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All Journal Journal of Biomedicine and Translational Research Jurnal Media Gizi Indonesia (MGI) Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Education The Indonesian Journal of Public Health Sari Pediatri Health Notions Amerta Nutrition Journal of Telenursing (JOTING) JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH Indian Journal of Forensic Medicine & Toxicology Archives of Pediatric Gastroenterology, Hepatology, and Nutrition Berita Kedokteran Masyarakat Asian Journal of Social and Humanities Jurnal Kesehatan Masyarakat Folia Medica Indonesiana
Nur Aisiyah Widjaja, Nur Aisiyah
Child Health Department, Faculty Of Medicine, Dr Soetomo General Hospital, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Effect of Different Complementary Feeding on Iron Deficiency Anemia and Growth in Breastfed Infants: Home-Made VS Commercial Irawan, Roedi; Widjaja, Nur Aisiyah; Hanindita, Meta Herdiana
Folia Medica Indonesiana Vol. 55, No. 2
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

After approximately 6 months of age, term breastfed infants are increasingly depend on other sources of iron to avoid iron deficiency anemia, due to the depletion of the low concentration of iron in human milk. The appropriate complementary feeding must include a balance composition of foods containing an adequate amount of macro- and micronutrients to avoid iron deficiency anemia. This study aimed to compare the risk of iron deficiency and growth in breastfeed infants receiving commercial fortified complementary foods or home-made. A cross-sectional study was held on April-June 2016 to evaluate infants aged 6-24 months with breast feeding intake for 6 month of life. Complementary feeding practices were determined by questionnaire; an unquantified food frequency and feeding practices questionnaire was used to determine usual food intake. Biochemical assessment of haemoglobin (Hb), serum ferritin (SF) and serum iron (SI) level were measured. Anthropometric were assessed using WHO Child Growth Standard 2005. Statistical analysis used were Chi-square Test. Thirty eight infants were enrolled, mean age of 16.2 (SD 10.5) months. 17 infants consumed commercial complementary foods and 21 infants use home-made. Infants with home-made had lower Hb level, SF and SI than those receiving commercial complementary food, and had higher risk of underweight, stunted and wasted. Infants with home-made complementary food had lower haemoglobin, serum feritin and serum iron levels than those in fortified complementary food CF; and a higher risk of stunted and wasted than children with commercial fortified CF.
Correlation of Neutrophil-Lymphocyte Ratio, Monocyte-Lymphocyte Ratio, and Platelet-Lymphocyte Ratio with Stunting in Children Stanpo, Gwyneth Trixie; Notopuro, Paulus Budiono; Widjaja, Nur Aisiyah
Journal of Biomedicine and Translational Research Vol 11, No 3 (2025): December 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i3.28088

Abstract

Background: Globally, stunting affected approximately 148 million children under five in 2022. Chronic infection contributes to stunting through immune hyperactivation and excessive cytokine release. Since anthropometric assessments are prone to errors and may not accurately reflect the underlying inflammatory status, common systemic inflammatory markers, such as the Neutrophil-Lymphocyte Ratio (NLR), Monocyte-Lymphocyte Ratio (MLR), and Platelet-Lymphocyte Ratio (PLR), can serve as alternatives. These markers are simple, affordable, and accessible in every health center.Objective: To analyze the correlation of NLR, MLR, and PLR with stunting.Methods: A cross-sectional study involving pediatric patients aged 1-5 years from the Nutrition and Metabolic Outpatient Clinic of Dr. Soetomo Regional Hospital in Surabaya from 2022 to 2023. Forty-one samples met the inclusion and exclusion criteria. Data on NLR, PLR, MLR, and other hematological variables were obtained from the patients' hematology profiles. Group differences, correlations, and diagnostic performance were analyzed using Kruskal–Wallis, Spearman, and ROC methods, respectively.Results: Forty-one subjects were obtained and divided into three groups: 21 (51.2%) normal, 10 (24.4%) stunted, and 10 (24.4%) severely stunted. RBC and lymphocytes significantly increased in normal patients, whereas neutrophils, platelets, NLR, MLR, and PLR significantly increased in severely stunted patients. NLR, MLR, and PLR differed significantly between normal and stunted children (p =<0.001; p =0.002; and p =<0.001, respectively) and showed positive correlations between the NLR (p =<0.001; r =0.687), MLR (p =<0.001; r =0.558), and PLR (p =<0.001; r =0.784) with stunting. At cutoff values of 0.844 (NLR), 88.527 (PLR), and 0.174 (MLR), their AUCs were 0.90, 0.95, and 0.82, with sensitivities of 75%, 80%, and 60%, respectively.Conclusion: NLR, MLR, and PLR significantly differ among normal, stunted, and severely stunted children, showing positive associations with stunting. These markers, particularly PLR, may serve as a practical screening tool, warranting further validation through larger studies.
InsuTAG and Early Salutogenic Screening of Cardiometabolic Risk in Obese Adolescents Inner Beauty Bilqis, Tiber Raniar; Widjaja, Nur Aisiyah; Devy, Shrimarti Rukmini; Indriani, Diah; Irawan, Nur Roedi; Hanindita, Meta Herdiana; Ardianah, Eva
Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Education Vol. 14 No. SI1 (2026): Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Educat
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jpk.V14.ISI1.2026.86-93

Abstract

Background: Insulin resistance (IR) is considered the common underlying cause of metabolic syndrome (MetS). Predicting the incidence of MetS and IR at the individual level is essential, especially in obese adolescents who are at high risk of cardiovascular disease (CVD). InsuTAG has shown reliable results in predicting IR and MetS in healthy elderly populations. This study aimed to investigate the use of InsuTAG as an assessment tool to predict IR and MetS in obese adolescents, using the homeostasis model assessment (HOMA) to quantify insulin resistance. Methods:  A cross-sectional analytic study was conducted from January to May 2020 in healthy obese adolescents aged 13-18 years-old. Blood analyses included lipid profile (LDL-c, HDL-c, total cholesterol, and triglycerides), fasting blood glucose, and fasting insulin. IR was defined as HOMA-IR > 5.22 for boys and > 3.82 for girls during the pubertal period. Results: The receiver operating characteristic (ROC) curve for InsuTAG demonstrated a greater area under the curve (AUC) for identifying IR than MetS (0.877 vs. 0.743, p = 0.000; 95% CI). The optimal InsuTAG cut-off to determine IR was > 23.48, with 78.43% sensitivity and 87.38% specificity. The cut-off to identify MetS was > 23.36, yielding 67.97% sensitivity and 72.82% specificity. Conclusion: InsuTAG is a useful tool for identifying IR and MetS. The optimal cut-off values are > 23.48 for IR and > 23.36 for MetS in obese adolescents. These findings support early prevention and health promotion efforts, ultimately strengthening self-care practices among obese adolescents.
RUTF: Could This Alternative Therapy be The Answer For Severely Malnourished Children In LMICs? a Critical Meta-Analysis Razan, Rafi Alfian; Widjaja, Nur Aisiyah; Shabrina, Farah Aisha; Ananda, Naoval Diza; Oktavian, Puguh
Media Gizi Indonesia Vol. 21 No. 2 (2026): MEDIA GIZI INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgi.v21i2.142-153

Abstract

Introduction: Childhood malnutrition in the under-5 age group represents a critical challenge to global health systems. Current WHO treatment protocols recommend standardized formula diet (F-100) following the stabilization period to facilitate catch-up growth. In recent years, Ready-to-Use Therapeutic Food (RUTF) has gained widespread adoption across low- and middle-income countries (LMIC) owing to its accessibility for community-level interventions. The established benchmark for appropriate weight gain in children between 6-60 months ranges from 5-10 g/kg/day. Objectives: The present investigation sought to evaluate the comparative effectiveness of RUTF versus F-100 in promoting weight gain among malnourished children. Methods: This investigation adhered to the 2020 PRISMA guidelines for systematic reviews and meta-analyses. Statistical analyses employed standard meta-analytic procedures with random effects modeling based on the classical DerSimonian–Laird approach, implemented in R version 4.4.1. Data from eight investigations involving 2084 participants were synthesized to evaluate the principal outcome of bodyweight increase. Results: Children receiving RUTF demonstrated significantly superior weight gain relative to those receiving F-100. RUTF administration resulted in an additional 2.96 g/kg/day weight gain compared to F-100 ([95% CI 1.82 to 4.16], p-value <0.001). Children managed with RUTF exhibited elevated rates of weight gain compared to F-100 recipients. Despite both interventions promoting weight increase, neither achieved the velocity necessary for adequate catch-up growth in LMIC children presenting with severe acute malnutrition (SAM). Conclusions: These findings emphasize the necessity for novel supplementation approaches to achieve optimal catch-up growth in children with SAM.
Co-Authors Adha, Aziza Zahrotul Alexander Leonard Caesar Josediputra Alexander, Yoppi Yeremia Alpha Fardah Athiyyah Amer Siddiq Amer Nordin Ananda, Naoval Diza Anggie Lorenza Ardianah, Eva Ardina Maharani, Putri Ariandi Setiawan Arief Wibowo Arifani, Rizka Azzahra', Lama'ah Bahmid, Moh Bahmid, Moh. Boerhan Hidayat Boerhan Hidayat, Boerhan Cahyanti, Ika Yuniar Christine Florens Christine Florens Claudia Felisia Magdalena Kurube Dewi Retno Suminar Diah Indriani Dina Angelika Dwi Lestari Avianti Eddy Bagus Wasito Febrina Mustika Santoso Hafiza Amadhin Rusti Hanindita, Meta Herdiana Hanindita, Meta Herdiana Hardiani, Kartika Hari Basuki Notobroto Harits, Muhammad Hendrayani, Ayu Ekanita HERMANTO, EDI Iitdrie Iitdrie, Iitdrie Inner Beauty Bilqis, Tiber Raniar Irawan, Nur Roedi Keya , Rino Tryanto Keya, Rino Tryanto Khadijah Rizky Sumitro Khadijah Rizky Sumitro KUNTORO Meity Ardiana Mochammad Bagus Qomaruddin Muthmainnah Muthmainnah Naoval Diza Ananda Notopuro, Paulus Budiono Noviyanti, Tausiyah Rohmah Noviyanti, Tausyiah Rohmah Nurfidaus, Yasmine Nurfirdaus, Yasmine Oktavian, Puguh Pebriaini, Prisma Andita Putri Ardina Maharani Rachmah Indawati Rafi Alfian Razan Razan, Rafi Alfian Rendi Aji Prihaningtyas Rendi Aji Prihaningtyas Rendi Aji Prihaningtyas Rendi Aji Prihaningtyas Rendi Aji Prihaningtyas Ria Puspitasari Roedi Irawan Rusti, Hafiza Amadhin Santoso, Febrina Mustika Shabrina, Farah Aisha Shrimarti Rukmini Devy Sigit Ari Saputro SITI NURUL HIDAYATI Soenarnatalina Melaniani Soenarnatalina, Melaniani Sri Widati Stanpo, Gwyneth Trixie Sulistiawati Vianca Samara Andhary Windhu Purnomo