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All Journal Jurnal Farmasi Udayana Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Indonesian Journal of Pharmaceutical Science and Technology Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Pharmascience Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Biodjati SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan MATAPPA: Jurnal Pengabdian Kepada Masyarakat Jurnal Serambi Engineering Surya Abdimas PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Mandala Pharmacon Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Abdimas Mahakam Pharmacoscript Jurnal Ilmu Kesehatan Lumbung Farmasi : Jurnal Ilmu Kefarmasian BERNAS: Jurnal Pengabdian Kepada Masyarakat BioEksakta : Jurnal Ilmiah Biologi Unsoed Jurnal Farmagazine Journal of Fundamental and Applied Pharmaceutical Science Jurnal Buana Farma Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Medical Sains : Jurnal Ilmiah Kefarmasian Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Sains dan Praktis Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian E-Amal: Jurnal Pengabdian Kepada Masyarakat Pharmacon: Jurnal Farmasi Indonesia Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Indonesian Journal of Jamu
Paula Mariana Kustiawan
Universitas Muhammadiyah Kalimantan Timur
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Ethnobotanical Study of Medicinal Plants Among the Paser Telake Tribe in Pinang Jatus Village, East Kalimantan, Indonesia Rani, Frederika Erwina; Kustiawan, Paula Mariana
Jurnal Biodjati Vol 10 No 2 (2025): November
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v10i2.44514

Abstract

Ethnobotany is an interdisciplinary field that explores the relationship between humans and plants, particularly in the context of traditional medicinal practices. In many rural and indigenous communities, traditional knowledge of medicinal plants remains essential for primary healthcare, especially where access to modern medical services is limited. Pinang Jatus Village, Paser District, East Kalimantan Province, is one such community where ethnobotanical practices continue to play a significant role in daily life. However, the specific plants used, methods of preparation, and ailments treated have not been systematically documented. This study aimed to identify the types of medicinal plants used by the residents of Pinang Jatus Village, the traditional methods of preparation, and the diseases commonly treated with these plants. A quantitative and descriptive research approach was applied, using purposive and snowball sampling techniques to select 30 informants. The study employed a qualitative framework through in-depth interviews, complemented by quantitative analyses using the Use Value (UV), Informant Consensus Factor (ICF), and Fidelity Level (FL) measures. Data were collected through semi-structured interviews. The study identified 24 plant species used for medicinal purposes, with the Asteraceae family being the most dominant. The most commonly utilized plant parts were leaves, followed by roots and seeds. The findings demonstrate that the community possesses rich ethnobotanical knowledge and continues to rely on a diverse range of plant species for traditional healing. These results not only fulfill the study’s objectives but also emphasize the importance of preserving traditional knowledge and highlight the potential for future pharmacological research based on these local practices.
Potensi Propolis Homotrigona apicalis Sebagai Inhibitor NLRP3 Pada Aterosklerosis: Studi in silico Lestari, Ika Widya; Siregar, Khalish Arsy Al Khairy; Kustiawan, Paula Mariana
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 10, No 3 (2025): October 2025
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v10i3.10862

Abstract

Peradangan adalah respons perlindungan sistem imun terhadap  kekebalan rangsangan berbahaya. Aterosklerosis, penyakit pembuluh darah progresif yang ditandai penumpukan plak lemak dinding arteri, disebabkan oleh peradangan. NLRP3 berperan dalam berbagai penyakit inflamasi, termasuk aterosklerosis. Alternatif berbasis bahan alami seperti propolis Homotrigona apicalis dapat mengurangi peradangan dan mencegah perkembangan penyakit. Sebaliknya, obat antiinflamasi seperti NSAID dan steroid sering memiliki efek samping. Untuk pemahaman dari interaksi ini, digunakan pendekatan molekuler docking. Pendekatan ini memungkinkan penggunaan senyawa propolis H.apicalis sebagai antiinflamasi yang aman dan efektif. Dengan menggunakan metode molekuler docking, penelitian ini mengkaji potensi senyawa propolis H. apicalis sebagai penghambat jalur peradangan NLRP3 pada aterosklerosis. Senyawa dalam propolis, seperti Alpha-Amyrin dan Beta-Amyrin, menunjukkan aktivitas anti-inflamasi melalui interaksi hidrofobik dengan residu kunci pada protein NLRP3. Nilai afinitas ikatan tinggi Alpha-Amyrin (-10,7) kcal/mol dan Beta-Amyrin (-10,6kcal/mol), menunjukkan potensi penghambatan inflamasi yang efektif. Maka dapat disimpulkan bahwa Senyawa Alpha-Amyrin dan Beta-Amyrin dari propolis H. apicalis memiliki potensi sebagai penghambatan jalur inflamasi NLRP3 dalam aterosklerosis. Hal ini mengindikasikan Alpha-Amyrin sebagai kandidat yang sangat kuat dengan Beta-Amyrin sebagai senyawa pendukung dengan potensi serupa.
UJI TOKSISITAS AKUT EKSTRAK PROPOLIS LEBAH KELULUT Geniotrigona thoracica DAN Heterotrigona itama TERHADAP MENCIT (Mus musculus L.) Nindya Ila Syafira Ramelan; Paula Mariana Kustiawan
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 10 No. 2 (2024): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v10i2.868

Abstract

Propolis is a product produced by bees that has various benefits. As a natural substance that can be used for medicinal purposes, propolis needs to undergo acute toxicity testing to determine the safety of its use and to estimate the degree of damage that may occur. This study aims to compare the acute toxicity potential of propolis extracts from two species of stingless bees, Geniotrigona thoracica and Heterotrigona itama, based on LD50 and to assess toxic symptoms. The testing was conducted using the Organization for Economic Co-operation and Development (OECD) No. 425 method: Acute Oral Toxicity (UDP). Phytochemical test results showed that propolis extracts from Geniotrigona thoracica and Heterotrigona itama have consistent levels of secondary metabolites, namely flavonoids, alkaloids, tanins, and phenolics. Based on the acute toxicity test results, it can be concluded that the propolis extracts from Geniotrigona thoracica and Heterotrigona itama have consistent LD50 values, exceeding 5000 mg/kg body weight, and are classified as non-toxic.
Eksplorasi potensi bisnis perguruan tinggi melalui hilirisasi riset dan inovasi Kafka Navisa Suwarno; Ika Ayu Mentari; Fenty Fauziah; Vera Herliana Pratiwi; Muhammad Ali Syahbana; Muhammad Nor Ichsan; Rika Pratika; Rika Nur Junnah; Andini Nur Amilia; Paula Mariana Kustiawan
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 8, No 2 (2024): June
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v8i2.23144

Abstract

Abstrak Hilirisasi riset dan inovasi merupakan strategi penting dalam menerjemahkan hasil penelitian akademis menjadi produk dan layanan yang dapat memberikan nilai tambah di pasar. Namun, tantangan seperti kurangnya sumber daya dan budaya kewirausahaan masih menjadi hambatan yang perlu diatasi. Kolaborasi antara perguruan tinggi, industri, dan pemerintah menjadi kunci untuk mengoptimalkan peluang bisnis dari riset dan inovasi. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk memberikan pemahaman terhadap peran penting perguruan tinggi dalam menghasilkan riset dan inovasi yang berpotensi menjadi peluang bisnis yang berkelanjutan, dan solusi terhadap permaslahan yang ada sekarang. Evaluasi terhadap kegiatan webinar dilakukan untuk meningkatkan efektivitas kegiatan pengabdian kepada masyarakat serupa di masa depan. Hasil dari evaluasi tersebut menunjukan adanya peningkatan pemahaman peserta terhadap pentingnya hilirisasi riset dan inovasi. Kegiatan ini diharapkan peserta untuk terus menjadi penggerak dalam menciptakan dampak positif secara ekonomi dan sosial melalui inovasi teknologi dan layanan. Kata kunci: hilirisasi riset; inovasi; perguruan tinggi; bisnis; kolaborasi; tantangan. Abstract  The research and innovation is an important strategy in output implemetation of academic research into products and services that can provide added value in the market. However, challenges such as the limited resources and entrepreneurial culture are still obstacles that need to be overcome. Collaboration between universities, industry and government is the key to optimizing business opportunities from research and innovation. This community service activity aims to provide an understanding of the important role of universities in producing research and innovation that has potential to become sustainable business opportunities and solutions to current problems. Evaluation of webinar activities is carried out to increase the effectiveness of future activities. The results of this evaluation showed that there was an increased in participants' understanding of the importance of downstream research and innovation. Participants in this community service activity hope that this activity can be a driving force in creating positive economic and social impacts through technological and service innovation. Keywords: research downstreaming; innovation; universities; business; collaboration; challenges.
Peningkatan pengetahuan taPeningkatan pengetahuan tentang kesehatan melalui penyuluhan kesehatan di panti asuhan Nurul Haq Samarindaentang kesehatan melalui penyuluhan kesehatan di panti asuhan Nurul Haq Samarinda Rimba Jagat Cahya Purnama; Norma Lisa; Aisyah Amalia; Aldo Pratama; Anisa Rahmadani; Aryantinur Azizah; Paula Mariana Kustiawan
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 8, No 4 (2024): December
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v8i4.26763

Abstract

Abstrak Anak-anak panti asuhan memiliki pengetahuan yang masih minim tentang kesehatan mengenai kebersihan mencuci tangan dan bahaya narkoba. Berdasarkan analisis situasi yang dilakukan tim pengabdi dengan mitra, masalah mengenai kesehatan terkait kebersihan mencuci tangan dan bahaya narkoba menjadi isu yang sangat penting untuk dibicarakan di lingkungan mereka. Selama ini belum ada kegiatan pemberian informasi tentang kesehatan mengenai kebersihan mencuci tangan dan bahaya narkoba. Tujuan kegiatan pengabdian ini adalah untuk meningkatkan pengetahuan anak-anak panti asuhan tentang kesehatan mengenai kebersihan mencuci tangan dan bahaya narkoba melalui penyuluhan kesehatan. Metode pelaksanaan kegiatan pengabdian yaitu dengan penyuluhan yang dilakukan dengan beberapa tahapan, diantaranya persiapan, pelaksanaan penyuluhan, monitoring dan evaluasi kegiatan. Sasaran dalam kegiatan penyuluhan ini sebanyak 20 orang anak-anak panti asuhan. Evaluasi kegiatan penyuluhan kesehatan dilakukan dengan memberikan pre-test dan post-test untuk mengetahui dampak kegiatan penyuluhan kesehatan yang dilakukan. Setelah dilakukan kegiatan penyuluhan kesehatan terjadinya peningkatan pengetahuan anak-anak di panti asuhan tersebut terhadap kesadaran kebersihan mencuci tangan dan bahaya narkoba. Pendampingan program kesehatan mengenai kebersihan mencuci tangan dan bahaya narkoba perlu dilakukan secara berkala pada anak-anak panti asuhan sehingga dapat meningkatkan pemahaman anak-anak tentang kesehatan untuk menjaga kebersihan agar selalu mencuci tangan dengan baik dan benar serta menghindari penyalahgunaan narkoba. Kata kunci: anak-anak; narkoba; pencegahan; penyuluhan; cuci tangan Abstract The orphanage children have a few knowledge about health regarding hygiene hand washing and the dangers of drugs. Based on the situation analysis conducted by the service team with partners, health issues related to hand washing hygiene and the dangers of drugs are very important issues to be discussed in their environment. So far there have been no activities to provide information about health regarding hand washing hygiene and the dangers of drugs. The purpose of this service activity is to increase the knowledge of orphanage children about health regarding hand washing hygiene and the dangers of drugs through health counseling. The method of implementing community service activities is by counseling which is carried out in several stages, including preparation, implementation of counseling, monitoring and evaluation of activities. The targets in this counseling activity were 20 orphanage children. Evaluation of health counseling activities is carried out by giving pre-test and post-test to determine the impact of health counseling activities carried out. The results showed that there was an increase in audience knowledge about health counseling regarding hand washing hygiene and the dangers of drugs. Health program assistance regarding hand washing hygiene and the dangers of drugs needs to be carried out regularly for orphanage children so that it can increase children's understanding of health to maintain cleanliness to always wash hands properly and correctly and avoid drug abuse. Keywords: children; drugs; prevention; counseling; washing hand
In Silico Analysis of Momordica charantia L. as Antidiabetic Agents of GSK-3β Receptors and It's Antioxidant Activity Pramesthi, Asri Dwi Endah Dewi; Khairunnisa, Khairunnisa; Zuliet, Aurelia Nabilla; Putri, Melani Pebriana; Kustiawan, Paula Mariana
Pharmacon: Jurnal Farmasi Indonesia Vol. 22 No. 2 (2025)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v22i2.13447

Abstract

Diabetes mellitus is included in the group of degenerative diseases with the highest incidence rate globally. This study was conducted to evaluate the potential of bioactive compounds contained in bitter melon (Momordica charantia L.) as antidiabetic and antioxidant agents using an in silico approach. The methods used include molecular docking simulations, pharmacokinetic and toxicological  analyses were carried out using Absorption, Distribution, Metabolism, Excretion, and Toxicology parameters as well as drug suitability tests based on the Lipinski rule of five. The test results showed that bitter melon juice obtained an IC50 of 63.18 μg/ml while vitamin C as a comparison obtained an IC50 of 7.60 μg/ml. The docking results show that the Kaemferol compound has the highest binding affinity (-6.64 Kcal/mol), Quercetin (-6.28 Kcal/mol) and Charantoside I (6.07 Kcal/mol) have stable binding energy, the interaction of charantin, quercetin, kaemferol and charantoside I residues is similar to native ligands such as Valine 135, Cysteine 199, Valine 70 and Lysine 85. Based on the ADMET profile results, the quercetin and kaemferol compounds have high absorption, Caco-2 permeability which supports oral bioavailability, and do not show the ability to penetrate the blood-brain barrier, which indicates safety for the central nervous system, as well as low AMES toxicity and hepatotoxicity. As the conclusion, kaempferol and quercetin compounds have  the potential as GSK-3β inhibitors. Antioxidant activity of bitter melon juice and vitamin C are categorized as strong. Further  research regarding the mechanism of action of Momordica charantia L. as an alternative therapeutic agent in the management of type  2 diabetes is needed. 
Co-Authors Aat Arafat Abdul Aziz Abdul Aziz Abdul Aziz Abdullah, Nur Laras Suci Agnes Monica Ahmad Suwandi Ahmad Suwandi Aisyah Amalia Aisyah, Novia Misnawati Aisyiyah, Novia Misnawati al farauqi, Mohamad dziqie aulia Al Khairy Siregar , Khalish Arsy Aldo Pratama Alfin Syahrian Dwi Nugraha Amilia, Andini Nur Andini Nur Amilia Andriani, Ainul Anis Siti Nurrohkayati Anisa Rahmadani Annisa Aulia Annisa Nurul Safitri Arbainsyah Arbainsyah Aryantinur Azizah Asmiranda Agustinur Avimaro, Rendri Arista Ayu Mentari, Ika Azzah Fatimah Zulfa Azzah Fatimah Zulfa Azzah Fatimah Zulfa Bunga Putri Sari Chaerul Fadly Mochtar Chairin Hanifa , Deasy Nur Chanchao, Chanpen Deasy Nur Chairin Hanifa Deasy Nur Chairin Hanifa Defi Lusi Anggraeni Deswita Maharani Dewi , Dea Puspita Dinata, Reviana Amalia Diniatik Egi Liani Puspita Evita Novi Yanti Fadhillah, Reza Nur Fauziah, Fenty Fauziyah, Nur Fenty Fauziah Guseynova, Sabina Hairunnisa, Indah Halida Suryadini Helni Helni Ichsan, Muhammad Nor Ika Ayu Mentari Indah Hairunisa Irfan Muris Setiawan Irsa Nur Hanifah Jati Pratiwi Jubaidi Jundy Eko Wahyudi Kafka Navisa Suwarno Khairun Nisa Khairunnisa Khairunnisa Khalish Arsy Al Khairy Siregar Khalish Arsy Al Khairy Siregar Latipah, Asslia Johar Lestari, Ika Widya Luthfiyah Mega Srikandi Dimar Mardiana Mardiana Meliyana Dwi Pangesti Muhammad Ali Syahbana Muhammad Alib Batistuta Muhammad Alib Batistuta Muhammad Alib Batistuta Muhammad Bayu , Radityo Muhammad Nor Ichsan Nanda Daru Wahdini Nindya Ila Syafira Ramelan Norma Lisa Novia Misnawati Aisyah Novia Misnawati Aisyiyah Novia Misnawati Aisyiyah Novia Misnawati Aisyiyah Nur Supianti Nurfadillah, Mursidah Oktavia Triwanti Pramesthi, Asri Dwi Endah Dewi Pratika, Rika Putri, Melani Pebriana Rabiatul Demiati Ramadhan, Donny Rani, Frederika Erwina Rendri Arista Avimaro Ressandy, Sylvan Septian Rika Nur Junnah Rika Pratika Rimba Jagat Cahya Purnama Riska Aulia Rizka Humaira Rofidatul Husna Romadhona Suci Adinda Ruly Emi Ruswanti Sabina Guseynova Safitri, Annisa Nurul Sarah, Aulia Shella Carlina Tasya Sinta Ratna Dewi Siregar, Khalis Arsy Al Khairy Siregar, Khalish Arsy Al Khairy Siska Siska Siti Rahma Siti Sulayha Suwandi, Ahmad Syahbana, Muhammad Ali Syahrul R, Syahrul Syaifie, Putri Hawa Sylvan Septian Ressandy Taghfirul Azhima Yoga Siswa Tri Purwoningsih Veggy Nadia Yuliawan Veggy Nadya Yuliawan Vera Anitra Vera Herliana Pratiwi Vera Herliana Pratiwi Yanti, Evita Novi Yogi Pratama Yuliawan, Veggy Nadia Zuliet, Aurelia Nabilla