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Aktivitas Analgetika dan Antiinflamasi Ekstrak Etanol dan Fraksi Daun Jambu Mawar (Syzygium jambos L.) Secara In Vivo: Analgetic and Anti-inflammatory Activity of Ethanol Extract and Fraction of Guava Leaf (Syzygium jambos L.) In Vivo Deden Winda Suwandi; Tita Puspita; Doni Anshar Nuari; Syifa Hamdani
Jurnal Sains dan Kesehatan Vol. 3 No. 2 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v3i2.279

Abstract

Syzygium jambos is a plant that has traditionally been used to treat several diseases, especially the leaves as a medicine for rheumatism. In this study, the ethanol extract, fraction of n-hexane, ethyl acetate, and water from its leaves were tested for analgesic and anti-inflammatory activity using the writhing method (Siegmund), hot plate, and the formation of swelling of the soles induced by carrageenan lamda. The results showed that the ethanol extract at doses of 100 and 200 mg/kg BW and fractions of n-hexane, ethyl acetate and water at doses of 50 and 100 mg/kg BW had analgesic and anti-inflammatory activities. The ethanol extract at doses of 100 and 200 mg/kg BW can reduce the amount of writhing every 5 minutes for 60 minutes of observation by 84 and 98 times with percent protection of 58.0 and 52.0%. The Ethyl acetate, n-hexane, and water fractions of 50 and 100 mg/kg BW can reduce the amount of animal writhing by 93 and 35 times, 75 and 100 times, as well as 84 and 124 times with the percent of protection is 54.45 and 82.85, 63.0 and 50.9, as well as 58.47 and 38.02%. The analgesic activity of the hot plate method, ethanol extract can increase the survival time of animals in the hot plate by 154.0 and 95.02%, while the animal survival time of the n-hexane fraction is 95.86 and 105.5, ethyl acetate by 143, 7 and 105.7, and the water fraction of 34.1 and 99.5%. The anti-inflammatory activity of ethanol extract at doses of 100 and 200 mg/kg BW was indicated by a decrease in the volume of rat leg edema at the time of observation for 6 hours with the percent inhibition of edema of 59.2 and 41.12%. The n-hexane, ethyl acetate, and water fractions have relatively the same ability, indicated by the edema inhibition value of the n-hexane fraction of 68.24 and 68.56%, the ethyl acetate fraction of 57.08 and 67.32% and the fraction water of 64.02 and 67.46%. The effective dose of extracts and fractions of n-hexane, ethyl acetate, and water as analgesics and anti-inflammatory is 100 mg/kg BW.
Pengaruh Iradiasi Sinar Gamma Dosis 7 Kgy Terhadap Kualitas Mikrobiologi Biskuit Pati Umbi Taka (Tacca leontopetaloides (L.) Kuntze): Effect of 7 Kgy Dosage Gamma Irradiation on Microbiological Quality of Tubers Taka (Tacca leontopetaloides (L.) Kuntze) Starch Biscuits Novriyanti Lubis; Doni Anshar Nuari; Shendi Suryana; Vingki Pratiwi Ganenggara; Rahmayanti Rahmayanti
Jurnal Sains dan Kesehatan Vol. 3 No. 4 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v3i4.458

Abstract

Pati merupakan homopolimer glukosa dengan ikatan ?-glikosidik. Pati terdiri dari butiran-butiran kecil yang disebut granula. Pati termodifikasi merupakan pati telah mengalami perubahan sifat menjadi lebih baik dari pati alaminya. Pemanfaatan pati lokal seperti umbi taka (Tacca leontopetaloides (L.) Kuntze) sebagai alternatif tepung komposit (umbi taka : tepung terigu) untuk mengurangi ketergantungan pada tepung terigu¹. Mengenai pengaruh modifikasi pati taka (Tacca leontopetaloides (L.) Kuntze) dengan menggunakan komponen minyak jahe. Salah satu pemanfaatan pati umbi taka tersebut dapat dibuat menjadi bahan pangan seperti biskuit. Hampir semua bahan pangan tercemar oleh berbagai mikroorganisme dari lingkungan sekitar seperti Esherichia coli, Staphylococcus aureus, dan Kapang Khamir. Penelitian ini bertujuan untuk memastikan bahwa produk biskuit taka memenuhi persyaratan kualitas biskuit.Berdasarkan penelitian ini, karakteristik biskuit umbi taka menghasilkan kadar air sebesar 4.567%, kadar abu sebesar 1.396%, kadar protein sebesar 8.718%, karbohidrat sebesar 75.28%, dan kandungan kalori sebesar 417.99 dan jumlah bakteri Salmonella sp dan Escherichia coli 0 cfu. Hasil pengujian AKK dan ALT yang memenuhi persyaratan SNI biskuit 2011 adalah ALT dosis 7 kGy, AKK tanpa iradiasi dan iradiasi 7 kGy pada H-0 dan H-30 yaitu ? 104 dan yang tidak memenuhi persyaratan adalah ALT dosis 7 kGy H-60 dan tanpa iradiasi pada H-0, H-30, H-60 yaitu ? 104.
ANTIBIOTIC RESISTANCE IN CIMANUK RIVER, GARUT REGENCY, WEST JAVA Syamsudin, Raden Aldizal Mahendra Rizkio; Sudjana, Shifa Nisrina; Nuari, Doni Anshar
Jurnal Kesehatan Farmasi Vol 6 No 2 (2024)
Publisher : Jurusan Farmasi, Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jkpharm.v6i2.2633

Abstract

Background: Antibiotic resistance could causing infectious treatment by antimicrobial agent become not effective anymore. This could result in longer care and higher cost for patient. This research aimed to understand antimicrobial resistance from microbe isolated from Cimanuk River, Garut Residence, West Java Province. Methods: Antibiotic resistance testing in river water was conducted by isolating bacteria into enrichment TSB media and then Blood Agar and also MacConkey Agar by spread plate method. Sample then incubated in 37 °C for 24 hours to gain growing bacterial colony. Colony identification and antibiotic resistance testing was done using BD Phoenix 50. Results: Result showed that 50% E. coli bacterial isolate from Cimanuk River already developed resistance to Ampicillin, Piperacillin-Tazobactam, and Tetracycline antibiotic. Conclusion: Antibiotic resistance already occurred in E. coli bacteria isolated from Cimanuk River
EVALUASI TINGKAT PENGETAHUAN TENTANG SEDIAAN, CARA PAKAI DAN EFEK SAMPING KONTRASEPSI SUNTIK AKSEPTOR KELUARGA BERENCANA (KB) DI KOTA BANDUNG Nuari, Doni Anshar; Anggadiredja, Kusnandar
Jurnal Ilmiah Farmako Bahari Vol 16 No 1 (2025): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kontrasepsi suntik adalah sediaan injeksi yang mengandung hormon untuk pencegahan kehamilan pada wanita. Kepatuhan dalam penggunaan kontrasepsi menjadi penentu keberhasilan dalam penggunaannya termasuk penggunaan pada kontrasepsi suntik ini. Salah satu yang mempengaruhi kepatuhan adalah tingkat kepatuhan pasien terhadap suatu terapi. Tujuan penelitian ini adalah untuk mengukur tingkat pengetahuan akseptor tentang bentuk sediaan cara pakai dan efek samping kontrasepsi suntik sebelum dan setelah pemberian informasi dari konselor. Penelitian ini dilakukan dengan mengukur pemahaman akseptor terhadap bentuk sediaan, cara pakai dan efek samping pasien sebelum dan setelah mendapatkan informasi dari konselor, pengujian menggunakan kuesioner yang dibuat dengan skala Guttman, data yang diperoleh dianalisis secara deskriptif dan kuantitatif menggunakan uji Wilcoxon. Tingkat pengetahuan bentuk sediaan telah baik sementara pengetahuan tentang efek samping dan cara pakai menunjukan nilai cukup.
The Relationship between Knowledge Level and Self-Medication Behavior for Scabies at SMK Plus Al-Istiqomah Sadino, Asman; Suwandi, Deden Winda; Susanti, Risa; Nuari, Doni Anshar; Renggana, Hesti; Rohimah, Vina Siti; Apriliani, Nisa Siti
Indonesian Journal of Community Empowerment (IJCE) Vol 5 No 02 (2024): Indonesian Journal of Community Empowerment (May)
Publisher : Fakultas Kewirausahaan Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35899/ijce.v5i2.712

Abstract

Scabies is a skin disease that is often ignored. Scabies is still common in Islamic boarding schools with a high prevalence rate. Self-medication is used to treat mild to moderate illnesses without consulting a doctor first. This community service aims to determine the relationship between the level of understanding of scabies' self-medication behavior at SMK Plus Al Istiqomah. The method used begins with the distribution of an initial questionnaire (pre-test), presentation of the material with the help of PowerPoint slides, a question and answer session between students (i) and the presenter, and distribution of the final questionnaire (post-test). The results of this community service activity showed an increase in knowledge of scabies from a percentage of 5% to 87.5%. This means that the education provided can be well received by students at SMK Plus Al-Istiqomah.
Studi Literatur : Aktivitas Antibakteri Daun Binahong (Anredera cordifolia) terhadap Staphylococcus aureus Damayanti, Sevira Putri; Mariani, Ria; Nuari, Doni Anshar
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 9 No. 1 (2022): Februari
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v9i1.3367

Abstract

Staphylococcus aureus merupakan bakteri yang dapat menyebabkan infeksi. Pengobatan infeksi biasanya menggunakan antibiotik, namun ditemukan masalah dalam penggunaan antibiotik salah satunya resistensi antibiotik. Binahong (Anredera cordifolia) dapat dijadikan sebagai alternative pengobatan antibakteri. Tujuan artikel review ini adalah untuk mereview ekstrak daun binahong yang dapat berpotensi menghambat pertumbuhan bakteri Staphylococcus aureus termasuk didalamnya menggali informasi mengenai konsentrasi yang memberikan zona hambat terhadap pertumbuhan Staphylococcus aureus dan golongan senyawa yang bertanggungjawab terhadap aktivitas antibakteri Staphylococcus aureus. Hasil uji antibakteri terhadap ekstrak daun binahong (Anredera cordifolia) dapat menghambat pertumbuhan bakteri Staphylococcus aureus dengan metode difusi pada konsentrasi 10%, 15%, 20% dengan diameter zona hambat 1,7 mm, 2,0 mm, 2,6 mm, sedangkan pada metode dilusi pada konsentrasi 25%. Pada fraksinasi daun binahong (Anredera cordifolia) dapat menghambat pertumbuhan Staphyloccus aureus (MIC 512 µg/ml). Hal ini dapat dikatakan bahwa ekstrak daun binahong (Anredera cordifolia) berpotensi dapat menghambat pertumbuhan bakteri Staphylococcus aureus. Golongan senyawa yang terkandung dalam ekstrak daun binahong (Anredera cordifolia) diduga adanya senyawa alkaloid, steroid, flavonoid dan fenol yang dapat menghambat pertumbuhan bakteri Staphylococcus aureus. 
Aksi Sosial Donor Darah Untuk Kemanusiaan Kolaborasi PMI Garut Dan FMIPA Universitas Garut Berikan Darah Berikan Harapan Nuari, Doni Anshar; Pitriani, Karina; Jamil, Widi Mahmuda Nur; Aulia, Ira; Muharram, Rahma Mekar; Fahmi, Ami Nur; Sambact, Jasminum; Lubis, Novriyanti
Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Vol 5, No 1 (2026)
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/phar.soc.v5i1.35973

Abstract

Darah sangat dibutuhkam untuk menunjang kesehatan, metabolisme dan mekanisme semua proses yang ada dalam tubuh. Darah sehat ditandai dengan warna merah cerah, viskositas (kekentalan) normal, pH stabil (7.35-7.45), serta parameter lab seperti kadar hemoglobin, kolesterol (HDL tinggi, LDL rendah), gula darah normal, dan trombosit seimbang, yang semua ini tercermin dari tubuh yang bugar, energi cukup, kulit merona, serta tidak mudah lelah. Ketersediaan darah yang aman dan berkualitas sangat penting untuk layanan transfusi darah. Salah satu cara penting untuk mendorong gaya hidup sehat dan memberikan kontribusi besar kepada kesehatan masyarakat dan individu adalah dengan donor darah. Kegiatan ini bertujuan sebagai aksi sosial kemanusiaan kolaborasi antara PMI Garut dan mahasiswa Farmasi UNIGA untuk membantu masyarakat dan meningkatkan kepedulian sosial. Kegiatan donor darah dilaksanakan di Kampus 3 Universitas Garut pada tanggal 15 November 2025 yang dikemas secara edukatif dan inspiratif melalui proses pre-test, penyampaian materi, demonstrasi, permainan edukatif cerdas cermat dan diakhiri dengan pos test. Dari 80 pendaftar, hanya 41 orang yang memenuhi persyaratanuntuk donor darah juga peserta didominasi oleh perempuan (93,2%). Golongan darah pendonor terbanyak adalah Golongan A (35,65%), disusul oleh golongan darah B (27,75%), O (25,75%) dan AB (10,8%). Motivasi utama berdonor adalah untuk kesehatan pribadi (75,1%). Meskipun sebagian besar pendaftar gagal melewati tahap skrining kesehatan awal, aksi sosial donor darah ini berjalan lancar dan berhasil meningkatkan kepedulian sosial dan meningkatkan ketersediaan darah. Melalui kegiatan donor darah ini, dapat memberikan harapan hidup yang lebih besar kepada yang membutuhkan.
Review of Utilization, Chemical Content, and Pharmacological Activity of Macroalgaes for Development and Empowerment of Natural Resources on South Garut, Indonesia Amalia, Nur; Okta, Fauzia Noprima; Zahra, Aliya Azkia; Noviyanti, Noviyanti; Najihudin, Aji; Nuari, Doni Anshar
Jurnal Ilmiah Farmako Bahari Vol 17 No 1 (2026): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v17i1.42460

Abstract

Macroalgae are autotrophic organisms that lack organs typically found in plants, such as roots, stems, and leaves. Macroalgae are grouped based on shape, size, and color. One of the coastal areas with abundant natural resources is the Garut Regency, Indonesia. This review aims to provide an updated assessment of the utilization, chemical composition, and pharmacological activities of macroalgae, to develop macroalgae as a natural resource. An updated review of macroalgae's utilization, chemical content, and pharmacological activities for developing and empowering macroalgae as natural resources in South Garut, Indonesia. This article was written by reviewing scientific articles published in the last 10 years on the utilization, chemical content, and pharmacological activities of macroalgae. In the coastal areas of Garut Regency, 44 species of macroalgae are found, comprising three divisions: Chlorophyta, Phaeophyta, and Rhodophyta. Macroalgae have benefited from an ecological and economic perspective. The chemical content of macroalgae can also be utilized as raw materials or additional ingredients in various industries, including the food, supplement, pharmaceutical, agricultural, and cosmetics industries. The bioactive compound content of each type of macroalgae can vary. Sargassum sp. contains bioactive compounds such as alkaloids, flavonoids, tannins, terpenoids, phenolics, saponins, steroids, glycosides, and chlorophyll. Glacilaria sp. contains bioactive compounds such as phenolic compounds, triterpenoids, flavonoids, and fatty acids. Ulva lactuca contains flavonoids, alkaloids, tannins, triterpenoids, saponins, catechins, quercetin, rutin, campherol, caffeic acid, ellagic acid, and chlorogenic acid. The influence of seasons and variations in harvest will influence the chemical content in macroalgae. Macroalgae possess several pharmacological properties, including antioxidant, antibacterial, anti-inflammatory, and anticancer effects. Various industries can utilize Macroalgae in the coastal waters of South Garut because they are rich in phytochemical content and pharmacological activity, making them suitable for the development and sustainable use of natural resources essential for human life.
TINJAUAN LITERATUR: AKTIVITAS ANTIDIABETES MELLITUS BEBERAPA TANAMAN FAMILI MALVACEAE Sadino, Asman; Nuari, Doni Anshar; Apriani, Riza; Muharam, Ceceng Fajar
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1650

Abstract

The Malvaceae family is a group of plants widely used empirically as traditional medicine to help control diabetes mellitus (DM) and has been supported by various experimental studies. This review aims to assess the types of Malvaceae family plants that have potential as antidiabetics and to summarize scientific evidence related to their pharmacological activity and the active compounds involved. The method used was a narrative review through a literature search in Google Scholar and PubMed for full-text articles published during 2011–2026. The included articles consisted of in vitro and in vivo studies discussing the antidiabetic or antihyperglycemic activity of Malvaceae family plants, while duplicate articles, review articles, proceedings, and irrelevant publications were excluded. Based on the selection process, several articles met the criteria for descriptive analysis. The results showed that several Malvaceae family plants have antidiabetic potential, including hibiscus (Hibiscus rosa-sinensis), roselle (Hibiscus sabdariffa), okra (Abelmoschus esculentus), durian (Durio zibethinus), sidaguri (Sida cordifolia), kapas hantu (Abroma augusta), biruan (Grewia asiatica), kapuk (Ceiba pentandra), kembang sore (Abutilon indicum), and pulutan (Urena lobata), all reported to have blood glucose-lowering effects. This activity is related to secondary metabolites such as flavonoids, alkaloids, tannins, saponins, and phenolic compounds, which act through antioxidant mechanisms, increased insulin sensitivity, inhibition of α-amylase and α-glucosidase enzymes, and protection of pancreatic β cells. Based on these findings, Malvaceae family plants have the potential to be developed as sources of natural medicine candidates and supportive therapies in the management of diabetes mellitus.
Co-Authors Aditya Aditya Aditya Aditya Ahmad Jaidi Aji Najihudin Aji Najihudin Apriani, Riza Apriliani, Nisa Siti Asholeha Lulu Asman Sadino Asman Sadino ASMAN SADINO, ASMAN Astrid Fauziyah Atun Qowwiyah Aulia, Ira Cindra Tri Yuniar Cindra Tri Yuniar Cindra Tri Yuniar Damayanti, Sevira Putri Deby Caroline Dede Ratih Hasanul Aliyah Devisi Eka Ariyo Masturoji Dina Eksyawati Eriyani Putri Muntaqin Euis Wartini Fahmi, Ami Nur Framesti Frisma Sriarumtias Framesti Prisma Sriarumtias Genialita Fadhila Hesti Renggana Husna Fauzia Ida Lisni Ikhwan Yuda Kusuma Jamil, Widi Mahmuda Nur Kusnandar Anggadiredja Mentari Novitasari Mida Yulia Eka Muharam, Ceceng Fajar Muharram, Rahma Mekar Najihudin, Aji Noviyanti Noviyanti, Noviyanti Novriyanti Lubis Novriyanti Lubis, Novriyanti Nur Amalia Okta, Fauzia Noprima Pitriani, Karina Rahmayanti Rahmayanti Renggana, Hesti Ria Mariani Ria Mariani Risa Susanti Riza Apriani Rohimah, Vina Siti Sambact, Jasminum Selvira Anandia Intan Maulidya Setiadi Ihsan Setyaningsih, Baiq Inges Sevira Putri Damayanti Silvia Anggraini Sitti Fatimah P.H. Sitti Fatimah Putri Hasyul Sitti Fatimah Putri Hasyul Sitti Fatimah Putri Hasyul Siva Hamdani Siva Hamdani Suci Hilwa Ainaya Sudjana, Shifa Nisrina Sumia Almarifah Suryana, Shendi Susanti, Risa Suwandi, Deden Winda Suwendar Suwendar Syamsudin, Raden Aldizal Mahendra Rizkio Syifa Hamdani Syifa Salsabila Tia Rahayu Tita Puspita Tita Puspitan Vingki Pratiwi Ganenggara Yosi Roila Julaikho Yuniar, Cindra Tri Zahra, Aliya Azkia