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All Journal Jurnal Online Mahasiswa (JOM) Bidang Ilmu Ekonomi Journal of the Indonesian Mathematical Society AGRIVITA, Journal of Agricultural Science EMITTER International Journal of Engineering Technology JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Teknologi Informasi MURA JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Pendidikan dan Pembelajaran Sains Indonesia (JPPSI) Al-Ard: Jurnal Teknik Lingkungan Medical and Health Science Journal Jurnal Pendidikan dan Pembelajaran Sains Indonesia (JPPSI) Jurnal Ilmiah Akuntansi Peradaban Jurnal Kewarganegaraan Ilomata International Journal of Social Science Narra J Journal of Rural and Urban Community Empowerment Jurnal Pengabdian Inovasi dan Teknologi Kepada Masyarakat Jurnal AGRISEP: Kajian Masalah Sosial Ekonomi Pertanian dan Agribisnis Masip: Jurnal Manajemen Administrasi Bisnis dan Publik Terapan Jurnal Teknologi Informasi Mura Asian Journal of Science, Technology, Engineering, and Art Jurnal Intelek Insan Cendikia African Multidisciplinary Journal of Sciences and Artificial Intelligence Open Access DRIVERset African Journal of Biochemistry and Molecular Biology Research Open Access DRIVERset African Journal of Sciences and Traditional Medicine Open Access DRIVERset Kwaghe International Journal of Sciences and Technology Open Access DRIVERset Kwaghe International Journal of Arts, Humanities and Religious Studies African Journal of Clinical Medicine and Pharmacy Research African Journal of Medicine, Surgery and Public Health Research
Muhammad Akram
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Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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 1 
Exploring the Dynamics of Enzyme Activity: Environmental and Biological Influences Akram, Muhammad; Rehman, Urooj; Ahmed, Misbah; Umaru, Isaac John
African Journal of Biochemistry and Molecular Biology Research Vol 2 No 2 (2025): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v2i2.5268

Abstract

The work presents the classification of enzymes and factors that are affecting enzymatic reactions in the living systems. Factors such as temperature, pH, enzyme concentration, substrate concentration, factors of inhibition, factors of activation, and incubation time are important in influencing enzyme reactions, which are responsible for controlling components in living systems. The majority of enzymes are three-dimensional molecules with complex molecular networks and sensitive to various environmental factors.
Phytochemistry and Pharmacology of Oxystelma Esculentum Chishti, Abdul Wadood; Akram, Muhammad; Rehman, Urooj; Khan, Fahad Said; Iftikhar, Momina; Umaru, Isaac John
African Journal of Biochemistry and Molecular Biology Research Vol 2 No 2 (2025): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v2i2.5269

Abstract

Several phytochemicals, including glycosides, alkaloids, flavonoids, and saponins, are present in the widespread medicinal herb Oxystelmaesculentum. These physiologically active substances contribute to the herb's pharmacological properties, which include anti-inflammatory, antioxidant, antibacterial, and antidiabetic effects. Research studies have shown that O. esculentum can be used medicinally to treat a variety of ailments, such as fever, pain, respiratory issues, and digestive issues. It may also have neuroprotective properties and help in blood sugar regulation. Even though its therapeutic qualities appear promising, more research must be done to verify its efficacy, safety, and potential for drug development.
Cutting-Edge Discoveries in Cancer Biology and Therapeutic Development Akram, Muhammad; Abdullah, Muhammad; Iftikhar, Momina; Umaru, Isaac John
African Journal of Biochemistry and Molecular Biology Research Vol 2 No 2 (2025): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v2i2.5306

Abstract

Growth in precision medicine, immunotherapy, genetics, and new therapeutic approaches is driving the rapid progression of cancer science and drug discovery. Greater tailor-made treatments attacking specific genetic abnormalities and immune systems have become an alternative to the one-size-fits-all approach, bringing renewed hope to patients for improved outcomes and fewer adverse effects. The most critical growth impacting the face of cancer research and drug discovery is summarized in this brief. Next-generation sequencing (NGS) and other methods enable complete genomic profiling, which identifies actionable mutations and guides targeted therapy. Stepping away from blanket chemotherapy, scientists can develop more effective and less toxic drugs by understanding the specific mutations that create each patient's cancer. By blocking the brakes of the immune system, these drugs allow T cells to better fight cancer cells. However, research is ongoing to maximize these treatments' efficacy and safety, particularly in the case of solid tumors. Targeting some of the TME components, such as the extracellular matrix or TME-dwelling immune cells, could provide new treatment strategies. Huge amounts of genetic information are being evaluated, potential medicine candidates are being identified, and patient outcomes are being forecast by AI algorithms. In addition, machine learning algorithms are being employed to improve patient stratification, optimize clinical trial design, and personalize treatment regimens using real-time data. Combination Treatments: Combination therapies employing multiple mechanisms of action are gaining increasing popularity as a result of the flexibility and complexity of cancer. For maximizing efficacy and overcoming resistance, researchers are incorporating immunotherapy with targeted therapy, chemotherapy, radiation therapy, and other modalities. The goal is to keep tumor cells from evading treatment by attacking cancer from a variety of angles. These combinations are currently under investigation in clinical trials, which have had promising results, particularly in cancers such as breast, lung, and melanoma.
The Future of Gene Therapy: Revolutionizing Modern Medicine Akram, Muhammad; Khan, Alam Afroz Urooj; Umaru, Isaac John
African Journal of Biochemistry and Molecular Biology Research Vol 2 No 2 (2025): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v2i2.5326

Abstract

The use of gene therapy paired with advanced technology may one day enable chronic illnesses, cancerous diseases, and even genetic defects to be treated via DNA alterations. With developments and promising results in gene CRISPR-Cas9 editing technology, improved treatments and promising results from clinical trials have made gene therapy a possibility. It is also predicted that gene therapy will be used in the future to combat heart issues, cancer, neurological diseases, and other hereditary attributes. Nonetheless, metastatic issues pertaining to ethics, engagement, spending, and the probability of negative consequences over time still remain. In the case of augmented medicine, incorporating stem cells with new artificial intelligence technology will ensure better and more accurate treatment along with greater personalization of gene therapies. This is expected to lead to a whole new realm of precision medicine.
Emerging Applications and Challenges of Nanotechnology in Medicine and Nutrition Akram, Muhammad; Mahmood, Abid; Hasan, Mohammed Khudhair; Umaru, Isaac John; Abdulghafoor, Hind A.; Khan, Fahad Said; Ozdemir, Fethi Ahmet; Sołowski, Gaweł; Ali, Jaouher Ben
African Journal of Biochemistry and Molecular Biology Research Vol 2 No 2 (2025): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v2i2.5484

Abstract

Emerging applications of nanotechnology in medicine and nutrition present both significant opportunities and challenges that warrant thorough investigation. This study aims to explore the intersection of nanotechnology and genomic nutrition, focusing on how these advancements can enhance preventive care and health outcomes. Employing a qualitative descriptive methodology, we conducted a comparative analysis of existing literature and case studies to assess the implications of these technologies on dietary customization and patient-provider relationships. Our findings reveal that nanotechnology facilitates the development of targeted nutritional interventions that align with individual genetic profiles, thereby improving adherence to dietary guidelines and mitigating disease risk. Furthermore, we identify that the integration of continuous health monitoring technologies fosters a collaborative partnership between patients and healthcare providers, enhancing communication and decision-making processes in treatment and preventive initiatives. The implications of this research underscore the necessity for healthcare systems to adopt technological advancements to address the complexities of modern medicine effectively. By embracing these innovations, the potential for precision medicine is significantly amplified, paving the way for improved health outcomes and personalized nutrition strategies in the future.
Evolution of DNA Technology in Treating Animal Diseases Akram, Muhammad; Umaru, Isaac John; Mahmood, Abid; Hasan, Mohammed Khudhair; Abdulghafoor, Hind A.; Khan, Fahad Said; Ozdemir, Fethi Ahmet; Sołowski, Gaweł; Ali, Jaouher Ben; Al-Musawi, Jehan Mohammad
African Journal of Biochemistry and Molecular Biology Research Vol 2 No 2 (2025): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v2i2.5582

Abstract

A single gene mutation can result in aberrant cell activity and the production of a faulty protein. The cell will certainly operate very poorly or not at all as a result of this mutation. Given that the genetic material may be a therapeutic agent; this might be seen as qualitatively distinct from other conventional drugs. Gene therapy may be able to rectify or perhaps cure the pathophysiology of a disease by changing the genetic composition of cells. In veterinary medicine, genetic engineering has been used to xenografts, and detects, prevent, and treat illnesses. Among the challenges that gene therapy faces include transfection, intracellular vector stability, cellular and nuclear entrance, and ethical concerns. Deficits in gene transfer vectors and a lack of knowledge about the biological interactions between these vectors and the host are two examples of fundamental challenges.
Microbial Genetics: Foundations, Applications, and Future Directions in Science and Biotechnology Akram, Muhammad; Umaru, Isaac John; Mahmood, Abid; Hasan, Mohammed Khudhair; Abdulghafoor, Hind A.; Khan, Fahad Said; Ozdemir, Fethi Ahmet; Sołowski, Gaweł; Ali, Jaouher Ben; Al-Musawi, Jehan Mohammad
African Journal of Biochemistry and Molecular Biology Research Vol 2 No 2 (2025): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v2i2.5652

Abstract

This field is essential to comprehending not just basic biological processes but also how they are used in biotechnology, agriculture, and medicine. Microbial genetics is the study of genetic material, which includes horizontal gene transfer, DNA replication, gene expression, and mutation. Many microorganisms, in contrast to larger species, have genomes that are small and relatively basic, enabling researchers to accurately examine the regulation and function of genes. Mechanisms like transformation, transduction, and conjugation, which speed up the acquisition and spread of genetic characteristics like antibiotic resistance, are primarily responsible for the genetic plasticity of microorganisms, especially bacteria. Given that existing treatment approaches are being challenged by the growth consequences. Additionally, using cutting-edge molecular methods like whole-genome sequencing, recombinant DNA technology, and CRISPR-Cas systems, microbial genetics aids in the creation of novel antibiotics, vaccines, and diagnostic instruments. The intricacies of microbial communities, or microbiomes, and their interactions with hosts and the environment have also been clarified by research in microbial genetics. Our knowledge of microbial ecology, pathogenicity, and symbiosis has increased as a result. The discipline is still developing in industrial settings, but the combination of systems genetics and computational biology holds promise for deciphering intricate regulatory networks and enabling predictive modeling of microbial behavior. As microbial genetics advances, ethical issues—especially those pertaining to gene editing and the discharge of genetically engineered organisms—become more significant. To sum up, microbial genetics is a fundamental component of contemporary biology and biotechnology, offering deep understanding of microbial life and laying the groundwork for advancement in a wide range of scientific and industrial domains. Addressing global health, sustainability, and environmental management concerns requires ongoing study in this area.
Cell Dynamics: Mechanisms, Technologies, and Applications in Health and Disease Akram, Muhammad; Umaru, Isaac John; Mahmood, Abid; Hasan, Mohammed Khudhair; Abdulghafoor, Hind A.; Khan, Fahad Said; Ozdemir, Fethi Ahmet; Sołowski, Gaweł; Ali, Jaouher Ben; Al-Musawi, Jehan Mohammad
African Journal of Biochemistry and Molecular Biology Research Vol 2 No 2 (2025): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v2i2.5653

Abstract

The intricate and well-coordinated activities of cells in response to both internal and external stimuli are referred to as cell dynamics. These behaviors help living things grow, differentiate, maintain, and adapt. Using a variety of interdisciplinary techniques from molecular biology, biophysics, computational modeling, and live-cell imaging, this field examines the dynamic processes that control cell morphology, intracellular transport, cytoskeletal reorganization, signal transduction, and cell motility. The capacity of cells to alter their structure and function in real time, allowing for quick reactions to changes in the environment, damage, or developmental signals, is a key component of cell dynamics. The complex coordination of cytoskeletal filaments, vesicle trafficking channels, and signaling networks that underpin activities including mitosis, migration, immunological surveillance, and synaptic plasticity has been made visible by developments in high-resolution imaging and single-cell analysis. Recent research has demonstrated that cellular activities incorporate stochastic fluctuations, spatial compartmentalization, and emergent features resulting from the combined actions of molecular complexes, in addition to deterministic biochemical routes. It has been demonstrated that the mechanical characteristics of the cellular microenvironment, such as the extracellular matrix composition and substrate stiffness, are essential for regulating dynamic cellular responses, especially during wound healing, tissue formation, and cancer progression. Additionally, the enormous datasets produced by live-cell imaging and omics technologies are being decoded more and more using computational models and artificial intelligence tools, which offer fresh perspectives on the temporal and spatial control of cellular activities. In addition to expanding our understanding of basic cell biology, an understanding of cellular dynamics may help develop therapeutic approaches that target dysregulated cellular activities in conditions including cancer, dementia, and immunological disorders. In order to anticipate cellular outcomes and manipulate cell destiny for applications in synthetic biology and regenerative medicine, it will be crucial to combine quantitative modeling with experimental data as we continue to clarify the fundamentals of cellular structure and adaptability.
Zinc Oxide Based Nanomaterials and Their Application in the Removal of Toxic Contaminants for Waste Water Matilda, Manasseh Ilumunter; Umaru, Isaac John; Umaru, Kerenhappuch Isaac; Akram, Muhammad
African Journal of Biochemistry and Molecular Biology Research Vol 2 No 2 (2025): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v2i2.5893

Abstract

The increasing global demand for clean water underscores the urgency of addressing environmental pollution, particularly through effective wastewater treatment. Rapid urbanization, population growth, and industrial expansion have significantly contributed to the degradation of water quality, making contamination a persistent and complex challenge. Despite numerous scientific efforts to develop remediation strategies, many existing techniques remain difficult to replicate or scale down effectively for widespread application. In this context, nanotechnology has emerged as a promising field, offering innovative solutions for environmental remediation. Among various nanomaterials, zinc oxide (ZnO) nanoparticles stand out due to their unique physicochemical and optical properties, which are substantially enhanced at the nanoscale. ZnO nanoparticles have gained considerable attention in material science, especially for their applications in photocatalysis, antimicrobial treatments, and environmental detoxification. However, their synthesis and functional performance are highly sensitive to several factors, including the pH of the reaction medium, calcination temperature, reaction time, stirring speed, the nature of capping agents, and the concentration of metal precursors. These variables critically influence the size, morphology, and surface activity of ZnO nanoparticles, thereby determining their effectiveness in water treatment applications. Understanding and optimizing these synthesis parameters are crucial for enhancing the reproducibility, efficiency, and scalability of ZnO-based nanotechnologies in real-world environmental contexts.
Cloning in Plants and Animals: Divergent Pathways and Ethical Boundaries in Biotechnology Akram, Muhammad; Umaru, Isaac John; Aslam, Nosheen; Hasan, Mohammed Khudhair; Abdulghafoor, Hind A.; Khan, Fahad Said; Ozdemir, Fethi Ahmet; Sołowski, Gaweł; Ali, Jaouher Ben; Al-Musawi, Jehan Mohammed; Mahmood, Abid
African Journal of Biochemistry and Molecular Biology Research Vol 2 No 2 (2025): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v2i2.6140

Abstract

The creation of genetically identical creatures by cloning is essential to contemporary biotechnology, agriculture, and medical research. Although the basic idea of cloning is the same in all kingdoms, there are substantial differences between plants and animals in terms of its use, effectiveness, and moral consequences. Cloning is a common, natural occurrence in plants and is frequently accomplished using asexual reproduction procedures such as tissue culture, grafting, and vegetative propagation. Because plant cells are highly totipotent, practically any somatic cell may grow again into a whole organism given the right circumstances. The production of genetically engineered plants with enhanced features, the preservation of uncommon species, and the large-scale multiplication of genetically uniform crops have all been made easier by this regenerative potential. Animal cloning, on the other hand, poses far more biological and technological difficulties. Due to developmental errors, aberrant gene expression, and insufficient reprogramming of the donor nucleus, this procedure usually has poor success rates and necessitates intricate management. It brings up important issues about biodiversity, animal care, and the ethical ramifications of cloning sentient creatures. Furthermore, animal cloning is more closely regulated and scrutinized by the public than plant cloning, which is generally recognized in agricultural operations and conservation initiatives. This is particularly true when it comes to food production and possible human cloning. The difference in the effectiveness and uses of cloning is mostly explained by the difference in totipotency between plant and animal cells. The accuracy of modification is becoming closer thanks to recent technological advancements like CRISPR-Cas9, yet the ethical and practical possibilities of cloning in these two domains are still not comparable. The intricate relationship between biological viability, technical development, and societal acceptability of interspecies cloning is shown by this comparative study. Guidance on the proper application and control of cloning technologies in biomedicine and agriculture depends on an understanding of these distinctions.
Co-Authors Abbas, Sabahat Abdulghafoor, Hind A. Addilah, M. Fikri Agussabti Agussabti Ahmed, Misbah Al-Musawi, Jehan Mohammad Al-Musawi, Jehan Mohammed Ali, , Jaouher Ben Ali, Jaouher Ben Andi Tenri Famauri Anggriani, Rara Dewi Anshar Saud Anwar, Hina Arie Arma Arsyad Aslam, Muhammad Tayyab Aslam, Nosheen Burhanuddin Burhanuddin Bustanul Arifin Chairul Amsal Chalirafi, Chalirafi Chishti, Abdul Wadood Dmitriy Kulikov Dyah Nur Sasanti Elly Susanti Erna Erna Fadhlullah M, Muhammad farendi, Arya Fathul, Muh. Fatihaturrahma, Annisya Faza, Farzana Fakhira Febiana, Dian Ghazwani, Eisa Yazeed Gustina Gustina Hansen Nasif Hasan, Mohammed Khudhair Henni Syawal Ibnu Sina Chandranegara Iftikhar, Momina Ikramuddin, Ikramuddin Indra Indra Javed, Amna Jehan Mohammed Al-Musawi, Jehan Mohammed K, Narayana Kamaruzzaman, Suraiya Khalil, Muhammad Talha Khan, Alam Afroz Urooj Khan, Fahad Said Khan, Muhammad Naeem Ahmed Khan, Usman Habib Kholik Prasojo Kurnianingtyas, Erlina Laila, Umme M, Shilpa Magsi, Irfan Ahmed Mahmood, Abid Maqbool, Tahmina Mardatillah Mardatillah Mariska, Refi Marlina Achmad Marzolina ' Matilda, Manasseh Ilumunter Mirza, Aamir Mehmood Mohammad Ali Shariati Mohiuddin, Ghulam Muchsin Muchsin Mufti, Aulia Annas Muh Tawil, Muh Muhammad Abdullah Muhammad Amjad Muhammad Imran Muhammad Nadeem Muhammad Nouman Tariq Muhammad Sajjad Mujiburrahmad Mujiburrahmad Murod, Ma’mun Mutawakkil, M. Mufid Al Muttiarni Muttiarni Nadezhda Kenijz Najmiatul Fitria novita sari, dian Nur Amsal, A.Muh Ihsan Ozdemi, Fethi Ahmet Ozdemir, Fethi Ahmet RA, Sayyidina Abdul Qabidhi Rahman, Dhaffa Mulya Rahmi Yosmar Ramadhanita, Ramadhanita Rashid, Abid Rehman, Urooj Sabir Alwy Sadia, Haleema Saputra, Anugerah Sarini Vita Dewi Shahid, Isbah Shariqa Fakhar Shumaila Hussain Sitara, Muzzamal Sołowski, Gaweł Suteji Anwar, Andika Syahruni Cangara, Arie Syed, Sadat Ali Tanjung, Yuliza Virliansyah Tanweer Aslam Gondal Taufiqurokhman Umaru, Isaac John Umaru, Kerenhappuch Isaac Wagan, Raja Asif Wibisono, Dany Kunto Yuni Lisafitri, Yuni Zafar, Sadia Zainab, Rida Zainuddin, Zainuddin Zazna Syaputri, Yolanda Zikri, Irfan