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All Journal JBIO: jurnal biosains (the journal of biosciences) Jurnal Kedokteran Syiah Kuala Majalah Kedokteran Bandung Dentika Dental Journal Jurnal Farmasi Klinik Indonesia The Indonesian Biomedical Journal Universa Medicina Majalah Kedokteran Nusantara The Journal Of Medical School Buletin Farmatera Sumatera Medical Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Caring : Indonesian Journal of Nursing Science Narra J Cermin Dunia Kedokteran Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy The Journal of Society Medicine (JSOCMED) Indonesian Journal of Endocrinology Metabolism and Diabetes (InaJEMD)
dharma Lindarto, dharma
Department Of Internal Medicine, Faculty Medicine, Universitas Sumatera Utara, Medan, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Universa Medicina

 1 
Elevated uric acid level decreases glycated hemoglobin in type 2 diabetes mellitus Muhammad Fahmi Hidayat; Santi Syafril; Dharma Lindarto
Universa Medicina Vol. 33 No. 3 (2014)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2014.v33.199-204

Abstract

BackgroundType 2 diabetes mellitus is a heterogeneous disease which is characterized by variable degrees of insulin resistance and impaired insulin secretion. Uric acid has been identified as a marker for a number of metabolic and hemodynamic abnormalities. In diabetic patients, there is biochemical interaction between serum glucose and purine metabolism, with increased excretion of uric acid during hyperglycemia and glycosuria. The objective of this study was to evaluate the correlation of serum uric acid levels with glycated hemoglobin (HbA1c) and blood glucose levels in type 2 diabetes patients.MethodsA cross sectional study from May until July 2014 had been done in 82 type 2 diabetes patients. Serum was analyzed for uric acid, fasting and 2-hour post prandial blood glucose and lipid profile. Spearman correlation test was used to assess associations of HbA1c, fasting and post prandial blood glucose with serum uric acid levels.ResultsThere was a negative correlation of HbA1c with serum uric acid levels (r=-0.407; p=0.000) and of fasting and post prandial blood glucose with serum uric acid levels (r=-0.338; p=0.002 and r=-0.318; p=0.004, respectively).ConclusionsSerum uric acid level was associated with HbA1c, fasting and post prandial blood glucose suggesting a significant role of serum uric acid in the deterioration of glucose toleration.
Mean platelet volume increases in proliferative retinopathy among diabetes mellitus subjects Mardiya Sari; Dharma Lindarto; Dairion Gatot
Universa Medicina Vol. 33 No. 1 (2014)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2014.v33.43-48

Abstract

BACKGROUND Mean platelet volume (MPV) shows the average size of platelets in the circulation and can be used to assess the activity of platelets. Increased of MPV can be sign of atherotrombosis and can be used to assess the risk of vascular complications such as retinopathy diabetic (RD). The aim of this study was to determine correlation between glycated haemoglobin (HbA1c), MPV with degree of retinopathy in diabetes mellitus (DM) patients. METHODS A cross sectional study from June until July 2013 was conducted involving 77 DM subjects. Anamnesis, laboratory examination and funduscopy had been done in all subjects. One way ANOVA was used to assess the differences between MPV with other parameters to the degree of retinopathy and continued with Bonferroni test to assess the differences between the degree of retinopathy with the parameters that significantly different in one way ANOVA. RESULTS One way ANOVA showed significance difference of mean MPV between normal funduscopy group compared than proliferative diabetic retinopathy (PDR) group (9.57 ± 0.63 fl vs 10.45 ± 0.51 fl, p=0.044). PDR group were older (p=0.001), longer suffered from DM (p=0.001) and hypertension (p=0.011). Bonferroni test showed no significance difference of mean MPV between normal funduscopy versus non-proliferative diabetic retinopathy (NPDR) group (p=0.290) and NPDR versus PDR (p=0.409). CONCLUSION There was a significance differences between MPV with the degree of retinopathy. Platelets may play a role in the pathogenesis of vascular complications and that MPV can be used as simple parameter to assess the vascular events in DM.
Renal cortex echogenicity increases degree of retinopathy in diabetes mellitus Indah Maulidawati; Abdurrahim Rasyid Lubis; Dharma Lindarto
Universa Medicina Vol. 35 No. 1 (2016)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.19-25

Abstract

BackgroundThe number of people with diabetes mellitus (DM) is increasing due to population growth, aging, and increasing prevalence of obesity. Diabetic retinopathy and diabetic nephropathy are two main complications of DM. Some studies suggest a correlation between diabetic nephropathy and diabetic retinopathy. However, other studies found that renal cortex echogenicity is associated with chronicity of kidney disease and renal histopathology. The aim of this study was to determine whether there is a correlation between renal cortex echogenicity as determined by renal ultrasonography and degree of retinopathy as determined by funduscopy in subjects with DM.MethodsA cross sectional study was conducted on 41 DM subjects from September to November 2014. Data obtained by anamnesis, physical examination, and examination of ureum, creatinine, urinalysis, glycated hemoglobin (HbA1c), renal and urinary tract ultrasonography and funduscopy, were collected from all subjects. Blood samples were taken from the median cubital vein for biochemical measurements using COBAS automated analyzers. Normality of data distribution was tested using the Shapiro-Wilk test. To determine the relationship between variables the Spearman correlation test was used. ResultsUsing the Spearman correlation test, a strongly significant correlation was found between degree of renal cortex echogenicity and degree of retinopathy (r=0.773; p=0.0001). A significant relationship was also found for the degree of retinopathy with age (r=0.317; p=0.044), duration of diabetes mellitus (r=0.639; p=0.0001) and HbA1c (r=0.681; p=0.001).ConclusionThis study found that renal cortex echogenicity increased the degree of diabetic retinopathy in diabetic subjects. Renal ultrasonography for patients with type 2 DM has a great role in diagnosing and grading diabetic retinopathy.
Co-Authors Abdurrahim Rasyid Lubis Achmad Rudijanto Adi Koesoema Aman Awaluddin Saragih Awaluddin Saragih Aznan Lelo Brama Ihsan Sazli Dairion Gatot, Dairion Darmadi Darmadi Dasopang, Eva S. Daulay, Milahayati Dewi Frintiana Silaban Dhini Sylvana Dian Anindita Lubis Efi Ramadhan Eva S. Dasopang Evi Karota Bukit Farik Zarmal Ferry Sandra Ginting, Fransiscus Gontar Alamsyah Siregar Hartono Apriliasta Purba Herniza Yusdani Ihsan, Brama Imelda Rey Imelda Rey Indah Maulidawati Irmayani Irmayani Juwita Sahputri Kembaren, Tambar Kumala, Poppy Malayana Rahmita Nasution Mardianto dr Mardianto Mardianto Mardiya Sari Masrul Lubis Melati Silvanni Nasution Muhammad Budiman Muhammad Diah Muhammad Fahmi Hidayat Mula Tarigan Muzasti, Riri A. Nasution, Melati Silvanni Nindia Sugih Arto Ozar Sanuddin Pertiwi, Vani Gita Priska Krinanta Ginting Purba, Ambrocious Puteri, Happy Helene Sulung Rahmawati Rahmawati Ratna Akbari Ganie Ratna Akbari Ganie, Ratna Akbari Sahputri, Juwita Sairomaito Harahap Santi Syafril Santi Syafril Santi Syafril Santi Syafril Santi Syafril Santi Syafril Santi Syafril Santi Syafril, Santi Sari Harahap Siahaan, Billy Stinggo Sinaga, Bintang YM Sitepu, Annisa Nidya Rahmatika Siti Zahara Nasution, Siti Zahara SN, Sigit Anugerah Putra SN Sondang Pintauli Stephen Udjung Suherdy Suherdy Sumadio Hadisahputra Sumantri, Imam Bagus Theresia, Lydia Tjokorda Gde Dalem Pemayun Urip Harahap Widya Deli Satuti Wismandari Wisnu Yetty Machrina Yulindaa, Wina Zulfikri Muhktar