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All Journal Jurnal Farmasi Udayana Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Indonesian Journal of Pharmaceutical Science and Technology Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Pharmascience Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Biodjati SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan MATAPPA: Jurnal Pengabdian Kepada Masyarakat Jurnal Serambi Engineering Surya Abdimas PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Mandala Pharmacon Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Abdimas Mahakam Pharmacoscript Jurnal Ilmu Kesehatan Lumbung Farmasi : Jurnal Ilmu Kefarmasian BERNAS: Jurnal Pengabdian Kepada Masyarakat BioEksakta : Jurnal Ilmiah Biologi Unsoed Jurnal Farmagazine Journal of Fundamental and Applied Pharmaceutical Science Jurnal Buana Farma Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Medical Sains : Jurnal Ilmiah Kefarmasian Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Sains dan Praktis Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian E-Amal: Jurnal Pengabdian Kepada Masyarakat Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Indonesian Journal of Jamu
Paula Mariana Kustiawan
Universitas Muhammadiyah Kalimantan Timur
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Formulasi Essence Sheet Mask Kombinasi Ekstrak Daun Bidara (Ziziphus spina-christi L.) dan Madu Trigona sp. Sebagai Anti-Acne: Formulation of Essence Sheet Mask Combination of Bidara Leaves Extract (Ziziphus Spina-Christi L.) and Trigona sp. Honey as Anti-Acne Agent Suwandi, Ahmad; Kustiawan, Paula Mariana
Jurnal Sains dan Kesehatan Vol. 6 No. 2 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i2.2292

Abstract

Bidara leaves contain secondary metabolite compounds such as saponins, tannins, alkaloids and flavonoids which have antibacterial activity. Apart from bidara leaves, another natural ingredient that has antibacterial activity is Trigona sp honey. The aim of this research is to create an essence sheet mask formulation combining bidara leaves extract and Trigona sp honey with FI (1%: 5%), FII (3%: 3%), FIII (5%: 1%). Then evaluation test was carried out: organoleptic (color, aroma, shape), homogeneity, pH, room temperature stability, viscosity, and antibacterial determination with Propionibacterium acnes. The results of pH measurements at FII and FIII showed stable results. The physical stability test of the essence preparation was stable in room temperature. Antibacterial activity test at FI 16.1 mm, FII 17.3 mm, and FIII 13.5 mm in the strong category. Essence sheet mask formulation blended with bidara leaves extract and Trigona sp honey is stable and has antibacterial activity against P. acnes.   Keywords:          Formulation, Bidara, Kelulut Honey, Mask, Anti-acne   Abstrak Daun bidara mengandung senyawa metabolit sekunder seperti saponin, tanin, alkaloid dan flavonoid yang memiliki aktivitas antibakteri. Selain daun bidara bahan alam lain yang memiliki aktivitas antibakteri adalah madu Trigona sp. Tujuan penelitian ini adalah membuat formulasi essence sheet mask kombinasi ekstrak daun bidara dan madu Trigona sp. dengan FI (1%:5%), FII (3%:3%), FIII (5%:1%). Kemudian dilakukan evaluasi sediaan secara organoleptis (warna, aroma, bentuk), uji homogenitas, pH, stabilitas suhu ruang, viskositas, dan uji antibakteri dengan Propionibacterium acnes. Hasil pengukuran pH pada FII dan FIII menunjukkan hasil yang stabil. Hasil uji stabilitas fisik sediaan essence memenuhi syarat dalam penyimpanan suhu ruangan. Uji aktivitas antibakteri pada FI 16,1 mm, FII 17,3 mm, dan FIII 13,5 mm  dengan kategori kuat. Formulasi essence sheet mask blended ekstrak daun bidara dan madu Trigona sp. dapat diformulasikan menjadi sediaan essence sheet mask yang stabil dan memenuhi syarat serta memiliki aktivitas antibakteri terhadap  P. acnes.   Kata Kunci:         Formulasi, Bidara, Madu kelulut, Masker, Anti-acne
Eksplorasi potensi bisnis perguruan tinggi melalui hilirisasi riset dan inovasi Suwarno, Kafka Navisa; Mentari, Ika Ayu; Fauziah, Fenty; Pratiwi, Vera Herliana; Syahbana, Muhammad Ali; Ichsan, Muhammad Nor; Pratika, Rika; Junnah, Rika Nur; Amilia, Andini Nur; Kustiawan, Paula Mariana
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 8, No 2 (2024): June
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v8i2.23144

Abstract

Abstrak Hilirisasi riset dan inovasi merupakan strategi penting dalam menerjemahkan hasil penelitian akademis menjadi produk dan layanan yang dapat memberikan nilai tambah di pasar. Namun, tantangan seperti kurangnya sumber daya dan budaya kewirausahaan masih menjadi hambatan yang perlu diatasi. Kolaborasi antara perguruan tinggi, industri, dan pemerintah menjadi kunci untuk mengoptimalkan peluang bisnis dari riset dan inovasi. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk memberikan pemahaman terhadap peran penting perguruan tinggi dalam menghasilkan riset dan inovasi yang berpotensi menjadi peluang bisnis yang berkelanjutan, dan solusi terhadap permaslahan yang ada sekarang. Evaluasi terhadap kegiatan webinar dilakukan untuk meningkatkan efektivitas kegiatan pengabdian kepada masyarakat serupa di masa depan. Hasil dari evaluasi tersebut menunjukan adanya peningkatan pemahaman peserta terhadap pentingnya hilirisasi riset dan inovasi. Kegiatan ini diharapkan peserta untuk terus menjadi penggerak dalam menciptakan dampak positif secara ekonomi dan sosial melalui inovasi teknologi dan layanan. Kata kunci: hilirisasi riset; inovasi; perguruan tinggi; bisnis; kolaborasi; tantangan. Abstract  The research and innovation is an important strategy in output implemetation of academic research into products and services that can provide added value in the market. However, challenges such as the limited resources and entrepreneurial culture are still obstacles that need to be overcome. Collaboration between universities, industry and government is the key to optimizing business opportunities from research and innovation. This community service activity aims to provide an understanding of the important role of universities in producing research and innovation that has potential to become sustainable business opportunities and solutions to current problems. Evaluation of webinar activities is carried out to increase the effectiveness of future activities. The results of this evaluation showed that there was an increased in participants' understanding of the importance of downstream research and innovation. Participants in this community service activity hope that this activity can be a driving force in creating positive economic and social impacts through technological and service innovation. Keywords: research downstreaming; innovation; universities; business; collaboration; challenges.
Ethnobotanical Study of Medicinal Plants Among the Paser Telake Tribe in Pinang Jatus Village, East Kalimantan, Indonesia Rani, Frederika Erwina; Kustiawan, Paula Mariana
Jurnal Biodjati Vol 10 No 2 (2025): November
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v10i2.44514

Abstract

Ethnobotany is an interdisciplinary field that explores the relationship between humans and plants, particularly in the context of traditional medicinal practices. In many rural and indigenous communities, traditional knowledge of medicinal plants remains essential for primary healthcare, especially where access to modern medical services is limited. Pinang Jatus Village, Paser District, East Kalimantan Province, is one such community where ethnobotanical practices continue to play a significant role in daily life. However, the specific plants used, methods of preparation, and ailments treated have not been systematically documented. This study aimed to identify the types of medicinal plants used by the residents of Pinang Jatus Village, the traditional methods of preparation, and the diseases commonly treated with these plants. A quantitative and descriptive research approach was applied, using purposive and snowball sampling techniques to select 30 informants. The study employed a qualitative framework through in-depth interviews, complemented by quantitative analyses using the Use Value (UV), Informant Consensus Factor (ICF), and Fidelity Level (FL) measures. Data were collected through semi-structured interviews. The study identified 24 plant species used for medicinal purposes, with the Asteraceae family being the most dominant. The most commonly utilized plant parts were leaves, followed by roots and seeds. The findings demonstrate that the community possesses rich ethnobotanical knowledge and continues to rely on a diverse range of plant species for traditional healing. These results not only fulfill the study’s objectives but also emphasize the importance of preserving traditional knowledge and highlight the potential for future pharmacological research based on these local practices.
Potensi Propolis Homotrigona apicalis Sebagai Inhibitor NLRP3 Pada Aterosklerosis: Studi in silico Lestari, Ika Widya; Siregar, Khalish Arsy Al Khairy; Kustiawan, Paula Mariana
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 10, No 3 (2025): October 2025
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v10i3.10862

Abstract

Peradangan adalah respons perlindungan sistem imun terhadap  kekebalan rangsangan berbahaya. Aterosklerosis, penyakit pembuluh darah progresif yang ditandai penumpukan plak lemak dinding arteri, disebabkan oleh peradangan. NLRP3 berperan dalam berbagai penyakit inflamasi, termasuk aterosklerosis. Alternatif berbasis bahan alami seperti propolis Homotrigona apicalis dapat mengurangi peradangan dan mencegah perkembangan penyakit. Sebaliknya, obat antiinflamasi seperti NSAID dan steroid sering memiliki efek samping. Untuk pemahaman dari interaksi ini, digunakan pendekatan molekuler docking. Pendekatan ini memungkinkan penggunaan senyawa propolis H.apicalis sebagai antiinflamasi yang aman dan efektif. Dengan menggunakan metode molekuler docking, penelitian ini mengkaji potensi senyawa propolis H. apicalis sebagai penghambat jalur peradangan NLRP3 pada aterosklerosis. Senyawa dalam propolis, seperti Alpha-Amyrin dan Beta-Amyrin, menunjukkan aktivitas anti-inflamasi melalui interaksi hidrofobik dengan residu kunci pada protein NLRP3. Nilai afinitas ikatan tinggi Alpha-Amyrin (-10,7) kcal/mol dan Beta-Amyrin (-10,6kcal/mol), menunjukkan potensi penghambatan inflamasi yang efektif. Maka dapat disimpulkan bahwa Senyawa Alpha-Amyrin dan Beta-Amyrin dari propolis H. apicalis memiliki potensi sebagai penghambatan jalur inflamasi NLRP3 dalam aterosklerosis. Hal ini mengindikasikan Alpha-Amyrin sebagai kandidat yang sangat kuat dengan Beta-Amyrin sebagai senyawa pendukung dengan potensi serupa.
UJI TOKSISITAS AKUT EKSTRAK PROPOLIS LEBAH KELULUT Geniotrigona thoracica DAN Heterotrigona itama TERHADAP MENCIT (Mus musculus L.) Nindya Ila Syafira Ramelan; Paula Mariana Kustiawan
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 10 No. 2 (2024): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v10i2.868

Abstract

Propolis is a product produced by bees that has various benefits. As a natural substance that can be used for medicinal purposes, propolis needs to undergo acute toxicity testing to determine the safety of its use and to estimate the degree of damage that may occur. This study aims to compare the acute toxicity potential of propolis extracts from two species of stingless bees, Geniotrigona thoracica and Heterotrigona itama, based on LD50 and to assess toxic symptoms. The testing was conducted using the Organization for Economic Co-operation and Development (OECD) No. 425 method: Acute Oral Toxicity (UDP). Phytochemical test results showed that propolis extracts from Geniotrigona thoracica and Heterotrigona itama have consistent levels of secondary metabolites, namely flavonoids, alkaloids, tanins, and phenolics. Based on the acute toxicity test results, it can be concluded that the propolis extracts from Geniotrigona thoracica and Heterotrigona itama have consistent LD50 values, exceeding 5000 mg/kg body weight, and are classified as non-toxic.
Co-Authors Aat Arafat Abdul Aziz Abdul Aziz Abdul Aziz Abdullah, Nur Laras Suci Agnes Monica Ahmad Suwandi Ahmad Suwandi Aisyah, Novia Misnawati Aisyiyah, Novia Misnawati al farauqi, Mohamad dziqie aulia Al Khairy Siregar , Khalish Arsy Alfin Syahrian Dwi Nugraha Amalia, Aisyah Amilia, Andini Nur Andriani, Ainul Anis Siti Nurrohkayati Anisa Rahmadani Annisa Aulia Annisa Nurul Safitri Arbainsyah Arbainsyah Asmiranda Agustinur Avimaro, Rendri Arista Ayu Mentari, Ika Azizah, Aryantinur Azzah Fatimah Zulfa Azzah Fatimah Zulfa Azzah Fatimah Zulfa Bunga Putri Sari Chaerul Fadly Mochtar Chairin Hanifa , Deasy Nur Chanchao, Chanpen Deasy Nur Chairin Hanifa Deasy Nur Chairin Hanifa Defi Lusi Anggraeni Deswita Maharani Dewi , Dea Puspita Dinata, Reviana Amalia Diniatik Diniatik Egi Liani Puspita Evita Novi Yanti Fadhillah, Reza Nur Fauziah, Fenty Fauziyah, Nur Guseynova, Sabina Hairunnisa, Indah Halida Suryadini Helni Helni Ichsan, Muhammad Nor Ika Ayu Mentari Indah Hairunisa Irfan Muris Setiawan Irsa Nur Hanifah Jati Pratiwi Jubaidi Jundy Eko Wahyudi Junnah, Rika Nur Kafka Navisa Suwarno Khairun Nisa Khalish Arsy Al Khairy Siregar Khalish Arsy Al Khairy Siregar Latipah, Asslia Johar Lestari, Ika Widya Lisa, Norma Luthfiyah Mega Srikandi Dimar Mardiana Mardiana Meliyana Dwi Pangesti Muhammad Alib Batistuta Muhammad Alib Batistuta Muhammad Alib Batistuta Muhammad Bayu , Radityo Nanda Daru Wahdini Nindya Ila Syafira Ramelan Novia Misnawati Aisyah Novia Misnawati Aisyiyah Novia Misnawati Aisyiyah Novia Misnawati Aisyiyah Nur Supianti Nurfadillah, Mursidah Oktavia Triwanti Pratama, Aldo Pratika, Rika Pratiwi, Vera Herliana Purnama, Rimba Jagat Cahya Rabiatul Demiati Ramadhan, Donny Rani, Frederika Erwina Rendri Arista Avimaro Ressandy, Sylvan Septian Riska Aulia Rizka Humaira Rofidatul Husna Romadhona Suci Adinda Ruly Emi Ruswanti Sabina Guseynova Safitri, Annisa Nurul Sarah, Aulia Shella Carlina Tasya Sinta Ratna Dewi Siregar, Khalis Arsy Al Khairy Siregar, Khalish Arsy Al Khairy Siska Siska Siti Rahma Siti Sulayha Suwandi, Ahmad Suwarno, Kafka Navisa Syahbana, Muhammad Ali Syahrul R, Syahrul Syaifie, Putri Hawa Sylvan Septian Ressandy Tagfirul Azima Yoga Siswa, Muspidar Mulyadi Tri Purwoningsih Veggy Nadia Yuliawan Veggy Nadya Yuliawan Vera Anitra Vera Herliana Pratiwi Yanti, Evita Novi Yogi Pratama Yuliawan, Veggy Nadia