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All Journal Jurnal Kreativitas PKM Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Parapemikir Jurnal Ilmiah Farmasi Borneo Journal of Pharmacy
Jamaludin, Wahyudin Bin
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Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Physics Public Health

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DAUN Alphitonia incana (Roxb.) Teijsm. & Binn. ex Kurz SEBAGAI ANTI-Escherichia coli: STUDI IN SILICO DAN IN VITRO Ramadhan, Hafiz; Forestryana, Dyera; Jamaludin, Wahyudin Bin; Hadi, Ahmad Nur; Raudatunnisa
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan 2023: Webinar Nasional & Call For Paper
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i3.1701

Abstract

This research was conducted to determine the potential of phytochemical contents in producing antibacterial activity from 70% ethanol extract of Balik Angin leaves  (Alphitonia incana (Roxb.) Teijsm . & Binn. ex Kurz) against Escherichia coli bacteria in silico and in vitro. In silico assay of 20 compounds contained in Alphitonia species against the DNA gyrase receptor using PLANTs. Anti-E.coli activity assay of Balik Angin leaves macerated with 70% ethanol solvent using the Well diffusion method. In silico studies show that β-Sitosterol, Stigmasterol, Rutin, Kaempferol 3-O-rutinoside, and Zizyphoiside C have binding energies with DNA gyrase that can exceed Ciprofloxacin. The antibacterial assay results at a highest concentration of 26.56 mg/ml can provide an average inhibitory zone diameter of 12.75 ± 0.2 mm with a minimum inhibitory concentration (MIC) of 1.66 mg/ml (5.87 ± 1.5 mm). The 70% ethanol extract of Balik Angin leaves has the potential as an anti-Escherichia coli, supported by the content of phytochemical compounds that can act as DNA gyrase inhibitors.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK METANOL DAUN RAMANIA (Bouea macrophylla Griffith) TERHADAP BAKTERI Staphylococcus epidermidis Murniati, Murniati; Fitriyanti, Fitriyanti; Jamaludin, Wahyudin Bin
Parapemikir : Jurnal Ilmiah Farmasi Vol 13, No 1 (2024): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v13i1.5786

Abstract

Daun ramania (B. Macrophylla Griffith) memiliki banyak manfaat dalam bidang kesehatan. Salah satu pemanfaatan sebagai tumbuhan obat yaitu dapat berefek sebagai antibakteri. Tujuan dari penelitian ini adalah untuk mengetahui senyawa metabolit sekunder yang terkandung di dalam ekstrak metanol daun Ramania (B.macrophylla Griffith) dan untuk mengetahui aktivitas antibakteri ekstrak metanol daun ramania (B. macrophylla Griffith) dalam menghambat pertumbuhan bakteri S. epidermidis. Uji aktivitas antibakteri ekstrak dilakukan dengan metode difusi sumuran terhadap bakteri S. epidermidis dengan 5 konsentrasi yaitu konsentrasi 10%, 20%, 30%, 40% dan 50%. Kontrol positif Klindamisin 2µg/disk dan kontrol negatif Na-CMC 0,5%. Hasil skrining fitokimia ekstrak metanol daun Ramania (B. macrophylla Griffith) mengandung flavonoid, tanin, saponin, steroid, dan fenol. Hasil uji aktivitas antibakteri ekstrak metanol  daun ramania (B. macrophylla Griffith) memperoleh nilai rata-rata diameter zona hambat dari konsentrasi 10% yaitu 9,875 dengan kategori sedang, pada konsentrasi 20%, 30%, 40%, dan 50% yaitu memiliki nilai masing-masing 11,338 mm; 13,44 mm; 16,025 mm; 16,4 mm dengan kategori kuat. Sedangkan pada kontrol positif Klindamisin 2 µg/disk yaitu 24,55 mm dengan kategori sangat kuat dan kontrol negatif Na-CMC 0,5% tidak memiliki daya hambat. Berdasarkan hasil yang diperoleh, dapat disimpulkan bahwa ekstrak metanol daun ramania (B. Macrophylla Griffith) mempunyai kemampuan sebagai antibakteri dalam kategori sedang, kuat, sampai sangat kuat dalam menghambat bakteri S. epidermidis.
Anti-Rheumatoid Arthritis Activity of 96% Ethanol Extract of Eleutherine bulbosa Bulbs with Arthritis Induction Adjuvant Method Muthia, Rahmi; Wati, Helmina; Jamaludin, Wahyudin Bin; Kartini, Kartini; Setiawan, Finna; Zanirah, Gina Rizki
Borneo Journal of Pharmacy Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i4.4704

Abstract

An autoimmune condition known as rheumatoid arthritis (RA) results in chronic joint inflammation. Side effects that occur during long-term RA treatment are dangerous. Therefore, many people prefer herbal medicines, estimated to have lower side effects; one such herb is bawang dayak (Eleutherine bulbosa Urb.) bulbs. This study aimed to determine the class of compounds and the effective dose of the 96% ethanol extract of E. bulbosa bulbs, which had an anti-RA effect in the Wistar strain with the Adjuvant Induced Arthritis (AIA) model. Eleutherine bulbosa bulb extract was macerated with 96% ethanol. In the tests with extract doses of 100, 200, and 400 mg/KgBW and methylprednisolone 15 mg/KgBW, the induction used Complete Freund's Adjuvant (CFA). Treatment was provided from day eight through 21 of the test's 21-day duration. Phytochemical screening results contain alkaloids, flavonoids, phenols, quinones, saponins, steroids, and tannins. The percentage inhibition of edema volume and joint thickness, respectively, extract doses of 100, 200, 400 mg/KgBW, and methylprednisolone 15 mg/KgBW were 27.9585%, 49.3446%, 53.3239%, and 58.4629%; as well as 64.9809%, 73.8022%, 74.1444%, and 74.1825%. After analyzing the results, it was determined that E. bulbosa bulb extracts in 96% ethanol can treat RA at effective 200 and 400 mg/KgBW (p-value <0.05).
Edukasi, Pemeriksaan Gula Darah dan Pendampingan Pembuatan Produk Fermentasi Probiotik Cuka Apel sebagai Upaya Pencegahan diabetes Melitus Torizellia, Cast; Nafila, Nafila; Jamaludin, Wahyudin Bin; Rahayu, Aesty
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 7, No 8 (2024): Volume 7 No 8 (2024)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v7i8.15419

Abstract

ABSTRAK Jenis pengendalian DM antara lain pengaturan makan, olahraga dan alternatif herbal. Jenis pengobatan diabetes melitus antara lain dengan pemberian Obat Anti Diabetes Melitus (OAD) dari tenaga medis, injeksi insulin atau pemberian OAD dan injeksi insulin. Mahalnya biaya pengobatan DM memicu pencarian obat alternatif dari bahan alami yang dapat dijangkau oleh masyarakat serta memiliki efek samping minimal dibandingkan pengobatan kimia. Mitra yang dilibatkan dalam kegiatan pengabdian ini adalah mitra non produktif yang berada di Kelurahan Sungai Tiung Wilayah kerja Puskesmas Cempaka. Mitra tersebut terdiri dari masyarakat berusia 25 tahun hingga 65 tahun.  Kegiatan di mulai dari perencanaan dan persiapan yaitu studi pendahuluan, perizinan dan koordinasi dengan kader posyandu. Pelaksanaan kegiatan terdiri dari tiga kegiatan utama yaitu edukasi materi diabetes melitus, pemeriksaan kadar gula dalam darah dan pelatihan pembuatan produk. Hasil dalam kegiatan ini adalah terjadi peningkatan pengetahuan dan keterampilan masyarakat mengenai diabetes melitus dan pembuatan cuka apel. Pengabdian kepada masyarakat berjalan dengan lancar di buktikan dengan antusiasme masyarakat dalam mengikuti kegiatan. Terjadi perubahan tingkat pengetahuan antara sebelum dan sesudah diberikan penyuluhan. Kata Kunci: Edukasi, Diabetes Melitus, Cuka Apel  ABSTRACT Types of DM control include eating arrangements, exercise and herbal alternatives. Types of diabetes mellitus treatment include the administration of Anti-Diabetes Mellitus (OAD) drugs from medical personnel, insulin injections or OAD and insulin injections. The high cost of DM treatment triggers the search for alternative drugs from natural ingredients that can be reached by the public and have minimal side effects compared to chemical treatment. The partners consist of people aged 25 years to 65 years.  Activities start from planning and preparation, namely preliminary studies, licensing and coordination with posyandu cadres. The implementation of activities consists of three main activities, namely education on diabetes mellitus material, checking blood sugar levels and training on making products. The result of this activity is an increase in public knowledge and skills regarding diabetes mellitus and making apple cider vinegar. Community service runs smoothly as evidenced by the enthusiasm of the community in participating in activities. There was a change in the level of knowledge between before and after counseling. Keywords: Education, Diabetes Melitus, Appel Cider Vinegar
Co-Authors Cast Torizellia Chandra, M. Andi Fitriyanti Fitriyanti Fitriyanti, Fitriyanti Forestryana, Dyera Hadi, Ahmad Nur Helmina Wati Kartini Kartini Murniati . Nafila, Nafila Pambudi, Didik Rio Rahayu, Aesty Rahmi Muthia Ramadhan, Hafiz Raudatunnisa Setiawan, Finna Siti Kholilah, Siti Zanirah, Gina Rizki