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All Journal Pharmaciana: Jurnal Kefarmasian MUDARRISA Indonesian Journal of Islamic Education Studies Jurnal Biologi Tropis Indonesian Journal of Chemistry PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JURNAL FARMASIMED (JFM) Jurnal Abdi Insani Pena : Jurnal Ilmu Pengetahuan dan Teknologi Jurnal Pengabdian kepada Masyarakat Nusantara Jurnal Insan Farmasi Indonesia Jurnal Farmasi Sasambo Journal of Pharmacy PENA ABDIMAS : Jurnal Pengabdian Masyarakat Jurnal Pengabdian Ilmu Kesehatan Journal of Pharmacy Science and Technology Benzena Pharmaceutical Scientific Journal Joong-Ki Medical Sains : Jurnal Ilmiah Kefarmasian Baktimu : Jurnal Pengabdian Kepada Masyarakat Joong-Ki Baktimu : Jurnal Pengabdian Kepada Masyarakat Jurnal Pengabdian Ilmu Kesehatan
Mahfur, Mahfur
Fakultas Farmasi Universitas Pekalongan
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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ANALISIS KADAR FLAVONOID TOTAL EKSTRAK BONGGOL PISANG KEPOK KUNING (Musa acuminata Colla) SECARA SPEKTROFOTOMETRI UV-Vis Rani, Kitia; Mahfur, Mahfur
BENZENA Pharmaceutical Scientific Journal Vol 2 No 01 (2023): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v2i01.3065

Abstract

Bonggol pisang kepok kuning merupakan bagian bawah batang pisang membentuk umbi yang belum banyak dimanfaatkan. Pada penelitian bonggol pisang kepok kuning dikembangkan sebagai agen antiinflamasi, antibakteri, dan dapat menurunkan kadar gula darah karena memiliki aktivitas antioksidan. Penelitian sebelumnya pada ekstrak bonggol pisang kepok kuning mengandung senyawa flavonoid. Tujuan penelitian ini adalah untuk mengetahui kadar senyawa flavonoid total yang terdapat pada ekstrak bonggol pisang kepok kuning (Musa acuminata Colla) dengan metode Spektrofotometri UV-Vis. Penelitian ini menggunakan metode non eksperimental. Ekstraksi menggunakan dilakukan dengan metode maserasi menggunakan pelarut etanol 70%, dan senyawa flavonoid diidentifikasi secara kualitatif menggunakan pereaksi warna Sitroborat, Bate Smite-Metcalfe, NaOH 10% dan uji Kromatografi Lapis Tipis (KLT). Pada analisis kuantitatif menggunakan spektrofotometri UV-Vis berdasarkan kemampuan flavonoid membentuk kompleks dengan reagen AlCl3 menggunakan baku pembanding kuersetin. Hasil penelitian identifikasi kualitatif ekstrak bonggol pisang kepok kuning (Musa acuminata Colla) dengan baku pembanding (kuersetin) menggunakan uji pereaksi warna flavonoid dan uji Kromatografi Lapis Tipis (KLT) terbukti mengandung flavonoid. Sedangkan analisis kuantitatif dilakukan secara spektrofotometri UV-Vis menggunakan metode AlCl3 dengan kuersetin sebagai standar pembanding. Pengukuran dilakukan dalam panjang gelombang maksimum 414 nm dengan operating time 8 menit. Hasil yang didapat kadar flavonoid total sebesar 0,29713 mg QE/g.Kata kunci :  bonggol pisang kepok kuning, ekstraksi, KLT, spektrofotometri UV-Vis 
OBAT TRADISIONAL SEBAGAI ADJUVAN UNTUK MENINGKATKAN KUALITAS HIDUP DAN PRODUKTIVITAS WARGA DESA KARANGANYAR PENDERITA DIABETES MELITUS Mahfur, Mahfur; Khasanah, Nunung; Nahdliyyah, Ade Irma; Arni, Aneke Desvita; Rohmaniah, Salis Alyatur
Jurnal Abdi Insani Vol 12 No 11 (2025): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v12i11.3153

Abstract

Karanganyar Village, Batang District, has great potential for utilizing traditional medicinal plants to improve community health. Cases of diabetes mellitus in the area have increased due to unhealthy lifestyles and excessive sugar consumption. Local plants such as bay leaves (Syzygium polyanthum), bitter leaf (Andrographis paniculata), cinnamon (Cinnamomum verum), and turmeric (Curcuma xanthorrhiza) possess proven antihyperglycemic effects and are safe for use as adjuvant therapy. This community service program aimed to educate and empower the community to independently utilize local resources. The activity, held at the Karanganyar Village Hall with 30 PKK women participants, employed pre-tests, material presentations, interactive discussions, and post-tests to assess knowledge improvement. Results showed that participants initially lacked understanding of adjuvant concepts and medicinal plant utilization. However, after the sessions, all participants demonstrated significantly better comprehension and confidence in applying traditional medicine to support diabetes management. The high engagement level indicated that the materials were relevant and beneficial to the community’s needs. This program effectively enhanced public knowledge of traditional medicine as an adjuvant for diabetes mellitus and has the potential for independent application in local health practices.  
Sosialisasi Dagusibu (Dapatkan, Gunakan, Simpan, Buang) Obat Dengan Benar Di Kelurahan Bandengan, Kota Pekalongan Khafid Mahbub; Mahfur Mahfur; Mochammad Ardy Wiyono; Noni Nur Ekayanti
Jurnal Pengabdian Ilmu Kesehatan Vol. 3 No. 2 (2023): Juli : Jurnal Pengabdian Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jpikes.v3i2.2084

Abstract

Medicine are something that is very easy to get. However, the lack of knowledge about drug management from getting it to disposing of it can cause various problems. In an effort to improve health, it is necessary to provide optimal education to the public to increase the level of public awareness of health. The purpose of carrying out this service is to increase the awareness of the people of Bandengan village in DAGUSIBU medicine. The implementation method used is the lecture method or direct presentation and discussion to the public. The results show that the role of education can increase the knowledge of the community related to drug management, starting from how to get it to properly dispose of the drug. This is shown by the increase in pre-test and post-test scores with significant results.
Antiinflamation Activity Assay of Ethanol Extract of Rhabdastrella sp Sponge Using Denaturation of Chicken Egg Albumin Protein Method Mahfur Mahfur; Khafid Mahbub; Dina Achada; Ika Vina Dika
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/3jvv5b49

Abstract

Inflammation is a body defense mechanism by the presence of cell damage against harmful stimuli caused by pathogens, toxic compounds, or irradiation. Drugs that have been used have adverse side effects for the body. The use of natural ingredients is an alternative, one of which is natural ingredients from the sea, namely Rhabdastrella sp. The sponge genus Rhabdastrella has various bioactivities such as anticancer, antimalarial, antibacterial, chemopreventive, anti-inflammatory, antioxidant, cardioprotective, insecticidal, antidiabetic, cytotoxic. Other species of the Genus Rhabdastrella, such as the sponge Rhabdastrella sp. has never been studied. The purpose of this study was to determine the antiinflamation activity of the ethanol extract of the sponge Rhabdastrella sp. The research method was carried out using the method of denaturation of chicken egg protein. The sponge Rhabdastrella sp. was extracted with 96% ethanol. The anti-inflammatory test with protein denaturation used spectrophotometry at a wavelength of 660 nm. concentrations of sample are 50 ppm, 100 ppm, 150 ppm, 200 ppm, and 250 ppm. The positive control comparison used sodium diclofenac with concentrations are 3.12 ppm; 6.25 ppm; 12.5 ppm; 25 ppm; and 50 ppm. The results showed that the ability to inhibit protein denaturation of 20% ethanol extract of Rhabdastrella sp. was obtained at 70.29 ppm, while the IC50 of the ethanol extract obtained was 280.33 ppm. These results were significantly different from the positive control of sodium diclofenac, which was 36.51 ppm. The anti-inflammatory activity of the sample sponge extract was very small because the content of compounds that have anti-inflammatory abilities, including flavonoids, was only about 2%. Based on this, the sponge extract of Rhabdastrella sp. is not potential as an anti-inflammatory.
Antibacterial Activity Assay of 96% Ethanol Extract of Strawberry Leaves (Fragaria × ananassa Duch.) Against Streptococcus mutans Using the Disc Diffusion Method and Phytochemical Analysis Mahfur Mahfur; Priatin Nova Adelina
Jurnal Biologi Tropis Vol. 26 No. 3 (2026): Juli - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i3.12903

Abstract

Abesah, N. H. S., & Mahfur, M. (2024). Isolasi dan identifikasi antioksidan jamur endofit umbi talas (Colocasia esculenta (L.) Schott) menggunakan pereaksi semprot DPPH secara bioautografi. Jurnal Insan Farmasi Indonesia, 7(3), 367–378. https://doi.org/10.36387/jifi.v7i3.2235 Allo. (2016). Uji aktivitas antibakteri dari ekstrak air kulit buah pisang Ambon lumut (Musa acuminata Colla) terhadap pertumbuhan Staphylococcus aureus (Skripsi). Universitas Sanata Dharma. Andesmora, E. V., Muhadiono, M., & Hilwan, I. (2017). Ethnobotanical study of plants used by people in Hiang Indigenous Forest, Kerinci, Jambi. Journal of Tropical Life Science, 7(2), 95–101. Bakti, T. E. K., & Mahfur, M. (2023). Skrining fitokimia dan analisis kadar flavonoid total fraksi etil asetat kulit buah durian merah (Durio graveolens Becc.) dengan metode spektrofotometri UV–Vis. Journal of Pharmacy Science and Technology, 4(1), 30–35. https://doi.org/10.30649/pst.v4i1.57 Bouyahya, A., et al. (2016). Determination of phenolic contents, antioxidant and antibacterial activities of strawberry tree (Arbutus unedo L.) leaf extracts. British Biotechnology Journal, 14(3), 1–10. https://doi.org/10.9734/BBJ/2016/26488 Elfeky, N., Mohamed Mousa, A. M., Abdelsameea Mahmoud, E., Mohammed Awad, S., El-Sabbagh, S. M., & Zayed, M. (2023). Antimicrobial activities of Fragaria × ananassa leaves against multidrug-resistant Acinetobacter baumannii. Delta Journal of Science, 47(1), 154–170. https://doi.org/10.21608/djs.2023.231555.1127 Engleberg, N. C., DiRita, V., & Dermody, T. S. (2006). Schaechter's mechanisms of microbial disease (4th ed.). Lippincott Williams & Wilkins. Fajrina, A., Jubahar, J., & Hardiana, N. (2017). Uji aktivitas fraksi dari ekstrak akar kangkung (Ipomoea aquatica Forssk.) terhadap bakteri Streptococcus mutans. Jurnal Farmasi Higea, 9(2). (DOI yang dicantumkan perlu diverifikasi karena tidak sesuai dengan jurnal). Ginting, M., Ginting, P., & Sari, S. A. (2023). Studi aktivitas antibakteri ekstrak etanol daun stroberi (Fragaria × ananassa (Weston) Rozier) terhadap bakteri Propionibacterium acnes. Journal of Pharmaceutical and Sciences, 6(1), 281–286. https://doi.org/10.36490/journal-jps.com.v6i1.56 He, M., Huang, Y., Wang, J., Chen, Z., Xie, J., Cui, Z., et al. (2025). Advances in polysaccharide-based antibacterial materials. International Journal of Biological Macromolecules, 308, 142598. (DOI perlu diverifikasi karena DOI yang dicantumkan mengarah ke jurnal lain.) Hirsch, M., Burges, P. L., Migueliz, L., Villarreal, N. M., & Marina, M. (2024). Isolation of beneficial bacteria from strawberry (Fragaria × ananassa Duch.): Potentialities for fungal disease control and plant growth promotion. Plant Growth Regulation, 102(1), 135–152. Jannah, A., Rachmawaty, D. U., & Maunatin, A. (2017). Uji aktivitas antibakteri ekstrak etanol, etil asetat, dan petroleum eter rambut jagung manis (Zea mays saccharata Sturt) terhadap bakteri Staphylococcus aureus dan Escherichia coli. Alchemy: Journal of Chemistry, 5(4). Kaur, A., Goindi, S., & Katare, O. P. (2016). Thermal analysis and quantitative characterization of compatibility between diflunisal and lipid excipients as raw materials for development of solid lipid nanoparticles. Thermochimica Acta, 643, 23–32. Mahfur, M. (2016). Uji sitotoksik fraksi etil asetat ekstrak etanol akar pasak bumi (Eurycoma longifolia Jack) terhadap sel kanker T47D dengan metode MTT. Pena: Jurnal Ilmu Pengetahuan dan Teknologi, 30(2), 57–64. https://doi.org/10.31941/jurnalpena.v30i2.497 Mahfur, M., Khasanah, K., Anindhita, M. A., Chandra, S. G., & Hidayah, A. N. (2023). Comparison of the total phenolic and flavonoid contents of Amomum compactum Sol. ex Maton from Linggo Asri and Paninggaran Districts, Pekalongan Regency. Sasambo Journal of Pharmacy, 4(1), 8–13. https://doi.org/10.29303/sjp.v4i1.212 Mahfur, M., Kamila, A., Abidah, J. F., Samirana, P. O., Hikmawan, B. D., & Pratimasari, D. (2023). Antibacterial activity of ethyl acetate extract of symbiont fungus Aspergillus sp. in the sponge Rhabdastrella sp. from Gili Layar Island, Lombok, Indonesia. Journal of Applied Pharmaceutical Science, 13(11), 144–151. https://doi.org/10.7324/japs.2023.146303 Mahnashi, M. H., & Alshehri, O. M. (2022). Isolation, in vitro and in silico anti-Alzheimer and anti-inflammatory studies on phytosteroids from aerial parts of Fragaria × ananassa Duch. Biomolecules, 12(10), 1430. Mazurel, D., Brandt, B. W., Boomsma, M., Crielaard, W., Lagerweij, M., Exterkate, R. A. M., & Deng, D. M. (2025). Streptococcus mutans and caries: A systematic review and meta-analysis. Journal of Dental Research, 104(6), 594–603. Rani, K., & Mahfur, M. (2023). Analisis kadar flavonoid total ekstrak bonggol pisang kepok kuning (Musa acuminata Colla) secara spektrofotometri UV–Vis. Benzena Pharmaceutical Scientific Journal, 2(1). (Halaman perlu dilengkapi.) Rusmalina, S., Mahfur, M., Ermawati, N., Maliah, N., Ananda, L., Pratama, K. B., et al. (2025). The optimization of fermentation for metabolite production by symbiont Penicillium nalgiovense from the sponge Gelliodes fibulata. Medical Sains: Jurnal Ilmiah Kefarmasian, 10(1), 9–18. https://doi.org/10.37874/ms.v10i1.1682 Salas-Arias, K., Irías-Mata, A., Sánchez-Kopper, A., Hernández-Moncada, R., Salas-Morgan, B., Villalta-Romero, F., & Calvo-Castro, L. A. (2023). Strawberry (Fragaria × ananassa cv. Festival): A polyphenol-based phytochemical characterization in fruit and leaf extracts. Molecules, 28(4), 1865. https://doi.org/10.3390/molecules28041865 Widyaningtias, et al. (2014). Uji aktivitas antibakteri ekstrak terpurifikasi daun sirih hijau (Piper betle L.) terhadap bakteri Propionibacterium acnes. Jurnal Farmasi Udayana, 3(1), 50–57. (Volume, nomor, dan halaman perlu diverifikasi.) Widiatmoko, H. (2016). Sehat tanpa obat dengan si merah stroberi. Rapha Publishing. Ye, D., Liu, Y., Li, J., Zhou, J., Cao, J., Wu, Y., et al. (2025). Competitive dynamics and balance between Streptococcus mutans and commensal streptococci in oral microecology. Critical Reviews in Microbiology, 51(3), 532–543. Zhou, Y., Chen, X., Chen, T., & Chen, X. (2022). A review of the antibacterial activity and mechanisms of plant polysaccharides. Trends in Food Science & Technology, 123, 264–280. https://doi.org/10.1016/j.tifs.2022.03.020
Co-Authors Abdul Aziz, Danang Achada, Dina Ade Irma Nahdliyyah Alfiana Nur Hidayah Ananda, Luthfiah Andre Kurniawan Anik Indriono Anik Indriyono Aprilya Kumala Shary Ardianto, Hery Arni, Aneke Desvita Bintang Pratama, Kevin Dika, Ika Vina Dina Achada Efrilia, Erin Ekayanti, Nonik Nur Evi Ulfiani , Riska Farchan Mushaf Al Ramadhani Fatkhiya, Musa Fitri Harwati, Wiwik Hasnawati Hasnawati Hidayah Syaro Abesah, Nur Hidayatullah, Adib Husain, Khafidz I Made Wisnu Adhi Putra Ika Vina Dika Ilma Faza, Febi Julian, Rixzal Azis Julian, Rixzal Aziz Khafid Mahbub Kharismatul Khasanah Khasanah, Nunung Kitia Rani Maliah, Nabilatun Maulida Nur Istiqomah Maulidya, Dina Achada Metha Anung Anindhita Mochammad Ardy Wiyono Mochammad Ardy Wiyono Mohamad Ramzi Arkanie Muhammad Walid Muhammad Walid Mulyanti Shofaro Nada Safira Salsabila Nathania, Jacinda Caroline Nila Oktaviani noni Nur Ekayanti Noni Nur Ekayanti Nunung Hasanah Nur Ermawati Nyoman Suarjana Priatin Nova Adelina Puji Nurhayati Quintanuha Meisa, Salsabiela Quintanuha Meisa, Salsabiela Rani, Kitia Rizki Nur Fadilah Rohmah, Salis Alyatur Rohmaniah, Salis Alyatur Safira Galuh Chandra Salsabiela Quintanuha Meisa Salsabila Hanifatul Ariqoh Shary, Aprilya Kumala Siska Rusmalina Sona, Sukma Tri Esti Kusuma Bakti Wiyono, Mochamad Ardy