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All Journal MEDISAINS Pharmascience Jurnal Fitofarmaka Indonesia BIOEDUSCIENCE Jurnal SOLMA Science Education and Application Journal Jurnal Ilmiah Biologi UMA (JIBIOMA) Journal of Biology Learning Jurnal Insan Farmasi Indonesia Jurnal Buana Farma Jurnal Penelitian Sains dan Pendidikan (JPSP) HJSE Lontara Journal Of Health Science And Technology
Nirmalasari, Ridha
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Nursing Physics Public Health Other

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Antihyperglicemic effect of Musa paradisiaca extract in vivo Hujjatusnaini, Noor; Nirmalasari, Ridha
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Early Release
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v0i0.18814

Abstract

Background: Musa paradisiaca has  been widely studied for its antihyperglycemic effects, showing potential as an alternative natural remedy for diabetes. However, variability in genetic factors, environmental conditions, and geographical origins may influence its bioactive compound composition and efficacy. Thus, further validation through controlled studies is required to ensure consistent therapeutic effects.Purpose: : This study aimed to evaluate the antihyperglycemic effect of Musa paradisiaca stem extract in vivo, providing additional validation for its therapeutic potential and determining the optimal concentration for clinical relevance.Method: An experimental posttest-only control group design was used. Thirty-five male Balb/c strain mice were induced into hyperglycemia using alloxan. They were then randomly divided into treatment groups receiving different concentrations of Musa paradisiaca stem extract (5%, 15%, 25%, 35%, and 45%), a positive control group (metformin), and a negative control group. Blood glucose levels were measured and analyzed statistically using One-Way ANOVA.Result: Administration of the stem extract at 15% concentration showed the most significant antihyperglycemic effect, with an average blood glucose level reduction to 63.8 mg/dL, comparable to the positive control group (metformin). Conversely, the highest concentration tested (45%) exhibited minimal effectiveness, with an average glucose level of 151.8 mg/dL, indicating reduced antihyperglycemic activity.Conclusion: The optimal antihyperglycemic effect of Musa paradisiaca stem extract was achieved at a concentration of 15%, demonstrating therapeutic efficacy comparable to metformin. This extract shows promise as a natural alternative agent in diabetes treatment. Further studies, including clinical trials, are recommended to confirm these findings.
Efek Antimikroba Kombinasi Ektrak Daun Isotoma longinflora (L). C. Presl dan Bunga Clitoria ternatea terhadap S. aureus dan Fusarium sp. sebagai Faktor Pemicu Resiko Infeksi Konjungtiva secara In Vitro Hujjatusnaini, Noor; Nirmalasari, Ridha; Amin, Astuti Muh; Mila, Nor; Rahman, Luthfi Aulia; Marshanda, Utin Tria; Awaluddin, Annisa Maharani; Putri, Ayu Tiara; Najwa, Fatri; Mila, Mila
Jurnal Pharmascience Vol 12, No 1 (2025): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v12i1.18409

Abstract

Infeksi konjungtiva sering disebabkan oleh berbagai mikroorganisme patogen, termasuk Staphylococcus aureus dan Fusarium sp. Isotoma longiflora dan Clitoria ternatea diketahui mengandung senyawa metabolit sekunder yang berpotensi sebagai agen antimikroba. Penelitian ini bertujuan untuk menguji efek antimikroba dari kombinasi ekstrak Isotoma longiflora dan Clitoria ternatea terhadap Staphylococcus aureus dan Fusarium sp., yang berpotensi menyebabkan infeksi konjungtiva secara in vitro. Kombinasi ekstrak kedua tanaman dibuat dalam formulasi 1:1, dengan mencampurkan 50% ekstrak Isotoma longiflora dan 50% Clitoria ternatea. Formulasi kombinasi ini diuji pada konsentrasi 50%, 60%, 70%, 80%, dan 90%, dengan waktu pengamatan selama 72 jam. Hasil uji statistik menggunakan One-Way ANOVA menunjukkan pengaruh signifikan dari kombinasi ekstrak terhadap pertumbuhan kedua mikroba (p=0,001; p<0,05). Kombinasi ekstrak Isotoma longiflora dan Clitoria ternatea memiliki efektivitas penghambatan lebih tinggi terhadap Staphylococcus aureus dibandingkan Fusarium sp., terutama pada konsentrasi 50%. Diduga dipengaruhi kandungan senyawa seperti flavonoid, tanin, dan saponin yang merusak dinding sel dan membran bakteri. Sebaliknya, efektivitas penghambatan terhadap Fusarium sp. relatif lebih rendah karena struktur dinding sel jamur yang lebih kompleks. Simpulan bahwa efek kombinasi ekstrak Isotoma longiflora dan Clitoria ternatea lebih besar sebagai antibakteri bakteri Gram-positif seperti S. aureus, dibandingkan terhadap Fusarium sp., sehingga diperlukan penelitian lanjutan untuk memvalidasi temuan dalam penelitian ini. Kata Kunci: Clitoria ternatea, Isotoma longinflora, S. aureus, Fusarium sp. Conjunctival infections are often caused by various pathogenic microorganisms, including Staphylococcus aureus and Fusarium sp. Isotoma longiflora and Clitoria ternatea are known to contain secondary metabolites with potential as antimicrobial agents. This study aimed to test the antimicrobial effects of a combined extract of Isotoma longiflora and Clitoria ternatea against Staphylococcus aureus and Fusarium sp., which can potentially cause conjunctival infections, in vitro. The combined extract of the two plants was formulated in a 1:1 ratio, mixing 50% Isotoma longiflora extract and 50% Clitoria ternatea. This combination was tested at concentrations of 50%, 60%, 70%, 80%, and 90%, with an observation period of 72 hours. Statistical testing using One-Way ANOVA showed a significant effect of the combined extract on the growth of both microorganisms (p=0.001; p<0.05). The combined extract of Isotoma longiflora and Clitoria ternatea exhibited a higher inhibitory effect against Staphylococcus aureus than Fusarium sp., especially at the 50% concentration. This effect is thought to be influenced by compounds such as flavonoids, tannins, and saponins that can damage bacterial cell walls and membranes. Conversely, the inhibition effect on Fusarium sp. was relatively lower, possibly due to the more complex structure of fungal cell walls. In conclusion, the combined extract of Isotoma longiflora and Clitoria ternatea demonstrates a stronger antibacterial effect against Gram-positive bacteria like Staphylococcus aureus compared to Fusarium sp., indicating a need for further research to validate these findings.
Pelatihan Pembuatan Pupuk Organik dari Bahan Nabati untuk Meningkatkan Produktivitas Pertanian di Desa Mantaren Nirmalasari, Ridha; Ramadhan, Ahmad Ananda; Noor, Muhammad Arifin; Jarkani, Muhammad; Jubaidah, Jubaidah; Afriliani, Hesti; Hujjatusnaini, Noor
Jurnal SOLMA Vol. 14 No. 1 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/solma.v14i1.16682

Abstract

Background: Desa Mantaren, produktivitas pertanian telah banyak mengalami tantangan berkelanjutan. Pengabdian ini berdasar pada hasil pelatihan pembuatan pupuk organik dari bahan nabati sebagai upaya untuk meningkatkan produktivitas pertanian di wilayah tersebut. Pengabdian ini bertujuan untuk membekali pengetahuan dan keterampilan terkait pengolahan pembuatan pupuk nabati untuk meningkatkan produktivitas hasil tani bagi para masyarakat di Desa mantaren yang mayoritas mata pencahariannya adalah bertani. Metode: Pendekatan Participatory Action Research (PAR). Mitra dalam pengabdian ini adalah dinas pertanian di Kabupaten Pulang Pisau. Kegiatan pengabdian dilakukan melalui pelatihan yang dihadiri oleh sekitar 50 warga Desa Mantaren yang berprofesi sebagai petani. Hasil: Pelatihan pembuatan pupuk organik secara signifikan meningkatkan pemahaman petani tentang penggunaan pupuk organik dan dampak positifnya terhadap tanaman. Setelah pelatihan, terjadi peningkatan yang nyata dalam hasil panen, khususnya pada tanaman padi dan sayuran. pupuk organik dapat diproduksi secara lokal lebih ekonomis dan ramah lingkungan dibandingkan dengan pupuk kimia. Dalam konteks Desa Mantaren, pelatihan ini telah membawa perubahan positif yang signifikan dalam produktivitas pertanian dan kualitas hasil panen. Implikasi dari penelitian ini menggarisbawahi pentingnya pendekatan berkelanjutan dalam pertanian dan memberikan panduan bagi komunitas agraris sejenis untuk mengadopsi praktik serupa. Kesimpulan: Warga desa diharapkan dapat melanjutkan dan mendukung inisiatif pembuatan pupuk organik lokal untuk meningkatkan ketahanan pangan dan keberlanjutan lingkungan di Desa Mantaren.
Eksplorasi Potensi Tumbuhan Berkhasiat Obat Diabetes Mellitus Pada Suku Dayak Bakumpai Barito Selatan Sebagai Penyusun Atlas Tanaman Berkhasiat Obat Muamar, Ilham; Lestariningsih, Nanik; Nirmalasari, Ridha
Lontara Journal of Health Science and Technology Vol. 2 No. 1 (2021): Ilmu dan Teknologi Kesehatan
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Politeknik Muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53861/lontarariset.v2i1.185

Abstract

The Bakumpai Dayak tribe is very close to their ancestral culture, including in their efforts to maintain their health and self-medication, which still chooses to use traditional methods such as gathering various plants taken from forests or gardens. This study aims to obtain information about the types of plants used, parts of plant organs used and to find out how to use medicinal plants to treat Diabetes Mellitus according to the customs of the Bakumpai Dayak Tribe, Dusun Selatan District, Baru Village. After conducting the research, there were 10 types of medicinal plants for the efficacy of Diabetes mellitus according to the Bakumpai Dayak tribe. The plants that are often used are Earth Pegs, Ulin Trees, Sandalwood Trees, Pare, Sapat Trees, Muhur, Noni, Bidders and Halaban Wood. The most widely used parts of the plant are the roots and leaves. Utilization of medicinal plants by the Bakumpai Dayak tribe by making pills, soaking, boiling, watering or washing, smearing or affixing them. How to use most medicinal plants by boiling and soaking.
EFEK ANTIMIKROBA EKSTRAK Arcangelisia flava, Curcuma longa, Curcuma zanthorrhiza TERHADAP Bacillus DAN Pseudomonas PENYEBAB DIARE Hujjastusnani, Noor; Amin, Astuti muh.; Nirmalasari, Ridha; Awaluddin, Annisa Maharani; Latifah, Nadia Dwi Nur; Riana, Rifa; Nisa, Khairun`; Ningsih, Ira Wahyu; Anisa, Nor
Jurnal Buana Farma Vol. 5 No. 1 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i1.1256

Abstract

Diarrhea is a major health issue often caused by Bacillus sp. and Pseudomonas aeruginosa. This study aims to evaluate the antibacterial activity of a combination of Arcangelisia flava, Curcuma longa, and Curcuma zanthorrhiza extracts against these bacteria. The research was conducted in vitro using a Completely Randomized Design (CRD) with extract concentrations of 30%, 50%, 75%, and 100%, along with positive and negative controls. Antibacterial tests were carried out using the disk diffusion method to measure the inhibition zones after 24, 48, and 72 hours of incubation. The results showed the highest inhibition zones at 100% concentration, reaching 1.38 mm for Bacillus sp. and 1.33 mm for Pseudomonas aeruginosa after 72 hours. This antibacterial activity is supported by active compounds such as flavonoids, alkaloids, and curcumin. In conclusion the combination of these extracts effectively inhibits diarrhea-causing bacteria and has potential as a safe herbal alternative to address antibiotic resistance.
Efektivitas Ekstrak Tumbuhan Terhadap Bakteri dan Jamur Penyebab Infeksi Pasca melahirkan Hujjatusnaini, Noor; Muh.amin, Astuti; Nirmalasari, Ridha; Karlina, Siti; Ajiza, Pratisa Deifirera; Saputra, Reski; Pitria, Pitria; Maysaroh, Siti; Yuliyana, Via; Respi, Respi
Jurnal Ilmiah Biologi UMA (JIBIOMA) Vol 7, No 1 (2025): May 2025
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/jibioma.v7i1.5589

Abstract

Postoperative infections, especially after childbirth, remain a serious medical issue as they can lead to complications, delay recovery, and increase antibiotic resistance due to the excessive use of synthetic drugs. Therefore, safer and more effective treatment alternatives, such as the use of natural substances, are needed. This study aims to examine the antimicrobial potential of a combination of Ageratum conyzoides, Mussaenda frondosa, and Acorus calamus extracts in inhibiting the growth of Staphylococcus aureus and Candida albicans, which are common pathogens in postnatal surgical wound infections. The study employed a true experimental method with an antimicrobial sensitivity test design using the maceration technique. Extraction was conducted using 96% ethanol with three concentration variations: 40%, 80%, and 120%, in a 3:2:1 mixture ratio. Phytochemical screening was carried out to identify secondary metabolite compounds, followed by an inhibition test using the disc diffusion method. The results showed that Acorus calamus extract contains flavonoids, alkaloids, and saponins. Ageratum conyzoides, Mussaenda frondosa, and Acorus calamus all contain saponins with potential antimicrobial activity. The combination of these extracts demonstrated inhibitory effects against the growth of pathogenic microorganisms in surgical wounds, as evidenced by the formation of inhibition zones during testing.
Co-Authors Achmad Zaini Afriliani, Hesti Ajiza, Pratisa Defiera Ajiza, Pratisa Deifirera Alia, Rahmah Alya Meiana, Nurma Amin, Astuti Muh Astuti Muh. Amin Awaluddin, Annisa Maharani Ayatusa'adah Ayatusa'adah, Ayatusa'adah Ayu Tiara Putri, Ayu Tiara Bueraheng, Robeeyah Bunga Nur Siammukaromah, Jamalika Fatimah Fauzy, Rahmad Febrianty, Riafany Hery Widijanto Hujjastusnani, Noor Ihsan, Afifi Raima Jarkani, Muhammad Jubaidah, Jubaidah Karlina, Siti Khalda, Nabilah Latifah, Nadia Dwi Nur Marshanda, Utin Tria Mila Mila mila Mila, Nor Muamar, Ilham Muh Amin , Astuti Muh.Amin, Astuti Mu’minah, Alfina Najwa, Fatri Nanik Lestariningsih, Nanik Ningsih, Ira Wahyu Nisa, Khairun` Noor Hujjatusnaini Noor, Muhammad Arifin Norhalipah, Norhalipah Nursalina, Nursalina Nurul Septiana, Nurul Pitria, Pitria Puteri Maharani, Septia Rahman, Luthfi Aulia Ramadhan, Ahmad Ananda Reski Saputra, Reski Respi, Respi Riana, Rifa Rohmadi , Mukhlis Sasmita Sasmita Siti Maysaroh Ulvah, Rohayati Yuliyana, Via