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Warouw, Finny
Fakultas Kesehatan Masyarakat Universitas Sam Ratulangi Manado
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Pengaruh Pemberian Kafein terhadap Luaran Klinis Penyakit Parkinson Skor UPDRS Adinata, Daniel N.; Sekeon, Sekplin A. S.; Warouw, Finny
e-CliniC Vol. 14 No. 2 (2026): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v14i2.66057

Abstract

Abstract: Parkinson’s disease is the second most common neurodegenerative disorder worldwide and still lacks of a disease-modifying therapy. Caffeine, an A2AR antagonist, may provide neuroprotection and modulate the dopaminergic system, potentially improving both motor and non-motor symptoms of this disease. This study aimed to evaluate the association of caffeine administration with Unified Parkinson’s Disease Rating Scale (UPDRS) score changes in patients with Parkinson’s disease through a meta-analysis of clinical trials. This meta-analysis showed that caffeine was associated with a statistically significant reduction in UPDRS III scores at enam weeks with moderate certainty, statistically insignificant reductions on UPDRS I, II, III (beyond six weeks), and IVFluctuations with moderate certainty, and statistically insignificant increases in UPDRS IVDyskinesia with low certainty. All UPDRS subscale changes might not be clinically meaningful. In conclusion, caffeine likely reduces UPDRS I, II, III, and IVFluctuation scores and may increase UPDRS IVDyskinesia, but may not be clinically meaningful. Nonetheless, caffeine remains a potential adjuvant candidate warranting further trials incorporating drug holidays to prevent tolerance Keywords: Parkinson’s disease; caffeine; Unified Parkinson’s Disease Rating Scale    Abstrak: Penyakit Parkinson merupakan penyakit neurodegeneratif kedua tersering di dunia dan masih belum memiliki terapi yang dapat memodifikasi progresifitasnya. Kafein, antagonis A2AR, diduga memiliki efek neuroprotektif dan modulasi sistem dopaminergik yang berpotensi memperbaiki gejala motorik maupun non-motorik penyakit ini. Penelitian ini bertujuan untuk menilai hubungan pemberian kafein terhadap perubahan skor Unified Parkinson’s Disease Rating Scale (UPDRS) pada pasien penyakit Parkinson melalui meta-analisis uji klinis. Hasil meta-analisis menunjukkan bahwa pemberian kafein secara statistik bermakna menurunkan skor UPDRS III durasi intervensi enam minggu dengan keyakinan sedang, tidak secara statistik bermakna menurunkan skor UPDRS I, II, III (selain durasi intervensi enam minggu), dan IVFluktuasi dengan keyakinan sedang, serta tidak secara statistik bermakna meningkatkan skor UPDRS IVDiskinesia dengan keyakinan rendah. Semua perubahan luaran subskala UPDRS mungkin tidak bermakna secara klinis. Simpulan penelitian ini ialah pemberian kafein kemungkinan besar menurunkan skor UPDRS I, II, III, dan IV bagian fluktuasi, serta mungkin meningkatkan skor UPDRS IVDiskinesia, tetapi mungkin tidak bermakna secara klinis. Meskipun demikian, terdapat potensi kafein sebagai adjuvan yang masih memerlukan penelitian lanjutan dengan drug holiday untuk mencegah toleransi. Kata kunci: penyakit Parkinson; kafein; Unified Parkinson’s Disease Rating Scale
Hubungan Penggunaan Dopamin Agonis dengan Kualitas Tidur pada Pasien Parkinson Silalahi, Elsa D.; Warouw, Finny; Mahama, Corry N.
Medical Scope Journal Vol. 8 No. 2 (2026): MEDICAL SCOPE JOURNAL
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v8i2.67062

Abstract

Abstract:  Parkinson’s disease is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms, including sleep disturbances that reduce quality of life. Dopamine agonists such as pramipexole and ropinirole not only improve motor symptoms but may also affect sleep quality in Parkinson’s disease patients. This study aimed to evaluate the correlation between the use of dopamine agonist and sleep quality in Parkinson’s disease patients. This was an analytical and observational study using a cross-sectional design, involving 34 outpatient Parkinson’s disease patients at the CVBC Neurology Clinic of Prof. Dr. R. D. Kandou Hospital in September 2025. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) and data were analyzed with the chi-square test. The results showed that of the 34 patients, 18 used dopamine agonists and 16 did not. Good sleep quality was observed in 72.2% of dopamine agonist users compared with 25% of non-users. There were significant correlations between dopamine agonist use and sleep quality (p=0.006), and between age and sleep quality (p=0.010). Meanwhile, sex, comorbidities, and disease duration did not show significant correlations. In conclusion, there is a significant correlation between the use of dopamine agonist and sleep quality in Parkinson’s disease patients. Dopamine agonist users tend to have better sleep quality than those who do not use them. Keywords: Parkinson’s disease; dopamine agonists; sleep quality; non-motor symptoms    Abstrak: Penyakit Parkinson (PP) merupakan gangguan neurodegeneratif progresif dengan gejala motorik dan nonmotorik, termasuk gangguan tidur yang dapat menurunkan kualitas hidup pasien. Dopamin agonis seperti pramipeksol dan ropinirol tidak hanya memperbaiki gejala motorik tetapi juga diduga berpengaruh terhadap kualitas tidur pasien PP. Penelitian ini bertujuan untuk mengetahui hubungan antara penggunaan dopamin agonis dengan kualitas tidur pada pasien PP. Jenis penelitian ialah observasional analitik dengan desain potong lintang yang melibatkan 34 pasien PP rawat jalan di Poliklinik Saraf CVBC RSUP Prof. Dr. R. D. Kandou Manado pada bulan September 2025. Teknik pengambilan sampel menggunakan consecutive sampling dengan menggunakan kuesioner Pittsburgh Sleep Quality Index (PSQI), data rekam medik, dan dianalisis menggunakan uji chi-square. Hasil penelitian mendapatkan dari 34 pasien, 18 pasien menggunakan dopamin agonis dan 16 pasien tidak. Sebanyak 72,2% pasien pengguna dopamin agonis memiliki kualitas tidur baik, sedangkan pada kelompok non-pengguna hanya 25%. Terdapat hubungan bermakna antara penggunaan dopamin agonis dan kualitas tidur (p=0,006); dan antara variabel usia dan kualitas tidur (p=0,010). Jenis kelamin, komorbiditas, dan lama menderita tidak menunjukkan hubungan bermakna. Simpulan penelitian ialah terdapat hubungan bermakna antara penggunaan dopamin agonis dengan kualitas tidur pada pasien penyakit Parkinson. Pasien penyakit Parkinson yang menggunakan dopamin agonis memiliki kualitas tidur yang lebih baik dibandingkan pasien yang tidak menggunakan. Kata kunci:  penyakit Parkinson; dopamin agonis; kualitas tidur; simtom nonmotorik
Phytochemical Compounds and Antibacterial Test of Theonella cylindrica against Staphylococcus aureus and Escherichia coli Mambo, Christi D.; Warouw, Finny; Nangoy, Edward; Rumengan, Inneke; Kepel, Billy; Bara, Robert
JURNAL BIOS LOGOS Vol. 15 No. 2 (2025): JURNAL BIOS LOGOS
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jbl.v15i2.59230

Abstract

Infectious diseases are a health problem faced by developing countries like Indonesia. This disease is caused by bacteria that attack humans. Improper use of antibiotics can cause bacterial resistance to antimicrobials. Antimicrobial resistance is the most significant public health threat, resulting in greater demand for finding new effective antimicrobials from natural products such as sea sponges. This research aimed to test the antibacterial activity of Theonella extract against Staphylococcus aureus and Escherichia coli and determine the class of chemical compounds contained therein. Research stages include sampling, sample preparation and extraction, qualitative phytochemical screening, making solutions, media creation, and antibacterial testing. The research showed that sponges metabolite compounds consisted of alkaloids, flavonoids, tannins, saponins, and phenolics. The diameter of the inhibition zone at concentrations of 80% and 100% showed potential antibacterial activity but more strongly inhibited the growth of Staphylococcus aureus bacteria than Escherichia coli bacteria.
Co-Authors Adinata, Daniel N. Akili, Rahayu H, Andika Surya Atmadja Anes, Brenda Militsia Christi Rosalina Angelina Stevany Regina Masengi Anthonius Kurniadi Assa, Winly Yuliana Billy Kepel Birang, Meirani F. Budi Ratag, Budi Budi Setiawan Chesya P.R. Salindeho Christoffel M. Memah Corry N. Mahama Daniel Febrian Sengkey Deeng, Gracia V. Y. Desy . Doda, Diana V.D. Edward Nangoy, Edward Frans Wantania Gampu, Agrisia Garusu, Ratna Santika Harvani Boky, Harvani Herlyani Khosama Hugo Dwiputra Inneke F. M Rumengan Jehosua, Seilly Yunita Jimmy Posangi Jootje M.L Umboh Junita Maja P.S Junita Maja Pertiwi Kamae, Sitti Ramlia Kawatu, Paul A.T Kumayas, Putri Elshadai Labagow, Elisa Lantang, Christina Laura Wulandary Kaeng Lengkong, Erlika Lihu, Tutin R. M.L, Jootje Maddusa, Sri Seprianto Mamahit, Juliet Merry Eva Mambo, Christi D. Mambo, Christi Diana Manabung, Apriliani R. Marthen Theogives Lasut, Marthen Theogives Melke J. Tumboimbela Mieke A. H. N. Kembuan Mieke A.H.N Kembuan Momole, Ansye Grace Nancy Mutiara Toreh Nike Gledis Monintja Oddi R Pinontoan Odi Pinontoan Odi Roni Pinontoan Paendong, Winner Hiskia George Paul A.T. Kawatu Pertiwi, Junita M. Pertiwi, Junita Maja Pua, Yohanes A. Rahayu H. Akili, Rahayu H. Ratumbanua, Fralen Julio Rianna J Sumampouw Ribka L. Wowor, Ribka L. Ricky C. Sondakh Rizal Tumewah Robert A. Bara Sekplin A. S. Sekeon, Sekplin A. S. Sengkey, Aprilia Sengkey, Omega Prisilia Silalahi, Elsa D. Soeratinoyo, Dewi K. Sugiarto, Natanael E. Sumigar, Cindy Keren Suoth, Lery F. Tewuh, Syeri Oktaviani Togelang, Mega Rossita Umboh, Jootje Marthen Luther Umboh, Jotje M.L Vriska V. Rambing Walewangko, Sarah Alni Wariki, Windy M. V. Wello, Novita L. L. Wiradarma, Elbert Woodford B. S. Joseph Woodford B.S. Joseph, Woodford B.S. Yantu, Sintia Salmawati Yonathan Andrian Yulianty Sanggelorang