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All Journal Jurnal Sain Veteriner Indonesia Medicus Veterinus Majalah Kedokteran Bandung Althea Medical Journal Media Kedokteran Hewan The Indonesian Biomedical Journal Jurnal Medik Veteriner JFIOnline The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Rosdianto, Aziiz Mardanarian
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health Veterinary

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Journal : The Indonesian Biomedical Journal

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Sarcopenic Obesity: The Underlying Molecular Pathophysiology and Prospect Therapies Meiliana, Anna; Dewi, Nurrani Mustika; Defi, Irma Ruslina; Rosdianto, Aziiz Mardanarian; Qiantori, Adziqa Ammara; Wijaya, Andi
The Indonesian Biomedical Journal Vol 16, No 4 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i4.3176

Abstract

BACKGROUND: Age contributes to body composition alteration, rises a common disorder in elderly known as sarcopenic obesity (SO), which is characterized by the combination of obesity (excess fat mass) and sarcopenia (reduced skeletal muscle mass) clinical form and function.CONTENT: The primary cause of SO is insulin resistance. Glucose transporter 4 (GLUT4) dysfunction results in impaired fatty acids oxidation. Decreased muscle mass results in lower mitochondria number and volume. Both will increase oxidative stress. Together with altered myokines in SO, oxidative stress was promoted and lead to higher M1 macrophages and failure in autophagy. The pro-inflammatory condition and dysbiosis links SO to a variety of cardiometabolic conditions, including non-alcoholic fatty liver disease, type 2 diabetes, and cardiovascular disease. The mortality, comorbidities, cardiometabolic diseases, and disability or impairment of SO is higher compare to obesity or sarcopenia alone. Some treatments have been developed for SO including adequate dietary intake, vitamin D and antioxidant supplementation, and exercises.SUMMARY: SO is more prevalent among the elderly and has a significant negative impact on their quality of life. Therefore, maintaining muscle mass and strength as well as preventing obesity should be the key goals of initiatives to support healthy aging.KEYWORDS: aging, body composition, obesity, sarcopenia, skeletal muscle, metabolic syndrome
Co-Authors Ade Zuhrotun Ambrosius Purba ANDI WIJAYA Anna Meiliana Ariefqi, Muhammad Naufal Darmesti, Daniswara Danindra Dewi, Sumartini Dwi Cipto Budinuryanto Enny Rohmawaty Gradia, Resti Hanna Goenawan HERA MAHESHWARI Hermawan, Firda Aisyah Hesti Lina Wiraswati Hidayatik, Nanik Irma Ruslina Defi Jatiswara, Ismaya Khairani, Shafia Leonardo Lubis Majid, Rully Abiyoga Mas Rizky A.A. Syamsunarno Muhammad Begawan Bestari Nenny Agustanti Nurrani Mustika Dewi, Nurrani Mustika Okta Wismandanu Permana, Noah Jefferson Qiantori, Adziqa Ammara Ramadhan, Putra Rejeki, Purwo Sri Rini Hendriani Ronny Lesmana Saragih, Winda A. M. Sarasati Windria Satryo, Faisal Amri Savira Ekawardhani Septiyani Septiyani, Septiyani Setiawan Setiawan Tarawan, Vita M. Tyagita Hartady Usman, Hermin A. Wasmen Manalu Wijaya, Muhammad Palar Yoga Windhu Wardhana