktor risiko terjadinya stunting. Mitra dari program pengabdian ini adalah keluarga ibu hamil yang berisiko mengalami status gizi kurang. Permasalahan prioritas yang akan ditangani adalah asupan zat gizi pada ibu hamil masih di bawah angka kecukupan gizi, pemanfaatan bahan pangan lokal dan pemasaran masih kurang. Solusi yang diusulkan untuk masalah kekurangan asupan gizi pada ibu hamil adalah peningkatan pengetahuan ibu hamil tentang pembuatan makanan sehat dari bahan pangan lokal, pemberian bantuan paket gizi serta pelatihan penggunaan media sosial sebagai sarana pemasaran. Program pendampingan keluarga ini akan dilaksanakan melalui tahapan sosialisasi kepada semua pihak yang terkait, dilanjutkan penyuluhan kepada ibu hamil tentang pola asupan gizi pada ibu hamil dan makanan sehat selama kehamilan, serta memberikan paket gizi. Metode yang digunakan dalam kegiatan ini adalah penyuluhan dan diskusi. Hasil kegiatan berupa peningkatan pengetahuan ibu hamil mengenai gizi seimbang selama kehamilan, cara mengolah bahan pangan lokal serta pemasaran bahan pangan. Evaluasi dilakukan setelah pelatihan dan setelah program selesai dengan memberikan pertanyaan posttest dan didapatkan pengetahuan meningkat sekitar 38% dibandingkan sebelum penyuluhan. Kata kunci : ibu hamil, gizi seimbang, status gizi
Karakteristik Keluarga dan Balita Stunting Kusumadewi, Ni Nyoman Sri; Trisnia, Putu Ayunda; Sumadewi, Komang Trisna
Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Vol 15 No 3 (2025): Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal: Juli 2025
Publisher : Sekolah Tinggi Ilmu Kesehatan Kendal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32583/pskm.v15i3.3747

Abstract

Stunting merupakan perawakan pendek atau sangat pendek dilihat dari kurva pertumbuhan WHO panjang badan atau tinggi badan menurut umur menunjukkan kurang dari -2 standar deviasi. Wilayah kerja Puskesmas Kediri I memiliki prevalensi stunting yaitu 7,1% dan merupakan daerah dengan jumah balita stunting terbanyak di Kabupaten Tabanan. Penelitian ini dilakukan untuk mengetahui karakteristik stunting di wilayah kerja Puskesmas Kediri I Kabupaten Tabanan berdasarkan pendapatan keluarga, jumlah anggota keluarga, usia ibu pada saat hamil, tingkat pendidikan ibu, pekerjaan ibu, prematur, BBLR, ASI eksklusif, infeksi berulang, dan pemberian MPASI. Desain penelitian menggunakan studi observasional deskriptif. Responden yang digunakan sebanyak 94 orang yang didapatkan menggunakan teknik purposive sampling. Analisis data dilakukan dengan analisis univariat. Berdasarkan hasil penelitian, didapatkan di wilayah kerja Puskesmas Kediri I Kabupaten Tabanan lebih banyak keluarga dari balita stunting memiliki pendapatan di bawah UMR (51,1%), dan mayoritas memiliki jumlah anggota keluarga 4 orang atau lebih (87,2%). Mayoritas balita stunting memiliki riwayat infeksi berulang (83%). Dari penelitian ini dapat disimpulkan bahwa pendapatan di bawah UMR, dan jumlah anggota keluarga 4 orang atau lebih merupakan karakteristik keluarga balita stunting serta infeksi berulang merupakan karakteristik balita stunting di wilayah kerja Puskesmas Kediri I.
NEUTROPHIL TO LYMPHOCYTE RATIO MEAN DIFFERENCE AMONG PEDIATRIC COVID-19 PATIENTS IN BALI: PRELIMINARY STUDY Maharani, Ni Luh Putu Silfia; Masyeni, Sri; Trisnia, Putu Ayunda; Paramasatiari, Anak Agung Ayu Lila
JURNAL WIDYA MEDIKA Vol. 11 No. 2 (2025): October
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v11i2.7703

Abstract

The Neutrophil-to-Lymphocyte Ratio (NLR) is a significant prognostic marker in COVID-19, reflecting the body's inflammatory immune response. This study aimed to analyze differences in mean NLR among paediatric COVID-19 patients in Bali, stratified by age and gender. A cross-sectional analytic study was conducted using data from 56 hospitalized paediatric patients at Sanjiwani Gianyar and Wangaya Hospitals. The sample comprised patients aged 0–18 years, distributed as follows: 0–5 years (41.1%), 5–10 years (32.1%), 10–15 years (21.4%), and 15–18 years (5.4%). The cohort included 31 males (55.4%) and 25 females (44.6%). Statistical analysis using the Kruskal-Wallis test revealed a significant difference in mean NLR across age groups (p = 0.037). Similarly, the Mann-Whitney test indicated a significant difference in mean NLR between genders (p = 0.004). These findings suggest that the inflammatory response to COVID-19 varies among paediatric patients by both age and gender. Consequently, clinicians should consider these demographic factors, as they may indicate a need for tailored therapeutic and monitoring strategies.
Faktor-Faktor yang Berpengaruh Terhadap Keparahan Infeksi Dengue pada Anak: English PUTU AYUNDA TRISNIA; SARASWATI LAKSMI DEWI; SRI MASYENI
Hang Tuah Medical Journal Vol 23 No 1 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v23i1.844

Abstract

Dengue infection is one of the significant global health problems, especially in children. This paper aims to identify factors that affect the severity of dengue infection in the child population. The factors analysed included age, infection status, obesity, viral genome and Ns1 protein titers of dengue. Children who are younger and have an obese nutritional status tend to experience more severe symptoms. In addition, high NS1 titers, viral genomes, and secondary infections also contribute to a higher risk of infection. Detecting warning signs is important because it can be used as a predictor of more severe dengue infection.
THE RELATIONSHIP BETWEEN MATERNAL KNOWLEDGE AND ATTITUDE AND THE INCIDENCE OF STUNTING Riandra, Ni Putu Indah Kusumadewi; Wijaya, Putu Austin Widyasari; Trisnia, Putu Ayunda
JURNAL WIDYA MEDIKA Vol. 12 No. 2 (2026): July
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v12i2.8206

Abstract

Children under five years old are the most vulnerable group to nutritional problems. Undernourished children are at risk of reduced intelligence quotient, decreased immunity, lower productivity, mental and emotional health problems, and growth failure. Various maternal factors, including knowledge, and attitude influence this nutritional problem among children under five. This study aimed to analyze the relationship between maternal knowledge level and attitude and the incidence of stunting among children under five in Bayung Gede Village, Kintamani District, Bangli, Bali. This observational study employed a cross-sectional design involving 48 mothers with children under the age of five, selected using consecutive sampling. Data were collected using a structured questionnaire to assess maternal knowledge and attitude toward stunting, while children’s nutritional status was determined based on height-for-age measurements. Statistical analysis was performed using the chi-square test. The results showed that 30 (62.5%) of mothers had good knowledge, and 29 (60.4%) demonstrated a positive attitude toward stunting prevention. A significant relationship was found between maternal knowledge and stunting incidence, with children of mothers who had poor knowledge being more likely to experience stunting. Maternal attitude was also significantly associated with stunting incidence, indicating that a negative attitude increased the likelihood of stunting. These findings suggest that maternal knowledge and attitude play important roles in the occurrence of stunting. Strengthening educational interventions and improving access to health information for mothers are essential strategies to reduce stunting incidence among children under five.
Faktor yang Berhubungan dengan Sulit Makan pada Balita di Wilayah Kerja Puskesmas Sukawati I Gianyar: Studi Cross-Sectional Savitri, Kadek Amanda; Budiapsari, Putu Indah; Riandra, Ni Putu Indah Kusumadewi; Winianti, Ni Wayan; Trisnia, Putu Ayunda
Sari Pediatri Vol 27, No 5 (2026)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp27.5.2026.323-8

Abstract

Latar belakang. Sulit makan merupakan masalah tingkah laku yang relatif umum yang sering dialami oleh balita. Anak yang sulit makan mempunyai peluang besar mengalami penurunan dalam proses pertumbuhan dan perkembangan tubuh hingga menderita kurang gizi (underweight). Sulit makan pada anak bersifat kompleks dan perlu dicermati faktor yang menjadi penyebab perilaku tersebut. Tujuan. Tujuan penelitian ini adalah menganalisis faktor yang berhubungan dengan sulit makan pada balita di wilayah kerja Puskesmas Sukawati I. Metode. Penelitian ini merupakan penelitian analitik observasional dengan desain penelitian cross sectional. Penelitian ini dilakukan pada bulan Desember 2024 di wilayah kerja Puskesmas Sukawati I dengan teknik pengumpulan sampel yaitu consecutive sampling sebanyak 53 orang tua balita. Data yang dikumpulkan pada penelitian ini adalah data primer. Semua data yang didapatkan dari kuesioner ditabulasi dalam tabel excel kemudian diindahkan ke program SPSS yang selanjutnya dianalisis menggunakan uji chi-square apabila expected count memenuhi kriteria uji chi-square. Apabila tidak memenuhi uji chi- square maka digunakan uji fisher’s exact. Faktor-faktor dikatakan berhubungan dengan perilaku sulit makan apabila nilai p<0,05. Hasil. Mayoritas ibu berada pada rentang usia produktif (20-35 tahun), yaitu sebanyak 90,6% dan sebagian besar balita yang mengalami sulit makan berada pada kelompok usia 2-5 tahun (84,9%) dengan jenis kelamin laki-laki sebanyak 49,1% dan perempuan sebanyak 50,9%. Kesimpulan. Faktor yang berhubungan dengan sulit makan pada balita adalah status pekerjaan ibu, pendapatan orang tua, pola asuh, dan variasi makanan.
HUBUNGAN KONSUMSI SUGAR-SWEETENED BEVERAGES DENGAN DURASI MENSTRUASI PADA REMAJA PUTRI Ekayanti, Ni Wayan Sri; Wijaya, Putu Austin Widyasari; Evayanti, Luh Gde; Ekayani, Ni Wayan Diana; Trisnia, Putu Ayunda
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 10 No. 1 (2026): APRIL 2026
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v10i1.56718

Abstract

Konsumsi minuman manis yang tinggi merupakan kebiasaan yang umum pada remaja dan berpotensi memengaruhi berbagai aspek kesehatan, termasuk fungsi reproduksi. Menstruasi merupakan salah satu indikator penting kesehatan endokrin pada remaja putri. Penelitian ini bertujuan untuk menganalisis hubungan antara tingkat konsumsi minuman manis dan durasi menstruasi pada remaja putri. Penelitian ini menggunakan desain cross-sectional dengan melibatkan 76 responden remaja putri yang dipilih menggunakan teknik simple random sampling. Konsumsi minuman manis diukur menggunakan Food Frequency Questionnaire (FFQ) dan dikategorikan menjadi rendah (≤2 kali/minggu), sedang (3–5 kali/minggu), dan tinggi (>5 kali/minggu). Durasi menstruasi dikategorikan menjadi singkat (<3 hari), normal (3–7 hari), dan panjang (>7 hari). Analisis bivariat dilakukan menggunakan uji Chi-square, dengan koreksi Fisher’s exact test pada sel dengan expected count kecil. Kekuatan hubungan dianalisis menggunakan koefisien Cramer’s V. Hasil penelitian menunjukkan adanya hubungan yang signifikan antara tingkat konsumsi minuman manis dan durasi menstruasi pada remaja putri (χ² = 11.82; p = 0.019). Namun kekuatan hubungan tergolong lemah (Cramer’s V = 0.28). Temuan ini menunjukkan bahwa konsumsi minuman manis berpotensi berkontribusi terhadap variasi durasi menstruasi pada remaja putri, meskipun faktor lain kemungkinan memiliki pengaruh yang lebih besar.
Dengue Neonatal : Sebuah Laporan Kasus: Laporan Kasus Wijaya, Lisa Amelia; Trisnia, Putu Ayunda; Suarca, I Kadek
Cermin Dunia Kedokteran Vol 53 No 04 (2026): April 2026
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v53i04.1833

Abstract

Introduction: Neonatal dengue is a rare but potentially lethal infectious disease, infected through maternal vertical transmission during pregnancy or via mosquito bites. Case: A 3-day-old, 3120-gram female neonate was admitted to the neonatal intensive care unit with fever and jaundice. Her mother was re-admitted for dengue infection 24 hours postpartum. The patient was hemodynamically stable, withno thrombocytopenia, and underwent phototherapy to treat jaundice (total bilirubin 15,7 mg/dL, indirect bilirubin 14,8 mg/dL). Neonatal dengue was diagnosed on the third day of admission since her temperature rose to 38,8oC and the NS1 antigen was reactive. The platelet count dropped from 257,000/mm3 to the lowest count of 15,000/mm3 on the sixth day of admission with the appearance of petechiae on her face, chest, back, and abdomen. No active bleeding was observed. Adequate treatment and close hemodynamic monitoring would lead to better outcomes. Discussion: Neonatal dengue is a rare condition that can occur through vertical transmission from the mother orhorizontal transmission via mosquito vectors, with diagnosis supported by tests such as the NS1 antigen or RT-PCR. Clinical manifestations in newborns vary widely, ranging from mild fever to severe complications such as thrombocytopenia, shock, and liver dysfunction. Conclusion: Neonatal dengue is a potentially lethal infectious disease. Early diagnosis and prompt treatment are needed, especially in endemic regions.
Co-Authors Anak Agung Sri Agung Aryastuti Anak Agung Sri Agung Aryastuti Anak Agung Sri Agung Aryastuti Asri Lestarini Asri Prima Dewi AA Ayu budiapsari, putu indah Desak Putu Citra Udiyani Desak Putu Citra Udiyani Dewa Ayu Agung Alit Suka Astini Ekayani, Ni Wayan Diana Ekayanti, Ni Wayan Sri Fransiscus Fiano Anthony Kerans Gde Candra Yogiswara Hendra Santoso Ida Bagus Krisna Jaya Sutawan Ida Kurniawati Ketut Dewi Kumara Wati Komang Ayu Witarini Komang Trisna Sumadewi Kusumadewi, Ni Nyoman Sri Luh Gde Evayanti Maharani, Ni Luh Putu Silfia Ni Putu Indah Kusumadewi Riandra Ni Wayan Sri Ekayanti Ni Wayan Sri Ekayanti Ni Wayan Sri Ekayanti Pande Ayu Naya Kasih Permatananda Paramasatiari, Anak Agung Ayu Lila Putu Diah Witari PUTU SARASWATI LAKSMI DEWI Savitri, Kadek Amanda Sri Masyeni, Dewa Ayu Putri Suarca, I Kadek Sumadewi, Komang Trisna Wijaya, Lisa Amelia Wijaya, Putu Austin Widyasari Winianti, Ni Wayan