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Specific function of vitamin D in bone Ramadhani, Dennisa Putri; AD, Hammanda; Azzahra, Salsabila; Rizkyadsyah, Akbar; Ulayya, Anis; Fendiyanto, Miftahul Huda
International Journal of Applied Mathematics, Sciences, and Technology for National Defense Vol 2, No 2 (2024): International Journal of Applied Mathematics, Sciences, and Technology for Natio
Publisher : FoundAE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58524/app.sci.def.v2i2.347

Abstract

There are two sources of vitamin D, namely from food and sun exposure. The content of vitamin D is given beneficial in bone and mineral metabolism. Vitamin D helps absorption of calcium in the intestines, thereby accelerating bone mineralization. Bone metabolism is a complex process that occurs throughout life. Very high doses of vitamin D can stimulate an increased rate of bone loss. Vitamin D deficiency causes bone demineralization. Which can cause a decrease in calcium absorption. The functions of these metabolites vary widely in vital metabolic pathways. This review aims to determine the specific function of vitamin D in bone. The search for the data base was carried out by the analytical method. Vitamin D which is absorbed from food or comes from the skin turns into an active form in the form of 1,25- (OH) 2-D3 which will enter the bloodstream, playing an important role in bone and extra-skeletal health.
Naringin Effect on SARS-CoV-2 Pseudovirus Entry and Spike Mediated Syncytia Formation in hACE2-overexpressing Cells Septisetyani, Endah Puji; Prasetyaningrum, Pekik Wiji; Paramitasari, Komang Alit; Suyoko, Ahmad; Himawan, Alayna Lillahida Indri; Azzahra, Salsabila; Wisnuwardhani, Popi Hadi; Anam, Khairul; Ramadani, Ratna Dwi; Santoso, Adi; Ningrum, Ratih Asmana; Herawati, Neng; Rubiyana, Yana
HAYATI Journal of Biosciences Vol. 31 No. 2 (2024): March 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.2.336-347

Abstract

A molecular docking study demonstrates the interaction between naringin, a citrus flavonoid, with SARS-CoV-2 spike RBD. Nevertheless, in vitro investigation of the inhibitory effect of naringin on SARS-CoV-2 entry and syncytia models has yet to be carried out. We synthesized VSV∆G-GFP/Spike* pseudovirus (PSV) as a SARS-CoV-2 model by pseudotyping VSV∆G-GFP/S* in BHK-21 cells overexpressing the SARS-CoV-2 spike glycoprotein. In the SARS-CoV-2 PSV entry assay, we utilized CHO-K1 cells transfected with hACE2 plasmid, which were then treated with naringin and SARS-CoV-2 PSV/naringin. After 16-18 h incubation, PSV internalization represented by the GFP signal was observed under a fluorescence microscope. Immunofluorescence staining was also performed to probe the SARS-CoV-2 spike and confirm the PSV entry. We performed a syncytia assay using 293T cells co-transfected with SARS-CoV-2 spike/hACE2. Six hours after transfection, the cells were treated with naringin and incubated for another 16-18 hours. Then, we observed syncytia using a phase contrast microscope. Based on fluorescence foci quantification, the results indicated that naringin might inhibit SARS-CoV-2 PSV entry at a concentration of 100 µM (P<0.05). However, naringin did not prevent syncytia formation compared to solvent control. These PSV entry and syncytia assay results suggested that naringin potentially inhibited SARS-CoV-2 viral infection but not cell-to-cell viral transmission.
Peningkatan Pengetahuan Masyarakat Dalam Mengungkap Potensi Desa Barusari Kabupaten Garut Di Bidang Pertanian Melalui Citizen Journalism Payu, Satria Muhammad Jahsy; Ridwan, Zalfa Adira; Siddiqa, Kamila; Nurhakim, Ridwan; Mulyani, Syifa Salsabila; Azzahra, Salsabila; Sumarna, Cahya; Azizah, Siti Nur; Sholihati, Rena; Widiarti, Intan; Fauzi, Muhammad
Jurnal Pengabdian Sosial Vol. 1 No. 11 (2024): September
Publisher : PT. Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/7071gh30

Abstract

Kemudahan masyarakat dalam mengakses internet belum dibarengi dengan kemampuan memanfaatkannya secara konstruktif. Program jurnalisme warga dapat menjadi salah satu cara pemanfaatan internet, khususnya melalui media sosial, untuk menstimulasi potensi desa. Keberadaan Internet telah memicu minat baru terhadap jurnalisme warga. Workshop Jurnalisme Warga Desa Barusari bertujuan untuk meningkatkan kapasitas masyarakat dalam mengeluarkan potensi lokal khususnya di sektor pertanian dan UMKM melalui pemberdayaan jurnalisme warga. Metode yang digunakan kuantitatif dengan memberikan edukasi dan pelatihan citizen journalism kepada masyarakat Desa Barusari melalui metode pembelajaran konvensional, diskusi, kemudian praktek setelah pemberian materi dan diskusi selesai dilakukan. Narasumber pelatihan Jurnalistik yaitu dari media Garut intan news dan Dinas pertanian. Hasil yang didapat ditunjukan untuk mengedukasi kepada masyarakat terkait pentingnya citizen journalism bagi desa agar dapat meningkatkan potensi yang ada di desa Barusari. Berdasarkan pada grafik.1 yang dihasilkan bahwa kegiatan program pelatihan ini sangat bermanfaat dan dapat membantu masyarakat khususnya warga Desa Barusari dalam peningkatan pengetahuan dalam mengungkap potensi desa di bidang pertanian melalui Citizen Journalism. Kesimpulan yang didapat untuk meningkatkan pengetahuan masyarakat tentang pentingnya citizen journalism dalam mengungkap potensi desa, khususnya di bidang pertanian.
Development of Flashcard Media Assisted by the SAS Method for Early Reading Teaching in Elementary Schools Azzahra, Salsabila; Rini, Titis Angga; Muzaki, Ferril Irham
Proceedings Series of Educational Studies 2024: The 3rd International Conference on Educational Management and Technology (ICEMT) 2024
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Researchers conducted research using observation techniques and interviews with grade 1 teachers of SDN Mandaranrejo 1 Pasuruan City, found 15 students whose reading skills were still classified as low. Flashcard media assisted by the SAS method was made with the aim of improving reading skills at an early stage aimed at low grades. Researchers developed learning media for early reading learning activities in the form of cards that include examples of words and sentences based on the SAS method along with images that can be interesting. This research and development aims to develop a product in the form of Flashcard media for beginning reading that is valid according to experts, namely material experts, media experts, and users, namely teachers and students. This research uses the R&D (Research and Development) research method of the ADDIE model which consists of 5 stages. This research and development obtained validation results by material experts of 97% and validation by media experts of 100%. While the results of user validation by teachers obtained 100% and by students at 98% so that Flashcard media assisted by the SAS method was included in the criteria very valid and interesting according to material experts, media experts, and users. Therefore, Flashcard media can be used for learning beginning reading. Keywords: Flashcards; SAS Method; Beginning Reading
PERAN INDONESIA DALAM PENYELESAIAN SENGKETA LAUT NATUNA Azzahra, Salsabila
Jurnal Res Justitia: Jurnal Ilmu Hukum Vol. 5 No. 1 (2025): Jurnal Res Justitia : Jurnal Ilmu Hukum
Publisher : LPPM Universitas Bina Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46306/rj.v5i1.220

Abstract

The Natuna Sea is located in the Riau Province of Indonesia which is in the middle of the South China Sea or at the border point of the China Sea and Indonesia. The Natuna Sea is a strategic area in terms of economy, natural resources, and security. This has led to complex disputes involving various national and international interests. This article discusses how Indonesia's role in resolving the Natuna Sea dispute involving various countries. The research method used is a juridical-normative approach with literature studies related to the title to be discussed. The type of data used in this research is secondary data through laws and regulations and legal materials related to the problems to be studied. The result of this research is that China's claim to the Natuna Sea has no legality and validity or known as the “nine dash line”. Therefore, Indonesia must continue this dispute to the International Court of Justice so that China complies with applicable legal provisions and Indonesia can maintain territorial sovereignty in Natuna so that regional stability is maintained and protect the sovereign rights of every country over its legal sea area.   
HUBUNGAN ANTARA DIMENSI KUALITAS PELAYANAN TERHADAP KEPUASAN PASIEN PADA UNIT RAWAT JALAN DI RUMAH SAKIT GRHA PERMATA IBU TAHUN 2024 Azzahra, Salsabila; Ningsih, Desy Kartika; Nursanty, Oci Etri
Jurnal Kesehatan Tambusai Vol. 6 No. 1 (2025): MARET 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i1.41268

Abstract

Hasil rekapitulasi angket kepuasan pasien dalam bentuk excel per satu bulan pada periode Desember tahun 2023 – Februari tahun 2024 dimana pada unit rawat jalan 3 bulan terakhir belum mencapai standar Indikator Nasional Mutu yaitu bulan Desember tahun 2023 sebesar 52,34% dengan pengisian angket yang mewakili hanya 0,0279%, bulan Januari tahun 2024 sebesar 89,84% dengan pengisian angket yang mewakili hanya 0,0125% dan bulan Februari sebesar 61,11% dengan pengisian angket yang mewakili hanya 0,062%. Selanjutnya, pasien juga menyampaikan ketidakpuasan mengenai layanan yang diterima melalui kolom masukan & saran pada angket serta ulasan google review seperti perawat dan dokter yang kurang maksimal dalam menangani karena terlalu banyak pasien, dan dokter yang tidak datang sesuai jam praktik, Tujuan penelitian ini untuk mengetahui hubungan antara dimensi kualitas pelayanan terhadap kepuasan pasien pada unit rawat jalan di Rumah Sakit Grha Permata Ibu. Penelitian ini adalah penelitian kuantitatif dengan pendekatan cross sectional. Pengambilan sampel pada penelitian ini menggunakan random sampling sebanyak 100 responden. Hasil penelitian menunjukkan adanya hubungan kualitas pelayanan pada dimensi bukti fisik (p=0,000), kehandalan (p=0,000), dan daya tanggap (p=0,000) terhadap kepuasan pasien. Kesimpulan dari penelitian ini adalah terdapat hubungan yang signifikan antara kualitas pelayanan pada dimensi bukti fisik, kehandalan, dan daya tanggap terhadap kepuasan pasien pada unit rawat jalan di rumah sakit grha permata ibu dengan nilai p<0,05.
Relevansi Bahasa Daerah Terhadap Identitas Batak Karo di Desa Kutalimbaru Azzahra, Aisya; Aulia, Lisa; Azzahra, Salsabila; Andini, Sri Wahyu; Wulandari, Tanya Chynta
Madani: Jurnal Ilmiah Multidisiplin Vol 3, No 5 (2025): Volume 3, Nomor 5, June 2025
Publisher : Penerbit Yayasan Daarul Huda Kruengmane

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.15556433

Abstract

This research investigates how regional languages, specifically the Karo language, influence the formation and preservation of Karo Batak ethnic identity in Kutalimbaru Village, Deli Serdang Regency, North Sumatra. Data were collected through participatory observation and in-depth interviews with informants from various generations within the Karo community. This data collection method uses a descriptive qualitative approach. The research results show that the Karo language is still used in daily life, especially within families and in traditional activities. However, due to the dominance of the Indonesian language, especially among teenagers, the Karo language is starting to change. Changes in the ethnic identity of the younger generation are indicated by the phenomenon of code-switching between Karo and Indonesian. However, the Karo language is still regarded as a marker of identity and respect for ancestors, and it remains an important symbol in traditional ceremonies and social interactions. External factors such as globalization, formal education, and migration pose significant challenges, while internal factors like the role of parents, religious institutions, and traditional leaders play a crucial role in language preservation. This research emphasizes that the preservation of the Karo language is crucial for maintaining the cultural identity of the Karo Batak amidst the ongoing social and cultural shifts.
ANALISIS PENGGUNAAN BAHASA GAUL GENERASI Z PADA BAHASA INDONESIA Algofiqi, Abdur Rahman; Septiansyah, Alghifari; Azzahra, Salsabila; Suyatman, Muhamad Padli; Rahman, Aam Ali
Bahtera Indonesia Jurnal Penelitian Bahasa dan Sastra Indonesia
Publisher : Universitas Wiralodra

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31943/bi.v10i2.1096

Abstract

Bahasa Indonesia adalah bahasa Nasional bangsa Indonesia, bahasa sangat berperan penting dalam kehidupan sehari-hari karena dengan bahasa kita dapat berkomunikasi dan berinteraksi secara baik. Bahasa gaul itu sendiri merupakan bahasa khas dari sekelompok remaja baik itu dikalangan siswa, karena kata yang diucapkan diubah sedemikian rupa sehingga hanya mereka saja yang mengerti dengan maksud dan tujuannya. Bahasa gaul yang diucapkannya tersebut dipengaruhi dari media sosial, hampir di seluruh kalangan pelajar yang menggunakannya. Pengaruh dari bahasa gaul ini dapat merusak kosa kata baku dari bahasa Indonesia itu sendiri, karena kosa kata yang pendek dan terjadinya penyerapan dari bahasa asing. Penelitian ini bertujuan untuk melihat pengaruh bahasa gaul yang digunakan oleh mahasiswa terhadap eksistensi bahasa Indonesia. Penelitian ini menggunakan metode kuantitatif. Sedangkan pengolahan dan teknik pengumpulan data dilakukan melalui observasi, wawancara dan catatan. Subjek dalam penelitian ini yaitu Mahasiswa UPI Kampus Sumedang. Lokasi penelitian ini yaitu di kampus UPI Sumedang. Hasil penelitian ini menunjukkan bahwa masih banyak mahasiswa yang menggunakan bahasa gaul, terlalu sering menggunakan bahasa gaul dapat berdampak pada cara mereka berbicara. Sebab, di setiap percakapan mereka masih terdengar kosa kata yang sulit dipahami oleh orang lain sehingga keberadaan dan perkembangan bahasa Indonesia terhambat. Padahal, saat berada di lingkungan formal seperti diskusi, ceramah, dan wawancara sangat mengutamakan berbahasa Indonesia baku yang baik dan benar. Jadi, kita sebagai bangsa Indonesia harus bangga menggunakan bahasa Indonesia serta membiasakan diri untuk berkomunikasi dalam kehidupan sehari-hari agar bahasa Indonesia tidak punah dan tidak menghambat perkembangannya.
IMPACT OF ULTRA-PROCESSED FOOD CONSUMPTION ON THE RISK OF OBESITY IN THE PRODUCTIVE AGE GROUP - LITERATURE REVIEW Azzahra, Salsabila; Rachman, Helwa; Krismawanti, Agisna Rafa; Nurul Azizah, Nazhifa; Pasaribu, Christiani; Ariyanto, Januar
HEARTY Vol 13 No 5 (2025): OKTOBER
Publisher : Fakultas Ilmu Kesehatan, Universitas Ibn Khaldun, Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/hearty.v13i5.20459

Abstract

Consumption of UPFs continues to increase with the development of the food industry and urbanization. UPFs are high in calories, fat, sugar, additives, and low in nutrients. Excessive intake of these foods leads to an energy surplus in the body, which can trigger fat accumulation and increase the risk of obesity. This study aims to examine the relationship between UPF consumption and the risk of obesity in productive-age Indonesians. This study employed a qualitative method through a literature review, analyzing scientific articles related to UPF and obesity in productive age groups from 2020 to 2025. The literature was searched online, selected based on inclusion criteria, and analyzed descriptively and qualitatively using a thematic approach. The study results show that most studies found a significant association between UPF consumption and an increased risk of obesity. Factors contributing to high consumption of ultra-processed foods among those of productive age include easy access, attractive packaging, delicious taste, low price, and convenient preparation. Psychological factors such as the reward system and dopamine play a role in regulating eating behavior and may encourage UPF consumption. High consumption of UPF is a major risk factor for obesity in the productive age group. Nutrition education, regulation of UPF product promotion, strengthening of labeling policies, and increased access to healthy foods are needed to reduce UPF consumption and reduce the prevalence of obesity in the productive age group.
Qibla Direction Determination: A Systematic Literature Review on The Role of Mathematics in Islamic Education Azzahra, Salsabila; Kariadinata, Rahayu; Rachmawati, Tika Karlina
(JIML) JOURNAL OF INNOVATIVE MATHEMATICS LEARNING Vol. 8 No. 3 (2025): VOLUME 8 NUMBER 3, SEPTEMBER 2025
Publisher : IKIP Siliwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22460/jiml.v8i3.28547

Abstract

Accurate Qibla direction is a fundamental aspect of Muslim worship, especially in prayer. However, many studies have reported significant inaccuracies in Qibla determination, particularly in areas lacking proper astronomical tools or knowledge. At the same time, interest in mathematics among students in Islamic education remains relatively low, despite its critical role in religious practices. This study aims to systematically review recent literature that explores the role of mathematics in Qibla direction determination and its integration into Islamic education. A Systematic Literature Review (SLR) was conducted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Fourteen articles published between 2020 and 2024 were selected from indexed journal databases based on specific inclusion and exclusion criteria. Data collection involved document analysis of journal articles, books, and theses using relevant keywords such as “Qibla direction,” “Islamic education,” and “mathematics.” The selected articles were analyzed thematically and categorized based on year of publication, mathematical concepts applied (e.g., spherical trigonometry), and educational integration. The results show that mathematical approaches particularly spherical trigonometry play a central role in achieving high accuracy in Qibla direction determination. Furthermore, the integration of these mathematical concepts into Islamic education enhances students’ understanding of the connection between science and religion. This review suggests that embedding mathematical applications into Islamic contexts can increase student motivation and strengthen the relevance of mathematics in daily worship.