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All Journal Jurnal Ilmiah Farmasi PHARMACON Jurnal Penelitian Farmasi Indonesia Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Pengabdian Masyarakat AbdiMas AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT Jurnal Ilmiah Farmasi Farmasyifa Jurnal Kefarmasian AKFARINDO Berkala Ilmiah Mahasiswa Farmasi Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Abdi Masyarakat Kita Jurnal Pengabdian Masyarakat (Jupemas) Jurnal Komunitas Farmasi Nasional PharmaCine: Journal of Pharmacy, Medical and Health Science Indonesian Journal of Herbal Science and Innovation Journal of Pharmascience
Istiqomah, Aulia Nurfazri
Universitas Bhakti Kencana
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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PELATIHAN PEMANFAATAN BAHAN HERBAL SEBAGAI JAMU IMUNOSTIMULAN BAGI KELOMPOK PKK RW 001 DESA MAJASETRA KECAMATAN MAJALAYA KABUPATEN BANDUNG Aulia nurfazri istiqomah; Asep Roni; Kharina Septi Lestari; Fikri Mourly Wahyudi; Agus Miraj Darajat; Novitasari tsamrotul fuadah
Jurnal Pengabdian Masyarakat (Jupemas) Vol 2, No 2 (2021)
Publisher : Universitas Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jupemas.v2i2.859

Abstract

Sampai saat ini, dapat dikatakan kita masih berada dalam kondisi pandemic COVID-19, khususnya di Indonesia. Telah kita ketahui bersama bahwa dalam menghadapi pandemic COVID-19 ini kita harus menjaga sistem kekebalan tubuh untuk meminimalisir kemungkinan terpaparnya tubuh oleh virus COVID-19 dan patogen lainnya. Program pengabdian kepada masyarakat ini dilaksanakan di Kp. Pangkalan RW. 001 Desa Majasetra, Kecamatan Majalaya, Kabupaten Bandung berupa pelatihan pemanfaatan bahan herbal sebagai jamu imunostimulan atau peningkat daya tahan tubuh kepada kelompok PKK setempat yang nantinya akan disebarluaskan kepada masyarakat. Dari hasil pelaksanaan kegiatan pengabdian kepada masyarakat ini, warga RW 001 Kp. Pangkalan, Desa Majasetra, Kecamatan Majalaya, Kabupaten Bandung telah menerima pemahaman akan pentingnya menjaga daya tahan tubuh terlebih dalam situasi pandemi dengan memanfaatkan bahan-bahan yang ada di sekitar kita.
Aktivitas Ekstrak Daun Keji Beling (Strobilanthes crispus Blume.) Pada Model Hewan Resistensi Insulin yang Diinduksi Pakan Tinggi Lemak dan Fruktosa Istiqomah, Aulia Nurfazri
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol. 10 No. 2 (2023): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v10i2.114

Abstract

Introduction: Various herbal plants are known to have activity towards increasing insulin sensitivity so that they have the potential to be used for the treatment of diabetes. One of the medicinal plants with this activity is the keji beling leaves (Strobilanthes crispus Blume). Several previous studies have used animal models of insulin resistance due to consumption of high- fat and fructose foods. Therefore, the purpose of this study was to determine the activity of ethanol extract of keji beling leaves on increasing insulin sensitivity in animal models of insulin resistance induced by high-fat and fructose diets. Methods: The method used to create insulin resistance animal models is by giving a high-fat and fructose diet 1800 mg/kgBB preventively for 42 days. The test animals were grouped into 6 groups, namely the negative control group, positive control, metformin 45mg/kgBW, Keji Beling Leaf Ethanol Extract 75mg/kgBB, 150mg/kgBW and 300mg/kgBW. The parameters observed were the value of fasting blood glucose levels on days 0 and 42 and the constant value of the insulin tolerance test (KTTI) on days 0, 21 and 42. Result: Ethanol extract of keji beling leaves had activity towards increasing insulin sensitivity, namely the dose of 75 mg/kgBW with an average reduction value of 12.57, a dose of 150 mg/kg BW with a value of 14.88 and a dose of 300 mg/kg BW with a value of 17.66. Conclusion: The ethanol extract of keji beling leaves has activity in increasing insulin sensitivity with the most effective dose being 150 mg/kgBW.
PELATIHAN PEMBUATAN TEH HERBAL UNTUK MENINGKATKAN KUALITAS KESEHATAN MASYARAKAT DI DESA CIBIRU WETAN Istiqomah, Aulia Nurfazri; Roni, Asep; Budiana, Wempi; Lisni, Ida; Zaelani, Diki; Sutrisno, Entris
Jurnal Pengabdian Masyarakat (Jupemas) Vol 5, No 1 (2024)
Publisher : Universitas Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jupemas.v5i1.1285

Abstract

The current condition of Indonesia can be said to be facing a triple burden. Based on research results from the Central Statistics Agency, the percentage of the population, especially the population of West Java, who had health complaints during the last month in 2022 showed an increase compared to the previous year (2021), this is of course related to the quality of public health. The problem currently faced by partners is the lack of information and education regarding the processing of nutritious plants. So far, the crops obtained have been used in simple ways, eaten directly as fresh vegetables or processed as food.This time the community service program was carried out in Cibiru Wetan Village, Cileunyi District, Bandung Regency. Activities include providing education regarding efficacious herbal plants and tutorials on making herbal tea as an effort to improve the quality of health.From the results of implementing this community service activity, the residents of Cibiru Wetan Village, Cileunyi District, Bandung Regency have understood the ingredients that can be used in an effort to improve the quality of health and one way of processing them
Proteksi Ekstrak Rimpang Pacing Terhadap Resistensi Insulin pada Model Hewan yang Diinduksi Pakan Tinggi Lemak Dan Fruktosa Aulia Nurfazri Istiqomah, Aulia Nurfazri Istiqomah; Kharina Septi Lestari; Imas Fauzya Zahra
Jurnal Komunitas Farmasi Nasional Vol. 4 No. 1 (2024): Jurnal Komunitas Farmasi Nasional
Publisher : Akademi Farmasi Yarsi Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Insulin resistance is a condition where the sensitivity of cells or tissues to insulin decreases, which is one of the main factors causing type 2 diabetes mellitus. Current diabetes therapy is still limited to synthetic drugs which can cause side effects, so alternative diabetes therapy is being sought. using natural materials, one of which is using pacing. The pacing rhizome plant contains the compound diosgenin which has antidiabetic properties. This study aims to determine the activity of ethanol extract of pacing rhizomes in increasing insulin sensitivity and the effective dose in increasing insulin sensitivity. Testing was carried out preventively using an animal model of insulin resistance induced by high fat and fructose feed orally for 42 days. The test animals were divided into six groups, namely normal, induction, comparison metformin 45 mg/KgBW, ethanol extract of rhizome pacing (EERP) dose 150 mg/KgBW, 300 mg/KgBW and 450 mg/KgBW. The parameters measured were blood glucose levels and insulin tolerance test constants. From the research results, it was found that ethanol extract of pacing rhizome at a dose of 300 mg/KgBW could increase insulin sensitivity. Keywords: insulin resistance, pacing, blood glucose levels, Costus speciosus
PENETAPAN TOKSISITAS AKUT DAN SUBKRONIK PADA EKSTRAK ETANOL DAUN KATUK (Sauropus androgynus (L). Merr) Putra, Hendra Mahakam; Sulaeman, Agus; Nurfazri Istiqomah, Aulia; Nurfadillah, Ilham
Majalah Farmasi dan Farmakologi Vol. 27 No. 3 (2023): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v27i3.26462

Abstract

Daun katuk (Sauropus androgynus) dapat digunakan sebagai obat herbal karena kaya akan kandungan metabolit sekunder dan nutrisi. Untuk menjamin keamanan dalam penggunaannya sebagai obat herbal, dilakukan uji toksisitas akut dan toksisitas subkronik dengan menggunakan ekstrak etanol daun katuk pada tikus wistar betina dengan mengacu pada dosis uji dari OECD dan Badan Pengawas Obat dan Makanan (BPOM) yaitu dosis tunggal 300 mg/kg bb, 2.000 mg/kg bb, 5.000 mg/kg bb untuk uji toksisitas akut dan dosis harian 50 mg/kg bb, 100 mg/kg bb, 200 mg/kg bb untuk uji toksisitas subkronik. Tikus diamati setiap hari untuk gejala toksik masing-masing selama 14 dan 28 hari, dan pada hari ke 0 dan 28, untuk uji toksisitas subkronik dilakukan pengukuran biokimia darah yaitu SGOT, SGPT, dan Kreatinin. Di akhir percobaan, indeks berat organ juga ditentukan untuk semua tikus. Hasil penelitian menunjukkan bahwa pemberian ekstrak etanol daun katuk tidak menimbulkan gejala toksik dan tidak menyebabkan kematian pada hewan uji. Pemberian ekstrak daun katuk juga tidak mempengaruhi bobot badan secara signifikan jika dibandingkan dengan kelompok yang diberi N-CMC 1%. Hasil uji biokimia SGOT, SGPT, dan kreatinin juga dalam batas normal dan tidak ada perbedaan bermakna (p>0,05) antara kelompok normal dan kelompok uji. Oleh karena itu, penelitian ini dapat disimpulkan bahwa ekstrak etanol daun katuk praktis tidak toksik dengan nilai LD50 >5.000 mg/kg bb dan aman digunakan untuk konsumsi sehari-hari.
DAUR ULANG MINYAK JELANTAH : EDUKASI DAN PEMANFAATAN LIMBAH MENJADI PRODUK RAMAH LINGKUNGAN Istiqomah, Aulia Nurfazri; Pratama, Reza
Jurnal Pengabdian Masyarakat AbdiMas Vol 11, No 03 (2025): Jurnal Pengabdian Masyarakat Abdimas
Publisher : Universitas Esa Unggul

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47007/abd.v11i03.8783

Abstract

Minyak jelantah, yang sering dianggap sebagai limbah rumah tangga, dapat memberikan dampak buruk terhadap lingkungan jika tidak dikelola dengan baik. Namun, limbah ini memiliki potensi untuk didaur ulang menjadi produk bermanfaat seperti sabun. Tim dosen Fakultas Farmasi Universitas Bhakti Kencana melaksanakan edukasi dan pelatihan di Desa Majasetra, Kecamatan Majalaya, Kabupaten Bandung, untuk meningkatkan kesadaran masyarakat terkait pengelolaan minyak jelantah. Kegiatan ini melibatkan pengumpulan bahan pada 15 November 2024 dan pelaksanaan edukasi serta pelatihan pada 21 November 2024. Hasil kuisioner menunjukkan adanya peningkatan signifikan pada pemahaman warga mengenai risiko penggunaan minyak jelantah berulang dan cara pengolahannya menjadi sabun. Pendekatan ini tidak hanya mengedukasi warga tentang pentingnya pengelolaan limbah rumah tangga, tetapi juga membekali mereka dengan keterampilan praktis untuk menghasilkan produk ramah lingkungan yang bernilai ekonomis. Edukasi ini diharapkan dapat berkontribusi pada keberlanjutan lingkungan dan pemberdayaan masyarakat.
UJI AKTIVITAS INHIBISI TIROSINASE EKSTRAK ETANOL RIMPANG PACING (Costus speciosus) Lestari, Kharina Septi; Wahyudi, Vierly Stephany Putri; Kaniawati, Marita; Istiqomah, Aulia Nurfazri; Pratama, Reza
Jurnal Kefarmasian Akfarindo Vol 11 No 1 (2026)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.1235

Abstract

Melanin merupakan pigmen utama yang menentukan warna kulit, namun produksinya yang berlebihan dapat menyebabkan hiperpigmentasi seperti melasma. Enzim tirosinase memiliki peran penting dalam biosintesis melanin, sehingga penghambatan aktivitas enzim ini menjadi target utama dalam penanganan hiperpigmentasi. Rimpang pacing (Costus speciosus) diketahui mengandung berbagai senyawa metabolit sekunder seperti flavonoid, fenolik, tanin, dan saponin yang dilaporkan memiliki aktivitas antioksidan serta berpotensi menghambat aktivitas tirosinase. Penelitian ini bertujuan untuk mengetahui aktivitas inhibitor tirosinase dari ekstrak etanol rimpang pacing (Costus speciosus), menentukan nilai persen inhibisi, serta nilai IC₅₀-nya. Penelitian ini merupakan penelitian eksperimental laboratorium yang dilakukan secara in vitro. Ekstraksi dilakukan menggunakan metode maserasi dengan pelarut etanol 96%. Penapisan fitokimia menunjukkan adanya kandungan flavonoid, alkaloid, tanin, saponin, steroid, dan senyawa fenolik. Uji aktivitas tirosinase dilakukan secara in vitro menggunakan metode ELISA dengan substrat L-DOPA dan enzim mushroom tyrosinase, serta pengukuran absorbansi pada panjang gelombang 490 nm. Data persen inhibisi dihitung dari nilai absorbansi hasil pengujian, kemudian digunakan untuk menentukan nilai IC₅₀ melalui analisis hubungan antara konsentrasi sampel dan persen inhibisi. Hasil penelitian menunjukkan bahwa ekstrak etanol rimpang pacing memiliki aktivitas penghambatan enzim tirosinase dengan persentase inhibisi tertinggi sebesar 65,91% pada konsentrasi 10.000 ppm. Aktivitas penghambatan ekstrak tergolong lebih lemah dibandingkan kontrol positif asam kojat yang memiliki nilai IC₅₀ sebesar 45,96 ppm. Dengan demikian, ekstrak rimpang pacing memiliki potensi sebagai agen anti-hiperpigmentasi alami, namun masih memerlukan pengembangan lebih lanjut untuk meningkatkan efektivitasnya.
Uji Toksisitas Subkronik Ekstrak Etanol Daun Sidaguri (Sida Rhombifolia L.) Terhadap Fungsi Hati dan Ginjal Pada Tikus: Subchronic Toxicity of Ethanol Extract of Sidaguri Leaves (Sida Rhombifolia L.) on Liver and Kidney Function in Rats Kharina Septi Lestari; Aulia Nurfazri Istiqomah; Reza Pratama; Boy Ignatius Simamora; Anissa Nadya Oktriyani
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 6 No. 2 (2025): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v6i2.13177

Abstract

Sidaguri leaves (Sida rhombifolia L.) have been widely used in traditional medicine due to their anti-inflammatory, diuretic, and analgesic properties. To ensure their safety, a subchronic toxicity study was conducted using ethanolic extracts of Sida rhombifolia leaves. The study involved male and female Wistar rats administered a dose of 14 mg/kg body weight (BW) daily for 90 days. Toxic symptoms were observed throughout the study period, followed by organ weight assessment, blood biochemical analysis (SGOT, SGPT, creatinine, and urea), and histological examination of heart and kidney tissues. The results showed no toxic symptoms or mortality in the test animals. Levels of SGOT, SGPT, creatinine, and urea remained within normal limits, with no statistically significant differences (p>0.05) between the control and treatment groups. Histological analysis revealed no signs of necrosis in heart and kidney tissues. In conclusion, the ethanolic extract of Sida rhombifolia leaves at a dose of 14 mg/Kg BW is non-toxic and considered safe for daily consumption. Keywords: Sidaguri leaves; Subchronic toxicity;  Histologic;  Liver;  Kidney.
Pengaruh Toksisitas Subkronik Ekstrak Etanol Rimpang Pacing (Costus speciosus) terhadap Fungsi Hati pada Tikus Aulia Nurfazri Istiqomah; Siti Kholisatun Nisa; Kharina Septi Lestari
Indonesian Journal of Herbal Science and Innovation Vol. 1 No. 1 (2025): Indonesian Journal of Herbal Science and Innovation
Publisher : PT CENDEKIA SCIENCE AND TECHNOLOGY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64673/ijherbsi.v1i1.1

Abstract

Traditional medicine has been an integral part of healing practices for thousands of years. With its rich biodiversity, Indonesia boasts approximately 30,000 plant species with potential medicinal properties, one of which is the rhizome of Costus speciosus (pacing). This plant is known for its various benefits, including antifungal, antioxidant, anthelmintic properties, and traditional contraceptive use. The aim of this study was to investigate the subchronic toxicity of ethanol extract from pacing rhizomes on liver function in male and female rats. The experiment was conducted using Wistar rats, with two groups (10 males and 10 females per group), which were treated with a 300 mg/kg body weight dose of the extract for 90 days. Liver histology, organ index, and levels of the enzymes SGOT and SGPT were observed. The results indicated that the ethanol extract of pacing rhizomes, at this dose, did not cause significant changes in body weight, liver organ index, or SGOT/SGPT levels in both male and female rats. In conclusion, the study suggests that the ethanol extract of pacing rhizomes at 300 mg/kg body weight for 90 days does not show signs of liver toxicity in rats. These findings support the potential use of pacing rhizomes as a safe ingredient in traditional medicine. However, further studies are needed to assess possible toxic effects and animal mortality over longer durations.
Pengaruh Toksisitas Akut Ekstrak Etanol Rimpang Pacing (Costus speciosus) pada Embrio Zebrafish (Danio rerio) Kharina Septi Lestari; Aulia Utami Widiati; Aulia Nurfazri Istiqomah
Indonesian Journal of Herbal Science and Innovation Vol. 1 No. 1 (2025): Indonesian Journal of Herbal Science and Innovation
Publisher : PT CENDEKIA SCIENCE AND TECHNOLOGY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64673/ijherbsi.v1i1.2

Abstract

The Costus speciosus plant, commonly known as pacing, is widely used both as an ornamental plant and in traditional medicine. All parts of the plant, particularly the rhizomes, are known to possess various pharmacological activities, including anti-diabetic, anti-cancer, anti-bacterial, and anti-inflammatory properties. However, with the extensive use of the rhizomes in traditional medicine, it is essential to assess their safety. This study aims to determine the LC50 value of ethanol extract from Costus speciosus rhizomes (EERP) and evaluate its acute toxicity level. The Fish Embryo Acute Toxicity (FET) Test was used to assess toxicity, employing zebrafish (Danio rerio) embryos as the model organism. Zebrafish are chosen because their genetic makeup shares about 60-70% similarity with humans, making them a suitable model for mapping toxic effects. The study involved seven experimental groups: two control groups (negative and positive controls) and five groups treated with varying concentrations of EERP (62.5 ppm, 31.25 ppm, 15.63 ppm, 7.81 ppm, and 3.91 ppm). The results revealed an LC50 value of 11.707 ppm for EERP, indicating that the extract falls under the "slightly toxic" category. These findings provide valuable insights into the potential toxicity of Costus speciosus, which is crucial for determining safe dosage levels in its use as a traditional medicine. Further research is needed to explore the underlying toxic mechanisms of this extract.
Co-Authors Agus Miraj Darajat Agus Sulaeman Agus Sulaeman Agus Sulaeman Ai Siti Farihah Anissa Nadya Oktriyani Aulia Utami Widiati Betti Risa O Boy Ignatius Simamora Budiana, Wempi Budy Nugraha Denny Galang Dian Eka Fakhira Dika Azhar Ramadhan Elis Susilawati Elis Susilawati Fikri Mourly Wahyudi Hapipah Nurjamilah Hasimun, Patonah Hendra Mahakam Putra Ida Lisni Imas Fauzya Zahra Intan Pertiwi Jumiatun Jumiatun Jutti Levita Kevin Efraim Lian Kharina Septi Lestari Marita Kaniawati Marita Kaniawati Ning Hayati Novitasari Tsamrotul Fuadah Nurfadillah, Ilham Ogi Dienda Pratama Oktriyani, Anissa Nadya PERTIWI, INTAN Pratama, Reza Putra, Hendra Mahakam Raihany Sholihatul Reza Pratama Roni, Asep Sekar Wulan Apriliasari Shintya Safitri Silvi Nur Amalia Simamora, Boy Ignatius Siti Kholisatun Nisa Sri Adi Sumiwi Susilawati, Elis Susilawati, Yasminwar Sutrisno, Entris Tri Nurjayanti Wahyu Wahdana Wahyudi, Vierly Stephany Putri Widhya Aligita Widhya Aligita Yani Mulyani Yasminwar Susilawati Yermia Ademi Dedeo Zaelani, Diki