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Kirana, Rita
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Journal : Medical Laboratory Technology Journal

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The Analgesic Effect and Toxicity of Red and White Ginger on Mus Musculus with the Acetate Writhing Test Dewi, Vonny Khresna; Barkinah, Tut; Kirana, Rita; Rizki, Muhammad Ikhwan
Medical Laboratory Technology Journal Vol. 10 No. 2 (2024): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v10i2.611

Abstract

Based on data from the World Health Organization in 2020, the incidence of dysmenorrhea was 1,769,425 (90%) women who suffered from dysmenorrhea, with 10-16% suffering from severe dysmenorrhea. The problem of pain is very disruptive to activities, so prevention and treatment of pain must be a concern. Ginger is a natural ingredient that grows in South Kalimantan and is empirically used to treat pain. The study aimed to determine the analgesic effects and toxicity of red and white ginger from Banjarmasin and Banjar Regency. The nutrient content profile of the soil where the ginger grew was analyzed, and it was determined by nitrogen content, cation exchange capacity, and soil pH. The content of active compound groups was analyzed using specific reagents to determine the presence of active compounds. Determination of total phenolic levels using a colorimetric method using a UV-Vis spectrophotometer. The instant ginger formula was optimized with organoleptic test result parameters. Acute toxicity tests using male Wistar rats with observations for 14 days. Analgesic tests were conducted on Mus musculus using the acetic acid writhing test. The results showed that the highest nitrogen (1,34%), cation exchange capacity (29.22 me/100 g), and soil pH levels (6,89) were in the soil where the ginger samples from Banjar Regency grew. The chemical compound content in all gingers contained the same phenolics, flavonoids, tannins, saponins, and terpenoids. The levels of marker compounds in succession from Banjarmasin red ginger, Banjarmasin white ginger, Banjar Regency red ginger, and Banjar Regency white ginger were 7.43%, 6.26%, 8.52%, and 7.12%, respectively. The results of formula optimization showed that all gingers had a sweet and spicy taste, a distinctive odor, powder form, and a reddish-brown color in red ginger and pale yellow in white ginger. The toxicity test results showed that at doses of 300 mg/Kg BW and 2000 mg/Kg BW, there was no toxic effect on the administration of ginger extract. Analgesic activity showed that all gingers had an analgesic effect at a dose of 200 mg/Kg BW. The analgesic effects from the strongest to the lowest were red ginger from Banjar Regency, red ginger from Banjarmasin, white ginger from Banjar Regency, and white ginger from Banjarmasin. This study concludes that red ginger from Banjar Regency has the most potent analgesic activity and no toxicity for all ginger.
Nutritional Content, Subchronic Toxicity, and Antidysmenorrhea Activity of Instant Herbal Medicine Mixture of Red Ginger and White Ginger Dewi, Vonny Khresna; Kirana, Rita; Rizki, Muhammad Ikhwan
Medical Laboratory Technology Journal Vol. 11 No. 2 (2025): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v11i2.685

Abstract

Dysmenorrhea is menstrual pain that occurs in 69.8% of women. Ginger (Zingiber officinale) contains various secondary metabolites with anti-inflammatory properties. This study aims to determine its characteristics, including nutritional value and stability, product safety through toxicity testing, and product efficacy. The research stages include research ethics testing and the production of instant powder from a mixture of red and white ginger. Nutritional content analysis included total fat, saturated fat, protein, and carbohydrates. Physical and chemical stability testing was carried out for three months. Subchronic toxicity testing used Wistar rats for 28 days by drawing blood before and after treatment, accompanied by liver delivery. Blood samples were analyzed for SGPT and SGOT levels. The test was conducted on 10 women aged 18-20, divided into two groups. The treatment group was given 20 grams of instant ginger in the morning and evening for 10 days, and compared with the control group without treatment. Pain was measured using a Visual Analog Scale (VAS) before and after the study. The study showed that instant ginger herbal medicine contained 0.83% total fat, 0.17% saturated fat, 3.73% total protein, and 35.42% total carbohydrates. The stability test results showed no changes in the physical and chemical parameters of the test. The results of the subchronic toxicity test showed that the body weight of mice, liver weight, SGOT levels, and SGPT levels of mice were normal. The activity test showed a decrease in pain from before to after administration of instant ginger, with an average VAS value of 7.8 to 4.2. This study concluded that instant ginger, a mixture of red and white ginger, has good nutritional content, is physically and chemically stable, is non-toxic, and is effective in reducing dysmenorrhea.
Co-Authors Adhiestya, Della Agus Rachmadi Animurti, Faradiba Anna Soraya Azzahra, Refina Barkinah, Tut BR. Purba, Eka Purnama Sari Dewi, Vonny Khresna Erni Yuliastuti Fitria Jannatul Laili Hapisah, Hapisah Hartini, Lily hasanah, Noor Hayati, Rahmi Huswatun Hasanah Isnaniah, Isnaniah Isrowiyatun Daiyah Januarsih Januarsih, Januarsih jenny saherna, jenny Khoirun Nisa Kristiana, Efi lia, Norlia Linda Mariani Mariani Maulida, Anggi Safira Megawati - Melinda, Feby Misbah, Siti Muhammad Ikhwan Rizki Muhammad Mukhtar Muhsinin Muhsinin, Muhsinin Mukhdarina, Yuli Noor Adha Aprilea Nurlaili, Anis Pramono, Ambulu Putri Prihatanti, Nur Rohmah Putri, Gt. Indah M. Rachmadi, Agus Rahmadi, Agus Rahmah, Nadia Rahima Rahmawati, Rahmawati Rahmina, Anita Ramanda, Della Rosalina, Dana Rubiati Hipni, Rubiati Rusmilawaty setiawati, erni Soleha, Siti Suhrawardi suhrawardi, suhrawardi Surahmi, Luklul SURYANTI Tut Barkinah Tyastuti, Anastasia Purba Puspita Yudha Training Yuniarti Yuniarti Yuniarti, Eny Yuniarti, Kristina Yusnita, Andi Erna