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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Medula Jurnal Dunia Kesmas Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) JURNAL PENELITIAN PERAWAT PROFESIONAL Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Kesehatan Tambusai MAHESA : Malahayati Health Student Journal Prosiding Konferensi Nasional PKM-CSR Jurnal Farmasetis Bagimu Negeri : Jurnal Pengabdian Kepada Masyarakat JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai
Kurniawaty, Evi
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Journal : Medula

 1 
PERBEDAAN PENGARUH PEMBERIAN TOPIKAL EKSTRAK DAUN BAKAU (Bruguiera gymnorrhiza) DAN GEL BIOPLACENTON PADA MAKROSKOPIS KULIT TIKUS PUTIH JANTAN (Rattus norvegicus) GALUR Sprague dawley DENGAN LUKA SAYAT Akib, Salsabila Nadhifa; Kurniawaty, Evi
Medula Vol 13 No 7 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i7.886

Abstract

Wound is loss of continuity from tissue’s anatomical structure which can be caused by pathological process from within or outside body. Wound healing process consists of four stages, namely haemostasis, inflammation, proliferation, and maturation. Bruguiera gymnorrhiza mangrove plant is a type of mangrove that is rich in bioactive compounds. Bruguiera gymnorrhiza leaf extract has bioactive compounds that can work as antibacterial, anti-inflammatory, analgesic and proliferative agents which affect wound healing process. This research is pure experimental with post test only control group design. Sample consisted of 30 rats divided into 3 groups. K-: 0,2 cc topical aquades, K +: 0,2 cc topical bioplacenton gel, P1: Bruguiera gymnorrhiza leaf extract 80% in 14 days of observation. Observation data were recorded in observation sheet and analyzed statistically. The results showed that topical extract of Bruguiera gymnorrhiza leaves 80% affected macroscopic wound healing in form of wound length’s reduction to 0.17 cm on 14th day but Kruskal-wallis test showed no significant macroscopic difference in wound healing (p > 0.05) between K-, K +, and P1. Topical extract of Bruguiera gymnorrhiza leaves 80% affected macroscopic wound healing in form of wound length’s reduction but there was no significant difference in incision wound healing macroscopically between K-, K +, and P1 at dose 0.2 cc / day.
Mekanisme Kerja & Penggunaan Klinis N-Acetylcystein (NAC) Pada Penyakit Paru & Saluran Napas Poty, Pitha Maykania; Mustofa, Syazili; Kurniawaty, Evi; Soleha, Tri Umiana
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.1083

Abstract

Lung disease is one of the leading causes of illness and death worldwide. Lung disease can be caused by inflammation of the tissues due to oxidative stress. Oxidative stress plays a role in the pathogenesis of lung disease, both acute and chronic. Oxidative stress in the lungs occurs when antioxidant capacity is depleted due to external exposures, such as changes in oxygen pressure due to pollutants, and internal exposures, such as systemic disease and activation of inflammatory cells in response to exposure. Oxidative stress is an imbalance in the production of oxidants and antioxidants in the body's metabolism. In lung disease, oxidative stress increases in endogenous metabolism so exogenous antioxidants in the form of N-acetylcysteine ​​(NAC) are needed. NAC is a glutathione precursor that can replenish total thiols (cysteine, cysteinylglycine, glutathione, and homocysteine). The mechanism of action of NAC is by interacting with ROS so that it can increase antioxidant capacity again. Oxidative stress can deplete antioxidants, NAC will release Thiol groups directly thereby neutralizing oxidants such as N and NO2. Clinically, NAC has been proven to be useful as a treatment for lung diseases such as COVID-19, asthma, bronchiectasis, COPD, and TB at high doses, namely 1200 mg/day.
Pengaruh Pemberian Minyak Jelantah 1,5 mL/Hari Selama 14 Hari Terhadap Histopatologi Hepar Rattus norvegicus Jantan Ersa, Rakhmigasti Citra; Susianti, Susianti; Kurniawaty, Evi; Mustofa, Syazili
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.1088

Abstract

Using cooking oil multiple times can caused bad effect on health one of them is liver damage. Free radical content in reused cooking oil trigger oxidative stress then disturb the cellular respons in liver. This study aimed to determine the effect of giving reused cooking oil for 14 days on rats (Rattus norvegicus) liver histopathology. This study was a true experimental using 10 rats (Rattus norvegicus) and were devided by 2 groups, which are normal group (KN) and treatment group (KP) that was given 1,5 mL reused cooking oil per day. After 14 days of treatment, rats were terminated and the liver were taken. To observe rats liver histopathology, cloudy swelling scoring were used on 5 field of view. Score 0: there was no cloudy swelling and necrosis found, score 1: there was 1-20% cloudy swelling and necrosis found, score 2: there was 21-50% cloudy swelling and necrosis found, score 3: there was 51-75% cloudy swelling and necrosis found, and score 4: there was more than 75% cloudy swelling and necrosis found.It was found a minimal cloudy swelling on KN with average liver damage score was 0,04. In group KP it were found cloudy swelling degeneration on all over the liver with average liver damage score was 4. Mann-Whitney test showed a significant difference between groups. Giving reused cooking oil 1,5 ml/day for 14 days caused damage on male rats liver histopathology.
Uji Efektivitas Ekstrak Kulit Batang Bakau Lindur (Bruigiera gymnorrhiza) Sebagai Antibakteri Terhadap Streptococcus pyogenes Annisa Fath; Kurniawaty, Evi; Graharti, Risti; Berawi, Khairun Nisa
Medula Vol 14 No 8 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i8.1250

Abstract

The bacterium Streptococcus pyogenes is a gram-positive bacterium that causes various diseases in humans. Pharyngitis is the most common infection caused by Streptococcus pyogenes, occurring in 15-30% of children and 5-10% of adults. The extract of mangrove bark contains bioactive compounds that can serve as an antibacterial alternative.  This research is an experimental study. The mangrove bark was extracted using 96% ethanol solvent through the maceration method and subjected to phytochemical testing. The treatment consists of 96% ethanol extract preparations with concentrations of 25%; 50%; 70%; 90%; and 100%, as well as a negative control using aquades and a positive control using amoxicillin. Each treatment was repeated 4 times. Antibacterial activity testing was conducted using the well method on Muller Hinton Agar. The results of the phytochemical test showed that the 96% ethanol extract positively contained flavonoid, phenol, alkaloid, tannin, saponin, steroid, and triterpenoid compounds. The results of the antibacterial activity study from 25%, 50%, 70%, 90%, and 100% concentrations of 96% ethanol extract produced zone diameters of 4.33 mm; 5.68 mm; 6.61 mm; 7.72 mm; and 9.02 mm. These results indicate that the 96% ethanol extract of the mangrove bark has an inhibitory effect on the growth of Streptococcus pyogenes. Data analysis of the 96% ethanol extract of the mangrove bark using the One-Way ANOVA test showed p< 0.05.
Literature Review : Antibacterial Activity of Various Mangrove Plant Species Extracts Balqis, Aurelia Corrinna; Kurniawaty, Evi; Maulana, Muhammad; Ramadhian, Muhammad Ricky
Medula Vol 14 No 9 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i9.1322

Abstract

The excessive and uncontrolled use of antibiotics has led to antibiotic resistance in pathogenic bacteria, which poses a serious threat to global health. To address this problem, alternative treatments from natural materials, such as mangrove plants, are starting to attract attention. Mangrove plants contain bioactive compounds that have antibacterial potential against various pathogenic bacteria. This study aims to review the antibacterial activity of various mangrove species in Indonesia. The method used was a literature study that included analysis of recent journals on the antibacterial activity of mangrove plants. The results showed that extracts from various mangrove species, such as Bruguiera gymnorrhiza, Rhizophora mucronata, and Heritiera littoralis, had significant antibacterial activity against Gram-positive and Gram-negative bacteria, such as Escherichia coli, Staphylococcus aureus, and Salmonella enterica. The zones of inhibition produced varied between 5 to 20 mm, with the ethanol extract from Bruguiera gymnorrhiza leaves showing the most potent activity. In addition, the assay results showed that the active compounds in the mangrove extracts had the ability to inhibit bacterial growth at low concentrations, indicating great potential for the development of more efficient and economical antibacterial drugs. This study provides evidence that mangrove plant extracts have potential as antibacterial agents that can be further developed for the treatment of infections caused by pathogenic bacteria, thus providing an effective alternative to overcome the problem of antibiotic resistance.
Review Article: Antibacterial Activity of Mangrove Lindur Extract (Bruguiera gymnorrhiza) Against Staphylococcus aureus Setyadi, Yudha Putra; Kurniawaty, Evi; Kusumaningtyas, Intan
Medula Vol 14 No 8 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i8.1300

Abstract

Infectious diseases remain prevalent in Indonesia, influenced by environmental factors such as poor sanitation, low public awareness of clean and healthy living behaviors, and a tropical climate. Infectious diseases are health issues caused by microorganisms, such as bacteria, viruses, or parasites, that enter the body. Staphylococcus aureus is one of the primary pathogens for humans and can cause various infections. The main treatment for Staphylococcus aureus infections is antibiotics. However, bacterial resistance to methicillin antibiotics (Methicillin-Resistant Staphylococcus aureus or MRSA) is increasingly common in Indonesia. Therefore, alternative antibiotic treatments based on plant-derived compounds are highly needed. One plant with potential antibacterial activity is Bruguiera gymnorrhiza. Commonly known as bakau lindur, various parts of Bruguiera gymnorrhiza, such as its bark, leaves, and roots, have antibacterial properties. This is attributed to the bioactive compounds present in its extracts, including flavonoids, saponins, alkaloids, phenols, steroids, terpenoids, and tannins.. This article aims to determine whether Bruguiera gymnorrhiza extract exhibits antibacterial activity against Staphylococcus aureus. Based on the literature review, Bruguiera gymnorrhiza extract has been proven to possess antibacterial activity against Staphylococcus aureus. The best antibacterial activity was observed in the 96% ethanol extract of Bruguiera gymnorrhiza bark at a concentration of 15,000 ppm, resulting in a 13.62 mm inhibition zone categorized as strong.
Resistensi Antibiotik terhadap Pseudomonas aeruginosa: Literature Review Syarif, Muhammad Reza; Kurniawaty, Evi; Rahmanisa, Soraya
Medula Vol 14 No 8 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i8.1324

Abstract

Pseudomonas aeruginosa is a gram-negative aerobic bacterium. This bacterium often causes infections in immunocompetent and immunocompromised hosts. This bacterium usually causes opportunistic infections and plays an important role in nosocomial infections. Treatment and eradication of Pseudomonas aeruginosa are very difficult because the mutation of this bacterium occurs rapidly and this bacterium is easily adaptable, causing high rates of antibiotic resistance in this bacterium. Pseudomonas aeruginosa is one of the bacteria included in the MDR ESKAPE pathogen group by WHO. This article is a literature review that examines several literatures to be made into a discussion and conclusion. Pseudomonas aeruginosa is resistant to various types of antibiotics through 3 mechanisms, namely intrinsic, acquired, and adaptive. This bacterium has minimal nutritional needs and can tolerate various temperatures, this is one of the strengthening factors for antibiotic resistance to this bacterium. WHO includes this bacterium in the critical list because of its resistance to carbapenem antibiotics. Research shows high resistance of P. aeruginosa to carbapenems, quinolones, and aztreonam. While piperacillin and tazobactam are the most effective antibiotics for this bacteria. Many classes of antibiotics have become resistant to this bacteria, so that renewal is needed in the line of treatment for infections by P. aeruginosa. Therefore, wise and rational use of antibiotics is needed so that the number of antibiotic resistance, especially to this bacteria, does not increase.
Co-Authors Akib, Salsabila Nadhifa Alvinasyrah, Alvinasyrah Andriani, Silvia Anita Febrina, Anita Annisa Fath Ari Irawan Asep Sukohar Audah, Kholis A. Audah, Kholis Abdurachim Ayu S, Putu Ristyaning Bainah Sari Dewi Balqis, Aurelia Corrinna Batubara, Razethy Berawi, Khairunisa Daulay, Suryani Agustina Dewi Nur Fiana Din, Bahesty Cut Nyak Dwi Indria Anggraini Elidiya, Anggun Ersa, Rakhmigasti Citra Ety Apriliana Hanna Mutiara, Hanna Hendri Busman Iffa Afiqa Khairani Intan Kusumaningtyas Intanri Kurniati Irmanida Batubara Julkipli Julkipli, Julkipli Justiani, Andinni Aurellia Karima, Nisa Kaskoyo, Hari Khairun Nisa Khairun Nisa Kurniati, Intanti Mallarangeng, Andi Nafisah Tendri Adjeng Muhammad Aditya, Muhammad Muhammad Arif Muhammad Maulana Muhammad Ricky Ramadhian Nuning Nurcahyani Nuriah, Nuriah Nurul Islamy Oktadoni Saputra, Oktadoni Oktafany, Oktafany Oktoba, Zulpakor Poty, Pitha Maykania Pramudyawati, Yustika Puspa, Egita Windrianatama Rahmansia, Soraya Rahmayani, Fidha Rasmi Zakiah Oktarlina Reni Zuraida Rini, Sandra Risti Graharti Rossa, Putri Emylia Sahroni, Mizan Samsul Bakri Sandro, Mario Sangging, Putu Ristyaning Ayu Setyadi, Yudha Putra Situmorang, Ephraim Matthew Sebastian Situmorang, Ezra Winandi Soraya Rahmanisa Suharyani Suharyani Susianti Susianti Sutarto Sutarto Sutyarso Sutyarso Sutyarso Syarif, Muhammad Reza Syazili Mustofa Taruna, Achmad Tiwuk Susantiningsih Tri Umiana Soleha Wijaya, Elza Winda Trijayanthi Utama, Winda Trijayanthi Wiwi Febriani Wulan, Anggraini Janar Yogi Catur Putra