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All Journal Jurnal Farmasi Udayana Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Indonesian Journal of Pharmaceutical Science and Technology Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Pharmascience Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Biodjati SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan MATAPPA: Jurnal Pengabdian Kepada Masyarakat Jurnal Serambi Engineering Surya Abdimas PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Mandala Pharmacon Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Abdimas Mahakam Pharmacoscript Jurnal Ilmu Kesehatan Lumbung Farmasi : Jurnal Ilmu Kefarmasian BERNAS: Jurnal Pengabdian Kepada Masyarakat BioEksakta : Jurnal Ilmiah Biologi Unsoed Jurnal Farmagazine Journal of Fundamental and Applied Pharmaceutical Science Jurnal Buana Farma Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Medical Sains : Jurnal Ilmiah Kefarmasian Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Sains dan Praktis Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian E-Amal: Jurnal Pengabdian Kepada Masyarakat Pharmacon: Jurnal Farmasi Indonesia Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Indonesian Journal of Jamu
Paula Mariana Kustiawan
Universitas Muhammadiyah Kalimantan Timur
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EDUKASI PEMANFAATAN BAHAN ALAM UNTUK KOSMETIK GUNA MEMBANGUN KESADARAN MASYARAKAT Kafka Navisa Suwarno; Vera Herliana Pratiwi; Sabina Guseynova; Annisa Nurul Safitri; Irsa Nur Hanifah; Aat Arafat; Nur Supianti; Ika Ayu Mentari; Paula Mariana Kustiawan
BERNAS: Jurnal Pengabdian Kepada Masyarakat Vol. 5 No. 3 (2024)
Publisher : Universitas Majalengka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31949/jb.v5i3.9256

Abstract

Kosmetik yang terbuat dari bahan alami semakin diminati sebagai alternatif yang ramah lingkungan dan memiliki efek samping yang lebih sedikit. Indonesia, dengan kekayaan alamnya yang melimpah, memiliki potensi besar dalam pengembangan produk kosmetik berbahan alam. Webinar dengan tema "Cantik Alami dengan Pemanfaatan Bahan Alam Sebagai Sumber Daya Kosmetik" diadakan untuk memperkenalkan potensi pemanfaatan bahan alam Indonesia dalam industri kosmetik. Metode kegiatan pengabdian masyarakat ini kami lakukan dalam bentuk Webinar Kesehatan mengenai pemanfaatan bahan alam sebagai sumber daya kosmetik. Rencana kegiatan dimulai dengan sesi pembukaan diikuti oleh presentasi materi dari narasumber melalui platform Zoom Meeting. Setelah sesi presentasi, dilakukan post-test untuk mengevaluasi pemahaman peserta selama kegiatan, dan akhirnya kegiatan ditutup dengan sesi evaluasi untuk meninjau tingkat pemahaman peserta. Berdasarkan hasil kuisioner sebelum penyuluhan, 88% responden menjawab dengan benar, sedangkan 12% responden menjawab salah. Mayoritas diagram lingkaran diisi oleh sektor yang mewakili responden yang menjawab dengan benar, menunjukkan bahwa sebagian besar peserta memiliki pemahaman yang kuat tentang penggunaan dan manfaat bahan alam. Meskipun sektor responden yang menjawab salah berukuran kecil, keberadaannya tetap penting karena menunjukkan bahwa ada sejumlah peserta yang mungkin memerlukan informasi tambahan atau pemahaman lebih lanjut tentang topik tersebut. Secara keseluruhan, webinar ini berhasil memberikan wawasan tentang kecantikan alami dan pemanfaatan bahan alam dalam kosmetik serta memberikan platform untuk kolaborasi dan inovasi di masa mendatang.
STUDY OF INDONESIAN STINGLESS BEE PROPOLIS POTENTIAL AS ANTIOXIDANT: A REVIEW Yanti, Evita Novi; Kustiawan, Paula Mariana
Jurnal Farmasi Sains dan Praktis Vol 9 No 3 (September-December 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i3.7105

Abstract

Indonesia is known have rich biodiversity, one of that is propolis. Propolis was an abundance bee product, especially from stingless bee species. Propolis has been known to have various health benefits, such as antioxidant and can maintain the immune system. However, comprehensive information regarding this potential is not widely known. The purpose of this study was to determine the potential of propolis Trigona sp. as an antioxidant from Indonesia. This study uses a screening method in journals that have been found through the search systems of Google Scholar, PubMed, Scopus and Garuda. Classification of data was based on inclusion and exclusion by selecting research journals that do not meet the criteria. The results of the screening that have been carried out show that the flavonoid and phenolic compounds present in the propolis Trigona sp. has potential as an antioxidant. The flavonoid and phenolic compounds contained in the propolis Trigona sp. has an important role in absorbing free radicals and has the potential to be developed as a product.
Effectiveness of Honey Bees Propolis Extract in The Treatment of Type 1 Diabetes Mellitus: Efektifitas Ekstrak propolis Lebah Madu pada Pengobatan Diabetes Tipe 1 Nisa, Khairun; Kustiawan, Paula M
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 9 No. 2 (2023): (October 2023)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2023.v9.i2.16297

Abstract

Background: Diabetes Mellitus (DM) is a health problem that affects more than 400 million people worldwide. Type 1 diabetes is an autoimmune disease characterized by damage of pancreatic cells followed by hyperglycemia and oxidative stress. Propolis is one of the natural ingredients of bee products. Propolis is known to have bioactive compounds that are rich in flavonoids, phenolic and antioxidant properties so that it has potential as an antidiabetic. Objectives: This writing aims to determine the activity of propolis in test animals of Type 1 DM model. Material and Methods: This research method uses a literature study using type 1 diabetic as inclusion criteria in journal screening. Keywords used include propolis, diabetes and hyperglycemia. Literature is obtained through an electronic data base, such as Google Scholar, PubMed, Scopus and Science Direct. Results: Based on the articles that have been collected, that Type 1 DM causes inflammation which is characterized by decreased immune function due to increased levels of IL-6, IL-1β and TNF-α. Propolis can reduce levels of pro-inflammatory cytokines, prevent the inflammatory process in diabetes and have hypoglycemic activity. Conclusions: The conclusion of the reviewed article that propolis from honey bee has effectiveness to improve the function of body cells and reduce diabetes complication.
Antioxidant and Antibacterial Activity of Extract Combination from Sonneratia alba and Heterotrigona itama Propolis Amilia, Andini Nur; Kustiawan, Paula Mariana
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, no. 3 (The 3rd Mandala Waluya International Conference on Pharmaceutical Science and
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i3.53776

Abstract

Sonneratia alba or rambai leaves are a plant from East Kalimantan that the community has used for generations as a cold powder. Antioxidants are needed to ward off free radicals, while bacteria are one of the causes of acne. Propolis also shows potential as an antioxidant and antibacterial agent. This research evaluated whether the combination of Sonneratia alba leaves extract and Heterotrigona itama propolis can increase antioxidant and antibacterial activity and whether this combination has synergistic potential. The S. alba leaves and H. itama propolis were macerated using ethanol as the solvent. The antioxidant activity test using the DPPH method with three comparisons of 1:1, 1:2, and 2:1 produced IC50 values of 12.669 µg/ml, 32.756 µg/ml, and 19.694 µg/ml, respectively. The IC50 value for ascorbic acid is 12.293 µg/ml. The results show that the combination of S. alba leaves and H. itama propolis ethanol extract has very strong antioxidant activity. The antibacterial activity test against Staphylococcus aureus bacteria with three concentrations of 60%, 80%, and 100% showed inhibition zones of 10.5 mm (medium category), 16 mm, and 17.5 mm (strong category), respectively.
Antioxidant Activity of Lotion From Sonneratia caseolaris Leaves and Trigona sp. Propolis Extract Safitri, Annisa Nurul; Kustiawan, Paula Mariana
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 7 No. 2 (2024): Oktober 2024
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v7i2.445

Abstract

Daily activities can trigger free radicals due to air pollution and increase the decline in skin health. One of the prevention efforts by using a lotion that made from natural ingredients. Natural ingredients such as Sonneratia caseolaris leaves and Trigona sp. bee propolis are still limited used in the form of lotion combination preparations. The purpose of this study was to explore the antioxidant activity of a combination lotion of S. caseolaris leaves and Trigona sp. bee propolis. Antioxidant activity was detemine by used the DPPH technique with lotion formula combination of S. caseolaris leaves and Trigona sp. bee propolis. F1 (1:1), F2 (2:1) and F3 (1:2) accompanied by a physical stability test of the lotion. The results showed that preparations F1, F2, F3 had strong antioxidants in the concentration range of 60-100 ppm. The three formulas met the criteria for a stable lotion preparation. The combination lotion formula has potential in the development of cosmetic products from natural ingredients.
Phytochemical Screening and Determination of Total Phenolic, Total Flavonoids Content ff Water and Ethanol Extract of Dayak Onion Bulbs (Eleutherine Americana Merr) Dinata, Reviana Amalia; Ayu Mentari, Ika; Hairunisa, Indah; Mariana Kustiawan, Paula
Jurnal Ilmu Kesehatan Vol 12 No 2 (2024): Jurnal Ilmu Kesehatan
Publisher : Universitas Muhammadiyah Kalimantan Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Free radicals are molecules that are inconsistent and reactive because they have a portion of the electron that does not have a mate. Free radicals in the body that exceed their capacity will result in oxidative stress. Oxidative Stress can induce damage to various instruments in cells, such as carbohydrates, proteins, DNA, and fat. If oxidational stress is not handled properly, then it will cause degenerative disease. Free radicals can be overcome with antioxidant compounds. Dayak onions (Eleutherine americana (L.) Merr) are suspected to contain flavonoids and phenolic substances that can be antioxidants. The study aims to determine the content of secondary metabolites, total phenolic levels, as well as the flavonoids of the water extract and the ethanol extract of Dayak onions (Eleutherine americana (L.) Merr) obtained from Tenggarong Seberang (L3), East Kalimantan. The method used to determine total phenolic levels using the Folin-Ciocalteu method, the determination of total flavonoid levels using the colorimetric method, as well as phytochemical screening tests using the tube method. Results obtained at the total phenolic content of dayak onions water extract 0.45±0.07 mg GAE/g and dayak onions ethanol extract 1.21±02.02 mg GAE/g, as well as the total level of flavonoids in dayak onions aquatic extracts 1.17±0.66 mg QE/g and dayak onions etanol extraction 1.33±0.41 mg QE/g, from such results indicate higher total levels of phenolics and flavanoids found in dayak onions ethanol extracted.
Investigating the Bioactivity Potential and Standardization of Two Stingless Bee Propolis from East Kalimantan Kustiawan, Paula Mariana; Syahbana, Muhammad Ali; Pratika, Rika; Ichsan, Muhammad Nor; Mentari, Ika Ayu; Hairunnisa, Indah; Setiawan, Irfan Muris; Syaifie, Putri Hawa; Ramadhan, Donny; Chanchao, Chanpen
Pharmaceutical Sciences and Research Vol. 11, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The standardization of raw materials from nature is essential before they are made into products. Until now, there is still limited information regarding the standardization of propolis from stingless bees. This research aims to determine the bioactivity with standardized specific and non-specific parameters of ethanol extracts from Homotrigona apicalis and Homotrigona fimbriata propolis. The methods include organoleptic tests, tests for water-soluble and ethanol-soluble compound content, drying shrinkage tests, specific gravity tests, water content tests, metal contamination tests, phytochemical screening, and determining total phenolic and flavonoid content. The free radical scavenging capacity was measured using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method, and antimicrobial activity against Candida albicans, Propionibacterium acnes, Streptococcus mutans, Salmonella typhi, and Escherichia coli was assessed using the agar well diffusion method. The results indicated that the standardization parameters tested on H. apicalis and H. fimbriata propolis met the standard criteria. Both species contain alkaloids, flavonoids, phenolics, tannins, and saponins. Generally, the propolis extracts from these two stingless bees exhibit potential antioxidant and antimicrobial effects. The total phenolic content for H. apicalis was 0.963 ± 0.041 mg GAE/g, while for H. fimbriata, it was 0.345 ± 0.004 mg GAE/g. The total flavonoid content for H. apicalis was 12.066 ± 0.465 mg QE/g, and for H. fimbriata, it was 9.325 ± 0.031 mg QE/g. All these results can be used as a reference for developing products derived from stingless bees.
Ketahanan Pangan Melalui Tanaman Hidroponik di Desa Melintang: Food Security Through Hydroponic Plants in Melintang Village Nurfadillah, Mursidah; Fauziah, Fenty; Kustiawan, Paula Mariana; Anitra, Vera; Al Farauqi, Mohamad Dziqie Aulia
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 3 (2025): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v10i3.8545

Abstract

Desa Melintang is one of the villages in East Kalimantan Province located in the Kota Bangun area, Muara Wis District, Kutai Kartanegara Regency, East Kalimantan Province. The area is a water or lake region, so Desa Melintang is situated above the water. With such regional conditions, Melintang village does not have land that can be used for gardening or farming due to the absence of land or soil. This affects the vegetable needs, which cannot be produced by the people of Melintang Village themselves, so they have to be brought in from outside the region to. The long distance traveled to obtain vegetables makes it necessary for the community to spend more time dan money if they want to get vegetables. Based on the aforementioned issues, the PKM team conducted community service activities by providing hydroponic plant training to the PKK mothers' group in Melintang Village, while also donating hydroponic equipment dan supplies to the community. The results of the activity are expected to be beneficial in increasing the community's knowledge about hydroponic plants. In addition, by producing their own vegetables, the quality or freshness of the vegetables can be better guaranteed, dan the community can also save on expenses, which is expected to impact food fulfillment dan improve the welfare of the community.
Uji Toksisitas Akut Ekstrak Propolis Lebah Kelulut Tetrigona apicalis dan Homotrigona fimbriata terhadap Mencit (Mus musculus L.) Ramadhan, Syahrul; Kustiawan, Paula Mariana
Jurnal Pharmascience Vol 12, No 1 (2025): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v12i1.20428

Abstract

Propolis merupakan campuran senyawa resin, minyak esensial, dan lilin yang didapatkan dari tunas, daun dan eksudat pohon yang kemudian disekresikan oleh lebah kelulut jenis Trigona sp. Pemanfaatan propolis telah dilakukan secara luas untuk kosmetik dan farmasi, namun penelitian terkait toksisitasnya masih sedikit dieksplorasi. Oleh karena itu, perlu dilakukan uji toksisitas dalam mengamankan mutu sediaan. Propolis dari dua jenis lebah kelulut asal Kalimantan Timur, yaitu Tetrigona apicalis dan Homotrigona fimbriata masih belum ada penelitian terkait uji toksisitasnya. Tujuan dilakukan penelitian ini adalah untuk mengetahui toksisitas akut dua propolis tersebut terhadap mencit (Mus musculus L.). Metode yang digunakan untuk uji toksisitas akut berdasarkan pedoman Organization for Economic Co-operation and Development (OECD) 425: Acute Oral Toxicity Up and Down Prosedure. Dosis yang diberikan yaitu 2000–5000 mg/kgBB ekstrak propolis lebah kelulut T. apicalisdan H. fimbriata dan untuk nilai LD50 didapatkan dari data kuantitatif yang didapatkan pada pengujian toksisitas akut yang dilakukan. Semua kelompok hewan uji sampai hari ke-14 tidak memperlihatkan ada kematian karena faktor toksisitas dari kontrol. Hasil penelitian menunjukan ekstrak propolis lebah kelulut T. apicalis dan H. fimbriata mempunyai toksisitas akut (LD50) > 5000 mg/kg BB. Kedua propolis tersebut menunjukan aktivitas tidak toksik terhadap hewan uji.
LITERATURE REVIEW: POTENSI FRAKSINASI PROPOLIS LEBAH KELULUT SEBAGAI PENELUSURAN AGEN ANTIDIABETES Sarah, Aulia; Kustiawan, Paula Mariana
Jurnal Buana Farma Vol. 5 No. 1 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i1.1295

Abstract

Diabetes mellitus is a metabolic disorder characterised by hyperglycaemia caused by abnormalities in insulin secretion and insulin action. Indications that arise in people with diabetes include polyuria, hyperphagia and polydipsia. Propolis or bee glue is a product made from plant sources by bees. This study aims to recognise the potential of propolis as an antidiabetic agent in diabetes mellitus. The research method in the literature study by applying journal searches on Google Scholar, PubMed, and ResearchGate databases published in 2010-2024. Based on the results of the article search, 7 suitable journals were identified. These articles consisted of 7 experimental articles. The results showed that propolis can be used as an effective antidiabetic agent to control blood glucose levels, repair damage to the islets of Langerhans, suppress oxidative stress and as an anti-inflammatory. Active compounds contained in kelulut bee propolis such as flavonoids and also other compounds such as phenolics, polyphenols and caffeic acid phenethyl ester (CAPE) compounds. It is also known that propolis treatment can reduce diabetic complications such as nephropathy, retinopathy, leg ulcers, and liver disease. propolis has great potential as a natural antidiabetic drug. The secondary metabolites in propolis, such as flavonoids, terpenoids and saponins, provide various properties including protecting pancreatic β-cells, reducing insulin resistance, and reducing oxidative stress. Fractionation can be one method of exploring the potential of propolis as an antidiabetic.
Co-Authors Aat Arafat Abdul Aziz Abdul Aziz Abdul Aziz Abdullah, Nur Laras Suci Agnes Monica Ahmad Suwandi Ahmad Suwandi Aisyah Amalia Aisyah, Novia Misnawati Aisyiyah, Novia Misnawati al farauqi, Mohamad dziqie aulia Al Khairy Siregar , Khalish Arsy Aldo Pratama Alfin Syahrian Dwi Nugraha Amilia, Andini Nur Andini Nur Amilia Andriani, Ainul Anis Siti Nurrohkayati Anisa Rahmadani Annisa Aulia Annisa Nurul Safitri Arbainsyah Arbainsyah Aryantinur Azizah Asmiranda Agustinur Avimaro, Rendri Arista Ayu Mentari, Ika Azzah Fatimah Zulfa Azzah Fatimah Zulfa Azzah Fatimah Zulfa Bunga Putri Sari Chaerul Fadly Mochtar Chairin Hanifa , Deasy Nur Chanchao, Chanpen Deasy Nur Chairin Hanifa Deasy Nur Chairin Hanifa Defi Lusi Anggraeni Deswita Maharani Dewi , Dea Puspita Dinata, Reviana Amalia Diniatik Egi Liani Puspita Evita Novi Yanti Fadhillah, Reza Nur Fauziah, Fenty Fauziyah, Nur Fenty Fauziah Guseynova, Sabina Hairunnisa, Indah Halida Suryadini Helni Helni Ichsan, Muhammad Nor Ika Ayu Mentari Indah Hairunisa Irfan Muris Setiawan Irsa Nur Hanifah Jati Pratiwi Jubaidi Jundy Eko Wahyudi Kafka Navisa Suwarno Khairun Nisa Khairunnisa Khairunnisa Khalish Arsy Al Khairy Siregar Khalish Arsy Al Khairy Siregar Latipah, Asslia Johar Lestari, Ika Widya Luthfiyah Mega Srikandi Dimar Mardiana Mardiana Meliyana Dwi Pangesti Muhammad Ali Syahbana Muhammad Alib Batistuta Muhammad Alib Batistuta Muhammad Alib Batistuta Muhammad Bayu , Radityo Muhammad Nor Ichsan Nanda Daru Wahdini Nindya Ila Syafira Ramelan Norma Lisa Novia Misnawati Aisyah Novia Misnawati Aisyiyah Novia Misnawati Aisyiyah Novia Misnawati Aisyiyah Nur Supianti Nurfadillah, Mursidah Oktavia Triwanti Pramesthi, Asri Dwi Endah Dewi Pratika, Rika Putri, Melani Pebriana Rabiatul Demiati Ramadhan, Donny Rani, Frederika Erwina Rendri Arista Avimaro Ressandy, Sylvan Septian Rika Nur Junnah Rika Pratika Rimba Jagat Cahya Purnama Riska Aulia Rizka Humaira Rofidatul Husna Romadhona Suci Adinda Ruly Emi Ruswanti Sabina Guseynova Safitri, Annisa Nurul Sarah, Aulia Shella Carlina Tasya Sinta Ratna Dewi Siregar, Khalis Arsy Al Khairy Siregar, Khalish Arsy Al Khairy Siska Siska Siti Rahma Siti Sulayha Suwandi, Ahmad Syahbana, Muhammad Ali Syahrul R, Syahrul Syaifie, Putri Hawa Sylvan Septian Ressandy Taghfirul Azhima Yoga Siswa Tri Purwoningsih Veggy Nadia Yuliawan Veggy Nadya Yuliawan Vera Anitra Vera Herliana Pratiwi Vera Herliana Pratiwi Yanti, Evita Novi Yogi Pratama Yuliawan, Veggy Nadia Zuliet, Aurelia Nabilla