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All Journal MEDISAINS Jurnal Kebidanan Jurnal Fitofarmaka Indonesia JURNAL KESEHATAN LINGKUNGAN: Jurnal dan Aplikasi Teknik Kesehatan Lingkungan BIOEDUSCIENCE Jurnal SOLMA Bioedusiana: Jurnal Pendidikan Biologi Science Education and Application Journal Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Ilmiah Biologi UMA (JIBIOMA) BioEksakta : Jurnal Ilmiah Biologi Unsoed Journal of Biology Learning Jurnal Insan Farmasi Indonesia Jurnal Buana Farma Jurnal Penelitian Sains dan Pendidikan (JPSP) HJSE Lontara Journal Of Health Science And Technology Bijaksana: Jurnal Pengabdian Masyarakat
Nirmalasari, Ridha
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Nursing Physics Public Health Veterinary Other

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Antihyperglicemic effect of Musa paradisiaca extract in vivo Hujjatusnaini, Noor; Nirmalasari, Ridha
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Early Release
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v0i0.18814

Abstract

Background: Musa paradisiaca has  been widely studied for its antihyperglycemic effects, showing potential as an alternative natural remedy for diabetes. However, variability in genetic factors, environmental conditions, and geographical origins may influence its bioactive compound composition and efficacy. Thus, further validation through controlled studies is required to ensure consistent therapeutic effects.Purpose: : This study aimed to evaluate the antihyperglycemic effect of Musa paradisiaca stem extract in vivo, providing additional validation for its therapeutic potential and determining the optimal concentration for clinical relevance.Method: An experimental posttest-only control group design was used. Thirty-five male Balb/c strain mice were induced into hyperglycemia using alloxan. They were then randomly divided into treatment groups receiving different concentrations of Musa paradisiaca stem extract (5%, 15%, 25%, 35%, and 45%), a positive control group (metformin), and a negative control group. Blood glucose levels were measured and analyzed statistically using One-Way ANOVA.Result: Administration of the stem extract at 15% concentration showed the most significant antihyperglycemic effect, with an average blood glucose level reduction to 63.8 mg/dL, comparable to the positive control group (metformin). Conversely, the highest concentration tested (45%) exhibited minimal effectiveness, with an average glucose level of 151.8 mg/dL, indicating reduced antihyperglycemic activity.Conclusion: The optimal antihyperglycemic effect of Musa paradisiaca stem extract was achieved at a concentration of 15%, demonstrating therapeutic efficacy comparable to metformin. This extract shows promise as a natural alternative agent in diabetes treatment. Further studies, including clinical trials, are recommended to confirm these findings.
Pelatihan Pembuatan Pupuk Organik dari Bahan Nabati untuk Meningkatkan Produktivitas Pertanian di Desa Mantaren Nirmalasari, Ridha; Ramadhan, Ahmad Ananda; Noor, Muhammad Arifin; Jarkani, Muhammad; Jubaidah, Jubaidah; Afriliani, Hesti; Hujjatusnaini, Noor
Jurnal SOLMA Vol. 14 No. 1 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/solma.v14i1.16682

Abstract

Background: Desa Mantaren, produktivitas pertanian telah banyak mengalami tantangan berkelanjutan. Pengabdian ini berdasar pada hasil pelatihan pembuatan pupuk organik dari bahan nabati sebagai upaya untuk meningkatkan produktivitas pertanian di wilayah tersebut. Pengabdian ini bertujuan untuk membekali pengetahuan dan keterampilan terkait pengolahan pembuatan pupuk nabati untuk meningkatkan produktivitas hasil tani bagi para masyarakat di Desa mantaren yang mayoritas mata pencahariannya adalah bertani. Metode: Pendekatan Participatory Action Research (PAR). Mitra dalam pengabdian ini adalah dinas pertanian di Kabupaten Pulang Pisau. Kegiatan pengabdian dilakukan melalui pelatihan yang dihadiri oleh sekitar 50 warga Desa Mantaren yang berprofesi sebagai petani. Hasil: Pelatihan pembuatan pupuk organik secara signifikan meningkatkan pemahaman petani tentang penggunaan pupuk organik dan dampak positifnya terhadap tanaman. Setelah pelatihan, terjadi peningkatan yang nyata dalam hasil panen, khususnya pada tanaman padi dan sayuran. pupuk organik dapat diproduksi secara lokal lebih ekonomis dan ramah lingkungan dibandingkan dengan pupuk kimia. Dalam konteks Desa Mantaren, pelatihan ini telah membawa perubahan positif yang signifikan dalam produktivitas pertanian dan kualitas hasil panen. Implikasi dari penelitian ini menggarisbawahi pentingnya pendekatan berkelanjutan dalam pertanian dan memberikan panduan bagi komunitas agraris sejenis untuk mengadopsi praktik serupa. Kesimpulan: Warga desa diharapkan dapat melanjutkan dan mendukung inisiatif pembuatan pupuk organik lokal untuk meningkatkan ketahanan pangan dan keberlanjutan lingkungan di Desa Mantaren.
Eksplorasi Potensi Tumbuhan Berkhasiat Obat Diabetes Mellitus Pada Suku Dayak Bakumpai Barito Selatan Sebagai Penyusun Atlas Tanaman Berkhasiat Obat Muamar, Ilham; Lestariningsih, Nanik; Nirmalasari, Ridha
Lontara Journal of Health Science and Technology Vol. 2 No. 1 (2021): Ilmu dan Teknologi Kesehatan
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Politeknik Muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53861/lontarariset.v2i1.185

Abstract

The Bakumpai Dayak tribe is very close to their ancestral culture, including in their efforts to maintain their health and self-medication, which still chooses to use traditional methods such as gathering various plants taken from forests or gardens. This study aims to obtain information about the types of plants used, parts of plant organs used and to find out how to use medicinal plants to treat Diabetes Mellitus according to the customs of the Bakumpai Dayak Tribe, Dusun Selatan District, Baru Village. After conducting the research, there were 10 types of medicinal plants for the efficacy of Diabetes mellitus according to the Bakumpai Dayak tribe. The plants that are often used are Earth Pegs, Ulin Trees, Sandalwood Trees, Pare, Sapat Trees, Muhur, Noni, Bidders and Halaban Wood. The most widely used parts of the plant are the roots and leaves. Utilization of medicinal plants by the Bakumpai Dayak tribe by making pills, soaking, boiling, watering or washing, smearing or affixing them. How to use most medicinal plants by boiling and soaking.
EFEK ANTIMIKROBA EKSTRAK Arcangelisia flava, Curcuma longa, Curcuma zanthorrhiza TERHADAP Bacillus DAN Pseudomonas PENYEBAB DIARE Hujjastusnani, Noor; Amin, Astuti muh.; Nirmalasari, Ridha; Awaluddin, Annisa Maharani; Latifah, Nadia Dwi Nur; Riana, Rifa; Nisa, Khairun`; Ningsih, Ira Wahyu; Anisa, Nor
Jurnal Buana Farma Vol. 5 No. 1 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i1.1256

Abstract

Diarrhea is a major health issue often caused by Bacillus sp. and Pseudomonas aeruginosa. This study aims to evaluate the antibacterial activity of a combination of Arcangelisia flava, Curcuma longa, and Curcuma zanthorrhiza extracts against these bacteria. The research was conducted in vitro using a Completely Randomized Design (CRD) with extract concentrations of 30%, 50%, 75%, and 100%, along with positive and negative controls. Antibacterial tests were carried out using the disk diffusion method to measure the inhibition zones after 24, 48, and 72 hours of incubation. The results showed the highest inhibition zones at 100% concentration, reaching 1.38 mm for Bacillus sp. and 1.33 mm for Pseudomonas aeruginosa after 72 hours. This antibacterial activity is supported by active compounds such as flavonoids, alkaloids, and curcumin. In conclusion the combination of these extracts effectively inhibits diarrhea-causing bacteria and has potential as a safe herbal alternative to address antibiotic resistance.
Efektivitas Ekstrak Tumbuhan Terhadap Bakteri dan Jamur Penyebab Infeksi Pasca melahirkan Hujjatusnaini, Noor; Muh.amin, Astuti; Nirmalasari, Ridha; Karlina, Siti; Ajiza, Pratisa Deifirera; Saputra, Reski; Pitria, Pitria; Maysaroh, Siti; Yuliyana, Via; Respi, Respi
Jurnal Ilmiah Biologi UMA (JIBIOMA) Vol 7, No 1 (2025): May 2025
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/jibioma.v7i1.5589

Abstract

Postoperative infections, especially after childbirth, remain a serious medical issue as they can lead to complications, delay recovery, and increase antibiotic resistance due to the excessive use of synthetic drugs. Therefore, safer and more effective treatment alternatives, such as the use of natural substances, are needed. This study aims to examine the antimicrobial potential of a combination of Ageratum conyzoides, Mussaenda frondosa, and Acorus calamus extracts in inhibiting the growth of Staphylococcus aureus and Candida albicans, which are common pathogens in postnatal surgical wound infections. The study employed a true experimental method with an antimicrobial sensitivity test design using the maceration technique. Extraction was conducted using 96% ethanol with three concentration variations: 40%, 80%, and 120%, in a 3:2:1 mixture ratio. Phytochemical screening was carried out to identify secondary metabolite compounds, followed by an inhibition test using the disc diffusion method. The results showed that Acorus calamus extract contains flavonoids, alkaloids, and saponins. Ageratum conyzoides, Mussaenda frondosa, and Acorus calamus all contain saponins with potential antimicrobial activity. The combination of these extracts demonstrated inhibitory effects against the growth of pathogenic microorganisms in surgical wounds, as evidenced by the formation of inhibition zones during testing.
ANALGETIC EFFECT OF COMBINATION 3:2:1 GEL EXTRACT Ageratum conyzoides Mussaenda frondosa) AND Curcuma domestica of Staphylococcus aureus INFECTED POST PARTUM MICE Hujjatusnaini, Noor; Nada, Ara Aulia; Jumrodah, Jumrodah; Nirmalasari, Ridha; Amin, Astuti Muh
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 3: September 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v8i3.2029

Abstract

The lack of knowledge about Ageratum conyzoides, Mussaenda frondosa, and Curcuma domestica as alternative medicines for treating postpartum infections, because there is still little research and documentation being carried out. Therefore, this research is expected to prove in vivo in order to know the analgesic effect of the combination formulation 3:2:1 extracts of Ageratum conyzoides, Mussaenda frondosa, and Curcuma domestica as therapy for post-partum infections. The research method used a true experimental post-test only control-group design, with 36 pregnant female mice as the test object. Ageratum conyzoides leaves, Mussaenda frondosa, and Curcuma domestica were prepared in a 3:2:1 formulation, with design levels of 40%, 60% and 80%. Analgesic-effect data were analyzed using the ANAVA statistical method and Duncan's test with a significant level of 1%. The results of the analgesic effect were obtained from the average number of S.aureus colonies and the vaginal mucosal fluid secretion index of mice infected with S.aureus. The results showed that the combination formulation of 3:2:1 extracts with a concentration of 30% had a significant effect on growth in S.aureus at a significant level of 1%. It was concluded that the 3:2:1 combination formulation can be recommended as the most effective in inhibiting infection S.aureus.
Potensi Terapi Kombinasi Ekstrak Piper crocatum dan Tinospora crispa dalam Memperbaiki Skin barrier Mencit Hiperglikemia Hidayati, Maulidia; Hujjatusnaini, Noor; Nirmalasari, Ridha
BioEksakta : Jurnal Ilmiah Biologi Unsoed Vol 7 No 1 (2025): BioEksakta
Publisher : Fakultas Biologi Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.bioe.2025.7.1.14812

Abstract

Hiperglikemia kronis dapat menyebabkan berbagai komplikasi, termasuk kerusakan pada Skin barrier. Ekstrak Piper crocatum dan Tinospora crispa diketahui mengandung senyawa bioaktif seperti flavonoid, saponin, alkaloid, dan tanin yang berpotensi memperbaiki gejala tersebut. Tujuan penelitian dilakukan untuk mengevaluasi efek kombinasi ekstrak P. crocatum dan T. crispa terhadap gejala kerusakan Skin barrier pada mencit hiperglikemia, menggunakan desain eksperimental dengan model mencit hiperglikemia yang dibagi menjadi enam kelompok perlakuan dengan dosis berbeda dari ekstrak kombinasi. Efek terapi diuji melalui pengamatan gejala iritasi dan infeksi, hiperpigmentasi, dan lama penyembuhan luka. Hasil analisis menunjukkan bahwa kombinasi ekstrak P. crocatum dan T. crispa secara signifikan memperbaiki gejala kerusakan Skin barrier melalui aktivitas antioksidan dan antiinflamasi. Selain itu, hasil penelitian ini mengungkapkan bahwa kombinasi ekstrak ini bekerja melalui mekanisme perlindungan seluler terhadap stres oksidatif serta modulasi respon inflamasi, yang berkontribusi pada peningkatan fungsi Skin barrier. Analisis statistik menggunakan uji One Way ANOVA menunjukkan adanya perbedaan yang signifikan antara kelompok perlakuan dan kontrol negatif (p < 0,05), yang diperkuat dengan uji lanjut Duncan’s Multiple Range Test (DMRT). Dengan demikian, kombinasi ekstrak P. crocatum dan T. crispa membuka peluang bagi pengembangan terapi berbasis bahan alami dalam menangani komplikasi hiperglikemia, khususnya yang berhubungan dengan kesehatan kulit. Studi lebih lanjut diperlukan untuk mengonfirmasi efektivitas dan keamanan ekstrak ini dalam skala klinis. Kata kunci : Piper crocatum, Tinospora crispa, Skin barrier, hiperglikemia, antiinflamasi, antioksidan
Jumlah Koloni Staphylococcus epidermidis pada Sel Epitel Saluran Urinaria Pasca Treatment Ekstrak Daun Kecombrang (Etlingera elatior) Dalila, Aupi; Hujjatusnaini, Noor; Sari, Lilin Ika Nur Indah; Nirmalasari, Ridha
BioEksakta : Jurnal Ilmiah Biologi Unsoed Vol 7 No 1 (2025): BioEksakta
Publisher : Fakultas Biologi Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.bioe.2025.7.1.14814

Abstract

Etlingera elatior dikenal memiliki efek antimikroba, tetapi potensinya sebagai agen terapi inflamasi cystitis akibat Staphylococcus epidermidis secara in vivo masih terbatas. Penelitian ini bertujuan untuk mengkaji sinergi senyawa bioaktif dan antioksidan Etlingera elatior dalam menekan stres oksidatif dan inflamasi yang menyertai infeksi, sehingga masih sangat diperlukan untuk memvalidasi temuan sebelumnya sebagai alternatif pengobatan cystitis. Penelitian menggunakan desain true-experimental posttest group. Intervensi melibatkan efek terapi pada mencit jantan galur Balb/c yang terinfeksi Staphylococcus epidermidis sebanyak 28 ekor. Ekstrak Etlingera elatior diuji pada konsentrasi 40%, 50%, 60%, 70%, dan 80%. Data dianalisis menggunakan metode statistik One-Way ANOVA. Hasil penelitian menunjukkan adanya signifikansi penurunan infeksi cystitis efektif pada konsentrasi 50%, berdasarkan morfologi dan total koloni pada saluran urinaria mencit pasca terapi. Penelitian ini membuktikan bahwa Pemberian Daun Kecombrang dapat menurunkan jumblah koloni staphylococcus epidermidis urinaria pasca treatment. Simpulan bahwa ekstrak Etlingera elatior berpotensi sebagai terapi efektif untuk infeksi cystitis terinfeksi Staphylococcus epidermidis secara in-vivo. Efek antimikroba, antiinflamasi, dan antioksidannya mampu menekan peradangan paling efektif pada konsentrasi 50%. Temuan ini memvalidasi hasil penelitian sebelumnya dan dapat dijadikan dasar untuk studi lanjutan terkait efektivitas ekstrak sebagai alternatif terapi cystitis. Kata kunci : Etlingera elatior; Cystitis; Antimikroba, Sel epitel; Koloni; Urinaria
Efektivitas E-Magazine Materi Pewarisan Sifat Terintegrasi Keislaman Terhadap HOTS (Higher Order Thinking Skills) Peserta Didik Puji Astuti, Pertiwi Adi; Septiana, Nurul; Rohmadi, Mukhlis; Nirmalasari, Ridha
Bioedusiana: Jurnal Pendidikan Biologi Vol 7, No 2 (2022): Bioedusiana
Publisher : Jurusan Pendidikan Biologi - Universitas Siliwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37058/bioed.v7i2.10077

Abstract

HOTS (Higher Order Thinking Skills) ialah salah satu aspek keterampilan yang mendasar di abad ke 21. Proses pembelajaran dalam pendidikan mengharuskan peserta didik berpikir kritis atau HOTS. Sehingga diharapkan dapat menghadapi tantangan-tantangan di masa depan. Namun, pada faktanya keterampilan berpikir peserta didik masih rendah, hasil survei PISA menempatkan Indonesia berada di urutan ke-74. Penelitian ini dilakukan untuk mengetahui efektivitas pemanfaatan media e-magazine pewarisan sifat terintegrasi keislaman terhadap HOTS (Higher Order Thinking Skills) peserta didik dalam ranah kognitif kemampuan menganalisis dan menilai. Teknik analisis data berupa analisis kuantitatif dengan menggunakan uji skor N-gain. Penelitian dilakukan di MTs Muslimat NU Palangka Raya dengan subjek penelitian peserta didik kelas IX C yang dilaksanakan dari bulan September sampai Oktober 2021. Hasil penelitian menunjukkan bahwa media e-magazine materi pewarisan sifat terintegrasi keislaman meningkatkan HOTS (Higher Order Thinking Skills) peserta didik dimana hasil N-gain pada indikator menganalisis sebesar 0,72 kategori “Tinggi”, dan indikator mengevaluasi sebesar 0,71 kategori “Tinggi”. Kata kunci: e-Magazine; materi pewarisan sifat terintegrasi keislaman; HOTS (Higher Order Thinking Skills)AbstractHigher order thinking skills are one of the basic skills in the 21st century. The learning process in education requires students to think critically or HOTS so that it is expected to face challenges in the future. However, the thinking skills of students are still low. The results of the PISA survey put Indonesia in 74th place. This study was conducted to determine the effectiveness of e-magazine media on the inheritance of integrated Islamic traits on students' higher-order thinking skills in the cognitive domain of analyzing and evaluation. The data analysis technique is in the form of quantitative analysis using the N-gain score test. The research was conducted at MTs Muslimat NU Palangka Raya with research subjects of class IX C students, which was carried out from September to October 2021. The results showed that the e-magazine media material for the inheritance of integrated Islamic traits was able to improve students' higher-order thinking skills were the results of N- the gain on the analyzing indicator is 0.72 in the "High" category, and the indicator evaluates 0.71 in the "High" category.
Ethanolic Extract Gel Of Planchonia Valida Leaves As An Antibacterial Agent Against Yersiniosis Infection Sari, Purwita; Hujjatusnaini, Noor; Nirmalasari, Ridha
JURNAL KESEHATAN LINGKUNGAN: Jurnal dan Aplikasi Teknik Kesehatan Lingkungan Vol 22 No 1 (2025): Jurnal Kesehatan Lingkungan Volume 22 No. 1, Januari 2025
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Kesehatan Lingkungan Banjarbaru

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/jkl.v22i1.906

Abstract

Planchonia valida (puting plant) contains ethanol, which is beneficial for treating skin infections and digestive problems, and is capable of inhibiting the growth of gram-negative bacteria such as Yersinia enterocolitica. This study aims to evaluate the adaptability of P. valida extract to Y. enterocolitica in vitro. This experimental research was statistically analyzed using Statistical Product and Service Solutions (SPSS). The adaptability of Y. enterocolitica was observed on nutrient agar (NA) medium in petri dishes treated with P. valida extract at concentrations of 30%, 40%, 50%, 60%, 70%, and 80%, with aquadest as the negative control and chloramphenicol as the positive control. Observations were conducted over three incubation periods (24, 48, and 72 hours) to monitor bacterial growth rate and adaptation. ANOVA results showed p-values at all incubation periods were below the significance level (α = 0.05), indicating significant differences in bacterial adaptation across treatments. The inhibition zone test revealed that the 40% extract concentration was as effective as higher concentrations (50%, 60%, 70%, and 80%). Although the 80% concentration exhibited the largest inhibition zone, its bactericidal effect was not statistically different from the lower concentrations. These results demonstrate the potential of Planchonia valida leaf extract as an effective antimicrobial agent and support further research into its development for the treatment or prevention of Y. enterocolitica infections.
Co-Authors Achmad Zaini Afriliani, Hesti Ajiza, Pratisa Defiera Ajiza, Pratisa Deifirera Alia, Rahmah Alya Meiana, Nurma Amin, Astuti Muh Ashari, Roulina astuti muh amin Astuti Muh. Amin Awaluddin, Annisa Maharani Ayatusa'adah Ayatusa'adah, Ayatusa'adah Ayu Tiara Putri, Ayu Tiara Bueraheng, Robeeyah Bunga Nur Siammukaromah, Jamalika Chairunnisa, Syinna Dalila, Aupi Dalila, Zahrah Dwi Rini Kurnia Fitri Fatimah Fauzy, Rahmad Febrianty, Riafany Gunawan Gunawan Haris Munandar Hery Widijanto Hidayati, Maulidia Hujjastusnani, Noor Ihsan, Afifi Raima Jarkani, Muhammad Jubaidah, Jubaidah Jumrodah Jumrodah, Jumrodah Karlina, Siti Khalda, Nabilah Khasanah, Purnama Uswatun Laksminarti Laksminarti Latifah, Nadia Dwi Nur Marshanda, Utin Tria Mila Mila mila Mila, Nor Muamar, Ilham Muh Amin , Astuti Muh.Amin, Astuti Mukhlis Rohmadi Mu’minah, Alfina Nada, Ara Aulia Najwa, Fatri Nanik Lestariningsih, Nanik Ningsih, Ira Wahyu Nisa, Khairun` Noor Hujjatusnaini Noor, Muhammad Arifin Norhalipah, Norhalipah Nursalina, Nursalina Nurul Septiana, Nurul Pitria, Pitria Puji Astuti, Pertiwi Adi Purwanti, Devi Yuni Purwita Sari, Purwita Puteri Maharani, Septia Rahma, Rima Hikmahtur Rahman, Luthfi Aulia Ramadhan, Ahmad Ananda Ravieq, Faris Rafi Asshiddik Reski Saputra, Reski Respi, Respi Riana, Rifa Rohmadi , Mukhlis Sari, Lilin Ika Nur Indah Sari, Santi Aulia Sasmita Sasmita Setianingsih, Ria Wahyu Setyawan , Dedy Siti Maysaroh Ulvah, Rohayati Yuliyana, Via