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All Journal Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan MPI (Media Pharmaceutica Indonesiana) Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Biodjati Jurnal Biologi Tropis SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan MATAPPA: Jurnal Pengabdian Kepada Masyarakat JOPS (Journal Of Pharmacy and Science) Jurnal Serambi Engineering Surya Abdimas PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Mandala Pharmacon Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Pharmacoscript Jurnal Farmamedika (Pharmamedica Journal) Jurnal Ilmu Kesehatan Jurnal Riset Kefarmasian Indonesia Lumbung Farmasi : Jurnal Ilmu Kefarmasian BERNAS: Jurnal Pengabdian Kepada Masyarakat BioEksakta : Jurnal Ilmiah Biologi Unsoed Jurnal Farmagazine Journal of Fundamental and Applied Pharmaceutical Science Jurnal Buana Farma Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Medical Sains : Jurnal Ilmiah Kefarmasian Pharmaceutical Sciences and Research (PSR) Journal of Tropical Food and Agroindustrial Technology Jurnal Farmasi Sains dan Praktis Journal of Biotechnology and Natural Science Jurnal Pengabdian Masyarakat Kesosi Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian E-Amal: Jurnal Pengabdian Kepada Masyarakat Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Indonesian Journal of Jamu Jurnal Abdimas Mahakam Journal of Pharmascience
Paula Mariana Kustiawan
Universitas Muhammadiyah Kalimantan Timur
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Antioxidant and Antibacterial Activity of Extract Combination from Sonneratia alba and Heterotrigona itama Propolis Amilia, Andini Nur; Kustiawan, Paula Mariana
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, no. 3 (The 3rd Mandala Waluya International Conference on Pharmaceutical Science and
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i3.53776

Abstract

Sonneratia alba or rambai leaves are a plant from East Kalimantan that the community has used for generations as a cold powder. Antioxidants are needed to ward off free radicals, while bacteria are one of the causes of acne. Propolis also shows potential as an antioxidant and antibacterial agent. This research evaluated whether the combination of Sonneratia alba leaves extract and Heterotrigona itama propolis can increase antioxidant and antibacterial activity and whether this combination has synergistic potential. The S. alba leaves and H. itama propolis were macerated using ethanol as the solvent. The antioxidant activity test using the DPPH method with three comparisons of 1:1, 1:2, and 2:1 produced IC50 values of 12.669 µg/ml, 32.756 µg/ml, and 19.694 µg/ml, respectively. The IC50 value for ascorbic acid is 12.293 µg/ml. The results show that the combination of S. alba leaves and H. itama propolis ethanol extract has very strong antioxidant activity. The antibacterial activity test against Staphylococcus aureus bacteria with three concentrations of 60%, 80%, and 100% showed inhibition zones of 10.5 mm (medium category), 16 mm, and 17.5 mm (strong category), respectively.
Antioxidant Activity of Lotion From Sonneratia caseolaris Leaves and Trigona sp. Propolis Extract Safitri, Annisa Nurul; Kustiawan, Paula Mariana
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 7 No. 2 (2024): Oktober 2024
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v7i2.445

Abstract

Daily activities can trigger free radicals due to air pollution and increase the decline in skin health. One of the prevention efforts by using a lotion that made from natural ingredients. Natural ingredients such as Sonneratia caseolaris leaves and Trigona sp. bee propolis are still limited used in the form of lotion combination preparations. The purpose of this study was to explore the antioxidant activity of a combination lotion of S. caseolaris leaves and Trigona sp. bee propolis. Antioxidant activity was detemine by used the DPPH technique with lotion formula combination of S. caseolaris leaves and Trigona sp. bee propolis. F1 (1:1), F2 (2:1) and F3 (1:2) accompanied by a physical stability test of the lotion. The results showed that preparations F1, F2, F3 had strong antioxidants in the concentration range of 60-100 ppm. The three formulas met the criteria for a stable lotion preparation. The combination lotion formula has potential in the development of cosmetic products from natural ingredients.
Phytochemical Screening and Determination of Total Phenolic, Total Flavonoids Content ff Water and Ethanol Extract of Dayak Onion Bulbs (Eleutherine Americana Merr) Dinata, Reviana Amalia; Ayu Mentari, Ika; Hairunisa, Indah; Mariana Kustiawan, Paula
Jurnal Ilmu Kesehatan Vol 12 No 2 (2024): Jurnal Ilmu Kesehatan
Publisher : Universitas Muhammadiyah Kalimantan Timur

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Abstract

Free radicals are molecules that are inconsistent and reactive because they have a portion of the electron that does not have a mate. Free radicals in the body that exceed their capacity will result in oxidative stress. Oxidative Stress can induce damage to various instruments in cells, such as carbohydrates, proteins, DNA, and fat. If oxidational stress is not handled properly, then it will cause degenerative disease. Free radicals can be overcome with antioxidant compounds. Dayak onions (Eleutherine americana (L.) Merr) are suspected to contain flavonoids and phenolic substances that can be antioxidants. The study aims to determine the content of secondary metabolites, total phenolic levels, as well as the flavonoids of the water extract and the ethanol extract of Dayak onions (Eleutherine americana (L.) Merr) obtained from Tenggarong Seberang (L3), East Kalimantan. The method used to determine total phenolic levels using the Folin-Ciocalteu method, the determination of total flavonoid levels using the colorimetric method, as well as phytochemical screening tests using the tube method. Results obtained at the total phenolic content of dayak onions water extract 0.45±0.07 mg GAE/g and dayak onions ethanol extract 1.21±02.02 mg GAE/g, as well as the total level of flavonoids in dayak onions aquatic extracts 1.17±0.66 mg QE/g and dayak onions etanol extraction 1.33±0.41 mg QE/g, from such results indicate higher total levels of phenolics and flavanoids found in dayak onions ethanol extracted.
Investigating the Bioactivity Potential and Standardization of Two Stingless Bee Propolis from East Kalimantan Kustiawan, Paula Mariana; Syahbana, Muhammad Ali; Pratika, Rika; Ichsan, Muhammad Nor; Mentari, Ika Ayu; Hairunnisa, Indah; Setiawan, Irfan Muris; Syaifie, Putri Hawa; Ramadhan, Donny; Chanchao, Chanpen
Pharmaceutical Sciences and Research Vol. 11, No. 3
Publisher : UI Scholars Hub

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Abstract

The standardization of raw materials from nature is essential before they are made into products. Until now, there is still limited information regarding the standardization of propolis from stingless bees. This research aims to determine the bioactivity with standardized specific and non-specific parameters of ethanol extracts from Homotrigona apicalis and Homotrigona fimbriata propolis. The methods include organoleptic tests, tests for water-soluble and ethanol-soluble compound content, drying shrinkage tests, specific gravity tests, water content tests, metal contamination tests, phytochemical screening, and determining total phenolic and flavonoid content. The free radical scavenging capacity was measured using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method, and antimicrobial activity against Candida albicans, Propionibacterium acnes, Streptococcus mutans, Salmonella typhi, and Escherichia coli was assessed using the agar well diffusion method. The results indicated that the standardization parameters tested on H. apicalis and H. fimbriata propolis met the standard criteria. Both species contain alkaloids, flavonoids, phenolics, tannins, and saponins. Generally, the propolis extracts from these two stingless bees exhibit potential antioxidant and antimicrobial effects. The total phenolic content for H. apicalis was 0.963 ± 0.041 mg GAE/g, while for H. fimbriata, it was 0.345 ± 0.004 mg GAE/g. The total flavonoid content for H. apicalis was 12.066 ± 0.465 mg QE/g, and for H. fimbriata, it was 9.325 ± 0.031 mg QE/g. All these results can be used as a reference for developing products derived from stingless bees.
Ketahanan Pangan Melalui Tanaman Hidroponik di Desa Melintang: Food Security Through Hydroponic Plants in Melintang Village Nurfadillah, Mursidah; Fauziah, Fenty; Kustiawan, Paula Mariana; Anitra, Vera; Al Farauqi, Mohamad Dziqie Aulia
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 3 (2025): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v10i3.8545

Abstract

Desa Melintang is one of the villages in East Kalimantan Province located in the Kota Bangun area, Muara Wis District, Kutai Kartanegara Regency, East Kalimantan Province. The area is a water or lake region, so Desa Melintang is situated above the water. With such regional conditions, Melintang village does not have land that can be used for gardening or farming due to the absence of land or soil. This affects the vegetable needs, which cannot be produced by the people of Melintang Village themselves, so they have to be brought in from outside the region to. The long distance traveled to obtain vegetables makes it necessary for the community to spend more time dan money if they want to get vegetables. Based on the aforementioned issues, the PKM team conducted community service activities by providing hydroponic plant training to the PKK mothers' group in Melintang Village, while also donating hydroponic equipment dan supplies to the community. The results of the activity are expected to be beneficial in increasing the community's knowledge about hydroponic plants. In addition, by producing their own vegetables, the quality or freshness of the vegetables can be better guaranteed, dan the community can also save on expenses, which is expected to impact food fulfillment dan improve the welfare of the community.
LITERATURE REVIEW: POTENSI FRAKSINASI PROPOLIS LEBAH KELULUT SEBAGAI PENELUSURAN AGEN ANTIDIABETES Sarah, Aulia; Kustiawan, Paula Mariana
Jurnal Buana Farma Vol. 5 No. 1 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i1.1295

Abstract

Diabetes mellitus is a metabolic disorder characterised by hyperglycaemia caused by abnormalities in insulin secretion and insulin action. Indications that arise in people with diabetes include polyuria, hyperphagia and polydipsia. Propolis or bee glue is a product made from plant sources by bees. This study aims to recognise the potential of propolis as an antidiabetic agent in diabetes mellitus. The research method in the literature study by applying journal searches on Google Scholar, PubMed, and ResearchGate databases published in 2010-2024. Based on the results of the article search, 7 suitable journals were identified. These articles consisted of 7 experimental articles. The results showed that propolis can be used as an effective antidiabetic agent to control blood glucose levels, repair damage to the islets of Langerhans, suppress oxidative stress and as an anti-inflammatory. Active compounds contained in kelulut bee propolis such as flavonoids and also other compounds such as phenolics, polyphenols and caffeic acid phenethyl ester (CAPE) compounds. It is also known that propolis treatment can reduce diabetic complications such as nephropathy, retinopathy, leg ulcers, and liver disease. propolis has great potential as a natural antidiabetic drug. The secondary metabolites in propolis, such as flavonoids, terpenoids and saponins, provide various properties including protecting pancreatic β-cells, reducing insulin resistance, and reducing oxidative stress. Fractionation can be one method of exploring the potential of propolis as an antidiabetic.
Stability of Hand Body Gel Formulated with Avocado (Persea americana), Stingless Bee Honey, and Bee Pollen Fauziyah, Nur; Kustiawan, Paula Mariana
Borneo Journal of Pharmacy Vol. 8 No. 2 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i2.6919

Abstract

The development of hand body care products in gel form, incorporating natural ingredients, remains an underexplored area, particularly concerning the combination of avocado (Persea americana) extract, Stingless bee (Trigona sp.) honey, and pollen in cosmetic formulations. Gel formulations are favored for their superior skin moisturizing properties and enhanced dermal absorption compared to lotions. This study aimed to evaluate the stability and moisturizing efficacy of novel hand body gel formulations containing varying ratios of P. americana extract combined with Trigona bee pollen and honey. Employing an experimental quantitative design, three distinct gel formulations were prepared with different concentrations of P. americana extract with Trigona bee pollen and honey. The stability of these formulations as skin moisturizers was assessed through a comprehensive evaluation encompassing organoleptic properties, homogeneity, potential for irritation, pH, spreadability, viscosity, and moisture content analysis using skin analysis instrumentation. The results indicated that the gel formulation designated F1, containing 2.5% P. americana extract and 7.5% honey combined with bee pollen, exhibited the highest skin moisture content, suggesting its potential as an effective moisturizing hand body gel.
Wound Healing Activity of Ethyl Acetate Extract of Piper crocatum Leaves Combined with Geniotrigona thoracica Propolis Dewi , Dea Puspita; Kustiawan, Paula Mariana
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 1 (2025): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i1.767

Abstract

Wounds are a common health issue caused by various types of injuries, burns, or infections. Although several wound healing methods are available, many rely on synthetic chemicals that may have side effects. Therefore, there is a need for safer and more effective alternatives. Piper crocatum leaves and Geniotrigona thoracica propolis are known to contain flavonoid compounds that have the potential to accelerate wound healing naturally. However, limited research has explored the combination of these two substances to enhance wound healing effectiveness. This study aims to provide scientific evidence regarding the potential of the combination of ethyl acetate extract of P. crocatum leaves and G. thoracica propolis as a more effective, safe, and natural alternative for wound healing treatment. The research involved creating wounds on the backs of male rabbits, which were divided into seven groups. Each group received different treatments, including ethyl acetate extract of P. crocatum leaves and G. thoracica propolis, combinations of both (P1-P5), and a positive control (bioplacenton), while the negative control received no treatment. The preparations were applied topically, and wound healing was monitored daily. The results indicate that the combination of ethyl acetate extract of P. crocatum leaves and G. thoracica propolis (1:3) promoted faster wound healing compared to other combination.
Antioxidant and Antibacterial Activity of Yellow Wood (Coscinium fenestratum) Fruits Peel from East Kalimantan: Aktivitas Antioksidan dan Antibakteri Kulit Buah Kayu Kuning (Coscinium fenestratum) Asal Kalimantan Timur Kustiawan, Paula Mariana; Arbainsyah, Arbainsyah; Setiawan, Irfan Muris
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 2 (2021): (October 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i2.15640

Abstract

Background: Yellow wood (Coscinium fenestratum) is one of the typical forest plants of East Kalimantan. The hallmark of this plant is the roots, stems and the fruits pulp have a yellow color. There have been many studies on its use and potential in treating liver disease. However, there is limited research about the use of their fruits peel. Objectives: The purpose of this study was as an initial screening of the antioxidant and antibacterial activity from yellow wood (Coscinium fenestratum) fruits peel. Material and Methods: The yellow wood fruits peel was extracted using methanol solvent to obtain the MeOH extract of their fruits peel. The DPPH test was carried out to determined its antioxidant activity (25,50 and 100 ppm). The agar well difusion method was carried out to determined its antibacterial activity. Phytochemical tests are also carried out to determined the secondary metabolites of that fruits peel. Results: The results of the phytochemical test showed that the fruits peel contained alkaloids, flavonoids, carbohydrates, and tannins, but there were no terpenoids or steroids. The fruits peel has an antioxidant activity (58%) at 100 ppm concentration. While the antibacterial test showed strong inhibition at 100 ppm concentration on S. mutans, S. aureus, P. acne and E. coli bacteria. Conclusions: The fruits peel of the yellow wood has compounds that have strong antibacterial activity and medium antioxidant activity.
PENGARUH KOMBINASI EKSTRAK PROPOLIS Heterotrigona itama DAN DAUN Sonneratia caseolaris TERHADAP AKTIVITAS ANTIOKSIDAN Muhammad Bayu , Radityo; Paula Mariana, Kustiawan
Pharmacoscript Vol. 8 No. 2 (2025): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v8i2.2126

Abstract

Radikal bebas adalah molekul reaktif yang mengandung satu atau lebih elektron tidak berpasangan dan dapat merusak jaringan tubuh seperti protein dan DNA. Antioksidan yang ditemukan di alam berperan dalam menetralkan radikal bebas dan mencegah kerusakan tersebut. Bahan alam propolis Heterotrigona itama dan daun Sonneratia caseolaris diketahui mengandung senyawa antioksidan alami. Penelitian ini dilakukan untuk mengetahui aktivitas antioksidan dari kombinasi ekstrak H. itama propolis dan daun S. caseolaris menggunakan metode DPPH. Hasil pengujian antioksidan menunjukkan bahwa variasi kombinasi ekstrak H. itama propolis (EP) dan daun S. caseolaris (ESC) rasio 1:1 (IC50 56,6 ppm), 2:1 (IC50 71,5 ppm), 0:1 (IC50 50,36 ppm), dan 1:0 (IC50 73,13 ppm). Sedangkan rasio 1:2 memiliki nilai IC50 35,1 ppm dan kategori aktivitas antioksidan yang sangat kuat dibandingkan variasi kombinasi ekstrak lainnya. Hal ini menunjukan kombinasi ekstrak tersebut dapat bersinergi dalam meningkatkan aktivitas antioksidan.
Co-Authors Aat Arafat Abdul Aziz Abdul Aziz Abdul Aziz Abdullah, Nur Laras Suci Adimas Dwi Tyassandi Agnes Monica Ahmad Suwandi Ahmad Suwandi Ainul Andriani Aisyah Amalia Aisyah Nabila Aisyah, Novia Misnawati Aisyiyah, Novia Misnawati al farauqi, Mohamad dziqie aulia Al Khairy Siregar , Khalish Arsy Aldo Pratama Alfin Syahrian Dwi Nugraha Amilia, Andini Nur Andini Nur Amilia Anis Siti Nurrohkayati Anisa Rahmadani Annisa Aulia Annisa Nurul Safitri Arbainsyah Arbainsyah Armia, Argadhika Rizqy Aryantinur Azizah Asmiranda Agustinur Aulia Rahman Ayu Mentari, Ika Azzah Fatimah Zulfa Azzah Fatimah Zulfa Azzah Fatimah Zulfa Bambang Mego Hantoro Basyir, Ahmad Bunga Putri Sari Chaerul Fadly Mochtar Chairin Hanifa , Deasy Nur Chanchao, Chanpen Chantika Noor Khalifah Clara Vinny Amalia Deasy Nur Chairin Hanifa Deasy Nur Chairin Hanifa Defi Lusi Anggraeni Deswita Maharani Dewi , Dea Puspita Dinata, Reviana Amalia Diniatik Egi Liani Puspita Evita Novi Yanti Fadhillah, Reza Nur Fauziah, Fenty Fauziyah, Nur Fenty Fauziah Frederika Erwina Rani Hairunnisa, Indah Halida Suryadini Harlinda Kuspradini Helni Helni Ichsan, Muhammad Nor Ika Ayu Mentari Indah Hairunisa Irfan Muris Setiawan Irsa Nur Hanifah Jati Pratiwi Jubaidi Jundy Eko Wahyudi Kafka Navisa Suwarno Khairun Nisa Khalish Arsy Al Khairy Siregar Khalish Arsy Al Khairy Siregar Latipah, Asslia Johar Lestari, Ika Widya Luthfiyah Mega Srikandi Dimar Mardiana Mardiana Meliyana Dwi Pangesti Mistahul Khalil Gibran Muhammad Ali Syahbana Muhammad Alib Batistuta Muhammad Alib Batistuta Muhammad Alib Batistuta Muhammad Bayu , Radityo Muhammad Nor Ichsan Nanda Daru Wahdini Nindya Ila Syafira Ramelan Norma Lisa Novia Misnawati Aisyah Novia Misnawati Aisyiyah Novia Misnawati Aisyiyah Novia Misnawati Aisyiyah Nur Fadhilah Nur Supianti Nurfadillah, Mursidah Nurhikmah Nurhikmah Nurwandah Muftadah Oktavia Triwanti Pramesthi, Asri Dwi Endah Dewi Pratika, Rika Putri Hawa Syaifie Rabiatul Demiati Ramadhan, Donny Rendra Kurniawan Rendri Arista Avimaro Rendri Arista Avimaro Ressandy, Sylvan Septian Rika Nur Junnah Rika Pratika Rimba Jagat Cahya Purnama Riska Aulia Rizka Humaira Rizki Ramdani Rofidatul Husna Romadhona Suci Adinda Ruly Emi Ruswanti Sabina Guseynova Safitri, Annisa Nurul Salsa Hermadhiyaa Jauzaa Sarah, Aulia Shella Carlina Tasya Sinta Ratna Dewi Siregar, Khalis Arsy Al Khairy Siregar, Khalish Arsy Al Khairy Siska Siska Siti Rahma Siti Sulayha Suwandi, Ahmad Syahbana, Muhammad Ali Syahrul R, Syahrul Syahrul Ramadhan Syaifie, Putri Hawa Sylvan Septian Ressandy Taghfirul Azhima Yoga Siswa Tiara Halidah Ratnasari Tri Purwoningsih Veggy Nadia Yuliawan Veggy Nadya Yuliawan Vera Anitra Vera Herliana Pratiwi Vera Herliana Pratiwi Yanti, Evita Novi Yogi Pratama Yuliawan, Veggy Nadia Yuliawan, Veggy Nadya