Article Per Year (5 Year)
p-Index From 2021 - 2026
8.901
P-Index
This Author published in this journals
All Journal Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Indonesian Journal of Pharmaceutical Science and Technology Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Biodjati Jurnal Biologi Tropis SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan MATAPPA: Jurnal Pengabdian Kepada Masyarakat Jurnal Serambi Engineering Surya Abdimas PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Mandala Pharmacon Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Pharmacoscript Jurnal Ilmu Kesehatan Jurnal Riset Kefarmasian Indonesia Lumbung Farmasi : Jurnal Ilmu Kefarmasian BERNAS: Jurnal Pengabdian Kepada Masyarakat BioEksakta : Jurnal Ilmiah Biologi Unsoed Jurnal Farmagazine Journal of Fundamental and Applied Pharmaceutical Science Jurnal Buana Farma Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Medical Sains : Jurnal Ilmiah Kefarmasian Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Sains dan Praktis Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian E-Amal: Jurnal Pengabdian Kepada Masyarakat Pharmacon: Jurnal Farmasi Indonesia Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Indonesian Journal of Jamu Jurnal Abdimas Mahakam Journal of Pharmascience
Paula Mariana Kustiawan
Universitas Muhammadiyah Kalimantan Timur
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

Published : 57 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 57 Documents
Search

 2   3   4   5   6 
Antioxidant and Antibacterial Activity of Extract Combination from Sonneratia alba and Heterotrigona itama Propolis Amilia, Andini Nur; Kustiawan, Paula Mariana
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, no. 3 (The 3rd Mandala Waluya International Conference on Pharmaceutical Science and
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i3.53776

Abstract

Sonneratia alba or rambai leaves are a plant from East Kalimantan that the community has used for generations as a cold powder. Antioxidants are needed to ward off free radicals, while bacteria are one of the causes of acne. Propolis also shows potential as an antioxidant and antibacterial agent. This research evaluated whether the combination of Sonneratia alba leaves extract and Heterotrigona itama propolis can increase antioxidant and antibacterial activity and whether this combination has synergistic potential. The S. alba leaves and H. itama propolis were macerated using ethanol as the solvent. The antioxidant activity test using the DPPH method with three comparisons of 1:1, 1:2, and 2:1 produced IC50 values of 12.669 µg/ml, 32.756 µg/ml, and 19.694 µg/ml, respectively. The IC50 value for ascorbic acid is 12.293 µg/ml. The results show that the combination of S. alba leaves and H. itama propolis ethanol extract has very strong antioxidant activity. The antibacterial activity test against Staphylococcus aureus bacteria with three concentrations of 60%, 80%, and 100% showed inhibition zones of 10.5 mm (medium category), 16 mm, and 17.5 mm (strong category), respectively.
Antioxidant Activity of Lotion From Sonneratia caseolaris Leaves and Trigona sp. Propolis Extract Safitri, Annisa Nurul; Kustiawan, Paula Mariana
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 7 No. 2 (2024): Oktober 2024
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v7i2.445

Abstract

Daily activities can trigger free radicals due to air pollution and increase the decline in skin health. One of the prevention efforts by using a lotion that made from natural ingredients. Natural ingredients such as Sonneratia caseolaris leaves and Trigona sp. bee propolis are still limited used in the form of lotion combination preparations. The purpose of this study was to explore the antioxidant activity of a combination lotion of S. caseolaris leaves and Trigona sp. bee propolis. Antioxidant activity was detemine by used the DPPH technique with lotion formula combination of S. caseolaris leaves and Trigona sp. bee propolis. F1 (1:1), F2 (2:1) and F3 (1:2) accompanied by a physical stability test of the lotion. The results showed that preparations F1, F2, F3 had strong antioxidants in the concentration range of 60-100 ppm. The three formulas met the criteria for a stable lotion preparation. The combination lotion formula has potential in the development of cosmetic products from natural ingredients.
Phytochemical Screening and Determination of Total Phenolic, Total Flavonoids Content ff Water and Ethanol Extract of Dayak Onion Bulbs (Eleutherine Americana Merr) Dinata, Reviana Amalia; Ayu Mentari, Ika; Hairunisa, Indah; Mariana Kustiawan, Paula
Jurnal Ilmu Kesehatan Vol 12 No 2 (2024): Jurnal Ilmu Kesehatan
Publisher : Universitas Muhammadiyah Kalimantan Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Free radicals are molecules that are inconsistent and reactive because they have a portion of the electron that does not have a mate. Free radicals in the body that exceed their capacity will result in oxidative stress. Oxidative Stress can induce damage to various instruments in cells, such as carbohydrates, proteins, DNA, and fat. If oxidational stress is not handled properly, then it will cause degenerative disease. Free radicals can be overcome with antioxidant compounds. Dayak onions (Eleutherine americana (L.) Merr) are suspected to contain flavonoids and phenolic substances that can be antioxidants. The study aims to determine the content of secondary metabolites, total phenolic levels, as well as the flavonoids of the water extract and the ethanol extract of Dayak onions (Eleutherine americana (L.) Merr) obtained from Tenggarong Seberang (L3), East Kalimantan. The method used to determine total phenolic levels using the Folin-Ciocalteu method, the determination of total flavonoid levels using the colorimetric method, as well as phytochemical screening tests using the tube method. Results obtained at the total phenolic content of dayak onions water extract 0.45±0.07 mg GAE/g and dayak onions ethanol extract 1.21±02.02 mg GAE/g, as well as the total level of flavonoids in dayak onions aquatic extracts 1.17±0.66 mg QE/g and dayak onions etanol extraction 1.33±0.41 mg QE/g, from such results indicate higher total levels of phenolics and flavanoids found in dayak onions ethanol extracted.
Investigating the Bioactivity Potential and Standardization of Two Stingless Bee Propolis from East Kalimantan Kustiawan, Paula Mariana; Syahbana, Muhammad Ali; Pratika, Rika; Ichsan, Muhammad Nor; Mentari, Ika Ayu; Hairunnisa, Indah; Setiawan, Irfan Muris; Syaifie, Putri Hawa; Ramadhan, Donny; Chanchao, Chanpen
Pharmaceutical Sciences and Research Vol. 11, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The standardization of raw materials from nature is essential before they are made into products. Until now, there is still limited information regarding the standardization of propolis from stingless bees. This research aims to determine the bioactivity with standardized specific and non-specific parameters of ethanol extracts from Homotrigona apicalis and Homotrigona fimbriata propolis. The methods include organoleptic tests, tests for water-soluble and ethanol-soluble compound content, drying shrinkage tests, specific gravity tests, water content tests, metal contamination tests, phytochemical screening, and determining total phenolic and flavonoid content. The free radical scavenging capacity was measured using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method, and antimicrobial activity against Candida albicans, Propionibacterium acnes, Streptococcus mutans, Salmonella typhi, and Escherichia coli was assessed using the agar well diffusion method. The results indicated that the standardization parameters tested on H. apicalis and H. fimbriata propolis met the standard criteria. Both species contain alkaloids, flavonoids, phenolics, tannins, and saponins. Generally, the propolis extracts from these two stingless bees exhibit potential antioxidant and antimicrobial effects. The total phenolic content for H. apicalis was 0.963 ± 0.041 mg GAE/g, while for H. fimbriata, it was 0.345 ± 0.004 mg GAE/g. The total flavonoid content for H. apicalis was 12.066 ± 0.465 mg QE/g, and for H. fimbriata, it was 9.325 ± 0.031 mg QE/g. All these results can be used as a reference for developing products derived from stingless bees.
Ketahanan Pangan Melalui Tanaman Hidroponik di Desa Melintang: Food Security Through Hydroponic Plants in Melintang Village Nurfadillah, Mursidah; Fauziah, Fenty; Kustiawan, Paula Mariana; Anitra, Vera; Al Farauqi, Mohamad Dziqie Aulia
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 3 (2025): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v10i3.8545

Abstract

Desa Melintang is one of the villages in East Kalimantan Province located in the Kota Bangun area, Muara Wis District, Kutai Kartanegara Regency, East Kalimantan Province. The area is a water or lake region, so Desa Melintang is situated above the water. With such regional conditions, Melintang village does not have land that can be used for gardening or farming due to the absence of land or soil. This affects the vegetable needs, which cannot be produced by the people of Melintang Village themselves, so they have to be brought in from outside the region to. The long distance traveled to obtain vegetables makes it necessary for the community to spend more time dan money if they want to get vegetables. Based on the aforementioned issues, the PKM team conducted community service activities by providing hydroponic plant training to the PKK mothers' group in Melintang Village, while also donating hydroponic equipment dan supplies to the community. The results of the activity are expected to be beneficial in increasing the community's knowledge about hydroponic plants. In addition, by producing their own vegetables, the quality or freshness of the vegetables can be better guaranteed, dan the community can also save on expenses, which is expected to impact food fulfillment dan improve the welfare of the community.
LITERATURE REVIEW: POTENSI FRAKSINASI PROPOLIS LEBAH KELULUT SEBAGAI PENELUSURAN AGEN ANTIDIABETES Sarah, Aulia; Kustiawan, Paula Mariana
Jurnal Buana Farma Vol. 5 No. 1 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i1.1295

Abstract

Diabetes mellitus is a metabolic disorder characterised by hyperglycaemia caused by abnormalities in insulin secretion and insulin action. Indications that arise in people with diabetes include polyuria, hyperphagia and polydipsia. Propolis or bee glue is a product made from plant sources by bees. This study aims to recognise the potential of propolis as an antidiabetic agent in diabetes mellitus. The research method in the literature study by applying journal searches on Google Scholar, PubMed, and ResearchGate databases published in 2010-2024. Based on the results of the article search, 7 suitable journals were identified. These articles consisted of 7 experimental articles. The results showed that propolis can be used as an effective antidiabetic agent to control blood glucose levels, repair damage to the islets of Langerhans, suppress oxidative stress and as an anti-inflammatory. Active compounds contained in kelulut bee propolis such as flavonoids and also other compounds such as phenolics, polyphenols and caffeic acid phenethyl ester (CAPE) compounds. It is also known that propolis treatment can reduce diabetic complications such as nephropathy, retinopathy, leg ulcers, and liver disease. propolis has great potential as a natural antidiabetic drug. The secondary metabolites in propolis, such as flavonoids, terpenoids and saponins, provide various properties including protecting pancreatic β-cells, reducing insulin resistance, and reducing oxidative stress. Fractionation can be one method of exploring the potential of propolis as an antidiabetic.
Aktivitas Antioksidan Formula Nano Gel Kombinasi Daun Sonneratia caseolaris dan Trigona sp. Propolis Guseynova, Sabina; Kustiawan, Paula Mariana
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 5, No 2 (2024): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v5i2.23417

Abstract

Sonneratia caseolaris and Kelulut propolis (Trigona sp.) are used by people to protect the face from sun exposure. Both have antioxidant potential, but until now no one has used the combination of these two natural ingredients as an antioxidant. The aims of this research were to obtain antioxidant activity from nano gel formula combination of Sonneratia caseolaris and Trigona sp Propolis extracts. The nano gel formulation was made into 3 formulations with concentrations of F1 (1:1), F2 (1:2) and F3 (2:1) by evaluating the preparation and antioxidant activity by using DPPH method. The evaluation results showed that all of the nano gel formulas were in accordance with the standard characteristics of the preparation and strong antioxidant activities with IC50 (µg/mL) result : F1 (17.568), F2 (35.112) and F3 (14.503). Based on the IC50 results, the greatest antioxidant activity was obtained in Formula 1.
Uji Aktivitas Antioksidan Madu Lebah Kelulut (Heterotrigona itama) Asal Samarinda Menggunakan Metode DPPH (2,2-diphenyl-1-picrylhydrazil) Andriani, Ainul; Avimaro, Rendri Arista; Kustiawan, Paula Mariana
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 6, No 2 (2025): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v6i2.25326

Abstract

Radiasi ultraviolet, polusi udara, dan asap rokok dapat memicu pembentukan radikal bebas yang disebut juga Reactive Oxygen Spesies (ROS). Oleh karena itu, diperlukan senyawa antioksidan yang dapat meredam efek negatif dari radikal bebas. Salah satu bahan alam yang mengandung antioksidan adalah madu lebah kelulut. Madu kelulut (Heterotrigona itama) asal Samarinda masih sedikit dilakukan kajian. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan madu H. itama yang berasal dari Samarinda, Kalimantan Timur. Metode yang digunakan adalah pengujian uji tabung fitokimia untuk mengetahui golongan senyawanya dan metode DPPH (2,2-diphenyl-1-picrylhydrazyl) menggunakan spektrofotometri UV-Vis untuk uji antioksidannya. Hasil penelitian menunjukkan bahwa madu H. itama mengandung metabolit sekunder seperti flavonoid, tannin, dan alkaloid serta nilai IC50 sebesar 44,82 ppm dimana masuk dalam kategori mengandung aktivitas antioksidan kuat. Madu H. itama tersebut memiliki potensi dikembangkan menjadi alternatif dalam menjaga daya tahan tubuh dari radikal bebas.
Stability of Hand Body Gel Formulated with Avocado (Persea americana), Stingless Bee Honey, and Bee Pollen Fauziyah, Nur; Kustiawan, Paula Mariana
Borneo Journal of Pharmacy Vol. 8 No. 2 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i2.6919

Abstract

The development of hand body care products in gel form, incorporating natural ingredients, remains an underexplored area, particularly concerning the combination of avocado (Persea americana) extract, Stingless bee (Trigona sp.) honey, and pollen in cosmetic formulations. Gel formulations are favored for their superior skin moisturizing properties and enhanced dermal absorption compared to lotions. This study aimed to evaluate the stability and moisturizing efficacy of novel hand body gel formulations containing varying ratios of P. americana extract combined with Trigona bee pollen and honey. Employing an experimental quantitative design, three distinct gel formulations were prepared with different concentrations of P. americana extract with Trigona bee pollen and honey. The stability of these formulations as skin moisturizers was assessed through a comprehensive evaluation encompassing organoleptic properties, homogeneity, potential for irritation, pH, spreadability, viscosity, and moisture content analysis using skin analysis instrumentation. The results indicated that the gel formulation designated F1, containing 2.5% P. americana extract and 7.5% honey combined with bee pollen, exhibited the highest skin moisture content, suggesting its potential as an effective moisturizing hand body gel.
Wound Healing Activity of Ethyl Acetate Extract of Piper crocatum Leaves Combined with Geniotrigona thoracica Propolis Dewi , Dea Puspita; Kustiawan, Paula Mariana
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 1 (2025): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i1.767

Abstract

Wounds are a common health issue caused by various types of injuries, burns, or infections. Although several wound healing methods are available, many rely on synthetic chemicals that may have side effects. Therefore, there is a need for safer and more effective alternatives. Piper crocatum leaves and Geniotrigona thoracica propolis are known to contain flavonoid compounds that have the potential to accelerate wound healing naturally. However, limited research has explored the combination of these two substances to enhance wound healing effectiveness. This study aims to provide scientific evidence regarding the potential of the combination of ethyl acetate extract of P. crocatum leaves and G. thoracica propolis as a more effective, safe, and natural alternative for wound healing treatment. The research involved creating wounds on the backs of male rabbits, which were divided into seven groups. Each group received different treatments, including ethyl acetate extract of P. crocatum leaves and G. thoracica propolis, combinations of both (P1-P5), and a positive control (bioplacenton), while the negative control received no treatment. The preparations were applied topically, and wound healing was monitored daily. The results indicate that the combination of ethyl acetate extract of P. crocatum leaves and G. thoracica propolis (1:3) promoted faster wound healing compared to other combination.
Co-Authors Aat Arafat Abdul Aziz Abdul Aziz Abdul Aziz Abdullah, Nur Laras Suci Agnes Monica Ahmad Suwandi Ahmad Suwandi Aisyah Amalia Aisyah Nabila Aisyah, Novia Misnawati Aisyiyah, Novia Misnawati al farauqi, Mohamad dziqie aulia Al Khairy Siregar , Khalish Arsy Aldo Pratama Alfin Syahrian Dwi Nugraha Amilia, Andini Nur Andini Nur Amilia Andriani, Ainul Anis Siti Nurrohkayati Anisa Rahmadani Annisa Aulia Annisa Nurul Safitri Arbainsyah Arbainsyah Aryantinur Azizah Asmiranda Agustinur Avimaro, Rendri Arista Ayu Mentari, Ika Azzah Fatimah Zulfa Azzah Fatimah Zulfa Azzah Fatimah Zulfa Bunga Putri Sari Chaerul Fadly Mochtar Chairin Hanifa , Deasy Nur Chanchao, Chanpen Deasy Nur Chairin Hanifa Deasy Nur Chairin Hanifa Defi Lusi Anggraeni Deswita Maharani Dewi , Dea Puspita Dinata, Reviana Amalia Diniatik Egi Liani Puspita Evita Novi Yanti Fadhillah, Reza Nur Fauziah, Fenty Fauziyah, Nur Fenty Fauziah Guseynova, Sabina Hairunnisa, Indah Halida Suryadini Helni Helni Ichsan, Muhammad Nor Ika Ayu Mentari Indah Hairunisa Irfan Muris Setiawan Irsa Nur Hanifah Jati Pratiwi Jubaidi Jundy Eko Wahyudi Kafka Navisa Suwarno Khairun Nisa Khairunnisa Khairunnisa Khalifah, Chantika Noor Khalish Arsy Al Khairy Siregar Khalish Arsy Al Khairy Siregar Latipah, Asslia Johar Lestari, Ika Widya Luthfiyah Mega Srikandi Dimar Mardiana Mardiana Meliyana Dwi Pangesti Muhammad Ali Syahbana Muhammad Alib Batistuta Muhammad Alib Batistuta Muhammad Alib Batistuta Muhammad Bayu , Radityo Muhammad Nor Ichsan Nanda Daru Wahdini Nindya Ila Syafira Ramelan Norma Lisa Novia Misnawati Aisyah Novia Misnawati Aisyiyah Novia Misnawati Aisyiyah Novia Misnawati Aisyiyah Nur Supianti Nurfadillah, Mursidah Oktavia Triwanti Pramesthi, Asri Dwi Endah Dewi Pratika, Rika Putri, Melani Pebriana Rabiatul Demiati Ramadhan, Donny Rani, Frederika Erwina Rendri Arista Avimaro Ressandy, Sylvan Septian Rika Nur Junnah Rika Pratika Rimba Jagat Cahya Purnama Riska Aulia Rizka Humaira Rofidatul Husna Romadhona Suci Adinda Ruly Emi Ruswanti Sabina Guseynova Safitri, Annisa Nurul Sarah, Aulia Shella Carlina Tasya Sinta Ratna Dewi Siregar, Khalis Arsy Al Khairy Siregar, Khalish Arsy Al Khairy Siska Siska Siti Rahma Siti Sulayha Suwandi, Ahmad Syahbana, Muhammad Ali Syahrul R, Syahrul Syahrul Ramadhan Syaifie, Putri Hawa Sylvan Septian Ressandy Taghfirul Azhima Yoga Siswa Tri Purwoningsih Veggy Nadia Yuliawan Veggy Nadya Yuliawan Vera Anitra Vera Herliana Pratiwi Vera Herliana Pratiwi Yanti, Evita Novi Yogi Pratama Yuliawan, Veggy Nadia Zuliet, Aurelia Nabilla