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Darmawi .
Faculty Of Engimeering, Department Of Mechanical Engineering Of Sriwijaya University
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Journal : Indonesian Journal of Cancer

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Diagnostic Accuracy of CA-125 Levels for Ovarian Tumor Patients with Suspected Malignancy Pangaribuan, Machyuddin Tumpak Marojahan; Razali, Renardy Reza; Darmawi, Darmawi
Indonesian Journal of Cancer Vol 19, No 1 (2025): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i1.1159

Abstract

Background: Ovarian cancer is a deadly gynecological cancer that appears in ovarian tissue. To detect earlier stages of ovarian cancer and prevent unnecessary surgery, an examination and screening strategy with higher sensitivity and specificity levels are needed. The CA-125 examination is available at Arifin Achmad Hospital and has often been performed on ovarian tumor patients with suspected malignancy. Currently, the accuracy of the CA-125 examination still raises debate in diagnosing malignant ovarian tumors. This study aims to determine the diagnostic accuracy of CA-125 levels in diagnosing ovarian cancer in ovarian tumor patients with suspected malignancy at Arifin Achmad Hospital. Method: This research is an analytical diagnostic test study with a cross-sectional approach, using secondary data recorded from medical records from 2019 to 2022 on ovarian tumor patients with suspected malignancy at Arifin Achmad Regional Hospital.Results: The diagnostic accuracy of CA-125 levels in ovarian cancer is 94.5%, the optimal cut-off value is 36.5 IU/ml, the sensitivity is 86.1%, the specificity is 90.1%, the positive predictive value is 89.4%, the negative predictive value 86.9%. The results of the study showed that there was a significant age difference between benign ovarian tumors and ovarian cancer. The most common histopathological feature of benign ovarian tumors is serous cystadenoma. The most common histopathological feature of malignant ovarian tumors is serous adenocarcinoma. There is a significant relationship between CA-125 levels and ovarian tumors.Conclusion: The identification of CA-125 levels in diagnosing ovarian cancer in ovarian tumor patients with suspected malignancy was a promising test with high diagnostic accuracy level
Co-Authors A, Yufrizal Ademi, Gressha Vionalle Aini, Sabrina Ambiyar, Ambiyar Amiruddin Amiruddin Anas, Marnisyah Aneka Firdaus Angraini, Nani Angreini, Meliyantika Annisa, Aiza Apriyan, Dian Arenja, Regina Trisya Arman Sayuti Arsih, Ulfi Widi Arwizet Arwizet, Arwizet Awaluddin Awaluddin Beočanin, Anđelija Budi Syahri budianto panjaitan Dion, Selin Dwinna Aliza Dwisnu, Erlian Erianza, Dava Erwin Erwin Etriwati E Fadhil Fuad Rachman Ferdian, Riyan Giovani, Edo Habibie, Maulana Hasan, Denny Irmawati Hasan, Maryatun Helmi, T. Zahrial Heni Pujiastuti Husni Hidayat Irwin Bizzy Jamil, Kurnian Fitri Khairussyifa, Najmi Kurnia F. Jamil Kusuma, Herwin Wijaya Lalu Muhammad Irham Liansyah, Tita M. M Amin Indra Putra M. Nur Salim M. Syukri Ismail Maimun Syukri, Maimun Maryanti, Yossi Moliwati, Moliwati MS, Firdaus Mukamal, M. Farda Insan Muslim Akmal N. Nazaruddin Nathania, Auren Ningrum, Sania Devita Nora Usrina Nurhaspika, Nurhaspika Nuzul Asmilia Pangaribuan, Machyuddin Tumpak Marojahan Prawana, Yogi Ramadhani, Fitria Sari Razali Daud Razali, Renardy Reza S, Donel Safika S, Safika Saud, Eddy Setiawan, Sepdirama Sibuan, Sibuan Siti Aisyah Solly Aryza Sugeng Prasetyo Sugito - Suhandri, Wiwin Sukma, Zahwa Tamara Sumanto Sumanto Suparno Suparno Syafruddin Syafruddin Tabrani, Tabrani Taufiq Taufiq Ummu Balqis Usman, Said Wenny Novita Sari Winarto Winarto Wirawan Adikusuma Wiwit Ade Fidiawati Yenni Yusriani Yuliani Yuliani Zahra, Leina Putri Zamzami, Rumi Sahara Zikra, Izza Fattalia Zulkifli, Baidillah Zuraidawati Zuraidawati, Zuraidawati