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All Journal Cendekia Journal of Pharmacy Jurnal Ilmiah Kesehatan Ar-Rum Salatiga PUBLIKASI PENELITIAN TERAPAN DAN KEBIJAKAN Jurnal DiMas (Jurnal Pengabdian Kepada Masyarakat) Jurnal Akademika Kimia Jurnal Bioteknologi & Biosains Indonesia (JBBI) Wallaby: Jurnal Manajemen, Bisnis & Akuntansi Jurnal Kesehatan Qamarul Huda Jurnal Bioteknologi & Biosains Indonesia
Elisa, Novi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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ANALISIS GOOD CORPORATE GOVERNANCE PADA PT. GUDANG GARAM, TBK. Elisa, Novi; Rabi, Jeklina; Agustian, Rendy Pratama Dayu; Aba, Wilhelmus Salfi; Cirawu, Agnes
Wallaby: Jurnal Manajemen, Bisnis & Akuntansi Vol 1 No 1 (2024): Wallaby: Jurnal Manajemen, Bisnis & Akuntansi
Publisher : Astha Grafika

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Abstract

Penelitian ini bertujuan untuk menganalisis penerapan Good Corporate Governance (GCG) pada PT Gudang Garam Tbk, salah satu perusahaan rokok terbesar di Indonesia. Good Corporate Governance adalah sistem yang digunakan untuk mengarahkan dan mengendalikan perusahaan agar berjalan secara transparan, akuntabel, bertanggung jawab, independen, dan adil. Dengan menerapkan prinsip-prinsip GCG, perusahaan diharapkan dapat meningkatkan kinerja, nilai perusahaan, serta melindungi hak-hak pemangku kepentingan. Penelitian ini menggunakan pendekatan deskriptif kualitatif, dengan data yang dikumpulkan dari laporan tahunan, laporan keberlanjutan, dan dokumen terkait lainnya. Hasil analisis menunjukkan bahwa PT Gudang Garam telah menerapkan berbagai prinsip GCG, termasuk transparansi dalam pelaporan keuangan dan kepatuhan terhadap regulasi pemerintah serta otoritas pasar modal. Namun, masih ada beberapa area yang perlu diperbaiki, seperti peningkatan partisipasi pemegang saham minoritas dan penguatan mekanisme pengawasan internal untuk mencegah praktik korupsi dan kecurangan.
Effect of Avocado Leaves Extract on Creatinin and Urea Levels in Rats Induced NaCl and Prednison Najwa, Hilya U.; Elisa, Novi; Puspitaningrum, Ika; Anggraeny , Ebta N.; Sundoro, Aries K.
Jurnal Akademika Kimia Vol. 12 No. 2 (2023)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24775185.2023.v12.i2.pp108-115

Abstract

Creatinine and urea are metabolic waste substances excreted by the kidneys. Kidneys excrete metabolic waste substances. Renal dysfunction is associated with the increased level of creatinine and urea in the blood. The ethanolic extract of avocado leaves (Persea americana Mill.) contains flavonoid compounds, alkaloids, tannins, saponins, and steroids which act as antioxidants and antihypertensive. It is known to reduce creatinine and urea levels in the blood. The animal model was divided into five groups: normal control, negative control (CMC - Na 0.5 %), and avocado leaves ethanolic extract group with doses of 75, 150, and 250 mg/kg BW rats. All groups except the normal control group were induced by oral administration of NaCl solution 2 % and prednisone suspension 1.5 mg/kg BW rats for 21 days and following treatment by oral administration for 7 days based on its group. Flavonoid compounds of avocado leave ethanolic extract identified as 5,7-di-OH-dihydroflavonol. Results show Kruskal - Wallis test between groups (p < 0.05) is significantly different. Concluded that administration of avocado leaves ethanol extract at doses of 75, 150, and 250 mg/kg BW rats might reduce creatinine levels, while avocado leaves ethanol extract at a dose of 250 mg/kg BW rats could reduce urea levels.
THE IN VITRO AND IN VIVO EFFECTS OF Persea Americana ETHANOL EXTRACT AS AN ANTIHYPERTENSIVE AND ANTIOXIDANT IN PREDNISONE-INDUCED RATS Elisa, Novi; Dian Advistasari, Yustisia; Sari, Wulan Kartika; Pratiwi, Mustika Endah; Tobi, Claudius Hendraman Boli; Murti, Bayu Tri; Putri, Athika Darumas
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 2 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.6583

Abstract

Hypertension impacts the quantity of free radicals within the body. This study aimed to investigate the effect of antihypertension based on free radical levels in the predni-sone-induced rats, focusing on evaluating specific anti-hypertensive fraction of avoca-do leaves. The study's methods conducting GC-MS, anti-hypertensive, and assessing malondialdehyde levels and catalase enzyme. Systolic blood pressure measurements indicated that the positive control (131 ± 3 mmHg) and ethyl acetate fraction (136 ± 4 mmHg) were statistically similar, significantly different from the negative control group. Diastolic blood pressure measurements showed a blood pressure decreasing in posi-tive control (105 ± 7) that similar statistically with ethyl acetate fraction (104 ± 6), and significantly difference with negative control group. Malondialdehyde levels were nota-bly elevated in both the positive control (37.79 ± 5.47) and ethyl acetate fraction (38.01 ± 5.47) compared to the negative control (-9.07 ± 10.10), indicating increased free rad-ical. Catalase activity demonstrated significant differences, with the positive control (44.06 ± 5.44) and ethyl acetate fraction (44.05 ± 5.45) showing similar levels, both substantially higher than the negative control (13.90 ± 21.50). In summary, this study indentificates several flavonoid compounds that promising anti-hypertension effect from ethyl acetate fraction of avocado leaves extract.
EXTRACT AND FRACTIONS EXPLORATION OF DAYAK ONION (Eleutherine America-na Merr.) WITH ANTIOXIDANTS POTENTIAL USING GC-MS and FTIR METHODS Elisa, Novi; Advistasari, Yustisia Dian; Lepangkari, Jaka Seprianto; Hidayatullah, Muhammad Haqqi
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 12 No. 1 (2025)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2025.9209

Abstract

Free radicals can cause various diseases in the body if not treated immediately. Large levels of free radicals may trigger damage to normally functioning tissues, lipid layers, blood vessels, DNA synthesis disturbances, and even destruction of cells. The objective is to evaluate the antioxidants potential of dayak onion extract and fractions. FTIR spectrophotometers, gas chromatography-mass spectrometry (GC-MS) and an antioxidants multimode reader are some of the research methods. The outcomes of this research are identifying plants that showed the dayak onion extract of the species Eleutherine Americana Merr. It contains compounds such as flavonoids, alkaloids, tannins, and saponins. In addition, the components found in the extract, water fraction, ethyl acetate fraction, and n-hexane fraction are octadecanoic acid 298 m/z, 9-octadecanoic acid 282 m/z, undecanoic acid 214 m/z, hexadecanoic acid 368 m/z, and nonadecanoic acid 326 m/z. Therefore, the antioxidants test using the DPPH method showed that the best IC50 value is for ethyl acetate with IC50 20.56 ppm.
Co-Authors Aba, Wilhelmus Salfi Advistasari, Yustisia Dian Agustian, Rendy Pratama Dayu Ahmad Fuad Masduqi Anggoro, A. Barry Anggoro, Aloysius Barry Anggraeny , Ebta N. Anggraeny, Ebta Narasukma Barry Anggoro, Aloysius Cirawu, Agnes Claudius Hendraman B. Tobi Dian Advistasari, Yustisia Eka Pratiwi, Arik Dian Endang Sri Sunarsih Fitriani Puspitasari, Dewi Ika Puspitaningrum Indriyanti, Erwin Jaka Seprianto Lepangkari Lepangkari, Jaka Seprianto Muhammad Haqqi Hidayatullah Murti, Bayu Tri Mustika Endah Pratiwi Najwa, Hilya U. Nurribkhudin, Muhamad Bhetran Pratiwi, Arik Dian Eka Purwaningsih, Yuliana Putri, Athika Darumas Rabi, Jeklina Ramonah, Dewi Salsa Dinurrosifa, Rahmawati Saputra, Aditya Nuryanto Sari, Wulan Kartika Sundoro, Aries K. Syukur, Mighfar W. S., F.X. Sulistiyanto W.S., FX. Sulistiyanto Wibowo, Patricia Sanggita Listyoputri wibowo, sulistiyanto Wulan Kartika Sari WULANDARI