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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Borneo Journal Of Pharmascientech Jurnal Sains dan Kesehatan
Yusuf, Helmy
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Studi in silico tentang naringin sebagai reseptor anti-HER-2 dalam pengobatan kanker payudara Abdurrahman, Abdurrahman; Rijal, Muh. Agus Syamsur; Yusuf, Helmy; Norhayati; Rizaldi, Gusti
BORNEO JOURNAL OF PHARMASCIENTECH Vol 8 No 2 (2024): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v8i2.535

Abstract

Overexpression of Human Epidermal Receptor-2 (HER-2) is the cause of the development of breast cancer, so HER-2 can be a target for anticancer therapy. Trastuzumab is the drug of choice in inhibiting the HER-2 receptor and tyrosine kinase, but the weakness of this drug is that drug resistance can occur. Naringin has potential as a breast cancer therapy. The research aims to determine the inhibiting overexpression of the HER-2 receptor by naringin using in silico method. Molecular docking has been carried out by optimizing naringin and trastuzumab, preparing the HER-2 protein target (PDB ID 3PP0), validating the molecular docking protocol, and docking naringin and trastuzumab on HER-2. The research produced a binding energy of -8,66 kcal/mol, while the binding energies of the original ligand and trastuzumab to HER-2 were -9,94 kcal/mol and -5,87 kcal/mol, respectively. The binding energy shows that naringin has potential as an anti-breast cancer agent as indicated by its stronger affinity for HER2.
Inovasi Produk Olahan Tahu dan Pengemasannya serta Pengembangan Pemasaran dalam Upaya Meningkatkan Pendapatan Perajin Tahu di Desa Karanganyar Kecamatan Wates Kabupaten Kediri: Innovation in Processed Tofu Products and Their Packaging and Marketing Development in an Effort to Increase the Income of Tofu Crafters in Karanganyar Village, Wates District, Kediri Regency Purwanto, Bambang Tri; Ekowati, Juni; Widiandani, Tri; Hariyadi, Dewi Melany; Hendradi, Esti; Yusuf, Helmy; Purnomo, Ahmad Toto; Ramadhani, Firmansyah Ardian; Siswandono, Siswandono; Wiyono, Anang Setyo; Yuliati, Ninis; Kristianingsih, Ida; Savitri, Orchidea Meidy Nurintan; Maulia, Arwinda; Rahman, Ave
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 11 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i11.8698

Abstract

MSMEs in the food sector are among the main supporters of Indonesia's economic activities. As a food production center in the form of tofu products, Kediri Regency is well known to the public, with white, yellow, silk, and other tofu products. Most of the tofu production carried out to date is only in the form of tofu products in their original form. This is because tofu craftsmen have not utilized other processed tofu products to increase their income. This community service activity aims to introduce innovations in processed tofu products, packaging, marketing, and processing of liquid tofu waste into new products which are expected to increase the income of tofu makers in Karanganyar village, Wates District, Kediri Regency. This community service activity was carried out using the media of presenting several materials and carrying out two-way interactive discussions. Evaluation of this activity was carried out with pre- and post-tests from the participants by answering 10 questions related to the three materials. The results obtained after being analyzed using the SPSS program showed differences between the pre-and post-tests of the participants, whereas the post-test results showed that the participants had understood the material provided during this activity. Thus, it can be concluded that this activity can be proven to be understood by the participants regarding innovation in processed tofu products and processing of tofu liquid waste.
Influence of Hesperetin Concentration in Poloxamer P84 and TPGS Mixed Micelles on Physical Characteristics and Cytotoxicity in T47D Cell Line Aulia, Nanda Intan; Rijal, Muh. Agus Syamsur; Yusuf, Helmy
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 1 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i12025.104-113

Abstract

Background: Hesperetin is a natural compound that has several properties including anticancer, but has limitation on low solubility in water. In this case, the development of a hesperetin delivery system using the micellar system is carried out. Objective: The current study aims to determine the effect of drug concentration on the physical characteristics and cytotoxicity of the mixed micelle. Methods: In this study, mixed micelles were formulated with D-a-tocopheryl polyethylene glycol 1000 succinate (TPGS) and poloxamer P84 as polymers through the thin film method, with hesperetin loaded at four different concentrations, i.e., 5 mg (F1), 10 mg (F2), 20 mg (F3), and 40 mg (F4). The mixed micelles were formulated using thin film hydration method. The evaluation of micelle’s physical characteristics was the measurement of particle size, Critical Micelle Concentration (CMC) value, drug loading, and drug entrapment efficiency. The evaluation of cytotoxicity used the T47D cell line and Micro Tetrazolium (MTT) method. Results: The CMC value of the mixed micelle was 0.0029% w/v, which was lower than the CMC of TPGS and poloxamer P84 only. The particle size of the micelles produced was between 17.07–20.37 nm. Among the various formulations, F3 showed relatively small particle size and has homogeneous particle size, high drug loading and encapsulation efficiency, and low IC50. Based on the study, particle size of F3 was 17.93  0.32 nm with polydispersity index (PDI) of 0.256 0.034. The drug loading percentage of F3 was 4.0092  0.0048% with an encapsulation efficiency of 94.5492 0.0013%. Based on cytotoxicity test using MTT method, F3 has low IC50, there was 4.036 ppm. Conclusion: Hesperetin-loaded mixed micelles offer potential as anticancer drugs that improve hesperetin efficacy. The results showed that F3 was the most potent anticancer formulation based on the physical characteristics and cytotoxicity tests.
Edukasi dan Pelatihan Pemanfaatan Tanaman Obat Keluarga di Desa Dlingo Bantul sebagai Upaya Pencapaian Tujuan SDGs di Bidang Kesehatan: Education and Training on the Use of Family Medicinal Plants in Dlingo Village, Bantul, as an Initiative to Support the Achievement of Health-Related SDGs Sukardiman, Sukardiman; Kusumawati, Idha; Handayani, Rosita; Sudjarwo, Sudjarwo; Munandar, Tristiana Erawati; Yusuf, Helmy; Diyah, Nuzul Wahyuning; Poerwono, Hadi; Purwanto, Bambang Tri
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 7 (2025): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v10i7.10042

Abstract

Global health issues have become increasingly urgent following the COVID-19 pandemic, which resulted in approximately 6.6 million deaths by 2022. This impact has prompted communities to revert to traditional medicines, aligning with the National Development Planning System (RPJPN) 2005-2025, which promotes a health paradigm through traditional remedies. Community service activities were carried out in partnership with the Ngudi Makmur Farmer Group (POKTAN) in Dlingo Village, Bantul Regency. The primary objective of this activity was to enhance residents’ knowledge in Dlingo Village regarding the benefits and processing of Family Medicinal Plants (TOGA). The methods employed included material development, counseling sessions, question-and-answer discussions, and direct practical training in the preparation of aromatherapy candles. Evaluation was undertaken using pretests and posttests, which demonstrated a significant increase in participants’ understanding. The average scores rose from 81.67 (pretest) to 132.5 (posttest), with a statistically significant difference (p <0.001). These findings indicate that the counseling was effective in improving knowledge about TOGA and its utilization in producing aromatherapy candles. Such activities not only enhance awareness but also reinforce community autonomy in managing traditional medicinal resources, in line with the health-related objectives of the Sustainable Development Goals (SDGs).
Efek Penambahan Kolesterol dan Tween 80 terhadap Karakteristik dan Stabilitas Fisik Liposom Hydrolyzed Collagen: The Effect of Adding Cholesterol and Tween 80 on the Physical Characteristics and Stability of Hydrolyzed Collagen Liposomes Amilia, Alya Nur; Rosita, Noorma; Yusuf, Helmy
Jurnal Sains dan Kesehatan Vol. 6 No. 1 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i1.2291

Abstract

Hydrolyzed collagen (HC) exhibits excellent anti-aging activity, but when applied topically, it faces limitations related to its physicochemical properties and low permeability to penetrate the skin. A system like liposomes is required. With the addition of cholesterol and Tween 80 surfactant to the liposome formulation, it is anticipated to enhance the characteristics and stability of the system in various combination ratios of Soy phosphatidylcholine: cholesterol: Tween 80, namely (F1= 4: 2: 1), (F2= 4: 1: 1), and (F3= 4: 1: 2). Characterization test results indicate that formula F3 exhibits the best characteristics, with respective values for particle size, PDI, zeta potential, and %EE being 63.26nm ± 0.73; 0.182 ± 0.011; 2.5mV ± 0.1; and 85.54% ± 0.20. Real-time stability test results, analyzed statistically using a Paired T-test, yield p-values for all three formulas (Sig 2-tailed) < 0.05, signifying a significant difference. Formula F2 demonstrates the smallest differences in particle size reduction and %EE. Hence, it can be observed that F2 stands out as the formula with the best characteristics and stability compared to F1 and F3. Keywords:          Characteristics; hydrolyzed collagen; liposomes; cholesterol; Tween 80   Abstrak Hydrolized Collagen (HC) memiliki aktivitas anti-aging yang sangat baik, namum secara topikal memiliki keterbatasan terkait sifat fisika kimia dan permeabilitasnya yang rendah untuk menembus kulit. Dibutuhkan suatu sistem seperti liposom. Dengan penambahan kolesterol dan surfaktan Tween 80 ke dalam formulasi liposom diharapkan akan meningkatkan karakteristik dan stabilitas sistem dalam beberapa perbandingan kombinasi formula Soy phospatidylcholine:  kolesterol: Tween 80 yaitu (F1= 4: 2: 1), (F2= 4: 1: 1), dan (F3= 4: 1: 2). Hasil uji karakteristik menunjukkan formula F3 memiliki karakteristik terbaik dengan nilai ukuran partikel, PDI, zeta potensial, dan %EE secara berturut-turut 63,26nm ± 0,73; 0,182 ± 0,011; 2,5mV ± 0,1; dan 85,54% ± 0,20. Hasil uji stabilitas real-time menunjukkan hasil analisis statistik menggunakan Paired T-test diperoleh p-value ketiga formula yaitu Sig (2- tailed) < 0,05, yang berarti terdapat perbedaan yang signifikan dan formula F2 yang memiliki selisih penurunan ukuran partikel dan %EE terkecil. Sehingga, dapat dilihat bahwa F2 merupakan formula yang memiliki karakteristik dan stabilitas paling baik dibandingkan dengan F1 dan F3. Kata Kunci:         Karakteristik; hydrolized collagen; liposom; kolesterol; tween 80
Co-Authors Abdurahman Abdurrahman Amilia, Alya Nur Anang Setyo Wiyono Aulia, Nanda Intan Bambang Tri Purwanto Diyah, Nuzul Wahyuning Esti Hendradi Hadi Poerwono Handayani, Rosita Hariyadi, Dewi Melany Ida Kristianingsih Idha Kusumawati Juni Ekowati Maulia, Arwinda Muhammad Agus Syamsur Rijal Munandar, Tristiana Erawati Ninis Yuliati, Ninis Noorma Rosita Norhayati Purnomo, Ahmad Toto Rahman, Ave Ramadhani, Firmansyah Ardian Rizaldi, Gusti Savitri, Orchidea Meidy Nurintan Siswandono, Siswandono Sudjarwo Sudjarwo Sukardiman Tri Widiandani