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All Journal Pharmaciana: Jurnal Kefarmasian MUDARRISA Indonesian Journal of Islamic Education Studies Jurnal Biologi Tropis Indonesian Journal of Chemistry PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JURNAL FARMASIMED (JFM) Social, Humanities, and Educational Studies (SHEs): Conference Series Pena : Jurnal Ilmu Pengetahuan dan Teknologi Jurnal Pengabdian kepada Masyarakat Nusantara Jurnal Insan Farmasi Indonesia Jurnal Farmasi Sasambo Journal of Pharmacy PENA ABDIMAS : Jurnal Pengabdian Masyarakat Jurnal Pengabdian Ilmu Kesehatan Journal of Pharmacy Science and Technology Benzena Pharmaceutical Scientific Journal Joong-Ki Medical Sains : Jurnal Ilmiah Kefarmasian Baktimu : Jurnal Pengabdian Kepada Masyarakat Joong-Ki Baktimu : Jurnal Pengabdian Kepada Masyarakat
Mahfur, Mahfur
Program Studi S1 Farmasi, Fakultas Farmasi, Universitas Pekalongan, Pekalongan, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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PEMANFAATAN ECO ENZYME UNTUK KESEHATAN LINGKUNGAN DAN PENINGKATAN KESEHATAN MASYARAKAT DESA SUSUKAN KABUPATEN PEMALANG Mahfur, Mahfur; Farchan Mushaf Al Ramadhani; Erin Efrilia; Salsabila Hanifatul Ariqoh; Rizki Nur Fadilah; Mulyanti Shofaro; Puji Nurhayati; Mohamad Ramzi Arkanie
BAKTIMU : Jurnal Pengabdian Kepada Masyarakat Vol 5 No 2 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/bm.v5i2.1740

Abstract

Desa Susukan di Kecamatan Comal, Kabupaten Pemalang, menghasilkan sampah organik dalam jumlah besar akibat aktivitas pertanian dan rumah tangga yang belum dikelola optimal, sehingga berpotensi mencemari lingkungan. Salah satu solusi yang ditawarkan adalah pemanfaatan limbah organik menjadi eco enzyme yang ramah lingkungan dan bermanfaat bagi lingkungan dan kesehatan. Kegiatan pengabdian ini bertujuan untuk meningkatkan pengetahuan dan keterampilan masyarakat, khususnya Kader PKK, dalam mengelola sampah organik menjadi eco enzyme di Desa Susukan. Metode pelaksanaan meliputi empat tahap, yaitu investigasi melalui observasi dan wawancara, persiapan berupa diskusi internal tim, tindakan berupa edukasi dan pelatihan pembuatan eco enzyme, serta refleksi melalui pre-test dan post-test untuk mengukur peningkatan pengetahuan peserta. Kegiatan dilaksanakan di Balai Desa Susukan dengan melibatkan 28 peserta yang mengikuti seluruh rangkaian mulai dari diseminasi materi hingga praktik langsung. Hasilnya menunjukkan peningkatan pengetahuan yang signifikan terhadap seluruh peserta (100%) pada seluruh aspek yang diukur yaitu pengetahuan tentang eco enzyme, manfaat, bahan, cara pembuatan, dan penyimpanan eco enzym setelah kegiatan pengabdian. Antusiasme peserta juga terlihat dari keaktifan dalam sesi praktik dan diskusi. Kegiatan ini menunjukkan bahwa pendekatan edukatif dan partisipatif efektif dalam meningkatkan kesadaran dan keterampilan masyarakat untuk mengelola sampah organik secara berkelanjutan.
THE OPTIMATION OF FERMENTATION FOR METABOLITE PRODUCTION BY SYMBIONT Penicillium nalgiovense FROM THE SPONGE Gelliodes fibulata Rusmalina, Siska; Mahfur, Mahfur; Ermawati, Nur; Maliah, Nabilatun; Ananda, Luthfiah; Bintang Pratama, Kevin; Evi Ulfiani , Riska; Abdul Aziz, Danang; Husain, Khafidz; Ilma Faza, Febi; Hidayatullah, Adib
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1682

Abstract

The fungi are sponge symbionts.  The fungus Penicillium nalgiovense acc MK087096  is a symbiont of the sponge Gelliodes fibulata. This symbiont has antibacterial activity, which supports the development of sponge-based drugs that are as effective as antibiotics. However, the primary challenge in developing marine resource-based medicine is the availability and sustainability of sponge raw materials. Fermentation biotechnology using sponge symbiont fumgi is an effective solution to address these challenges, as it allows the production of bioactive secondary metabolite compounds in large quantities, which can be used as raw materials for pharmaceutical preparation. The aim of this study was to determine the optimal medium and fermentation duration for producing secondary metabolites with antibiotic properties from the symbiotic fungus Penicillium nalgiovense, isolated from the sponge Gelliodes fibulata. This study was conducted naturally. The symbiotic fungus from the sponge Gelliodes fibulata was cultivated to facilitate growth. Fermentation was conducted with variations in secondary metabolite harvesting times of 2, 4, 6, 8, 10, and 12 days.  Secondary metabolites were obstained using liquid-liquid extraction with ethyl acetate. The optimal medium and fermentation time were determined based on the yield percentage for each medium across the six time variations. The fermentation biotechnology of the symbiotic fungus Penicillium nalgiovense acc MK087096 from the spone Gelliodes fibulata was carried out on SDB, PDB, also coconut flake-enriched PDB media.  The results showed the growth of the fungus and the production of bioactive secondary metabolites with antibiotic properties ...
A Synergistic Effect of Free Radical Scavenging Activity of the Combination of Mangifera indica and Euphorbia hirta Extracts Putra, I Made Wisnu Adhi; Suarjana, Nyoman; Mahfur, Mahfur; Hasnawati, Hasnawati
Indonesian Journal of Chemistry Vol 25, No 5 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.104706

Abstract

Due to its synergistic effect, the extract-extract combination is essential in traditional medicine formulation. The combination of Mangifera indica and Euphorbia hirta extracts can produce a synergistic effect if combined in a proper ratio. This investigation reported the synergistic antioxidant effect of M. indica and E. hirta. The ethanolic extracts of M. indica leaf (MILE) and E. hirta aerial part (EHAE) were acquired by the maceration method, followed by evaporation to remove the solvent. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) tests were used to assess the extracts' capacity to scavenge radicals. MILE and EHAE were combined with a ratio of 1:3 (comb. 1), 1:1 (comb. 2), and 3:1 (comb. 3). This work disclosed that the extract combinations showed all types of interactions. However, of all combinations, only comb. 3 depicted the synergistic interaction caused by the regeneration effect of EHAE on MILE. This finding has important implications for health, particularly disease prevention. M. indica and E. hirta extracts with high phenolic and flavonoid contents can work together to reduce oxidative stress and protect the body from a variety of diseases.
Anti-Inflammatory Activity Assay of Ethanol Extract of Agelas cavernosa Sponge using Protein Denaturation Method Walid, Muhammad; Nila Oktaviani; Julian, Rixzal Aziz; Rohmah, Salis Alyatur; Achada, Dina; Dika, Ika Vina; Mahfur, Mahfur
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7661

Abstract

Inflammation is a tissue response to cell damage, and alternative medicine is needed to treat this like a sponge. Indonesia is a country that has a lot of biodiversity originating from the sea. Agelas cavernosa is a sponge of the Demospongiae class, this class is the largest class that includes 90% of all types of sponges. Agelas Cavernosa sponge is known to contain triterpenoids and has antibacterial activity. Data on research on the activity of Agelas cavernosa sponge as an anti-inflammatory as far as researchers know has not been carried out. The aim of this study was to determine the anti-inflammatory activity of the ethanol extract of the Agelas cavernosa sponge. The research method was carried out using the protein denaturation method. The Agelas cavernosa sponge extracted with etanol 96%. The assay of anti-inflammatory with protein denaturation using spectrophotometry at wavelengths 660 nm. The results showed that the inhibition ability of 20% protein denaturation of ethanol extract of Agelas cavernosa was obtained at a concentration of 150 ppm. The results of the study showed that the IC50 of the ethanol extract obtained was 455.96 pppm, significantly different from the positive control of sodium diclofenac, which was 36.51 ppm. Based on the data obtained from the research results, it shows that the ethanol extract of Agelas cavernosa sponge does not have the potential as an anti-inflammatory.
Toxicity and Apoptosis Test of 96% Ethanol Extract of Agelas Cavernosa on Vero Cells Mahbub, Khafid; Rusmalina, Siska; Indriono, Anik; Mahfur, Mahfur; Julian, Rixzal Azis; Maulidya, Dina Achada; Dika, Ika Vina; Rohmaniah, Salis Alyatur
Jurnal Biologi Tropis Vol. 25 No. 1 (2025): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i1.8262

Abstract

Agelas cavernosa sponge is a sponge from the Demospongiae class which includes 90% of all types of sponges. Agelas cavernosa sponge is known to have antibacterial activity. Research data on the toxicity and apoptosis test of Agelas cavernosa sponge on vero cells as far as researchers know has not been tested. The purpose of this study was to determine the toxicity and apoptosis of Agelas cavernosa ethanol extract. The research method was carried out using the MTT Assay method for toxicity testing and the flowsitometry method for apoptosis testing. Alkaloids, flavonoids, saponins, terpenoids, and polyphenols were all detected in the Agelas cavernosa ethanol extract, according to the results of phytochemical screening. The apoptosis test yielded vero cell viability of 82.2%, whereas the toxicity test yielded an LC50 value for vero cells of 197.84 ppm.
Pemanfaatan Potensi Jahe Menjadi Jamu Instan Berbasis Home Industri Mahbub, Khafid; Mahfur, Mahfur; Indriono, Anik; Ardianto, Hery; Sona, Sukma; Kurniawan, Andre
Jurnal Pengabdian kepada Masyarakat Nusantara Vol. 5 No. 2 (2024): Jurnal Pengabdian kepada Masyarakat Nusantara (JPkMN)
Publisher : Lembaga Dongan Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55338/jpkmn.v5i2.3420

Abstract

Jahe merupakan tanaman yang banyak tumbuh di Indonesia. Jahe merupakan tanaman yang memiliki khasiat yang bermanfaat bagi kesehatan. Akan tetapi pembuatan minuman jahe yang membutuhkan waktu lama sehingga peminat minuman jahe berpindah ke minuman lain yang lebih praktis. Perlu dilakukan inovasi dalam pembuatan jamu untuk mengatasi permasalahan tersebut. Salah satu cara yang dapat dilakukan yaitu dengan membuat inovasi jamu instan dari jahe. Supaya masyarakat akan lebih mudah menikmati minuman jahe serta dapat menjadi peluang usaha untuk meningkatkan penghasilan terutama untuk ibu-ibu. Metode pelaksanaan yang digunakan yaitu berbentuk penyuluhan dan pelatihan pembuatan jamu serbuk instan kepada masyarakat. Hasil pelatihan menunjukan jahe instan dapat dibuat dengan mengunakan bahan dasar jahe air dan gula pasir. Prinsip dari pembuatan serbuk jamu instan yaitu proses kristalisasi dari gula pasir. Berdasarkan hasil evaluasi pretest dan post test menunjukkan bahwa terdapat peningkatan pengetahuan dari para peserta pengabdian kepada masyarakat berkaitan dengan pemahaman manfaat jahe serta tata cara pembuatan serbuk jahe instan berbasis home industry.
The Optimation of Fermentation Time, Antibacterial Activity and Profiling Secondary Metabolite of Symbiont Fungi from Sponge Gelliodes fibulata Rusmalina, Siska; Mahfur, Mahfur; Hasanah, Nunung; Wiyono, Mochamad Ardy; Ekayanti, Nonik Nur; Nathania, Jacinda Caroline
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.27137

Abstract

Symbiont fungi are organisms that live in sponges tissue. Sponges are known to contain many metabolites which have the potential to be used as raw materials for medicine. Sponge Gelliodes fibulata is belongs to category demospongiae. The purpose of this study was to determine the optimal time to obtain the best secondary metabolite profile results in the sponge symbiont fungus Gelliodes fibulata. This research is included in experimental research. Beginning with the fungi culture of the sponge Gelliodes fibulata. Followed by a fermentation process with variations in time 2, 4, 6, 8, 10, 12, and 14 days to get the secondary metabolites produced. A liquid extraction process is carried out to obtain secondary metabolites produced during fermentation. The final stage is to carry out qualitative analysis with TLC and antibacterial testing with the well-diffusion method. The results obtained show that the long fermentation time influences the secondary metabolites obtained, and the metabolites possessed influence their antibacterial activity. The profile of secondary metabolites from TLC showed that the 10th day of fermentation had the most complex secondary metabolites and the highest yield 0.086%. The results of antibacterial activity showed that the 10th day of fermentation had the largest inhibition zone with 7.75 ± 0.44 mm compared to the other days of fermentation.
Antiinflamation Activity Assay of Ethanol Extract of Rhabdastrella sp Sponge Using Denaturation of Chicken Egg Albumin Protein Method Mahfur, Mahfur; Mahbub, Khafid; Achada, Dina; Dika, Ika Vina
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/3jvv5b49

Abstract

Inflammation is a body defense mechanism by the presence of cell damage against harmful stimuli caused by pathogens, toxic compounds, or irradiation. Drugs that have been used have adverse side effects for the body. The use of natural ingredients is an alternative, one of which is natural ingredients from the sea, namely Rhabdastrella sp. The sponge genus Rhabdastrella has various bioactivities such as anticancer, antimalarial, antibacterial, chemopreventive, anti-inflammatory, antioxidant, cardioprotective, insecticidal, antidiabetic, cytotoxic. Other species of the Genus Rhabdastrella, such as the sponge Rhabdastrella sp. has never been studied. The purpose of this study was to determine the antiinflamation activity of the ethanol extract of the sponge Rhabdastrella sp. The research method was carried out using the method of denaturation of chicken egg protein. The sponge Rhabdastrella sp. was extracted with 96% ethanol. The anti-inflammatory test with protein denaturation used spectrophotometry at a wavelength of 660 nm. concentrations of sample are 50 ppm, 100 ppm, 150 ppm, 200 ppm, and 250 ppm. The positive control comparison used sodium diclofenac with concentrations are 3.12 ppm; 6.25 ppm; 12.5 ppm; 25 ppm; and 50 ppm. The results showed that the ability to inhibit protein denaturation of 20% ethanol extract of Rhabdastrella sp. was obtained at 70.29 ppm, while the IC50 of the ethanol extract obtained was 280.33 ppm. These results were significantly different from the positive control of sodium diclofenac, which was 36.51 ppm. The anti-inflammatory activity of the sample sponge extract was very small because the content of compounds that have anti-inflammatory abilities, including flavonoids, was only about 2%. Based on this, the sponge extract of Rhabdastrella sp. is not potential as an anti-inflammatory.
Skrining Fitokimia Dan Uji Kadar Kurkumin Pada Fraksi Etil Asetat Rimpang Kunyit (Curcuma Longa) Dengan Metode Klt Dan Spektrofotometri Uv-Vis Shary, Aprilya Kumala; Mahfur, Mahfur
Pena: Jurnal Ilmu Pengetahuan dan Teknologi Vol. 37 No. 2 (2023): PENA SEPTEMBER 2023
Publisher : LPPM Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/jurnalpena.v37i2.3080

Abstract

Turmeric (Curcuma longa) is a medicinal plant from the Zingiberaceae family which has the potential to be developed as a superior plant that has benefits and efficacy as a medicinal ingredient. Turmeric has a yellow dye called curcuminoids as much as 5% (50-60% curcumin, demethoxycurcumin and bisdemethoxycurcumin). The very basic content of turmeric is Curcuma or curcumin because it has the largest component. The purpose of this study was to determine the phytochemical content by conducting a screening test on the ethyl acetate fraction of turmeric rhizome using the TLC method and UV-Vis Spectrophotometry. This research method used descriptive method by means of observation or non-experimental. Phytochemical screening included tests for flavonoids, alkaloids, saponins, phenols, tannins and steroids/triterpenoids which carried out to determine the class of compounds contained in turmeric rhizome. The ethyl acetate fraction in turmeric rhizome suspected to contain curcumin, so a test for the levels of curcumin contained in turmeric rhizome was carried out. The results showed that the positive turmeric rhizome samples contained flavonoids, tannins, phenols and steroids. As well as negatively contain alkaloid compounds and saponins. The results of identification with TLC samples containing curcumin compounds according to the literature and the standard Rf value of curcumin is 0.75-0.80. The assay results using the UV-Vis Spectrophotometry method for the ethyl acetate fraction of turmeric rhizome samples yielded an average concentration of 159.79 mg⁄g.
NARRATIVE REVIEW: KAJIAN FITOKIMIA DAN MEKANISME AKSI AKTIVITAS ANTIOKSIDAN PADA TANAMAN NANGKA (ARTOCARPUS HETEROPHYLLUS LAM.) Quintanuha Meisa, Salsabiela; Mahfur, Mahfur
BENZENA Pharmaceutical Scientific Journal Vol 1 No 01 (2022): BENZENA Pharmaceutical Scientific Journal
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v1i01.2041

Abstract

Latar bekalang : Antioksidan adalah senyawa yang memiliki berat molekul kecil namun dapat mengeliminasi senyawa radikal bebas di dalam tubuh sehingga tidak menginduksi suatu penyakit.             Tanaman nangka (Artocarpus heterophyllus Lam) memiliki banyak kandungan antioksidan di dalamnya mulai dari akar, batang, daun, buah, biji, dan kulit. Kajian aspek fitokimia meliputi kandungan kimia yang ada pada akar, bunga, daun, biji, kulit dan buah.Tujuan : Untuk mendeskripsikan fitokimia dan mekanisme aksi aktivitas antioksidan pada tanaman nangka (Artocarpus heterophyllus Lam). Analisa penelitian kelayakan jurnal dilakukan dengan cara menyaring dengan semua jurnal yang ditemukan pada basis data berdasarkan judul, abstrak, dan kriteria inklusi yang sesuai dengan judul penelitian dengan menggunkan metode PICO.Metode : Penelitian ini menggunakan metode Narrative Review, dimana jurnal literature diperoleh dari database Google Scholar, Elsevier, dan PubMed yang ditemukan berdasarkan kata kunci yang dipilih. Kemudian jurnal dilakukan identifikasi dengan database Scorpus dan Sinta.Hasil : Hasil penelitian menunjukkan bahwa senyawa fitokimia terbanyak yang dihasilkan adalah golongan fenolik. Golongan fenolik memiliki beberapa turunan salah satunya adalah flavonoid. Sedangkan mekanisme aktivitas antioksidan banyak digunakan adalah metode DPPH (2,2-diphenyl-1-picrylhidrazyl) dengan nilai IC50 yang paling kuat adalah bagian tanaman pada buah nangka sebesar 0,68 ppm.Kesimpulan : Senyawa fitokimia terbanyak yang dihasilkan adalah golongan fenolik. Sedangkan aktivitas antioksidan nya adalah metode DPPH (2,2-diphenyl-1-picrylhidrazyl) masuk dalam golongan Penangkapan Radikal Bebas dengan nilai IC50 sebesar 0,68 ppm pada bagian tanaman buah nangka. Kata kunci: Arthocarpus heteropyllus Lam., antioxidant, narrative review.
Co-Authors Abdul Aziz, Danang Achada, Dina Alfiana Nur Hidayah Ananda, Luthfiah Andre Kurniawan Anik Indriono Anik Indriyono Aprilya Kumala Shary Ardianto, Hery Bintang Pratama, Kevin Dika, Ika Vina Ekayanti, Nonik Nur Erin Efrilia Evi Ulfiani , Riska Farchan Mushaf Al Ramadhani Fatkhiya, Musa Fitri Harwati, Wiwik Hasnawati Hasnawati Hidayah Syaro Abesah, Nur Hidayatullah, Adib Husain, Khafidz I Made Wisnu Adhi Putra Ilma Faza, Febi Julian, Rixzal Azis Julian, Rixzal Aziz Khafid Mahbub Kharismatul Khasanah Kitia Rani mahbub, khafid Maliah, Nabilatun Maulida Nur Istiqomah Maulidya, Dina Achada Metha Anung Anindhita Mochammad Ardy Wiyono Mohamad Ramzi Arkanie Muhammad Walid Muhammad Walid Mulyanti Shofaro Nada Safira Salsabila Nathania, Jacinda Caroline Nila Oktaviani noni Nur Ekayanti Nunung Hasanah Nur Ermawati, Nur Nyoman Suarjana Puji Nurhayati Quintanuha Meisa, Salsabiela Quintanuha Meisa, Salsabiela Rani, Kitia Rizki Nur Fadilah Rohmah, Salis Alyatur Rohmaniah, Salis Alyatur Safira Galuh Chandra Salsabiela Quintanuha Meisa Salsabila Hanifatul Ariqoh Shary, Aprilya Kumala Siska Rusmalina Sona, Sukma Tri Esti Kusuma Bakti Wiyono, Mochamad Ardy