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All Journal Jurnal Rekayasa Mesin Jurnal Ilmu Kedokteran (Journal of Medical Science) Pharmaciana: Jurnal Kefarmasian Jurnal Rekayasa Mesin Turbo : Jurnal Program Studi Teknik Mesin Al Qalam: Jurnal Ilmiah Keagamaan dan Kemasyarakatan Jurnal Literasiologi Teknomekanik Narra J Jurnal Farmanesia Indonesian Journal of Cancer Jurnal Kedokteran Hewan The International Journal of Tropical Veterinary and Biomedical Research Al-Muhith : Jurnal Ilmu Qur'an dan Hadits Jurnal Kewirausahaan dan Bisnis Jurnal Medika Veterinaria
Darmawi .
Faculty Of Engimeering, Department Of Mechanical Engineering Of Sriwijaya University
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Journal : Pharmaciana: Jurnal Kefarmasian

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Repurposing drugs in endometrial cancer using genomic variants database Darmawi, Darmawi; S, Donel; Suhandri, Wiwin; Winarto, Winarto; Adikusuma, Wirawan; Irham, Lalu Muhammad; Fidiawati, Wiwit Ade; Razali, Renardy Reza; Nathania, Auren; Zahra, Leina Putri
Pharmaciana Vol. 13 No. 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.27201

Abstract

Endometrial cancer (EC) is the fourth most frequent gynecological cancers, and its incidence and mortality rates have increased over the last decade. Cytotoxic therapy with carboplatin and paclitaxel is the recommended first-line treatment for EC patients. However, the options for following therapy are limited. The latest advances in molecular studies have uncovered the nature of genetic alterations in EC, compelling methods for further research into the treatment of EC since they may disclose to tailored pharmacological therapy. The aim of this study to identify novel drug candidates in treating EC using genomics variants and biological pathway. The genomic variants of  EC were downloaded from cBioportal database. We established connection between the biological EC risk genes from cBioportal database and the DrugBank database. Finally, we used Connectivity Map (CMap) analysis to identify possible drugs whose mechanisms coincided with therapeutic targets and rank them based on the scoring system. We identified novel potential candidate drugs for EC, they are Bosutinib and Nilutamide which exhibit robust scores in the CMap analysis compare to paclitaxel. We also discovered BCR-ABL1 and AR as potential biomarker-driven therapy in EC. This study demonstrates the possibility of using genetic network analysis combined with bioinformatics to repurpose drugs for the treatment of EC. Further study will investigate the mechanisms of using BCR-ABL1 and AR targeting in the treatment of EC.
Co-Authors A, Yufrizal Ademi, Gressha Vionalle Aini, Sabrina Ambiyar, Ambiyar Amiruddin Amiruddin Anas, Marnisyah Aneka Firdaus Angraini, Nani Angreini, Meliyantika Annisa, Aiza Apriyan, Dian Arenja, Regina Trisya Arman Sayuti Arsih, Ulfi Widi Arwizet Arwizet, Arwizet Awaluddin Awaluddin Beočanin, Anđelija Budi Syahri budianto panjaitan Chatarina Umbul Wahyuni Dion, Selin Dwinna Aliza Dwisnu, Erlian Erianza, Dava Erwin Erwin Etriwati E Fadhil Fuad Rachman Ferdian, Riyan Giovani, Edo Habibie, Maulana Hasan, Denny Irmawati Hasan, Maryatun Helmi, T. Zahrial Heni Pujiastuti Husni Hidayat Irwin Bizzy Jamil, Kurnian Fitri Khairussyifa, Najmi Kurnia F. Jamil Kusuma, Herwin Wijaya Lalu Muhammad Irham Liansyah, Tita M. M Amin Indra Putra M. Nur Salim M. Syukri Ismail Maimun Syukri, Maimun Maryanti, Yossi Moliwati, Moliwati MS, Firdaus Mukamal, M. Farda Insan Muslim Akmal N. Nazaruddin Nathania, Auren Ningrum, Sania Devita Nora Usrina Nurhaspika, Nurhaspika Nuzul Asmilia Pangaribuan, Machyuddin Tumpak Marojahan Prawana, Yogi Ramadhani, Fitria Sari Razali Daud Razali, Renardy Reza S, Donel Safika S, Safika Saud, Eddy Setiawan, Sepdirama Sibuan, Sibuan Siti Aisyah Solly Aryza Sugeng Prasetyo Sugito - Suhandri, Wiwin Sukma, Zahwa Tamara Sumanto Sumanto Suparno Suparno Syafruddin Syafruddin Tabrani, Tabrani Taufiq Taufiq Ummu Balqis Usman, Said Wenny Novita Sari Winarto Winarto Wirawan Adikusuma Wiwit Ade Fidiawati Yenni Yusriani Yuliani Yuliani Zahra, Leina Putri Zamzami, Rumi Sahara Zikra, Izza Fattalia Zulkifli, Baidillah Zuraidawati Zuraidawati, Zuraidawati