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All Journal VALENSI ILMU KELAUTAN: Indonesian Journal of Marine Sciences GRADIEN Jurnal Tadris Kimiya Alotrop Jurnal Pendidikan dan Ilmu Kimia Jurnal Laot Ilmu Kelautan Hydrogen: Jurnal Kependidikan Kimia Filogeni: Jurnal Mahasiswa Biologi Journal of Fisheries & Marine
Yosie Andriani
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Education Immunology & microbiology Materials Science & Nanotechnology Mathematics Physics

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Antioxidant of Ethanol Extract and Toxicity of Fractions from Aspergillus unguis a Marine Sponge Symbiont of Aaptos suberitoides Masyerli, Scify Bilqis Nawafi; Efdi, Mai; Bashari, Muhammad Hasan; Untung Kurnia Agung, Mochamad; Subhan, Beginer; Efahmi, Efahmi; Andriani, Yosie; Syafrizayanti, Syafrizayanti
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 1 (2025): February 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i1.14645

Abstract

The marine sponge Aaptos suberitoides has been shown to have anticancer properties, with clear evidence of its capacity to suppress the growth of cancer cells. However, the pharmaceutical exploration of chemicals from marine organisms causes significant environmental concerns. Aspergillus unguis, a fungal symbiont of the marine sponge A. suberitoides, has been isolated for its potential in sustainable natural products resources. This study assesses the antioxidant activity of ethanol extract and the toxicity of four levels fractions from ethanol extracts of A. unguis mycelium and these results were reported for the first time in this study. The antioxidant of ethanol extract was determined using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) method. The fractions were examined for toxicity using the Brine Shrimp Lethality Test (BSLT). The ethanol extract of A. unguis shows very strong antioxidant bioactivity (IC50 = 42.84 mg/L). The LC50 values for hexane, chloroform, ethyl acetate, and butanol fractions were determined to be 74.11 µg/mL, 93.84 µg/mL, 59.37 µg/mL, and 142.79 µg/mL, respectively. It indicates significant toxicity. These preliminary results are important knowledge for further research into the bioactivity potential of the metabolites as candidate anticancer compounds, aligning with marine pharmaceutical drug development.
Co-Authors Afrizal Mayub Agustiningtias, Wardah Izzati Aisyah, Siti Zanuba Andi Parenrengi Asy’ari, Mukhammad Ayu, Inna Puspa Bashari, Muhammad Hasan Beginer Subhan BHAKTI KARYADI Choirunnisa, Nur Fadilla Dewi Handayani Dondy Arafat Efahmi, Efahmi Elfahmi Elfahmi, Elfahmi Emma Suryati Herlinah Herlinah Hermansyah Amir, Hermansyah Ismiyarto Ismitarto Jasnizat Saidin Mai Efdi Masyerli, Scify Bilqis Nawafi Mohamad Gazali Nebuchadnezzar Akbar NEVIATY PUTRI ZAMANI Ngadiwiyana M.Si. S.Si. Ni Kadek Dita Cahyani, Ni Kadek Dita Nor Basid Adiwibawa Prasetya Noraznawati Ismail Novriyandi Hanif Nurhamidah Nurhamidah Purbowatiningrum Ria Sarjono Riezky Maya Probosari Rosmiati Rosmiati Salsabila, Salsabila Samuel Lante, Samuel Sani, Lalu M. Iqbal Sulaeman Sulaeman Sutarno Sutarno Syafrizayanti, Syafrizayanti Triwijayanti, Yunita Untung Kurnia Agung, Mochamad Yahya, Rodhiyah Zahrani , Arifah