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All Journal Jurnal Farmasi Udayana Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Indonesian Journal of Pharmaceutical Science and Technology Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Pharmascience Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Biodjati SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan MATAPPA: Jurnal Pengabdian Kepada Masyarakat Jurnal Serambi Engineering Surya Abdimas PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Mandala Pharmacon Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Abdimas Mahakam Pharmacoscript Jurnal Ilmu Kesehatan Lumbung Farmasi : Jurnal Ilmu Kefarmasian BERNAS: Jurnal Pengabdian Kepada Masyarakat BioEksakta : Jurnal Ilmiah Biologi Unsoed Jurnal Farmagazine Journal of Fundamental and Applied Pharmaceutical Science Jurnal Buana Farma Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Medical Sains : Jurnal Ilmiah Kefarmasian Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Sains dan Praktis Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian E-Amal: Jurnal Pengabdian Kepada Masyarakat Pharmacon: Jurnal Farmasi Indonesia Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Indonesian Journal of Jamu
Paula Mariana Kustiawan
Universitas Muhammadiyah Kalimantan Timur
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Aktivitas Antioksidan Formula Nano Gel Kombinasi Daun Sonneratia caseolaris dan Trigona sp. Propolis Guseynova, Sabina; Kustiawan, Paula Mariana
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 5, No 2 (2024): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v5i2.23417

Abstract

Sonneratia caseolaris and Kelulut propolis (Trigona sp.) are used by people to protect the face from sun exposure. Both have antioxidant potential, but until now no one has used the combination of these two natural ingredients as an antioxidant. The aims of this research were to obtain antioxidant activity from nano gel formula combination of Sonneratia caseolaris and Trigona sp Propolis extracts. The nano gel formulation was made into 3 formulations with concentrations of F1 (1:1), F2 (1:2) and F3 (2:1) by evaluating the preparation and antioxidant activity by using DPPH method. The evaluation results showed that all of the nano gel formulas were in accordance with the standard characteristics of the preparation and strong antioxidant activities with IC50 (µg/mL) result : F1 (17.568), F2 (35.112) and F3 (14.503). Based on the IC50 results, the greatest antioxidant activity was obtained in Formula 1.
Uji Aktivitas Antioksidan Madu Lebah Kelulut (Heterotrigona itama) Asal Samarinda Menggunakan Metode DPPH (2,2-diphenyl-1-picrylhydrazil) Andriani, Ainul; Avimaro, Rendri Arista; Kustiawan, Paula Mariana
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 6, No 2 (2025): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v6i2.25326

Abstract

Radiasi ultraviolet, polusi udara, dan asap rokok dapat memicu pembentukan radikal bebas yang disebut juga Reactive Oxygen Spesies (ROS). Oleh karena itu, diperlukan senyawa antioksidan yang dapat meredam efek negatif dari radikal bebas. Salah satu bahan alam yang mengandung antioksidan adalah madu lebah kelulut. Madu kelulut (Heterotrigona itama) asal Samarinda masih sedikit dilakukan kajian. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan madu H. itama yang berasal dari Samarinda, Kalimantan Timur. Metode yang digunakan adalah pengujian uji tabung fitokimia untuk mengetahui golongan senyawanya dan metode DPPH (2,2-diphenyl-1-picrylhydrazyl) menggunakan spektrofotometri UV-Vis untuk uji antioksidannya. Hasil penelitian menunjukkan bahwa madu H. itama mengandung metabolit sekunder seperti flavonoid, tannin, dan alkaloid serta nilai IC50 sebesar 44,82 ppm dimana masuk dalam kategori mengandung aktivitas antioksidan kuat. Madu H. itama tersebut memiliki potensi dikembangkan menjadi alternatif dalam menjaga daya tahan tubuh dari radikal bebas.
Stability of Hand Body Gel Formulated with Avocado (Persea americana), Stingless Bee Honey, and Bee Pollen Fauziyah, Nur; Kustiawan, Paula Mariana
Borneo Journal of Pharmacy Vol. 8 No. 2 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i2.6919

Abstract

The development of hand body care products in gel form, incorporating natural ingredients, remains an underexplored area, particularly concerning the combination of avocado (Persea americana) extract, Stingless bee (Trigona sp.) honey, and pollen in cosmetic formulations. Gel formulations are favored for their superior skin moisturizing properties and enhanced dermal absorption compared to lotions. This study aimed to evaluate the stability and moisturizing efficacy of novel hand body gel formulations containing varying ratios of P. americana extract combined with Trigona bee pollen and honey. Employing an experimental quantitative design, three distinct gel formulations were prepared with different concentrations of P. americana extract with Trigona bee pollen and honey. The stability of these formulations as skin moisturizers was assessed through a comprehensive evaluation encompassing organoleptic properties, homogeneity, potential for irritation, pH, spreadability, viscosity, and moisture content analysis using skin analysis instrumentation. The results indicated that the gel formulation designated F1, containing 2.5% P. americana extract and 7.5% honey combined with bee pollen, exhibited the highest skin moisture content, suggesting its potential as an effective moisturizing hand body gel.
Wound Healing Activity of Ethyl Acetate Extract of Piper crocatum Leaves Combined with Geniotrigona thoracica Propolis Dewi , Dea Puspita; Kustiawan, Paula Mariana
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 1 (2025): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i1.767

Abstract

Wounds are a common health issue caused by various types of injuries, burns, or infections. Although several wound healing methods are available, many rely on synthetic chemicals that may have side effects. Therefore, there is a need for safer and more effective alternatives. Piper crocatum leaves and Geniotrigona thoracica propolis are known to contain flavonoid compounds that have the potential to accelerate wound healing naturally. However, limited research has explored the combination of these two substances to enhance wound healing effectiveness. This study aims to provide scientific evidence regarding the potential of the combination of ethyl acetate extract of P. crocatum leaves and G. thoracica propolis as a more effective, safe, and natural alternative for wound healing treatment. The research involved creating wounds on the backs of male rabbits, which were divided into seven groups. Each group received different treatments, including ethyl acetate extract of P. crocatum leaves and G. thoracica propolis, combinations of both (P1-P5), and a positive control (bioplacenton), while the negative control received no treatment. The preparations were applied topically, and wound healing was monitored daily. The results indicate that the combination of ethyl acetate extract of P. crocatum leaves and G. thoracica propolis (1:3) promoted faster wound healing compared to other combination.
Antioxidant and Antibacterial Activity of Yellow Wood (Coscinium fenestratum) Fruits Peel from East Kalimantan: Aktivitas Antioksidan dan Antibakteri Kulit Buah Kayu Kuning (Coscinium fenestratum) Asal Kalimantan Timur Kustiawan, Paula Mariana; Arbainsyah, Arbainsyah; Setiawan, Irfan Muris
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 2 (2021): (October 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i2.15640

Abstract

Background: Yellow wood (Coscinium fenestratum) is one of the typical forest plants of East Kalimantan. The hallmark of this plant is the roots, stems and the fruits pulp have a yellow color. There have been many studies on its use and potential in treating liver disease. However, there is limited research about the use of their fruits peel. Objectives: The purpose of this study was as an initial screening of the antioxidant and antibacterial activity from yellow wood (Coscinium fenestratum) fruits peel. Material and Methods: The yellow wood fruits peel was extracted using methanol solvent to obtain the MeOH extract of their fruits peel. The DPPH test was carried out to determined its antioxidant activity (25,50 and 100 ppm). The agar well difusion method was carried out to determined its antibacterial activity. Phytochemical tests are also carried out to determined the secondary metabolites of that fruits peel. Results: The results of the phytochemical test showed that the fruits peel contained alkaloids, flavonoids, carbohydrates, and tannins, but there were no terpenoids or steroids. The fruits peel has an antioxidant activity (58%) at 100 ppm concentration. While the antibacterial test showed strong inhibition at 100 ppm concentration on S. mutans, S. aureus, P. acne and E. coli bacteria. Conclusions: The fruits peel of the yellow wood has compounds that have strong antibacterial activity and medium antioxidant activity.
PENGARUH KOMBINASI EKSTRAK PROPOLIS Heterotrigona itama DAN DAUN Sonneratia caseolaris TERHADAP AKTIVITAS ANTIOKSIDAN Muhammad Bayu , Radityo; Paula Mariana, Kustiawan
Pharmacoscript Vol. 8 No. 2 (2025): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v8i2.2126

Abstract

Radikal bebas adalah molekul reaktif yang mengandung satu atau lebih elektron tidak berpasangan dan dapat merusak jaringan tubuh seperti protein dan DNA. Antioksidan yang ditemukan di alam berperan dalam menetralkan radikal bebas dan mencegah kerusakan tersebut. Bahan alam propolis Heterotrigona itama dan daun Sonneratia caseolaris diketahui mengandung senyawa antioksidan alami. Penelitian ini dilakukan untuk mengetahui aktivitas antioksidan dari kombinasi ekstrak H. itama propolis dan daun S. caseolaris menggunakan metode DPPH. Hasil pengujian antioksidan menunjukkan bahwa variasi kombinasi ekstrak H. itama propolis (EP) dan daun S. caseolaris (ESC) rasio 1:1 (IC50 56,6 ppm), 2:1 (IC50 71,5 ppm), 0:1 (IC50 50,36 ppm), dan 1:0 (IC50 73,13 ppm). Sedangkan rasio 1:2 memiliki nilai IC50 35,1 ppm dan kategori aktivitas antioksidan yang sangat kuat dibandingkan variasi kombinasi ekstrak lainnya. Hal ini menunjukan kombinasi ekstrak tersebut dapat bersinergi dalam meningkatkan aktivitas antioksidan.
Ethnopharmacological Study of Medicinal Plants Used by the Dayak Tunjung Benuaq Tribe in East Kalimantan, Indonesia Fadhillah, Reza Nur; Kustiawan, Paula Mariana
Jurnal Jamu Indonesia Vol. 10 No. 3 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i3.376

Abstract

Ethnopharmacology is a scientific approach used to document traditional knowledge regarding the use of medicinal plants. The Dayak Tunjung Benuaq Tribe in Putak Village, East Kalimantan, Indonesia, continues to rely on herbal remedies for treating various ailments. This study aimed to identify plant species used, their therapeutic applications, and preparation methods. Data were collected through purposive and snowball sampling techniques, using semi-structured interviews with knowledgeable informants. Quantitative analysis was performed using Use Value (UV), Informant Consensus Factor (ICF), and Fidelity Level (FL). A total of 31 species from 19 families were recorded, including Carica papaya, Zingiber officinale, Psidium guajava, and Eleutherine bulbosa. Leaves were the most commonly used plant part (58%), most often prepared by boiling (93.6%) and administered orally (93.6%). C. papaya had the highest UV (0.23), while seven disease categories, such as malaria, fever, and joint pain, achieved perfect consensus (ICF = 1.0). Several species, including E. bulbosa and Syzygium polyathum, reached 100% FL, reflecting strong cultural preference for specific treatments. These findings emphasize the significance of traditional knowledge within the community, the need for documentation and preservation, and the potential of these plants for future pharmacological exploration and biodiversity conservation.
Aktivitas Antioksidan Fraksi N-Heksana Propolis Lebah Homotrigona fimbriata Abdullah, Nur Laras Suci; Kustiawan, Paula Mariana
BioEksakta : Jurnal Ilmiah Biologi Unsoed Vol 7 No 1 (2025): BioEksakta
Publisher : Fakultas Biologi Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.bioe.2025.7.1.13104

Abstract

Antioksidan memiliki kemampuan dalam mengatasi kerusakan elemen penting di dalam sel tubuh kita. Antioksidan juga dapat kita peroleh dari mengkonsumsi produk lebah kelulut, seperti propolis, polen dan madu. Sebelumnya, telah diketahui bahwa propolis Homotrigona fimbriata diketahui memiliki metabolit sekunder polifenol (flavonoid, asam fenolik, dan esternya), terpenoid, asam amino dan steroid. Sampai saat ini penelitian tentang fraksi propolis H. fimbriata masih terbatas. Tujuan dari penelitian ini untuk pengetahuan tentang aktivitas antioksidan fraksi N-heksana propolis H. fimbriata. Metode penelitian dilakukan proses ekstraksi dan fraksinasi dengan pelarut n-heksana. Analisis kualitatif dengan menggunakan uji tabung digunakan untuk mengetahui metabolit sekundernya, sedangkan pengujian antioksidan metode DPPH. Hasil penelitian menunjukkan bahwa fraksi propolis tersebut memiliki kandungan senyawa alkaloid, flavonoid dan terpenoid. Aktivitas antioksidan menunjukan IC50 419 ppm termasuk dalam kategori sangat lemah. Perlu dilakukan uji aktivitas lain untuk mengetahui potensi fraksi n-heksana propolis H. fimbriata tersebut. Kata kunci: Antioksidan, Homotrigona fimbriata, Propolis, Lebah Kelulut, Fraksi N-Heksana
Standardized Herbal Extract for Wound Healing: A Comparative Study of Centella asiatica, Curcuma domestica, and Heterotrigona itama Honey Combination in Rabbits Diniatik, Diniatik; Kustiawan, Paula Mariana; Suryadini, Halida
Borneo Journal of Pharmacy Vol. 7 No. 4 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i4.5803

Abstract

Centella asiatica and Curcuma domestica are recognized for their wound-healing properties. This study investigated the synergistic effects of combining these plant extracts with stingless bee (Heterotrigona itama) honey on wound healing in rabbits. Ethanolic extracts of C. asiatica and C. domestica were prepared in a 1 : 10 ratio. Blended formulations containing 20% plant extracts and 80% honey were created in two ratios: 1 : 1 and 2 : 1. The total flavonoid and tannin content of the plant extracts were quantified. Male rabbits were subjected to a wound-healing model, and the formulations were applied topically for seven days. Wound healing was assessed, and the results were compared to a positive control. The ethanolic extracts of C. asiatica and C. domestica were rich in flavonoids and tannins. The blended honey formulations exhibited promising wound-healing effects, with Formula 2 (2 : 1 ratio of plant extracts) demonstrating slightly superior results compared to Formula 1 and the positive control. These findings suggest the potential of the combined extracts of C. asiatica, C. domestica, and H. itama honey as effective wound-healing agents.
Formulasi Essence Sheet Mask Kombinasi Ekstrak Daun Bidara (Ziziphus spina-christi L.) dan Madu Trigona sp. Sebagai Anti-Acne: Formulation of Essence Sheet Mask Combination of Bidara Leaves Extract (Ziziphus Spina-Christi L.) and Trigona sp. Honey as Anti-Acne Agent Suwandi, Ahmad; Kustiawan, Paula Mariana
Jurnal Sains dan Kesehatan Vol. 6 No. 2 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i2.2292

Abstract

Bidara leaves contain secondary metabolite compounds such as saponins, tannins, alkaloids and flavonoids which have antibacterial activity. Apart from bidara leaves, another natural ingredient that has antibacterial activity is Trigona sp honey. The aim of this research is to create an essence sheet mask formulation combining bidara leaves extract and Trigona sp honey with FI (1%: 5%), FII (3%: 3%), FIII (5%: 1%). Then evaluation test was carried out: organoleptic (color, aroma, shape), homogeneity, pH, room temperature stability, viscosity, and antibacterial determination with Propionibacterium acnes. The results of pH measurements at FII and FIII showed stable results. The physical stability test of the essence preparation was stable in room temperature. Antibacterial activity test at FI 16.1 mm, FII 17.3 mm, and FIII 13.5 mm in the strong category. Essence sheet mask formulation blended with bidara leaves extract and Trigona sp honey is stable and has antibacterial activity against P. acnes.   Keywords:          Formulation, Bidara, Kelulut Honey, Mask, Anti-acne   Abstrak Daun bidara mengandung senyawa metabolit sekunder seperti saponin, tanin, alkaloid dan flavonoid yang memiliki aktivitas antibakteri. Selain daun bidara bahan alam lain yang memiliki aktivitas antibakteri adalah madu Trigona sp. Tujuan penelitian ini adalah membuat formulasi essence sheet mask kombinasi ekstrak daun bidara dan madu Trigona sp. dengan FI (1%:5%), FII (3%:3%), FIII (5%:1%). Kemudian dilakukan evaluasi sediaan secara organoleptis (warna, aroma, bentuk), uji homogenitas, pH, stabilitas suhu ruang, viskositas, dan uji antibakteri dengan Propionibacterium acnes. Hasil pengukuran pH pada FII dan FIII menunjukkan hasil yang stabil. Hasil uji stabilitas fisik sediaan essence memenuhi syarat dalam penyimpanan suhu ruangan. Uji aktivitas antibakteri pada FI 16,1 mm, FII 17,3 mm, dan FIII 13,5 mm  dengan kategori kuat. Formulasi essence sheet mask blended ekstrak daun bidara dan madu Trigona sp. dapat diformulasikan menjadi sediaan essence sheet mask yang stabil dan memenuhi syarat serta memiliki aktivitas antibakteri terhadap  P. acnes.   Kata Kunci:         Formulasi, Bidara, Madu kelulut, Masker, Anti-acne
Co-Authors Aat Arafat Abdul Aziz Abdul Aziz Abdul Aziz Abdullah, Nur Laras Suci Agnes Monica Ahmad Suwandi Ahmad Suwandi Aisyah Amalia Aisyah, Novia Misnawati Aisyiyah, Novia Misnawati al farauqi, Mohamad dziqie aulia Al Khairy Siregar , Khalish Arsy Aldo Pratama Alfin Syahrian Dwi Nugraha Amilia, Andini Nur Andini Nur Amilia Andriani, Ainul Anis Siti Nurrohkayati Anisa Rahmadani Annisa Aulia Annisa Nurul Safitri Arbainsyah Arbainsyah Aryantinur Azizah Asmiranda Agustinur Avimaro, Rendri Arista Ayu Mentari, Ika Azzah Fatimah Zulfa Azzah Fatimah Zulfa Azzah Fatimah Zulfa Bunga Putri Sari Chaerul Fadly Mochtar Chairin Hanifa , Deasy Nur Chanchao, Chanpen Deasy Nur Chairin Hanifa Deasy Nur Chairin Hanifa Defi Lusi Anggraeni Deswita Maharani Dewi , Dea Puspita Dinata, Reviana Amalia Diniatik Egi Liani Puspita Evita Novi Yanti Fadhillah, Reza Nur Fauziah, Fenty Fauziyah, Nur Fenty Fauziah Guseynova, Sabina Hairunnisa, Indah Halida Suryadini Helni Helni Ichsan, Muhammad Nor Ika Ayu Mentari Indah Hairunisa Irfan Muris Setiawan Irsa Nur Hanifah Jati Pratiwi Jubaidi Jundy Eko Wahyudi Kafka Navisa Suwarno Khairun Nisa Khairunnisa Khairunnisa Khalish Arsy Al Khairy Siregar Khalish Arsy Al Khairy Siregar Latipah, Asslia Johar Lestari, Ika Widya Luthfiyah Mega Srikandi Dimar Mardiana Mardiana Meliyana Dwi Pangesti Muhammad Ali Syahbana Muhammad Alib Batistuta Muhammad Alib Batistuta Muhammad Alib Batistuta Muhammad Bayu , Radityo Muhammad Nor Ichsan Nanda Daru Wahdini Nindya Ila Syafira Ramelan Norma Lisa Novia Misnawati Aisyah Novia Misnawati Aisyiyah Novia Misnawati Aisyiyah Novia Misnawati Aisyiyah Nur Supianti Nurfadillah, Mursidah Oktavia Triwanti Pramesthi, Asri Dwi Endah Dewi Pratika, Rika Putri, Melani Pebriana Rabiatul Demiati Ramadhan, Donny Rani, Frederika Erwina Rendri Arista Avimaro Ressandy, Sylvan Septian Rika Nur Junnah Rika Pratika Rimba Jagat Cahya Purnama Riska Aulia Rizka Humaira Rofidatul Husna Romadhona Suci Adinda Ruly Emi Ruswanti Sabina Guseynova Safitri, Annisa Nurul Sarah, Aulia Shella Carlina Tasya Sinta Ratna Dewi Siregar, Khalis Arsy Al Khairy Siregar, Khalish Arsy Al Khairy Siska Siska Siti Rahma Siti Sulayha Suwandi, Ahmad Syahbana, Muhammad Ali Syahrul R, Syahrul Syaifie, Putri Hawa Sylvan Septian Ressandy Taghfirul Azhima Yoga Siswa Tri Purwoningsih Veggy Nadia Yuliawan Veggy Nadya Yuliawan Vera Anitra Vera Herliana Pratiwi Vera Herliana Pratiwi Yanti, Evita Novi Yogi Pratama Yuliawan, Veggy Nadia Zuliet, Aurelia Nabilla