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All Journal VISIKES Indonesian Journal of Chemistry JKPK (Jurnal Kimia dan Pendidikan Kimia) Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Jurnal Ilmiah Cendekia Eksakta Jurnal Abdimas Ilmiah Citra Bakti (JAICB) Jurnal DiMas (Jurnal Pengabdian Kepada Masyarakat) Jurnal Akademika Kimia
Syukur, Mighfar
Departmen Pharmacy, Semarang Pharmaceutical College, Jl. Letjend Sarwo Edhie Wibowo KM 1, Plamongansari, Semarang, 50192, Central Java
Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Mechanical Engineering Medicine & Pharmacology Physics Public Health Social Sciences Other

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UJI AKTIVITAS ANTIBAKTERI MASKER GEL PEEL OFF EKSTRAK DAUN PLETEKAN (Ruellia tuberosa L.) TERHADAP Staphylococcus aureus Mighfar Syukur; Ahmad Fuad Masduqi
VISIKES: Jurnal Kesehatan Masyarakat Vol 21, No 1 (2022): VISIKES
Publisher : Dian Nuswantoro Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33633/visikes.v21i1Supp.5962

Abstract

Staphylococcus aureus is one of the pathogenic bacterial species. Pletekan plant has potential as a medicinal plant. This plant contains secondary metabolites and has been shown to have an antibacterial effect. The purpose of this study was to determine whether the peel off gel mask pletekan leaf extract could inhibit the growth of Staphylococcus aureus and whether there was a difference in the antibacterial activity of the peel off gel mask pletekan leaf extract at concentrations of 20%, 25%, and 30%. This research used maceration extraction method, phytochemical filtering and TLC. Peel off gel mask formulation from extracts with different concentrations. Furthermore, the research was carried out to test the antibacterial activity by using the well-drilled method on the peel off gel mask of pletekan leaf extract (Ruellia tuberosa L.) against the growth of Staphylococcus aureus. The results of screening and TLC showed pletekan leaf extract containing flavonoids, steroids, triterpenoids, and alkaloids. The peel off gel mask preparation test includes organoleptic, pH, homogeneity, adhesion, dispersion and drying time included in the Indonesian National Standard Criteria. The results showed that pletekan leaf extract (Ruellia tuberosa L.) in a peel off gel mask could inhibit the growth of Staphylococcus aureus. The results of statistical tests showed that the data were normally distributed and homogeneous. There was a significant difference in antibacterial activity in the peel off gel mask of pletekan leaf extract with concentrations of 20%, 25% and 30%, which were 4.323mm; 5.218mm; and 6.509mm. The antibacterial activity showed that the concentration was directly proportional to the resulting inhibition zone.
Esterification of Cinnamic Acid using Menthol and its Activity as Lowering Glucose Levels using Anthrone Sulfate yuliana purwaningsih; Mighfar Syukur; Wulandari Wulandari
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 7, No 1 (2022): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v7i1.55532

Abstract

This study aimed to synthesize menthyl cinnamate and its activity as a glucose-lowering agent. Synthesis of methyl cinnamate using Fischer esterification of cinnamic acid and menthol with sulfuric acid as a catalyst using reflux at a temperature of 60oC with a synthesis time variation of 4,5 and 6 hours. Identification of synthesis results using FTIR spectrophotometry and GC-MS. Glucose lowering activity of the synthesis product using anthrone sulfate. The synthesized compound was a yellow oil liquid with a sweet fruity aroma typical of cinnamic esters with a yield % of 95.83%, 96.38, and 91.79%, respectively, at 4, 5, and 6 hours. The synthesized product was soluble in nonpolar solvents. Analysis by FTIR showed several functional groups such as C=O, C=C, C-O, and C-H aliphatic. Analysis of the synthesis results with GC-MS showed a retention time of 18.38 minutes for menthyl cinnamate with m/z = 286. Test with anthrone sulfate gave an optimum concentration of 300 ppm with a % decrease in the glucose of 48.62%. Based on these results, it can be concluded that menthyl cinnamate can be synthesized with optimum yield in 5 hours and has potential as an antidiabetic agent.
Sonochemical Synthesis of Ethyl Cinnamate Yuliana Purwaningsih; Mighfar Syukur; Ungsari Rizki Eka Purwanto
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 5, No 1 (2020): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (887.485 KB) | DOI: 10.20961/jkpk.v5i1.35525

Abstract

This research aimed to determine the yield of ethyl cinnamate synthesized by the sonochemical method and its potency as a sunscreen agent. Ethyl cinnamate was synthesized from cinnamic acid and ethanol with concentrated sulfuric acid as catalysts assisted by ultrasonic waves. The Identification of compounds was carried out by infrared spectrophotometry and gas chromatography-mass spectroscopy. Synthesis of ethyl cinnamate resulted in the form of clear yellow liquid with a fragrant aroma of a cinnamon ester with a 96.61% yield. Identification by an infrared spectrophotometer showed many functional groups of ethyl cinnamate.  Identification by GC-MS was given a relative abundance of 98.96%. The product of synthesis had SPF number 4.769 at 10 ppm used Mansur Equation. Based on this research, it concluded that it has potential as a sunscreen agent. The sonochemical method provides an excellent yield of ethyl cinnamate.
Synthesis of Core-Shell Fe3O4/C18/SiO2/[3 (2-Aminoethyl amino) propyl] Trimethoxy Silane and The Study of The Adsorption Kinetics Model of Cu2+ and Cr6+ Ions Mighfar Syukur; Ahmad Fuad Masduqi
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 5, No 2 (2020): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v5i2.37820

Abstract

Synthesis of Core-Shell Fe3O4/C18/SiO2/[3 (2-Aminoetil amino) propyl] Trimethoxy silane has been conducted to study its adsorption kinetics of Cu2+ and Cr6+ ions. Fe3O4 synthesis was carried out to form cores that have magnetic properties. The aim of the coating C18/SiO2/[3(2-Aminoetilamino) propyl] trimethoxy silane was to protect these cores from physical degradation due to acids and bases, as well as the application of synthetic materials. The sono-coprecipitation method showed good results under N2 gas flow with the results of black crystals. The success of SiO2 and [3(2-Aminoethylamino) propyl coatings the transformation of the color showed Trimethoxy silane into brown and weight gain of the synthesis result. Analysis of XRD data showed that little Fe2O3 impurities were clarified by FTIR data showing the presence of amine groups from the starting material. The SEM-EDX and TEM showed a spherical shape with a core-shell system. The adsorption kinetics model was studied using two kinetics models for Cu2+ and Cr6+ ions. The results were demonstrated by the suitability of Cu adsorption to the pseudo order 1, with an adsorption rate of 0.0333 min-1, whereas for Cr corresponded to pseudo order 2 with an adsorption rate of 0.00536 gmM-1min-1.
Functionalization of Fe3O4/SiO2 with N-(2-Aminoethyl)-3-aminopropyl for Sorption of [AuCl4]- Nuryono Nuryono; Mighfar Syukur; Agus Kuncaka; Satya Candra Wibawa Sakti
Indonesian Journal of Chemistry Vol 16, No 2 (2016)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (395.514 KB) | DOI: 10.22146/ijc.21155

Abstract

Synthesis of Fe3O4/SiO2 modified with N-(2-aminoethyl)-3-aminopropyl group (Fe3O4/SiO2/ED) via coating method and its application for adsorption-desorption of anionic gold in aqueous solution have been conducted. The synthesized product was characterized with an X-ray diffractometer (XRD), a Fourier transform infrared (FT-IR) spectrophotometer and a transmission electron microscopy (TEM). Adsorption of Au(III) was conducted in a batch system and the variables included pH, contact time, and initial concentration were investigated. Results showed that magnetite/silica has been successfully functionalized with N-(2-aminoethyl)-3-aminopropyl in a homogeneous system. Kinetics study showed that adsorption of Au(III) followed the pseudo-second order model with rate constant of 0.710 g mmol L-1min-1. Furthermore, the experimental data fitted well with the Langmuir isotherm model with the maximum adsorption capacity for Au(III) of 142.9 mg g-1 and the energy of 25.0 kJ mol-1. Gold loaded on the Fe3O4/SiO2/ED could be easily desorbed with 0.2 mol L-1 HCl containing 2 wt.% of thiourea with recovery of 99.8%. Fe3O4/SiO2/ED was reusable and stable in 5 cycles of adsorption-desorption with recovery more than 90%. Fe3O4/SiO2/ED showed high selectivity towards Au(III) in the multimetal system Au(III)/Cu(II)/Cr(VI) with the coefficient selectivity for αAu-Cu of 227.5and for αAu-Cr of 12.3.
Minyak Sereh dan Ekstrak Daun Pandan Wangi sebagai Lotion Antinyamuk di Desa Karangaji Anggoro, Aloysius Barry; Erwin Indriyanti; Mighfar Syukur; R. Salsa Dinurrosifa
Jurnal Dimas Vol 5 No 1 (2023): Jurnal Pengabdian Kepada Masyarakat
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/dimas.v5i1.53

Abstract

Abstrak Desa Karangaji, merupakan salah satu desa di Kecamatan Kedung, Kabupaten Jepara, daerah pesisir pantai yang berbatasan langsung dengan Laut Jawa. Wilayah ini merupakan lingkungan yang kurang tertata, beberapa daerah yang selalu tergenang air, serta saluran air dengan drainase yang kurang baik. Pola hidup masyarakat yang kurang memperhatikan lingkungan dan status pekerjaan serta ekonomi masyarakatnya yang sebagian besar tidak bekerja dan sebagai pengurus rumah tangga menambah buruknya kondisi lingkungan sekitar sehingga menimbukan tingginya penyakit DBD. Metode pengabdian yang dilakukan dengan survei lapangan, rapat koordinasi tim pengabdian dengan mitra, kemudian dilakukan penyuluhan kesehatan lingkungan dengan metode ceramah, diskusi, tanya jawab, dilakukan penyerahan tanaman TOGA dan pelatihan pembuatan lotion antinyamuk dengan bahan dasar minyak sereh dan ekstrak daun pandan wangi. Pembuatan lotion dilakukan dengan mencampur fase air (gliserin, TEA, akuades) ke fase minyak (setil alkohol, asam stearat) yang telah dicairkan. Penambahan ekstrak pandan wangi, minyak sereh, VCO dan metil paraben dilakukan setelah pendinginan, kemudian produk yang didapat ditambah akuades hingga kekentalan lotion yang cukup. Dari evaluasi kegiatan didapatkan bahwa kegiatan memiliki manfaat dan sesuai dengan kebutuhan warga masyarakat. Harapan dari tim pengabdian adalah warga dapat membuat lotion antinyamuk dan dapat mengusahakan ijin untuk pemasaran sehingga dapat meningkatkan ekonomi warga.
AKTIVITAS TABIR SURYA EKSTRAK ETANOL, FRAKSI N-HEKSANA DAN FRAKSI ETIL ASETAT TANAMAN PEGAGAN (Centella asiatica (L.) Urban) Mutiara, Erlita Verdia; Wildan, Achmad; Syukur, Mighfar; Indriyani, Erwin
CENDEKIA EKSAKTA Vol. 8 No. 2 (2023)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/ce.v8i2.10066

Abstract

Tanaman Pegagan (Centella asiatica (L.) Urban) adalah tumbuhan yang banyak ditemukan di Asia terutama Indonesia. Tanaman pegagan mempunyai kandungan terpenoid, flavonoid dan minyak esensial  yang mempunyai efek farmakologis seperti antiinflamasi, antiantibakteri, antioksidan dan antiaging.Gugus kromofor pada senyawa flavonoid mempunyai potensi sebagai tabir surya yang mampu menghamabat sinar UV sehingga mengurangi intensitasnya pada kulit. Tujuan dari penelitian ini adalah untuk mengetahu kemampuan ekstrak etanol, fraksi n-heksana dan fraksi etil asetat tanaman pegangan (Centella asiatica (L.) Urban) sebagai tabir surya yang dinyatakan dengan nilai SPF. Metode yang digunakan untuk mengukur nilai Sun Protection Factor adalah dengan perhitungan Metode Mansur. Hasil penelitian menunjukkan ekstrak etanol, fraksi etil asetat dan fraksi n-heksana masing-masing memberikan nilai SPF sebesar  7,34, 6,39 dan 4,37 pada konsentrasi  200 ppm.Kata kunci : Ekstrak Etanol, Fraksi Etil Asetat,, SPF, Tabir Surya, Tanaman Pegagan.
KAJIAN NANO PARTIKEL CORE SHELL N-OKTIL SINAMAT SEBAGAI ANTI ERITEMA Wildan, Achmad; Mutiara, Erlita Verdia; Syukur, Mighfar; Indriyani, Erwin
CENDEKIA EKSAKTA Vol. 9 No. 1 (2024)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/ce.v9i1.11023

Abstract

N-oktil sinamat merupakan senyawa yang mempunyai potensi sebagai antioksidan, anti inflamasi dan anti eritema.  N-oktil sinamat mempunyai sifat sukar larut dalam air sehingga mempengaruhi rendahnya bioavailabilitas dalam sirkulasi sistemik. Untuk mengurangi  permasalahan tersebut, n-oktil sinamat diformulasikan dalam bentuk nanopartikel core shell dengan menggunakan polimer kitosan. Penelitian ini bertujuan untuk mensintesis nanopartikel n-oktil sinamat menggunakan metode core shell menggunakan kitosan dan natrium alginat serta mengevaluasi kemampuan stabilitas nanopartikel secara in vitro. Karakterisasi nanopartikel yang dilakukan meliputi uji efisiensi adsorpsi, penentuan ukuran partikel dengan a;atParticle Size Analyzer dan pengamatan morfologi dengan alat Transmisi Electron Microscopy (TEM) serta untuk identifikasi digunakan FTIR dan GC-MS. Uji anti eritema dilakukan untuk mengetahui potensi senyawa hasil sintesis dengan menghitung persen eritema. Hasil penelitian menunjukkanberdasarkan FTIR dan GC-MS senyawa yang terbentuk adalah n-oktil sinamat.  Nanopartikel core shell n-oktil sinamat  mempunyai ukuran partikel rata-rata adalah 68,1 nm berdasarkan pengujian Particle Size Analyzer.. Pengamatan morfologi menunjukkan bahwa partikel mempunyai bentuk bulat dengan permukaan tidak rata. Nanopartikel n-oktil sinamat/Alginat/Kitosan 500 ppm mempunyai kemampuan antieritema dengan besar persen eritema sebesar 0,712 % yang masuk dalam kategori sunblock. Hal ini menunjukkan nanopartikel n-oktil siamat/alginat/kitosan berpotensi untuk dikembangkan sebagai anti eritema Kata kunci: anti eritema, core shell, nanopartikel, n-oktil sinamat
Pembuatan Sirup Maklanjaku (Madu Klanceng, Jahe, Kurma) Sebagai Antioksidan Alami Pada Peternak Madu Klenceng Adhityasmara, Dhimas; Syukur, Mighfar; Ramonah, Dewi
Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Vol 7, No 2 (2024): Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstormin
Publisher : Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/japhb.v7i2.6299

Abstract

Kelurahan Gunungpring, Kec. Muntilan Kota Magelang merupakan salah satu kelurahan yang terletak dilereng gunung Merapi. Kondisi geografis desa yang masih banyak hutan mengakibatkan warga mempunyai pekerjaan sampingan sebagai peternak madu. Pada peternak madu yang ada di kelurahan Gunungpring dalam hal penyarian masih menggunakan metode konvensional. Produk yang dijual masih dalam madu (bahan mentah) hal ini mengakibatkan nilai produk hanya bernilai kurang tinggi. Tujuan pengabdian ini adalah untuk meningkatkan kualitas produk dengan mengedukasi peternak madu. Pengabdian ini dibagi menjadi beberapa tahap. Pada tahap ini dilakukanah proses pelatihan peternak madu untuk membuat produk turunan yaitu Sirup “Maklanjaku”. Sirup “Maklanjaku” merupakan singkatan dari (Madu Klanceng Jahe dan Kurma). Diharapkan madu yang tadinya bernilai biasa saja dengan dibuat produk turunan seperti sirup, menjadikan madu mempunyai nilai tambah baik secara ekonomi maupun secara khasiat untuk Kesehatan. Pencampuran jahe dan kurma dikarenakan khasiatnya sebagai anti oksidan dan dapat sebagai obat herbal berbagai macam penyakit. Hasil dari pengabdian masyrakat ini adalah telah dibuatnya sirup dengan formula yang telah diformulasikan dengan bahan yaitu madu Klanceng, jahe dan kurma.
Synthesis of Dibenzalacetone using Sonochemistry and Its Antibacterial Activity Against Escherichia coli Purwaningsih, Yuliana; Indriyanti, Erwin; Syukur, Mighfar; Wigati, Dyan
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 8, No 3 (2023): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v8i3.65172

Abstract

The synthesis of dibenzalacetone, a ketone compound with potential antibacterial properties, especially against Escherichia coli, has typically involved time-consuming methods. This study adopts sonochemistry, an increasingly popular technique recognized for its efficiency and quick yield. The aim is to synthesize dibenzalacetone using the sonochemical method and evaluate its antibacterial efficacy against E. coli. The synthesis process includes a cross-aldol condensation reaction between acetone and benzaldehyde, catalyzed by NaOH, conducted in an ultrasonic bath at 35 °C for 1-5 minutes. The optimal synthesis condition, achieved in 4 minutes, resulted in a 76.56% yield of dibenzalacetone, characterized as a bright yellow solid with a melting point of 111-114°C. Techniques such as FT-IR, GC-MS, 1H-NMR, and 13C-NMR spectrometry were employed for structural characterization. The FTIR analysis revealed various functional groups, including C=O ketone, C=C aromatic, and C-H aromatic. GC-MS data confirmed the molecular weight of dibenzalacetone at m/z 234.1. Furthermore, 1H-NMR and 13C-NMR analyses provided detailed insights into the compound's chemical shifts and structural groups, affirming the successful synthesis of dibenzalacetone. The antibacterial activity of dibenzalacetone against E. coli was tested at concentrations ranging from 5% to 20%. Notably, at a 15% concentration, dibenzalacetone exhibited antibacterial activity comparable to amoxicillin. These findings suggest that dibenzalacetone, efficiently synthesized via sonochemistry, not only achieves a high yield but also has potential as an antibacterial agent against E. coli. This research highlights the efficacy of sonochemistry for the rapid and effective synthesis of compounds with significant medical applications.
Co-Authors Achmad Wildan Agus Kuncaka Ahmad Fuad Masduqi Ahmad Wildan, Ahmad Anggoro, Aloysius Barry Bekti Nugraheni Dhimas Adhityasmara Dinurrossifa, Rahmawati S. Dyan Wigati Elisa, Novi Erlita Verdia Mutiara Erwin Indriyanti Etty Sulistyowati Indriyani, Erwin Indriyanti, Erwin Kartika Sari, Wulan kartika, wulan Kyky Herlyanti, Kyky Masduqi, Ahmad F. Mutiara, Erlita V. Nafasya, Meyra Wahyu NSH, Maria Caecilia Nuryono Nuryono Pancasona, Putri Yuliana Praharsiwi, Masitoh S. Prahasiwi, Masitoh Suryaning Prasetyawan, Nanda Daffa Pratiwi, Arik Dian Eka Purwaningsih, Yuliana Putri, Athika Darumas R. Salsa Dinurrosifa Ramonah, Dewi Satya Candra Wibawa Sakti Setyowatiningsih, Endang Sholikhah, Maratus Suryaning Prahasiwi, Masitoh Suryaning, Masitoh Ungsari Rizki Eka Purwanto wibowo, sulistiyanto Wulan Kartika Sari Wulandari Wulandari Wulandari Wulandari Yuliana Purwaningsih