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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Pharmacon Pharmascience Buletin Farmatera Indonesian Food Science and TechnologyJournal FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Ilmiah Farmako Bahari Indonesian Journal of Community Empowerment Sains Medisina Jurnal Kesehatan Farmasi Borneo Journal of Pharmacy Jurnal Sains dan Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Nuari, Doni Anshar
FMIPA Universitas Garut
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health Social Sciences Other

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ANALISIS DRUG-RELATED PROBLEMS PENGGUNAAN ANTIBIOTIK FLUOROKUINOLON DI SALAH SATU PUSKESMAS KABUPATEN GARUT Sitti Fatimah Putri Hasyul; Doni Anshar Nuari; Silvia Anggraini; Aditya Aditya; Ida Lisni
Jurnal Ilmiah Farmako Bahari Vol 11, No 2 (2020): Jurnal Ilmiah Farmako Bahari
Publisher : Fakultas MIPA Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jfb.v11i2.888

Abstract

Identifikasi masalah terkait obat atau drug-related problems (DRPs) adalah salah satu kegiatan pelayanan kefarmasian di puskesmas berdasarkan Peraturan Menteri Kesehatan No. 74/2016 yang dilakukan saat melakukan pengkajian resep untuk meningkatkan efektivitas terapi dan meminimalkan efek samping penggunaan obat. Fluorokuinolon adalah salah satu antibiotik yang sering digunakan dalam pelayanan kesehatan yang belakangan ini ditemukan berbagai laporan reaksi obat merugikan terkait penggunaan fluorokuinolon. Penelitian ini bertujuan untuk mengidentifikasi masalah terkait obat dari fluorokuinolon di salah satu Puskesmas Kabupaten Garut pada bulan Oktober 2017-Maret 2018, meliputi kesesuaian indikasi, dosis, dan potensi interaksi obat. Penelitian ini merupakan jenis penelitian non-eksperimental dengan pengumpulan data secara retrospektif dan dianalisis secara deskriptif. Dari 181 kasus, hasil penelitian menunjukkan 30,38% tidak sesuai indikasi, 1,11% dosis tidak sesuai, dan 37,44% potensi interaksi obat mayor dan 59,36% interaksi obat moderat. Kata kunci: drug-related problems, fluorokuinolon, puskesmas, siprofloksasin
Studi Literatur : Aktivitas Antibakteri Daun Binahong (Anredera cordifolia) terhadap Staphylococcus aureus Sevira Putri Damayanti; Ria Mariani; Doni Anshar Nuari
Jurnal Farmasi Sains dan Terapan Vol 9, No 1 (2022): Februari
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v9i1.3367

Abstract

Staphylococcus aureus merupakan bakteri yang dapat menyebabkan infeksi. Pengobatan infeksi biasanya menggunakan antibiotik, namun ditemukan masalah dalam penggunaan antibiotik salah satunya resistensi antibiotik. Binahong (Anredera cordifolia) dapat dijadikan sebagai alternative pengobatan antibakteri. Tujuan artikel review ini adalah untuk mereview ekstrak daun binahong yang dapat berpotensi menghambat pertumbuhan bakteri Staphylococcus aureus termasuk didalamnya menggali informasi mengenai konsentrasi yang memberikan zona hambat terhadap pertumbuhan Staphylococcus aureus dan golongan senyawa yang bertanggungjawab terhadap aktivitas antibakteri Staphylococcus aureus. Hasil uji antibakteri terhadap ekstrak daun binahong (Anredera cordifolia) dapat menghambat pertumbuhan bakteri Staphylococcus aureus dengan metode difusi pada konsentrasi 10%, 15%, 20% dengan diameter zona hambat 1,7 mm, 2,0 mm, 2,6 mm, sedangkan pada metode dilusi pada konsentrasi 25%. Pada fraksinasi daun binahong (Anredera cordifolia) dapat menghambat pertumbuhan Staphyloccus aureus (MIC 512 µg/ml). Hal ini dapat dikatakan bahwa ekstrak daun binahong (Anredera cordifolia) berpotensi dapat menghambat pertumbuhan bakteri Staphylococcus aureus. Golongan senyawa yang terkandung dalam ekstrak daun binahong (Anredera cordifolia) diduga adanya senyawa alkaloid, steroid, flavonoid dan fenol yang dapat menghambat pertumbuhan bakteri Staphylococcus aureus. 
INHIBITION OF SELECTIVE AND NON-SELECTIVE SICLOOXYIGENASE ON ANSIOLITIC EFFECTS INDUCED DIAZEPAM IN MICE Doni Anshar Nuari; Cindra Tri Yuniar; Ahmad Jaidi; Siva Hamdani; Genialita Fadhila
Jurnal Ilmiah Farmako Bahari Vol 13, No 2 (2022): Jurnal Ilmiah Farmako Bahari
Publisher : Fakultas MIPA Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jfb.v13i2.1910

Abstract

Stress is the source of many sociological, medical, and economic problems. Moreover, stresses are known as the etiology of several diseases. Prostaglandins and all four receptors affect the brain, even thought to affect behavior. Hence, the inactivation of cyclooxygenase (COX) causes a decrease in levels of prostaglandins that contribute to stress development, thus decreasing the anxiolytic effect of diazepam. This study aims to see the effect of selective and non-selective COX inhibitors decreasing the Anxiolytic effect of diazepam using the EPM (Elevated Plus Maze) method in male white mice; animals were grouped to use Tragakan 2%, Diazepam 0.065 mg/kg BB and Tragakan 2% after an hour, Diazepam 0.065 mg/kg BB and then an hour later gives Ketoprofen 0.65 mg/kg BB for non-selective COX Inhibitor effect group, Diazepam 0.065 mg/kg BW, and then an hour later gives Celecoxib 0.65 mg/kg BB for group use of selective Cox-2 Inhibitor, test parameter in this study is the duration in open arm. Results showing decreased duration on open arm group has given diazepam combination ketoprofen or celecoxib are different P value <0.05 than diazepam only. Decline duration was highest shown by animals given celecoxib, so that could be stated gift selective COX-2 inhibitors bring down the effect of anxiolytic diazepam bigger.
STUDY OF DOSAGE ADJUSTMENT OF ORAL ANTIDIABETIC DRUG IN TYPE II DIABETES MELLITUS PATIENTS WITH DISORDERS KIDNEY FUNCTION AT DR. SOEKARDJO TASIKMALAYA HOSPITAL Risa Susanti; Doni Anshar Nuari; Sitti Fatimah P.H.; Astrid Fauziyah
Jurnal Ilmiah Farmako Bahari Vol 14, No 1 (2023): Jurnal Ilmiah Farmako Bahari
Publisher : Fakultas MIPA Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jfb.v14i1.2196

Abstract

Diabetic nephropathy is one of the complications in DM that can end up becoming DM kidney failure. Nephropathy complications, if not handled properly, will lead to terminal chronic kidney disease. One of the factors that trigger complications of diabetic nephropathy in DM patients is the long-term use of oral anti-diabetic drugs. Therefore, proper dosage adjustment of these antidiabetic drugs, which are excreted through the kidneys, is required. The purpose of this study was to determine whether the dose received by type II DM patients with impaired renal function in the hospital was appropriate or not. This research will be carried out quantitatively and retrospectively by collecting patient medical record data at the hospital, and then the data obtained will be analyzed descriptively by calculating the creatinine clearance using the Cockcroft & Gault formula and comparing it with the literature dose based on the value of creatinine clearance. The sampling technique used was purposive sampling using the inclusion and exclusion criteria determined by the researcher. The inclusion criteria are data on type II diabetes mellitus patients with impaired kidney function at dr. Soekardjo Tasikmalaya Hospital in October–December 2020 who were treated with oral anti-diabetic drugs. The exclusion criteria were type II DM patients with impaired renal function who were treated with insulin, type I DM patients, and type II DM patients with impaired renal function who were treated with oral antidiabetic with incomplete laboratory data. Based on research that has been conducted on 35 samples, as many as 25 people, or 71.43 percent of patients, received therapeutic doses that were not in accordance with their kidney conditions. Meanwhile, 10 people, or 28,57% of patients, received a therapeutic dose according to their kidney condition.
ANTIDIARE INFUSA DAUN LEUNCA (SOLANUM AMERICANUM MILLER.) PADA MENCIT JANTAN GALUR SWISS WEBSTER Setiadi Ihsan; Doni Anshar Nuari; Suwendar Suwendar; Dede Ratih Hasanul Aliyah
Jurnal Ilmiah Farmako Bahari Vol 14, No 1 (2023): Jurnal Ilmiah Farmako Bahari
Publisher : Fakultas MIPA Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jfb.v14i1.2352

Abstract

Diare merupakan penyakit yang umum dijumpai, dapat menyerang anak-anak dan orang dewasa. Diare ditandai dengan terjadinya peningkatan frekuensi defekasi yang disertai dengan feses yang cair. Penggunaan obat baik sintetis maupun alami telah diketahui dapat menanggulangi diare yang terjadi, salah satu tanaman sebagai obat alami yang digunakan masyarakat secara empiris adalah daun leunca (Solanum americanum Miller) namun belum ada  bukti ilmiah penggunaan empiris tersebut. Penggunaan di masyarakat berupa rebusan daun leunca mendorong peneliti melakukan pengujian aktivitas antidiare infusa daun leunca (Solanum AmericanumMiller.) pada mencit jantan galur Swiss Webster dengan metode proteksi terhadap oleum ricini dan transit intestinal. Infusa daun leunca pada dosis 0,0325, 0,065, dan 0,13 g/Kg BB memiliki aktivitas antidiare dengan menurunkan bobot feses, dan frekuensi defekasi serta  meningkatkan konsistensi feses, disertai kecenderungan dalam penurunan gerak peristaltik usus pada dosis 0,13 g/Kg BB berbeda bermakna terhadap kontrol positif (p≤0,05).
The Safety Evaluation of Some Plants of the Zingibereceae Family Doni Anshar Nuari; Asman Sadino; Suci Hilwa Ainaya
Buletin Farmatera Vol 8, No 1 (2023)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v8i1.11478

Abstract

Larvicide Activity and Anti-Mosquito Activity of Several Plants in Indonesia Against Aedes Aegypti: Review Articles Asman Sadino; Doni Anshar Nuari; Devisi Eka Ariyo Masturoji; Riza Apriani
Buletin Farmatera Vol 8, No 2 (2023)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v8i2.12972

Abstract

Abstract: As one of the world's tropical countries with high air humidity, Indonesia is a breeding ground for mosquitoes such as Aedes aegypti, one of the dengue vectors. The search for alternative treatments using plants continues to date. This article review aims to find out and review scientific information from research that has been carried out related to plant activity as larvicide and anti-mosquito. The method of writing this article review uses literature studies through search engines in the form of Google Scholar, PubMed, and NCBI. 27 journals were obtained that were included in the inclusion criteria, The inclusion criteria used are national and international journals that discuss larvicide and anti-plant mosquito activities against Aedes aegypti mosquitoes, Journals published in the last 10 years (2012-2022), and journals in full-text form. From the results of searches related to plants that have activity as a larvicide and anti-mosquito Aedes aegypti, there are as many as 27 plant species, as many as 16 plant species have activity as a larvicide and 11 plant species have activity as anti-mosquito activity. Some of these plants can be used as natural insecticides that are environmentally friendly and contain secondary metabolites such as alkaloids, flavonoids, tannins, phenols, terpenoids, saponins and steroids that are effective as substances that kill larvae and repel mosquitoes.
Antibacterial Activity of Bandotan (Ageratum conyzoides L) Leaves Extracts Against Methicillin-Resistant Staphylococcus aureus Selvira Anandia Intan Maulidya; Doni Anshar Nuari; Shendi Suryana; Sumia Almarifah
Borneo Journal of Pharmacy Vol. 3 No. 4 (2020): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v3i4.1552

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of nosocomial infections throughout the world and can be life-threatening as well. This study aimed to determine the antibacterial activity of Bandotan (Ageratum conyzoides L) leaves ethanolic extract against MRSA's growth. Ageratum conyzoides leaves were extracted by ethanol and screened for their phytochemical constituent. Ethanolic extracts of A. conyzoides leaves were evaluated for their potential antibacterial activity using disc diffusion assay. The minimum inhibitory concentration (MIC) value was determined using the agar dilution method. Phytochemical screening shows that the extracts contain alkaloids, flavonoids, saponins, tannins, and steroids or triterpenoids. Ageratum conyzoides leaves extract shows a 25.1 mm inhibitory zone at 12.5% extract concentration with MIC value equivalents to 4.46 x 10-6 g of gentamicin. This study concludes that A. conyzoides leaves ethanolic extracts have potential antibacterial activity against MRSA.
Uji Aktivitas Antidiare Ekstrak Etanol Batang Dan Daun Kelakai (Stenochlaena palustris (Burm.F) Bedd) Pada Mencit Jantan Galur Swiss Webster Fauzia, Husna; Yuniar, Cindra Tri; Nuari, Doni Anshar
Sains Medisina Vol 2 No 2 (2023): Sains Medisina
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/snsmed.v2i2.312

Abstract

Diare adalah buang air besar encer dengan atau tanpa darah atau lendir, dapat pula disertai frekuensi defekasi yang meningkat dan merupakan gejala dari penyakit-penyakit tertentu atau gangguan lainnya. Penelitian Khair (2012) dan Yosika (2014) menyebutkan Kelakai (Stenochlaena palustris (Burm.F.) Bedd) dapat digunakan sebagai obat tradisional karena mengandung golongan senyawa flavonoid dan tanin yang di antaranya berfungsi mengobati diare. Penelitian ini melakukan pengujian aktivitas antidiare ekstrak etanol batang dan daun kelakai dengan metode proteksi terhadap oleum ricini dan metode transit intestinal pada mencit jantan galur Swiss Webster. Dari hasil penelitian diperoleh bahwa ekstrak etanol batang dan daun kelakai dosis 400 mg/kgBB, 200 mg/kgBB, dan 100 mg/kgBB memiliki aktivitas antidiare dengan menurunkan bobot feses, menurunkan frekuensi defekasi meningkatkan konsistensi feses, mengurangi lamanya diare, serta menekan waktu muncul diare berbeda bermakna terhadap kontrol (p ≤ 0,05) dengan disertai kecenderungan penekanan gerakan peristaltik usus.
Analysis of Shelf Life and Antibacterial Actvity of Sumbawa Wild Horse Milk against Escherecia Coli and Staphylococcus Aureus Bacteria Lubis, Novriyanti; Setyaningsih, Baiq Inges; Nuari, Doni Anshar
Indonesian Food Science and Technology Journal Vol. 6 No. 2 (2023): Volume 6. Number 2, July 2023 |IFSTJ|
Publisher : Department of Technology of Agricultural product (THP) Jambi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/ifstj.v6i2.24191

Abstract

Sumbawa wild horse mik is pure milk produced by a mare which is bred in sumbawa and is a healthy drink that has antibacterial activity and longer shelf life duration without using preservatives. This study aims to analyze the shelf life and antibacterial activity of Sumbawa wild horse milk (SWHM) against Escherecia coli and Staphylococcus aureus bacteria, with test parameters including water content, fat content, protein content, pH, and testing was carried out on the 15th day and 30th day after milking and storage at room temperature. The results showed that SWHM did not decay or changes in levels that were far different during the storage period of 15-30 days at room temperature, with the results of fat content of 86.182% and 1.6650%, protein content of 2.1624% and 2.2961%, 86.1821% water content and pH 5.21 and 4.00. Antibacterial activity plays more role in inhibiting Escherichia coli bacteria compared to Staphylococcus aureus with a concentration of 50%, 75%, and 100% with a maximum inhibition of 12.77 mm.
Co-Authors Aditya Aditya Aditya Aditya Ahmad Jaidi Aji Najihudin Aji Najihudin Apriliani, Nisa Siti Asholeha Lulu Asman Sadino Asman Sadino ASMAN SADINO, ASMAN Astrid Fauziyah Atun Qowwiyah Cindra Tri Yuniar Cindra Tri Yuniar Cindra Tri Yuniar Damayanti, Sevira Putri Deby Caroline Dede Ratih Hasanul Aliyah Devisi Eka Ariyo Masturoji Dina Eksyawati Eriyani Putri Muntaqin Euis Wartini Framesti Frisma Sriarumtias Framesti Prisma Sriarumtias Genialita Fadhila Hesti Renggana Husna Fauzia Ida Lisni Ikhwan Yuda Kusuma Kusnandar Anggadiredja Mentari Novitasari Mida Yulia Eka Novriyanti Lubis Novriyanti Lubis, Novriyanti Rahmayanti Rahmayanti Renggana, Hesti Ria Mariani Ria Mariani Risa Susanti Riza Apriani Rohimah, Vina Siti Selvira Anandia Intan Maulidya Setiadi Ihsan Setyaningsih, Baiq Inges Sevira Putri Damayanti Silvia Anggraini Sitti Fatimah P.H. Sitti Fatimah Putri Hasyul Sitti Fatimah Putri Hasyul Sitti Fatimah Putri Hasyul Siva Hamdani Siva Hamdani Suci Hilwa Ainaya Sudjana, Shifa Nisrina Sumia Almarifah Suryana, Shendi Susanti, Risa Suwandi, Deden Winda Suwendar Suwendar Syamsudin, Raden Aldizal Mahendra Rizkio Syifa Hamdani Syifa Salsabila Tia Rahayu Tita Puspita Tita Puspitan Vingki Pratiwi Ganenggara Yosi Roila Julaikho Yuniar, Cindra Tri