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All Journal Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Indonesian Journal of Pharmaceutical Science and Technology Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Biodjati Jurnal Biologi Tropis SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan MATAPPA: Jurnal Pengabdian Kepada Masyarakat Jurnal Serambi Engineering Surya Abdimas PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Mandala Pharmacon Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Pharmacoscript Jurnal Ilmu Kesehatan Jurnal Riset Kefarmasian Indonesia Lumbung Farmasi : Jurnal Ilmu Kefarmasian BERNAS: Jurnal Pengabdian Kepada Masyarakat BioEksakta : Jurnal Ilmiah Biologi Unsoed Jurnal Farmagazine Journal of Fundamental and Applied Pharmaceutical Science Jurnal Buana Farma Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Medical Sains : Jurnal Ilmiah Kefarmasian Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Sains dan Praktis Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian E-Amal: Jurnal Pengabdian Kepada Masyarakat Pharmacon: Jurnal Farmasi Indonesia Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Indonesian Journal of Jamu Jurnal Abdimas Mahakam Journal of Pharmascience
Paula Mariana Kustiawan
Universitas Muhammadiyah Kalimantan Timur
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Antioxidant activity of ethanolic extract Tetragonula testaceitarsis propolis combined with of Lepisanthes amoena leaves Yogi Pratama; Paula Mariana Kustiawan
Jurnal Mandala Pharmacon Indonesia Vol. 9 No. 1 (2023): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v9i1.303

Abstract

The illnesses brought on by free radicals are a common source of health issues. Pathogenic processes and tissue damage are both significantly influenced by free radicals. Natural ingredients from Indonesia has been carried out for generations by the community with various kinds of treatments according to existing tribes, for example, such as kelulut bee (Tetragonula testaceitarsis) propolis and kokang (Lepisanthes amoena) leaves. Stingless bee propolis has several bioactivities to prevent diseases. The research about T.  testaceitarsis propolis still limited. The purpose of this research to find out whether the combination of T. testaceitarsis propolis and L. amoena leaves extracts has antioxidant activity. Ethanol extract T. testaceitarsis. propolis and ethanol extract L. amoena leaves was collected and then tested for antioxidant activity using the DPPH method. The results showed that all three concentrations had very strong antioxidant activity. T. testaceitarsis propolis extract (50%) combined with L. amoena leaves (50%) showed strong antioxidant activity (92%) in 25 ppm concetration. Then 75% T. testaceitarsis propolis extract and 25% L. amoena leaves extract had the highest antioxidant activity (95%) at a concentration of 50 ppm concentration. This strong antioxidant activity was prospected to be continued as a pharmaceutical product.
ANTIOXIDANT ACTIVITY OF EXTRACT COMBINATION FROM Averrhoa bilimbi L. LEAVES AND STINGLESS BEE HONEY Bunga Putri Sari; Paula Mariana Kustiawan
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 5, No. 1 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v0i0.45987

Abstract

Belimbing wuluh (Averrhoa bilimbi L.) leaves and stingless bee honey contains phenolic compounds that can act as antioxidants. This study aims to find out the antioxidant activity of extract combination from stingless bee honey (Trigona spp.) and Belimbing Wuluh (Averrhoa bilimbi L.) leaves. This research was used DPPH (2,2-diphenyl-1-picrilhidrazyl) method. Then measured by UV-VIS spectrophotometry. The results showed the greatest IC50 of extract combination from stingless bee honey and Averrhoa bilimbi L. leaves was 2:1  (90,36 ppm) and was classified as strong activity. This activity was influenced by the synergistic effect between the combination of secondary metabolites contained therein.
Phytochemical Analysis and Anti-Inflammatory Activity of The Combination of Trigona apicalis propolis Extract and Honey Paula Mariana Kustiawan; Chaerul Fadly Mochtar Luthfi M; Sinta Ratna Dewi; Jati Pratiwi; Novia Misnawati Aisyiyah; Alfin Syahrian Dwi Nugraha; Irfan Muris Setiawan
Borneo Journal of Pharmacy Vol. 6 No. 2 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i2.4696

Abstract

Chronic inflammation is common in infectious diseases, rheumatoid arthritis, gout, and autoimmune diseases. However, using non-steroidal anti-inflammatory drugs (NSAIDs) is accompanied by dangerous side effects. Therefore, searching for safer alternative therapies without side effects is very important. A natural blend of ingredients produced by stingless bees from plants was potential as a remedy. Meanwhile, the potential of kelulut bee products from East Kalimantan as an anti-inflammatory is still unknown. This study aimed to compare the chemical composition of kelulut bee (Trigona apicalis) products and evaluate the anti-inflammatory effect of honey, propolis, and their combination. Propolis extract and honey were determined as secondary metabolites. An anti-inflammatory in vivo assay triggered the edema using carrageenan on male mice and measured its anti-inflammatory power value. Propolis extract and honey from T. apicalis have a promising anti-inflammatory effect and are significantly higher than the positive control. Meanwhile, combining propolis extract and honey did not enhance the anti-inflammatory effect. In addition, combining honey and propolis preparations with a ratio of 75 : 25 has a better effect on reducing edema volume than the other two combinations. Still, it is not better than the treatment with propolis extract or honey alone. The content of polyphenol compounds found in honey and propolis preparations is thought to have an important role in reducing edema volume.
AKTIVITAS ANTIOKSIDAN FRAKSI N-HEKSAN PROPOLIS LEBAH KELULUT (Geniotrigona thoracica): ANTIOXIDANT ACTIVITY ON N-HEKSANE FRACTION OF STINGLESS BEE’S PROPOLIS (Geniotrigona thoracica) Muhammad Alib Batistuta; Azzah Fatimah Zulfa; Paula Mariana Kustiawan
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 2 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i2.340

Abstract

Propolis telah lama diketahui memiliki berbagai aktivitas terapi, salah satunya sabagai antioksidan. Pemanfaatan propolis lebah kelulut Geniotrigona thoracica di Samarinda masih terbatas. Sejauh ini penyarian bioaktivitas hanya terbatas pada proses ekstraksi dan masih sedikit yang bembahas fraksi nonpolar propolis.  Tujuan penelitian ini adalah untuk mengetahui aktivitas antioksidan pada fraksi n-heksan propolis lebah kelulut (Geniotrigona thoracica) asal Samarinda. Ekstrak metanol propolis dilakukan fraksinasi dengan menggunakan partisi cair-cair menggunakan n-heksan dan diambil filtrat nya untuk didapatkan fraksi n-heksan. Fraksi tersebut dilakukan uji DPPH (2,2-diphenyl-1-picrylhydrazyl) dengan menggunakan spektrofotometri UV-Vis dan penentuan aktivitas antioksidan menggunakan parameter IC50. Hasil pengujian menujukkan bahwa nilai IC50 fraksi n-heksan propolis lebah kelulut adalah 143,637 ppm dan termasuk katagori sedang. Hal ini menunjukan fraksi n-heksan juga memiliki potensi pengembangan produk sebagai antioksidan.
ANTIOXIDANT ACTIVITY OF Homotrigona fimbriata PROPOLIS EXTRACT Rabiatul Demiati; Rendri Arista Avimaro; Paula Mariana Kustiawan
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.916

Abstract

Antioxidant compounds have a role in protecting the body from free radicals, Propolis from Homotrigona fimbriata species is widely used as an alternative to natural healing in East Kalimantan. The secondary metabolite compounds in propolis contain many flavonoids and phenolic compounds. These compounds can be utilized to fight free radicals. The purpose of this study was to determine the antioxidant content of stingless bee (Homotrigona fimbriata) propolis extract. This was a quantitative study of the antioxidant potential of propolis extract. The benchmark antioxidant activity was measured based on its ability to counteract free radicals using the DPPH method. The results of this study showed the presence of secondary metabolites of alkaloids, flavonoids, tannins, and saponins as well as antioxidant activity of Homotrigona fimbriata propolis extract with a value of   95,8 ppm as strong category. This can be caused by differences in geographical location, and various resins found in the trees around the beehive will affect antioxidant activity. Keywords: Homotrigona fimbriata, antioxidant, stingless bee
EDUKASI PENTINGNYA KONSUMSI VITAMIN SERTA POLA PENERAPAN HIDUP SEHAT SEBAGAI UPAYA PENCEGAHAN COVID-19 DI KALANGAN ANAK PANTI ASUHAN Romadhona Suci Adinda; Riska Aulia; Rizka Humaira; Tri Purwoningsih; Paula Mariana Kustiawan
E-Amal: Jurnal Pengabdian Kepada Masyarakat Vol 4 No 1: Januari-April 2024
Publisher : LP2M STP Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47492/eamal.v4i1.3189

Abstract

The aim of this education was to increased public knowledge and understanding about the use of vitamins as an effort to prevent Covid-19, and encouraging the public to adopt a healthy lifestyle that can suppress the spread of the Covid-19 virus. Participants in community service are students and orphanage administrators. Consumption of vitamins and a healthy lifestyle will also affect the immune system, especially during the Covid-19 pandemic. The activity method used is the direct counseling method through interactive lectures and activity evaluations. The results of the service activities are increasing awareness of maintaining a healthy lifestyle and understanding of community service participants reaching a value of 81%. The implementation of this activity received a good response and could provide an understanding of the importance of consuming vitamins and maintaining a healthy lifestyle during the pandemic
EDUKASI KEPADA IBU PKK RT 46, KELURAHAN LEMPAKE MENGENAI SWAMEDIKASI PENYAKIT FLU, BATUK DAN DEMAM PADA ANAK Deswita Maharani; Egi Liani Puspita; Ruly Emi Ruswanti; Paula Mariana Kustiawan
E-Amal: Jurnal Pengabdian Kepada Masyarakat Vol 4 No 1: Januari-April 2024
Publisher : LP2M STP Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47492/eamal.v4i1.3191

Abstract

Swamedikasi merupakan upaya yang sering dilakukan seseorang untuk mengatasi gejala suatu penyakit atau penyakit yang dideritanya sebelum berkonsultasi dengan dokter. Swamedikasi akan berdampak buruk jika terjadi kesalahan dalam mengenali gejala, memilih obat, dosis dan keterlambatan dalam mencari informasi. Oleh karena itu, hal ini mungkin menjadi faktor terjadinya kesalahan pengobatan. Batuk dan flu sering terjadi pada anak-anak. Orang tua perlu memperoleh pemahaman dan pengetahuan tentang pengobatan batuk dan flu sendiri yang dapat dilakukan secara farmakologis dan tradisional. Upaya yang dapat dilakukan adalah dengan memberikan edukasi pengobatan mandiri kepada masyarakat. Kegiatan ini bertujuan untuk meningkatkan edukasi pada masyarakat setempat tentang pengobatan mandiri batuk dan pilek pada anak. Metode yang digunakan dalam pengabdian ini adalah edukasi melalui leaflet. Edukasi diberikan untuk memberikan pengetahuan kepada peserta dan mencegah kepanikan jika anak mengalami batuk dan flu. Peserta memberikan respon yang baik terhadap pemberian edukasi dan hasilnya menunjukkan bahwa peserta memahami pengobatan mandiri untuk batuk dan flu pada anak (95%)
EDUKASI PEMANFAATAN BAHAN ALAM UNTUK KOSMETIK GUNA MEMBANGUN KESADARAN MASYARAKAT Kafka Navisa Suwarno; Vera Herliana Pratiwi; Sabina Guseynova; Annisa Nurul Safitri; Irsa Nur Hanifah; Aat Arafat; Nur Supianti; Ika Ayu Mentari; Paula Mariana Kustiawan
BERNAS: Jurnal Pengabdian Kepada Masyarakat Vol. 5 No. 3 (2024)
Publisher : Universitas Majalengka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31949/jb.v5i3.9256

Abstract

Kosmetik yang terbuat dari bahan alami semakin diminati sebagai alternatif yang ramah lingkungan dan memiliki efek samping yang lebih sedikit. Indonesia, dengan kekayaan alamnya yang melimpah, memiliki potensi besar dalam pengembangan produk kosmetik berbahan alam. Webinar dengan tema "Cantik Alami dengan Pemanfaatan Bahan Alam Sebagai Sumber Daya Kosmetik" diadakan untuk memperkenalkan potensi pemanfaatan bahan alam Indonesia dalam industri kosmetik. Metode kegiatan pengabdian masyarakat ini kami lakukan dalam bentuk Webinar Kesehatan mengenai pemanfaatan bahan alam sebagai sumber daya kosmetik. Rencana kegiatan dimulai dengan sesi pembukaan diikuti oleh presentasi materi dari narasumber melalui platform Zoom Meeting. Setelah sesi presentasi, dilakukan post-test untuk mengevaluasi pemahaman peserta selama kegiatan, dan akhirnya kegiatan ditutup dengan sesi evaluasi untuk meninjau tingkat pemahaman peserta. Berdasarkan hasil kuisioner sebelum penyuluhan, 88% responden menjawab dengan benar, sedangkan 12% responden menjawab salah. Mayoritas diagram lingkaran diisi oleh sektor yang mewakili responden yang menjawab dengan benar, menunjukkan bahwa sebagian besar peserta memiliki pemahaman yang kuat tentang penggunaan dan manfaat bahan alam. Meskipun sektor responden yang menjawab salah berukuran kecil, keberadaannya tetap penting karena menunjukkan bahwa ada sejumlah peserta yang mungkin memerlukan informasi tambahan atau pemahaman lebih lanjut tentang topik tersebut. Secara keseluruhan, webinar ini berhasil memberikan wawasan tentang kecantikan alami dan pemanfaatan bahan alam dalam kosmetik serta memberikan platform untuk kolaborasi dan inovasi di masa mendatang.
STUDY OF INDONESIAN STINGLESS BEE PROPOLIS POTENTIAL AS ANTIOXIDANT: A REVIEW Yanti, Evita Novi; Kustiawan, Paula Mariana
Jurnal Farmasi Sains dan Praktis Vol 9 No 3 (September-December 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i3.7105

Abstract

Indonesia is known have rich biodiversity, one of that is propolis. Propolis was an abundance bee product, especially from stingless bee species. Propolis has been known to have various health benefits, such as antioxidant and can maintain the immune system. However, comprehensive information regarding this potential is not widely known. The purpose of this study was to determine the potential of propolis Trigona sp. as an antioxidant from Indonesia. This study uses a screening method in journals that have been found through the search systems of Google Scholar, PubMed, Scopus and Garuda. Classification of data was based on inclusion and exclusion by selecting research journals that do not meet the criteria. The results of the screening that have been carried out show that the flavonoid and phenolic compounds present in the propolis Trigona sp. has potential as an antioxidant. The flavonoid and phenolic compounds contained in the propolis Trigona sp. has an important role in absorbing free radicals and has the potential to be developed as a product.
Effectiveness of Honey Bees Propolis Extract in The Treatment of Type 1 Diabetes Mellitus: Efektifitas Ekstrak propolis Lebah Madu pada Pengobatan Diabetes Tipe 1 Nisa, Khairun; Kustiawan, Paula M
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 9 No. 2 (2023): (October 2023)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2023.v9.i2.16297

Abstract

Background: Diabetes Mellitus (DM) is a health problem that affects more than 400 million people worldwide. Type 1 diabetes is an autoimmune disease characterized by damage of pancreatic cells followed by hyperglycemia and oxidative stress. Propolis is one of the natural ingredients of bee products. Propolis is known to have bioactive compounds that are rich in flavonoids, phenolic and antioxidant properties so that it has potential as an antidiabetic. Objectives: This writing aims to determine the activity of propolis in test animals of Type 1 DM model. Material and Methods: This research method uses a literature study using type 1 diabetic as inclusion criteria in journal screening. Keywords used include propolis, diabetes and hyperglycemia. Literature is obtained through an electronic data base, such as Google Scholar, PubMed, Scopus and Science Direct. Results: Based on the articles that have been collected, that Type 1 DM causes inflammation which is characterized by decreased immune function due to increased levels of IL-6, IL-1β and TNF-α. Propolis can reduce levels of pro-inflammatory cytokines, prevent the inflammatory process in diabetes and have hypoglycemic activity. Conclusions: The conclusion of the reviewed article that propolis from honey bee has effectiveness to improve the function of body cells and reduce diabetes complication.
Co-Authors Aat Arafat Abdul Aziz Abdul Aziz Abdul Aziz Abdullah, Nur Laras Suci Agnes Monica Ahmad Suwandi Ahmad Suwandi Aisyah Amalia Aisyah Nabila Aisyah, Novia Misnawati Aisyiyah, Novia Misnawati al farauqi, Mohamad dziqie aulia Al Khairy Siregar , Khalish Arsy Aldo Pratama Alfin Syahrian Dwi Nugraha Amilia, Andini Nur Andini Nur Amilia Andriani, Ainul Anis Siti Nurrohkayati Anisa Rahmadani Annisa Aulia Annisa Nurul Safitri Arbainsyah Arbainsyah Aryantinur Azizah Asmiranda Agustinur Avimaro, Rendri Arista Ayu Mentari, Ika Azzah Fatimah Zulfa Azzah Fatimah Zulfa Azzah Fatimah Zulfa Bunga Putri Sari Chaerul Fadly Mochtar Chairin Hanifa , Deasy Nur Chanchao, Chanpen Deasy Nur Chairin Hanifa Deasy Nur Chairin Hanifa Defi Lusi Anggraeni Deswita Maharani Dewi , Dea Puspita Dinata, Reviana Amalia Diniatik Egi Liani Puspita Evita Novi Yanti Fadhillah, Reza Nur Fauziah, Fenty Fauziyah, Nur Fenty Fauziah Guseynova, Sabina Hairunnisa, Indah Halida Suryadini Helni Helni Ichsan, Muhammad Nor Ika Ayu Mentari Indah Hairunisa Irfan Muris Setiawan Irsa Nur Hanifah Jati Pratiwi Jubaidi Jundy Eko Wahyudi Kafka Navisa Suwarno Khairun Nisa Khairunnisa Khairunnisa Khalifah, Chantika Noor Khalish Arsy Al Khairy Siregar Khalish Arsy Al Khairy Siregar Latipah, Asslia Johar Lestari, Ika Widya Luthfiyah Mega Srikandi Dimar Mardiana Mardiana Meliyana Dwi Pangesti Muhammad Ali Syahbana Muhammad Alib Batistuta Muhammad Alib Batistuta Muhammad Alib Batistuta Muhammad Bayu , Radityo Muhammad Nor Ichsan Nanda Daru Wahdini Nindya Ila Syafira Ramelan Norma Lisa Novia Misnawati Aisyah Novia Misnawati Aisyiyah Novia Misnawati Aisyiyah Novia Misnawati Aisyiyah Nur Supianti Nurfadillah, Mursidah Oktavia Triwanti Pramesthi, Asri Dwi Endah Dewi Pratika, Rika Putri, Melani Pebriana Rabiatul Demiati Ramadhan, Donny Rani, Frederika Erwina Rendri Arista Avimaro Ressandy, Sylvan Septian Rika Nur Junnah Rika Pratika Rimba Jagat Cahya Purnama Riska Aulia Rizka Humaira Rofidatul Husna Romadhona Suci Adinda Ruly Emi Ruswanti Sabina Guseynova Safitri, Annisa Nurul Sarah, Aulia Shella Carlina Tasya Sinta Ratna Dewi Siregar, Khalis Arsy Al Khairy Siregar, Khalish Arsy Al Khairy Siska Siska Siti Rahma Siti Sulayha Suwandi, Ahmad Syahbana, Muhammad Ali Syahrul R, Syahrul Syahrul Ramadhan Syaifie, Putri Hawa Sylvan Septian Ressandy Taghfirul Azhima Yoga Siswa Tri Purwoningsih Veggy Nadia Yuliawan Veggy Nadya Yuliawan Vera Anitra Vera Herliana Pratiwi Vera Herliana Pratiwi Yanti, Evita Novi Yogi Pratama Yuliawan, Veggy Nadia Zuliet, Aurelia Nabilla