Article Per Year (5 Year)
p-Index From 2021 - 2026
2.217
P-Index
This Author published in this journals
All Journal IDJP (Indonesian Journal of Pharmaceutics) Jurnal SOLMA Jurnal Kreativitas PKM Jurnal Ilmiah Farmako Bahari Borneo Journal Of Pharmascientech Jurnal Mandala Pengabdian Masyarakat Edu Masda Journal Jurnal Sains dan Teknologi Farmasi Indonesia Journal of Pharmaceutical and Sciences. Usadha Journal of Pharmacy JI-KES (Jurnal Ilmu Kesehatan)
Deby Tristiyanti
Sekolah Tinggi Farmasi Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

Published : 21 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 21 Documents
Search

 1   2   3 
Formulasi dan Uji Aktivitas Antibakteri Sediaan Gel Ekstrak Buah Murbei Hitam (Morus nigra L.) sebagai Antijerawat Yola Desnera Putri; Susi Sulastri; Deby Tristiyanti; Adit Andriyannto
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1471

Abstract

Acne is one of the most common skin disorders affecting various age groups, particularly adolescents, and is caused by inflammation of the pilosebaceous follicles associated with bacterial proliferation. The primary bacteria involved in acne pathogenesis are Propionibacterium acnes (P. acnes) and Staphylococcus epidermidis (S. epidermidis). This study aimed to formulate an anti-acne gel containing ethanol extract of black mulberry (Morus nigra L.) fruit and to evaluate its antibacterial activity. The black mulberry fruit was extracted by maceration using 96% ethanol. The resulting extract was formulated into a Carbopol 940-based gel at three different concentrations: 1.25% (F1), 2.5% (F2), and 5% (F3). The formulated gels were evaluated for organoleptic properties, homogeneity, pH, viscosity, spreadability, antibacterial activity using the agar well diffusion method, and skin irritation using the Draize method. The results showed that the ethanol extract of black mulberry fruit exhibited antibacterial activity against P. acnes and S. epidermidis, with inhibition zone diameters of 12.0 ± 0.90 mm and 12.8 ± 0.59 mm, respectively, at a concentration of 1.25%, indicating strong antibacterial activity. After formulation into a gel, the highest antibacterial activity was observed in Formula 3 (F3) after 28 days of storage, with inhibition zone diameters of 15.1 ± 0.06 mm against P. acnes and 15.3 ± 0.10 mm against S. epidermidis. All formulations met the required physical evaluation parameters and showed no signs of irritation in a preliminary Draize irritation test during the observation period. Therefore, the ethanol extract of black mulberry fruit has the potential to be developed as a topical anti-acne gel with antibacterial activity against P. acnes and S. epidermidis.
Co-Authors Aang Hanafiah R.Wangsaatmadja Adit Andriyannto Alidya Canticha Sari Aneu Nurdiana Arum Yunita Eswinawati Azkiani, Hani Amila Dewi Yustika Sari Dian - Rohita Diki Prayugo Wibowo Eka Rusmana, Wempi Eky Septian Pradana Falerina Puspita Fathurrahman, Muhammad Hilmi Faturrahman, M. Hilmi Fitriani, Dewi Fatimah Irma Erika Herawati Irma Erika Herawati K Sari, Nia Linda Suci Ramdianti M. Hilmi Fathurrahman MARIA ULFAH Maria Ulfah Marianta - Teresia Melvia Sundalian NIA KURNIA SARI Nia Kurnia Sari Normila Normila Novi Irwan Fauzi P Legowo, Wahyu Puspita, Falerina Revika Rachmaniar Risfayanti, Iffa Riski Nur Utami S, Irmawati Shafa Nurul Fadilla Sriwidodo Sriwidodo Susi Sulastri Sutriyawan, Agung Syarif Hamdani Triyadi, Fakhri Humaidi Wahyu Priyo Legowo Yola Desnera Putri