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All Journal Jurnal Ilmiah Farmasi PHARMACON Jurnal Penelitian Farmasi Indonesia Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Pengabdian Masyarakat AbdiMas AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT Jurnal Ilmiah Farmasi Farmasyifa Jurnal Kefarmasian AKFARINDO Berkala Ilmiah Mahasiswa Farmasi Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Abdi Masyarakat Kita Jurnal Pengabdian Masyarakat (Jupemas) Jurnal Komunitas Farmasi Nasional PharmaCine: Journal of Pharmacy, Medical and Health Science Indonesian Journal of Herbal Science and Innovation Journal of Pharmascience
Istiqomah, Aulia Nurfazri
Universitas Bhakti Kencana
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Evaluation of Subchronic Toxicity of Costus speciosus Rhizome Through Changes in Renal Function in White Rats Aulia Nurfazri Istiqomah; Ogi Dienda Pratama; Agus Sulaeman
Indonesian Journal of Herbal Science and Innovation Vol. 1 No. 2 (2025): Indonesian Journal of Herbal Science and Innovation (IJHerbSI)
Publisher : PT CENDEKIA SCIENCE AND TECHNOLOGY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64673/ijherbsi.v1i2.10

Abstract

Costus speciosus (commonly known as pacing rhizome) has been traditionally used for various therapeutic purposes, yet data on its long-term safety, particularly regarding renal function, remain limited. This study aimed to evaluate the subchronic toxicity of C. speciosus rhizome extract through renal function assessment in white Wistar rats, addressing a critical gap in preclinical safety evidence and supporting the development of standardized herbal preparations. Forty healthy Wistar rats, equally divided by sex, were acclimatized for seven days and randomly assigned to control and treatment groups. The treatment group received C. speciosus rhizome extract orally at a dose of 300 mg/kg body weight daily for 90 days, while the control group received a vehicle solution (Na-CMC). Body weight was monitored regularly, and at baseline (T0) and at the end of the study (T90), blood samples were collected for biochemical analysis of serum creatinine and urea levels. Additionally, kidney organ indices were determined, and histopathological examinations were performed to detect potential structural changes. The results indicated that body weight gain in both male and female rats was comparable between control and treatment groups throughout the study, with no statistically significant differences. Serum creatinine and urea levels remained within normal physiological ranges at both T0 and T90, and no significant differences were observed between groups. Kidney organ indices showed minor variations that were not statistically significant, and histopathological evaluation revealed no treatment-related abnormalities. In conclusion, subchronic oral administration of C. speciosus rhizome extract at 300 mg/kg body weight for 90 days did not produce nephrotoxic effects in Wistar rats. The extract was well tolerated, and renal function remained intact, supporting its safety profile. These findings provide foundational evidence for the safe development of C. speciosus as a standardized herbal medicinal product, addressing the urgent need for scientifically validated data on its long-term safety.
Potensi Anti-inflamasi Ekstrak Euphorbia heterophylla Desf.: Penelitian In Vitro dan In Vivo Elis Susilawati; Intan Pertiwi; Aulia Nurfazri Istiqomah; Yasminwar Susilawati; Jutti Levita; Sri Adi Sumiwi
Journal of Pharmascience Vol. 12 No. 2 (2025): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v12i2.23814

Abstract

Masyarakat secara tradisional menggunakan daun Kate Mas (Euphorbia heterophylla Desf.) untuk mengatasi kesulitan buang air besar. Penelitian sebelumnya melaporkan daun E. heterophylla memiliki aktivitas antioksidan DPPH dan anti-inflamasi pada tikus diinduksi karagenan. Penelitian ini bertujuan untuk menganalisis pengaruh pemberian ekstrak E. heterophylla (EEH) secara in vitro pada suspensi sel darah merah yang diinduksi larutan hipotonik, serta untuk mengevaluasi efek EEH dalam uji in vivo pada hewan yang diinduksi dengan larutan putih telur 1%. Studi in vitro menggunakan metode HRBC (Human Red Blood Cell) dengan darah yang dirusak larutan hipotonik sebagai media uji yang diukur menggunakan spektrofotometer UV-vis pada panjang gelombang 560 nm. Metode in vivo dilakukan pada tikus yang dibagi secara acak menjadi lima kelompok (n=5): kelompok kontrol positif (Na-CMC), kelompok pembanding (diklofenak natrium 4,5 mg/kg BB), dan tiga kelompok uji (EEH 50, 100, 200 mg/kg BB). Semua kelompok diinduksi dengan putih telur 1% pada telapak kaki tikus. Parameter yang diukur adalah nilai IC50 dan persentase inhibisi edema pada kaki tikus setiap 30 menit selama 180 menit. Hasil: Skrining metabolit sekunder pada EEH menunjukkan adanya flavonoid, alkaloid, saponin, tanin, kuinon, dan steroid/triterpenoid. EEH menunjukkan nilai IC50 yang tergolong aktif sebagai anti-inflamasi dan mampu mengurangi volume edema. Kesimpulan: EEH berpotensi untuk dikembangkan sebagai pengobatan anti-inflamasi. Kata Kunci: Anti-Inflamasi, Euphorbia heterophylla, Putih Telur, Larutan Hipotonik, Human Red Blood Cell The community traditionally uses Kate Mas (Euphorbia heterophylla Desf.) leaves to alleviate constipation. Previous studies reported that E. heterophylla leaves possess DPPH antioxidant and anti-inflammatory activities in carrageenan-induced rats. This study aims to analyze the effect of E. heterophylla extract (EEH) administration in vitro on red blood cell suspensions induced by a hypotonic solution, and to evaluate the effects of EEH in vivo on animals induced with 1% egg white solution. The in vitro study was conducted using the Human Red Blood Cell (HRBC) method, where red blood cells were subjected to damage by a hypotonic solution as the test medium. The measurement was performed using a UV-Vis spectrophotometer at a wavelength of 560 nm. The in vivo method was conducted on rats randomly divided into five groups (n=5): positive control group (Na-CMC), comparison group (diclofenac sodium 4.5 mg/kg BW), and three test groups (EEH 50, 100, 200 mg/kg BW). All groups were induced with 1% egg white on the rat's paw. The parameters measured were the IC50 value and the percentage of edema inhibition in the rat’s paw every 30 minutes for 180 minutes. Results: Secondary metabolite screening of EEH showed the presence of flavonoids, alkaloids, saponins, tannins, quinones, and steroids/triterpenoids. EEH demonstrated an IC50 value classified as active anti-inflammatory and was able to reduce edema volume. Conclusion: EEH has the potential to be developed as an anti-inflammatory treatment.
POTENSI KOMBINASI EKSTRAK ETANOL DAUN DADAP SEREP (Erythrina subumbrans) DAN PEGAGAN (Centella asiatica) DALAM MENURUNKAN RISIKO DISFUNGSI ENDOTEL PADA TIKUS DENGAN DIET TINGGI FRUKTOSA Marita Kaniawati; Agus Sulaeman; Aulia Nurfazri Istiqomah; Kevin Efraim Lian
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2875

Abstract

Fructose has long been known as a sugar additive or sweetener, commonly found in soft drinks, pastries, and other processed foods. High levels of added sugar in the daily diet increase the risk of various metabolic disorders, including insulin resistance. Insulin resistance can lead to impaired endothelial function (endothelial dysfunction), which can lead to impaired vasodilation responses. Endothelial dysfunction can lead to an increased risk of cardiovascular diseases such as atherosclerosis, coronary heart disease (CHD), hypertension, and other vascular diseases. The aim of this study was to identify the potential of a combination of dadap serep (Erythrina subumbrans) and pegagan (Centella asiatica) to reduce the risk of endothelial dysfunction (as measured by nitric oxide (NO) levels) triggered by high fructose consumption. This research method is an in vivo experimental preventive using 36 rats divided into normal group, induction group, comparison group of curcumin 9 mg/kgBW, test group 1 EEPDS 50:100 mg/kgBW, test group 2 EEPDS 100:100 mg/kgBW and test group 3 EEPDS 100:50 mg/kgBW. Measurement of NO levels using the Griess method, while insulin resistance examination was carried out using the insulin tolerance test method. The results showed that the combination group of EEPDS 100:50 mg/kgBW was the group that showed the most optimal effect in maintaining endothelial function and had the best insulin sensitivity. The conclusion of this study shows that the combination of EEPDS 100:50 mg/kgBW is effective in maintaining insulin sensitivity and maintaining endothelial function in rats.
POTENSI ANTIATEROGENIK KOMBINASI EKSTRAK ETANOL RIMPANG KUNYIT DAN DAUN PEGAGAN DALAM MENURUNKAN RISIKO PENYAKIT KARDIOVASKULAR PADA MODEL HEWAN TIKUS OBES Kharina Septi Lestari; Aulia Nurfazri Istiqomah; Ai Siti Farihah; Dika Azhar Ramadhan; Marita Kaniawati; Agus Sulaeman
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2882

Abstract

Obesity is a major risk factor for atherosclerosis and cardiovascular disease, characterized by dyslipidemia and oxidative stress. This study aimed to evaluate the anti-atherogenic effects of a combination of ethanol extracts of turmeric rhizome (Curcuma longa) and gotu kola leaves (Centella asiatica) in obese–hyperlipidemic rats.  Male rats were divided into seven groups: normal, induction, comparator (orlistat 10.8 mg/kgBW), and treatment groups receiving single and combined extracts (ERK, EDP, ERKDP 200:100, ERKDP 100:200 mg/kgBW). Obesity and hyperlipidemia were induced using a high-fat and fructose diet for 60 days. Parameters measured included body weight, lipid profile (TG, HDL, LDL, total cholesterol), Atherogenic Index of Plasma (AIP), and aortic histology. The induction group showed significant increases in body weight, triglycerides, LDL, and AIP (P<0.05). All treatment groups significantly improved lipid profiles and reduced AIP compared to the induction group. The ERKDP 100:200 mg/kgBW combination showed the most optimal effect, with a 51.83% reduction in LDL, a 54.60% decrease in AIP, and a 146% increase in HDL. Histological analysis also demonstrated reduced foam cell formation and improved aortic structure in this group. In conclusion, the combination of turmeric and gotu kola extracts, particularly at a dose of 100:200 mg/kgBW, exhibits significant anti-atherogenic potential through lipid profile improvement, AIP reduction, and vascular protection.
Co-Authors Agus Miraj Darajat Agus Sulaeman Agus Sulaeman Agus Sulaeman Ai Siti Farihah Anissa Nadya Oktriyani Aulia Utami Widiati Betti Risa O Boy Ignatius Simamora Budiana, Wempi Budy Nugraha Denny Galang Dian Eka Fakhira Dika Azhar Ramadhan Elis Susilawati Elis Susilawati Fikri Mourly Wahyudi Hapipah Nurjamilah Hasimun, Patonah Hendra Mahakam Putra Ida Lisni Imas Fauzya Zahra Intan Pertiwi Jumiatun Jumiatun Jutti Levita Kevin Efraim Lian Kharina Septi Lestari Marita Kaniawati Marita Kaniawati Ning Hayati Novitasari Tsamrotul Fuadah Nurfadillah, Ilham Ogi Dienda Pratama Oktriyani, Anissa Nadya PERTIWI, INTAN Pratama, Reza Putra, Hendra Mahakam Raihany Sholihatul Reza Pratama Roni, Asep Sekar Wulan Apriliasari Shintya Safitri Silvi Nur Amalia Simamora, Boy Ignatius Siti Kholisatun Nisa Sri Adi Sumiwi Susilawati, Elis Susilawati, Yasminwar Sutrisno, Entris Tri Nurjayanti Wahyu Wahdana Wahyudi, Vierly Stephany Putri Widhya Aligita Widhya Aligita Yani Mulyani Yasminwar Susilawati Yermia Ademi Dedeo Zaelani, Diki