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All Journal JURNAL KIMIA SAINS DAN APLIKASI Jurnal Kedokteran Elkawnie Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Pro Food Lantanida Journal Al-Kimia Acta Pharmaciae Indonesia : Acta Pharm Indo Majalah Farmaseutik Indonesian Journal of Chemistry Jurnal Agrotek UMMat JCES (Journal of Character Education Society) WIDYABHAKTI Jurnal Ilmiah Populer J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Acta Chimica Asiana Amina Lumbung Farmasi : Jurnal Ilmu Kefarmasian SPIN: Jurnal Kimia & Pendidikan Kimia Jurnal Ilmiah Abdi Mas TPB Unram Journal of Multidisciplinary Applied Natural Science Sasambo Journal of Pharmacy INDRA: Jurnal Pengabdian kepada Masyarakat Journal of Molecular Docking Jurnal Pijar MIPA Jurnal Pendidikan dan Pengabdian Masyarakat Molekul: Jurnal Ilmiah Kimia
Agus Dwi Ananto, Agus
Universitas Mataram
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Social Sciences Other

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Analysis of BKO Content (Antalgin and Dexamethasone) in Herbal Medicine Using Iodimetry Titration and HPLC Method Agus Dwi Ananto; Lalu Undrus Yusditia M. G; Lalu Sanik Wahyu F. A
Elkawnie: Journal of Islamic Science and Technology Vol 6, No 1 (2020)
Publisher : Universitas Islam Negeri Ar-Raniry Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v6i1.5428

Abstract

Abstract : Misuse of adding chemical drugs – BKO – into herbal medicines is often done by irresponsible people. The aim is to increase efficacy instantly, to attract consumer interest. BKO, which are often added to herbal medicine, are antalgin and dexamethasone. Antalgin content analysis was carried out quantitatively using the iodimetry titration method by conducting a preliminary test. The dexamethasone content analysis was carried out with qualitative and quantitative methods. The qualitative method was carried out using TLC. The quantitative method was carried out using the HPLC technique. The results obtained for the analysis of antalgin content of 10 samples were obtained two samples of herbal medicine containing antalgin, respectively 0,0749% and 0,1083%. Analysis of the dexamethasone content from 10 samples obtained 5 herbal samples containing dexamethasone respectively 0.0979%, 0.222%, 0.4521%, 0.5131% and 0.2809%. So based on these results, it is necessary to take action from the relevant institution regarding the discovery of the content of BKO in the herbal medicine on the market in Lombok.Abstrak : Penyalahgunaan penambahan bahan kimia obat (BKO) kedalam jamu sering sekali dilakukan oleh oknum yang tidak bertanggung jawab. Hal ini dilakukan dengan tujuan meningkatkan khasiat secara instan, sehingga dapat menarik minat konsumen. BKO yang sering ditambahkan kedalam jamu adalah antalgin dan deksametason. Analisis kandungan antalgin dlakukan dengan cara kuantitatif menggunakan metode titrasi iodimetri dengan melakukan uji pendahuluan. Sedangkan analisis kandungan deksametason dilakukan dengan metode kualitatif dan kuantitatif. Metode kualitatif dilakukan dengan menggunakan KLT. Metode kuantitatif dilakukan dengan menggunakan teknik HPLC. Hasil yang diperoleh untuk analisis kandungan antalgin dari 10 sampel didapat 2 sampel jamu yang mengandung antalgin masing-masing sebesar 0,0749% dan 0,1083%. Analisis kandungan deksametason dari 10 sampel diperoleh 5 sampel jamu yang mengandung deksametason masing masing sebesar 0,0979%; 0,222%; 0,4521%; 0,5131% dan 0,2809%. Sehingga berdasarkan hasil tersebut maka perlu dilakukan adanya tindakan dari instansi terkait perihal masih ditemukannya kandungan BKO dalam sediaan jamu yang beredar di pasaran pulau Lombok.
ANALISIS KANDUNGAN NUTRISI BUAH RENGGA (Amomum dealbatum Roxb) Handa Muliasari; Agus Dwi Ananto; Muhsinul Ihsan
Jurnal Agrotek Ummat Vol 6, No 2 (2019): August
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (463.588 KB) | DOI: 10.31764/agrotek.v6i2.1218

Abstract

Tanaman rengga (Amomum dealbatum Roxb) tergolong family Zingiberaceae. Tanaman ini merupakan tanaman khas Pulau Lombok yang masih jarang dimanfaatkan potensinya. Buah tanaman rengga biasa dikonsumsi oleh masyarakat setempat, namun kandungan nutrisinya belum dilaporkan. Penelitian ini bertujuan untuk menganalisis kandungan nutrisi pada buah rengga yang terdapat di Pulau Lombok. Kandungan nutrisi meliputi kadar air, kadar abu, kadar serat, lemak, protein dan karbohidrat menggunakan analisis proksimat mengikuti metode AOAC 2005. Hasil analisis proksimat menunjukkan kandungan nutrisi buah rengga yaitu kadar air 55,19±0,27%; kadar abu 3,72±0,10%; kadar karbohidrat 34,51±0,03%; serat 6,46±0,57%; lemak 2,87±0,05%; dan protein 3,13±0,09%.
PELATIHAN PENGGUNAAN OBAT SECARA TEPAT UNTUK SWAMEDIKASI Handa Muliasari; Agus Dwi Ananto; Candra Eka Puspitasari; Rizqa Fersiyana Deccati; Virnia Wanda Utami
JCES (Journal of Character Education Society) Vol 3, No 3 (2020): October
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jces.v3i3.2750

Abstract

Abstrak: Telah dilakukan kegiatan pengabdian kepada masyarakat di Desa Lembah Sempaga, Kecamatan Narmada, Kabupaten Lombok Barat yang bertujuan untuk memberikan pemahaman kepada masyarakat tentang penggunaan obat secara tepat dalam melakukan swamedikasi. Kegiatan pengabdian dilakukan dengan memberikan sosialisasi tentang penggunaan obat yang tepat yang dilanjutkan dengan workshop mengisi identitas obat dan penggunaan umum obat. Peserta kegiatan dapat memahami materi yang disampaikan yang ditunjukkan dengan kemampuan menjawab pertanyaan ketika diskusi. Pemahaman penggunaan obat yang tepat juga terukur dari kemampuan mengisi catatan identitas obat dan menggunakan obat dengan benar, serta dapat menyampaikannya di depan forum diskusi dengan baik. Pemahaman yang baik tentang penggunaan obat yang tepat diharapkan dapat menjadi panduan masyarakat dalam melakukan swamedikasi, sehingga tidak terjadi kesalahan pengobatan maupun resiko efek samping obat.Abstract: Community service activities have been carried out in Lembah Sempaga Village, Narmada District, West Lombok Regency, which aims to provide understanding to the community about the proper use of drugs in conducting self-medication. Community service activities are carried out by providing socialization about the proper use of drugs, followed by workshop to fill in the drug identities and general use of drugs. The participants were able to understand the material presented which is shown by the ability to answer questions during the discussion. Understanding of proper drug use was also measured by the ability to fill in the records of drug identity and drug use properly. The participants were also able to convey it in front of discussion forums properly. A good understanding of proper drug use is expected to be a guide for the community in conducting self-medication, so that there is no medication error or the risk of drug side effects.
Studi In Silico Bioaktivitas Antikanker Senyawa Aktif Dalam Minyak Biji Buah Wali [Brucea javanica (L.) Merr] Agus Dwi Ananto; Handa Muliasari; Candra Dwipayana Hamdin
Sasambo Journal of Pharmacy Vol. 1 No. 2 (2020): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (201.127 KB) | DOI: 10.29303/sjp.v1i2.13

Abstract

Insilico study of anticancer bioactivity in oil of “buah wali” [Brucea javanica (L.) Merr] has been successfully carried out. “Buah Wali” (Brucea javanica (L.) Merr) is known to treat various diseases such as diabetes, diarrhea, and malaria. In addition, “buah wali” seeds are supported to have antidiabetic, antioxidant, and anticancer activities. The stages of the study began by taking a sample of “buah wali”seeds, then extracted to get oil of “buah wali”. While GC-MS analysis resulted Octadec-9-enoic acid (56.25%), palmitic acid (13.82%), stearic acid (10.57%), and acids -9-octadecanoate (5.91%) were found as the major components of the seed oil. Based on these compounds, docking molecular was carried out to find anticancer bioactivity. The results obtained are compounds that have lower binding energy than the native ligands [Octadec-9-enoic acid (-72.4518), hexadecanoic acid (-70.2136), octadecanoic (-72.2362).
Aktivitas antioksidan ekstrak etanol daun pecut kuda (Stachytarpheta jamaicensis (L.) Vahl) menggunakan metode ekstraksi berbasis gelombang ultrasonic Rian Jumawardi; Agus Dwi Ananto; Rizqa Fersiyana Deccati
Sasambo Journal of Pharmacy Vol. 2 No. 2 (2021): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (262.456 KB) | DOI: 10.29303/sjp.v2i2.85

Abstract

 Free radical is an atom or molecule that has unpaired electrons, is reactive and unstable which can cause damage to cells and tissues. Secondary metabolite compounds in plants such as phenolics, flavonoids, tannins, and saponins can inhibit free radicals. One of the plants that has the potential as an antioxidant is a Stachytarpheta jamaicensis (L.) Vahl. The part of the plant that is often used as a medicinal ingredient by Indonesian people is the leaf part. The leaves of snakeweed are natural ingredients that are rich in phenolic compounds, flavonoids, tannins, and saponins. This study aims to determine the activity of free radical inhibition in the snakeweed leaf extract with Ultrasound Assisted Extraction method. Determination of free radical inhibition activity was examined using DPPH method at the concentration series of snakeweed leaf extracts of 60, 65, 70, 75, 80, and 85 ppm. The comparison solution used was vitamin C made with a concentration series of 4, 5, 6, 7, 9, and 11 ppm. The results showed that vitamin C had a free radical inhibitory activity with an IC50 value of 9.40 ± 0.07 ppm, while the extract of snakeweed leaf had free radical inhibition activity with an IC50 value of 74.32 ± 0.71 ppm. Based on the IC50 value, the intensity of free radical inhibition activity in vitamin C is classified as very strong and the extract of snakeweed leaf is strong
Workshop Pangan Jajanan Anak Sekolah (PJAS) dan Inovasi Sarapan Sehat untuk Anak Usia Sekolah Siti Rahmatul Aini; Iman Surya Pratama; Agus Dwi Ananto; Luh Putu Gina Sri Budiani
INDRA: Jurnal Pengabdian kepada Masyarakat Vol. 1 No. 1 (2020): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (558.424 KB) | DOI: 10.29303/indra.v1i1.17

Abstract

Abstract: Nutritious and safe intake is a prerequisite for the growth and development of school-age children. Poor breakfast habits and snacks for school children that do not meet the requirements contribute significantly to the nutritional problems of school-age children. This is one of the priority health problems. Low achievement in the implementation of school children's nutrition programs has led to healthy breakfast and snack innovations workshops at one of the elementary schools in Sekarbela sub-district, Mataram city. The workshop participants included 50 people consisting of school-age children, parents, teachers, and canteen vendors. The workshop was guided by a nutritionist, and he explained the selection of nutritional intake, both through breakfast and snack. Also, participants were trained to practice a variety of healthy breakfast innovation menus. After the workshop, participants were able to practice and be actively involved in making a healthy breakfast innovation menu. The response of participants to the menu is quite good. After mentoring by a nutritionist, parents and teachers can solve the problems encountered. Cafeteria vendors get input regarding snacks supply after expert review. This workshop has been going well and has produced the results as targeted.Keywords: PJAS, healthy breakfast, workshop, school-age children.
Edukasi dan sosialisasi gerakan masyarakat cerdas menggunakan obat (Gema Cermat) dengan metode CBIA Handa Muliasari; Agus Dwi Ananto; Baiq Sofianti Annisa; Lalu Husnul Hidayat; Candra Eka Puspitasari
INDRA: Jurnal Pengabdian kepada Masyarakat Vol. 2 No. 2 (2021): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (307.144 KB) | DOI: 10.29303/indra.v2i2.131

Abstract

A community service about the education of Gema Cermat has been conducted in Lebah Sempaga village, West Lombok, NTB. The objective of these activities was to increase people’s knowledge and skills regarding the use of medicines in a right and rational way. The community service was held in three main steps of Community Based Interactive Method, namely presentation of the materials of Gema Cermat by pharmacist leader in NTB, assessments of people’s knowledge before and after socialization by using questionnaires, and evaluation of the participant skills in medicine identifications through the presentation of the participant representations. 23 people are participating in these activities, dominated by females with the age of about 29-50 years old. However, only 13 of them were finishing the questionnaires. Overall, the result of assessments, as well as the evaluation, showed that there was a noticeable improvement in the understanding of people about Gema Cermat, the precise and rational ways in using medicines, with the percentage of 16% increase.  Hopefully, people in that area could spread the information to others so that the side effects due to the non-appropriate use of medicines will reduce
Analisis tingkat pengetahuan penggunaan antibiotik di masyarakat Desa Lebah Sempage Kabupaten Lombok Barat Candra Eka Puspitasari; Handa Muliasari; Agus Dwi Ananto
INDRA: Jurnal Pengabdian kepada Masyarakat Vol. 3 No. 1 (2022): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/indra.v3i1.141

Abstract

Antibiotics are drugs used to treat infections caused by bacteria. The results of RISKESDAS in 2013 showed that there were 27.8% of the public storing antibiotics without a doctor's prescription, which could lead to bacterial resistance. One of the factors that influence the use of antibiotics in community is the level of knowledge. The purpose of this study was to determine the level of public knowledge regarding the use of antibiotics using the CBIA (Active Human Learning Way) method. This research is descriptive using the CBIA method. Respondents were given a pre-test questionnaire followed by the delivery of material related to antibiotics, then continued with the post-test. The results showed that there was an increase in public knowledge regarding the use of antibiotics by 16.25% using the CBIA method.
In vitro concentration optimization of ethanol extract from Makasar fruit seeds (Brucea javanica L. Merr) as an anti-inflammatory agent Diva Almira; Windah Anugrah Subaidah; Agus Dwi Ananto; Rizqa Fersiyana Deccati; Handa Muliasari
Jurnal Pijar Mipa Vol. 16 No. 5 (2021): November 2021
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (302.503 KB) | DOI: 10.29303/jpm.v16i5.2655

Abstract

Anti-inflammatory medications are necessary to treat excessive inflammation reactions due to injury, infection, or irritation. The emergence of several adverse effects associated with synthetic anti-inflammatory drugs has prompted the continued use of anti-inflammatory agents derived from natural products with low side effects and a high therapeutic effect. While it is well established that the seeds of the Makassar fruit (Brucea javanica (L.) Merr.)  have anti-inflammatory activity, the optimal concentration of Makasar fruit seed extract for anti-inflammatory activity is unknown. This study aims to determine the optimal Makassar fruit seed extract concentration as an in vitro anti-inflammatory. The seeds of the Makasar fruit were extracted using the sonication method (3 x 35 minutes) in 96% ethanol and then concentrated using a rotary evaporator. The secondary metabolites of Makasar fruit seed extract were then identified in the test tubes, and the anti-inflammatory activity was determined using the protein denaturation inhibition method. The results indicated that the extract produced had a yield of 10.03%. The Makassar fruit seed extract contains secondary metabolites of phenolics, flavonoids, and terpenoids. Makasar fruit seed extract exhibited the optimum anti-inflammatory activity at a concentration of 1%, with a 55.47% inhibition of protein denaturation.
Analisis Kualitatif Kandungan Fenolik dalam Fraksi Etil Asetat dan Fraksi Metanol dari Ekstrak Kulit Jagung (Zea mays L.) Yuniarthi Dwi Suputri; Agus Dwi Ananto; Yayuk Andayani
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 2, No 1 (2021): JANUARI
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v2i1.3758

Abstract

ABSTRAKProduksi tanaman jagung yang semakin meningkat menyebabkan peningkatan limbah kulit jagung semakin tinggi. Kulit jagung dapat dimanfaatkan dalam bidang kesehatan dan berpotensi sebagai antioksidan. Kulit jagung mengandung senyawa fenolik dan flavonoid yang dapat bertindak sebagai antioksidan. Tujuan dari penelitian ini adalah untuk mengetahui kandungan senyawa pada fenolikfraksi etil asetat dan fraksi metanol kulit jagung. Ekstraksi kulit jagung dilakukan dengan metode maserasi menggunakan pelarut etanol 96%. Fraksinasi ekstrak etanol kulit jagung dilakukan dengan fraksinasi bertingkat menggunakan pelarut metanol dan etil asetat. Kedua fraksi yang diperoleh kemudian dianalisis secara kualitatif dengan metode Kromatografi Lapis Tipis. Fase diam yang digunakan adalah plat silica gel G60F254 dan fase gerak yang digunakan adalah kombinasi eluen kloroform: etil asetat: n-butanol: asam format (5:2:2:1). Hasil pemisahan ditandai dengan munculnya noda bercak saat diamati dengan sinar UV 254 nm dan 366 nm. Nilai Rf bercak yang muncul kemudian dihitung lalu dibandingkan dengan nilai Rf literatur untuk mengidentifikasikan senyawa yang terpisah. Hasil analisis kualitatif fraksi etil asetat dan fraksi metanol kulit jagung menunjukkan keberadaan senyawa fenolik. Hasil ini ditunjukkan dengan munculnya noda bercak dengan nilai Rf 0,75 yang memiliki kemiripan dengan nilai Rf asam galat (0,76). Kata kunci : Kulit jagung; Kromatografi lapis tipis; Analisis kualitatif. ABSTRACTCorn production keeps increasing causing increasing in corn husk waste. Cornhusk can be used in medical field and have potential as an antioxidant. Cornhusk contains phenol and flavonoid metabolites that can act as antioxidants. The aim of this study is to determine the presence of phenol metabolites in ethyl acetate and methanol fraction of cornhusk. Cornhusk extraction was carried out by a maceration method using ethanol 96%. Fractionation of ethanolic cornhusk extract was carried out by liquid-liquid extraction using a separating funnel with methanol and ethyl acetate solvent. The two fractions then analyzed qualitative by Thin Layer Chromatography. The stationary phase used is silica gel G60F254. The mobile phase used is a combination of chloroform: ethyl acetate: n-butanol: formic acid (5:2:2:1). The separation result marked by the presence of stains when observed by UV 254 nm and 366 nm light. The Rf value then measured and compared to Rf value in the literature to determine the separated substance. The qualitative analysis result of corn husk ethyl acetate fraction and methanol fraction indicated the presence of phenolic metabolites. This result is showed by the presence of stain with Rf value 0,75 that has similarity with Rf value of gallic acid (0,76). Keywords : Cornhusk; Thin layer chromatography; Qualitative analysis.
Co-Authors Agus saputra Anjar Purba Asmara Baiq Ressa Puspita Rizma Baiq Ressa Puspita Rizma Baiq Sofianti Annisa Candra D Hamdin Candra Dwipayana Hamdin Candra Dwipayana Hamdin Candra Eka Puspitasari Deccati, Rizqa Fersiyana Dian Fathita Dwi Lestari Diantama Hiraswari Rahmadari Diva Almira Dwiki Setyo Nugroho Dyke Gita Wirasisya Erwinayanti, Gusti Ayu Putu Sri Eti Nurwening Sholikhah Evie Kama Lestari Fitria, Anggit Handa Muliasari Handa Muliasari Handa Muliasari Handa Muliasari Handa Muliasari Handa Muliasari Harno Dwi Pranowo I Made Sudarma Iman Surya Pratama Jumina Jumina Kurniawan, Yehezkiel Steven Lalu Aang Robby Dewantara Lalu Husnul Hidayat Lalu Sanik Wahyu F. A Lalu Undrus Yusditia M. G Luh Putu Gina Sri Budiani Maulida Septiyana Mudasir Mudasir Muhsinul Ihsan Muhsinul Ihsan Muhsinul Ihsan Muliasari, Handa Muliasari, Handa Murniyati Murniyati Murniyati, Murniyati ndayani, Yayuk Ni Made Detia Suryadnyani Nokman Riyanto Prasetyo, Niko Pratama, Iman Surya Rahmatul Aini, Siti Ria Armunanto Rian Jumawardi Rizqa Fersiyana Deccati Rizqa Fersiyana Deccati Rizqa Fersiyana Deccati Rizqa Fersiyana Deccati Royana Ari Pratiwi Putri Saprizal Hadisaputra Saprizal Handisaputra Siti Rahmatul Aini Sunarwidhi, Anggit Listyacahyani Suryadnyani, Ni Made Detia Syarah Megianti Fahira Virnia Wanda Utami Wahida Hajrin Wahida Hajrin Widayanti Supraba Winarto Haryadi Windah Anugrah Subaidah Yayuk Andayani Yek Zen Mubarok Yohanes Juliantoni Yohanes Juliantoni Yohanes Juliantoni, Yohanes Yuniarthi Dwi Suputri Yuyun Ramdani