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All Journal VALENSI ILMU KELAUTAN: Indonesian Journal of Marine Sciences GRADIEN Jurnal Tadris Kimiya Alotrop Jurnal Pendidikan dan Ilmu Kimia Jurnal Laot Ilmu Kelautan Hydrogen: Jurnal Kependidikan Kimia Filogeni: Jurnal Mahasiswa Biologi Journal of Fisheries & Marine
Yosie Andriani
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Education Immunology & microbiology Materials Science & Nanotechnology Mathematics Physics

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Uji Aktivitas Antioksidan Ekstrak Betaglukan Dari Saccharomyces Cerevisiae Andriani, Yosie
GRADIEN : Jurnal Ilmiah MIPA Vol 3, No 1 (2007): (Januari 2007)
Publisher : Universitas Bengkulu

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Abstract

Telah dilakukan penelitian uji aktivitas antioksidan ekstrak betaglukan dari Saccharomyces cerevisiae padahewan coba tikus putih jantan galur Sparaque Dawley, dewasa, sehat dan memiliki aktivitas normal dengan bobotbadan antara 150-300 gram, Ekstrak betaglukan dari Saccharomyces cerevisiae isolate ragi tape dan ragi roti. Reagen Kit untuk analisis kolesterol diperoleh dari RandoxTM dan aktivitas antioksidan dilakukan dengan uji tiobarbiturat (TBA). Sebanyak 15 ekor tikus dikelompokkan menjadi 5, masing-masing terdiri dari 3 ekor. Kelompok A (non kolesterol) mengkonsumsi pakan standar, kelompok B (hiperkolesterolemia) mengkonsumsi pakan kolesterol danPTU, kelompok C dan D mengkonsumsi pakan kolesterol dan di cekok dengan betaglukan dari Saccharomycescerecisiae asal ragi roti dan ragi tape, dan kelompok E mengkonsumsi betaglukan standar. Pada awal percobaan tikus diadaptasi dengan pakan standar (20g/ekor/hari) dan minum air secara adlibitum sampai mencapai bobot antara 200- 300 g (relatif homogen). Pengambilan darah dilakukan pada akhir masa adaptasi (base line) yaitu pada hari ke-0, dan masa perlakuan yaitu pada hari ke-7, 14, 21, dan 28 guna analisis kolesterol darah, dan kadar lipid peroksida darah tikus putih. Setelah masa perlakuan dilanjutkan dengan wash out selama satu minggu. Setelah itu dilakukanpengukuran kadar kolesterol dan lipid peroksida darah tikus. Pemberian ekstrak betalukan dari Saccharomycescerevisiae isolat ragi roti, ragi tape dan beta glukan standar dengan dosis 1 mg/kgBB/hari mampu menekan kadarkolesterol darah tikus, serta mampu mencegah tingginya kadar lipid peroksida darah tikus. Hal ini mengindikasikanadanya aktivitas antioksidan dari ekstrak betaglukan yang digunakan.   
Pengaruh Ekstrak Daun Jati Belanda (Guazuma ulmifolia Lamk.) Terhadap Bobot Badan Kelinci Yang Diberi Pakan Berlemak Andriani, Yosie
GRADIEN : Jurnal Ilmiah MIPA Vol 1, No 2 (2005): (Juli 2005)
Publisher : Universitas Bengkulu

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Abstract

Telah diteliti pengaruh ekstrak daun Jati Belanda (Guazuma Ulmifolia Lamk.) terhadap bobot badan (BB) hewan coba kelinci lokal jantan yang diberi pakan berlemak. Kelinci dibagi menjadi 4 kelompok perlakuan masing-masing 5 ekor : Perlakuan kontrol (80 g/kgBB/hari), perlakuan ekstrak air (1 g/kgBB/hari), perlakuan ekstrak etanol (1g/kgBB/hari), perlakuan fraksi aktif steroid (0,15 g/kgBB/hari, setara dengan dosis1g/kgBB/hari). Perlakuan dilakukan selama 7 minggu, 3 minggu pertama dengan pakan yang mengandungkolesterol 0,25% saja tanpa lemak, 4 minggu terakhir selanjutnya kelinci diberi pakan berlemak yangmengandung kolesterol 0,25% dan minyak kelapa 5%. Bobot badan kelinci perlakuan kontrol relatif lebih rendahdibandingkan dengan ketiga perlakuan ekstrak, ini berhubungan dengan jumlah konsumsi kelompok perlakuanketiga ekstrak yang 3,9 % lebih besar dibandingkan kontrol yang hanya mengkonsumsi lemak saja. Hal inimengindikasikan ekstrak daun Jati Belanda tidak mampu menekan pertambahan bobot badan kelinci.
The Anticancer Potency of Pandanus odoratissimus Extracts In Human Breast Cancer (MCF-7) Cell Line Andriani, Yosie; Yahya, Rodhiyah; Gazali, Mohamad; Amir, Hermansyah; Subhan, Beginer
Jurnal Laot Ilmu Kelautan Vol 6, No 1 (2024): Jurnal Laot Ilmu Kelautan
Publisher : Universitas Teuku Umar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35308/jlik.v6i1.9275

Abstract

The development of novel chemical entities, novel pharmaceuticals, and novel drug leads frequently involves the use of natural sources. One of the most well-known plants, Pandanus odoratissimus (Pandanaceae), is native to Malaysia and has long been used in Ayurvedic medicine to treat a variety of illnesses. The purpose of this study is to determine P odoratissimus's antioxidant and anticancer properties against MCF-7 human breast cancer cell lines. The 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity was used to assess antioxidant activity, and among the other extracts, core exhibited the highest antioxidant value. An MTT assay was used to assess the effects of plant components on MCF-7 cell lines (3-(4, 5-dimethylthiazolyl)-2, 5-diphenyl-tetrazolium bromide). The concentration of samples was shown to considerably boost the antioxidant activities in P. odoratissimus extracts. Our findings demonstrated that, after receiving treatment for 72 hours, sample treated cancer cells experienced a decline in cell viability. The IC50 value of 88.00 mg/ml indicates that the extracts have a poor cytotoxic impact and have no promise as anticancer agents against MCF-7, which is why it’s killing efficiency in cancer cells is regarded as lower.
SYSTEMATIC LITERATURE REVIEW OF TRENDS AND DEVELOPMENT IN ANTIHYPERTENSIVE EFFECT OF SEAWEED RESEARCH: SCIENTOMETRIC ANALYSIS Mohamad Gazali; Yosie Andriani; Jasnizat Saidin; Noraznawati Ismail
ALOTROP Vol. 8 No. 2 (2024): Alotrop 2024
Publisher : University of Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/alo.v8i2.36875

Abstract

Hypertension is the most alarming disease that causes cardiovascular risk for human health Worldwide. Thus, the author has explored marine natural marine macroalgae that possess antihypertension activity to lower blood pressure. Marine macroalgae or seaweed tropical marine organisms from marine biodiversity that are distributed widely in the subtropic and tropical oceans. Marine macroalgae have a significant role in preventing hypertension risk with a unique biochemical compound that is not contained in a terrestrial plant. However, antihypertension of seaweed research using scientometric analysis is limited. This study collected scientific information from relevant literature to determine the recent development and trends regarding antihypertension of seaweed research Worldwide. Many researchers, academia, and practitioners will have a wide understanding of the recent novelty finding in seaweed prospect to prevent antihypertension disease with a scientometric analysis approach to interpret data using CiteSpace. The literature review using scientometric analysis regarding antihypertension of seaweed research from 1991 until 2022. The result showed Suetsuna K is the most influential author (sigma score =1.52, centrality score =0.24 and degree score =51). Advances in Food and Nutrition Research is the leading journal. The most popular keywords in common cluster related antihypertension of seaweed research area are seaweed, hypertension, algae, in vitro, and dietary fiber. On the other hand, various stakeholders need to know the development and trends of a marine drug for antihypertensive effect from various seaweeds or marine macroalgae.
Antioxidant of Ethanol Extract and Toxicity of Fractions from Aspergillus unguis a Marine Sponge Symbiont of Aaptos suberitoides Masyerli, Scify Bilqis Nawafi; Efdi, Mai; Bashari, Muhammad Hasan; Untung Kurnia Agung, Mochamad; Subhan, Beginer; Efahmi, Efahmi; Andriani, Yosie; Syafrizayanti, Syafrizayanti
Hydrogen: Jurnal Kependidikan Kimia Vol 13, No 1 (2025): February 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i1.14645

Abstract

The marine sponge Aaptos suberitoides has been shown to have anticancer properties, with clear evidence of its capacity to suppress the growth of cancer cells. However, the pharmaceutical exploration of chemicals from marine organisms causes significant environmental concerns. Aspergillus unguis, a fungal symbiont of the marine sponge A. suberitoides, has been isolated for its potential in sustainable natural products resources. This study assesses the antioxidant activity of ethanol extract and the toxicity of four levels fractions from ethanol extracts of A. unguis mycelium and these results were reported for the first time in this study. The antioxidant of ethanol extract was determined using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) method. The fractions were examined for toxicity using the Brine Shrimp Lethality Test (BSLT). The ethanol extract of A. unguis shows very strong antioxidant bioactivity (IC50 = 42.84 mg/L). The LC50 values for hexane, chloroform, ethyl acetate, and butanol fractions were determined to be 74.11 µg/mL, 93.84 µg/mL, 59.37 µg/mL, and 142.79 µg/mL, respectively. It indicates significant toxicity. These preliminary results are important knowledge for further research into the bioactivity potential of the metabolites as candidate anticancer compounds, aligning with marine pharmaceutical drug development.
Challenges in Molecular and Morphological Identification of Sponge Species in Raja Ampat Aisyah, Siti Zanuba; Zamani, Neviaty Putri; Cahyani, Ni Kadek Dita; Elfahmi, Elfahmi; Syafrizayanti, Syafrizayanti; Andriani, Yosie; Arafat, Dondy; Bashari, Muhammad Hasan; Hanif, Novriyandi; Sani, Lalu M. Iqbal; Ayu, Inna Puspa; Akbar, Nebuchadnezzar; Subhan, Beginer
ILMU KELAUTAN: Indonesian Journal of Marine Sciences Vol 30, No 1 (2025): Ilmu Kelautan
Publisher : Marine Science Department Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/ik.ijms.30.1.115-125

Abstract

Sponges (Phylum Porifera) are a group of highly diverse, sessile, and filter-feeding basal metazoans, except spongillids. The majority of sponges are marine species that play an important role in benthic habitat by maintaining the stability of marine ecosystems through nutrient cycling, habitat provision, and bioerosion. However, marine sponges are not easily identifiable because of their lack of species-level distinctive morphological features, which limits efforts to monitor actual species biodiversity. Indonesia is home to approximately 850 identified species of marine sponges, and Raja Ampat archipelago of West Papua province is known for its exceptional marine biodiversity. Despite the species abundance, the exact number of sponges in the region is not well-documented due to the lack of specific studies providing comprehensive data on their diversity. Therefore, this study aimed to conduct a DNA barcoding analysis using the mitochondrial cytochrome oxidase I (COI) gene as a marker, combined with morphological analyses of 22 individuals collected in the waters of Waigeo, Mansuar, and Gam Islands in Raja Ampat. The results showed that 3 samples were identified at the species level (Halichondria sp. and Stylissa carteri) with good query cover and percent identity. This showed the possible presence of undescribed or cryptic species, suggesting a severe lack of reference data for both morphology and molecular analyses of marine sponges in the region. Consequently, the analysis showed the presence of a significant gap in the understanding of sponge biodiversity in Raja Ampat's waters.
Eksplorasi Potensi Tumbuhan Sebagai Pewarna Alami Batik Besurek Bengkulu Ramah Lingkungan Zahrani , Arifah; Sutarno, Sutarno; Bhakti karyadi; Riezky Maya Probosari; Afrizal Mayub; Yosie Andriani
Filogeni: Jurnal Mahasiswa Biologi Vol 5 No 1 (2025): Januari-April
Publisher : Program Studi Biologi Fakultas Sains dan Teknologi Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/filogeni.v5i1.56996

Abstract

Batik besurek merupakan warisan budaya khas Bengkulu yang dalam praktiknya pewarnaannya masih banyak menggunakan zat pewarna sintetis, yang berpotensi menimbulkan dampak negatif terhadap kesehatan dan lingkungan. Penelitian ini bertujuan untuk mengidentifikasi potensi tumbuhan lokal sebagai pewarna alami dalam pembuatan batik besurek, serta mengevaluasi kualitas dan ketahanan warnanya berdasarkan standar SNI ISO-105. Penelitian dilakukan dengan pendekatan eksploratif untuk mengidentifikasi tumbuhan lokal berpigmen alami, serta pendekatan eksperimental untuk menguji ketahanan warna hasil pewarnaan terhadap pencucian (ISO 105-C06), penjemuran (ISO 105-B02), dan gesekan (ISO 105-X12). Ekstraksi dilakukan menggunakan teknik maserasi dan boiling treatment, serta diaplikasikan pada kain mori menggunakan 3 jenis mordan yaitu tawas, tunjung, dan kapur sirih. Empat tanaman yang digunakan dalam penelitian ini, yaitu Hibiscus rosa-sinensis, Archidendron pauciflorum, Bougainvillea sp., dan Curcuma longa yang dikenal mengandung pigmen alami. Hasil menunjukkan bahwa Curcuma longa memiliki ketahanan warna tertinggi, dengan kategori “tidak pudar” untuk semua parameter ISO-105. Sebaliknya, Bougainvillea sp. menunjukkan ketahanan warna terendah, hanya mencapai skor 1-4 pada beberapa uji. Hasil ini menunjukkan bahwa penggunaan pewarna alami berbasis tumbuhan lokal memiliki potensi besar sebagai alternatif ramah lingkungan dalam pembuatan batik besurek. Pendekatan ini mendukung pelestarian lingkungan, pemanfaatan biodiversitas lokal, serta dapat diterapkan dalam pembelajaran kontekstual di sekolah.
Development of STEAM-Based Electronic Practicum Module on the Topic of Saponification Handayani, Dewi; Agustiningtias, Wardah Izzati; Nurhamidah, Nurhamidah; Andriani, Yosie
Jurnal Tadris Kimiya Vol 10 No 1 (2025)
Publisher : Department of Chemistry Education, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/jtk.v10i1.44033

Abstract

The integration of STEAM (Science, Technology, Engineering, Arts, and Mathematics) approaches in chemistry education offers new opportunities to foster active, interdisciplinary, and skills-oriented learning. However, practical resources that align with this pedagogical framework, particularly in laboratory instruction, remain limited. This study aims to develop and evaluate a STEAM-based electronic practicum guide on the topic of saponification, focusing on its feasibility, student responses, and its effectiveness in enhancing students' psychomotor skills. The development process followed the 4D model (Define, Design, Develop, and Disseminate), with implementation limited to the development stage. Participants included fourth-semester chemistry education students. The practicum guide underwent expert validation and was trialed through student feedback and performance-based observation of psychomotor competencies. The results revealed that the practicum guide achieved a high validity score (87.8%), received very positive student responses (93.1%), and significantly supported the development of psychomotor skills, with an average performance score of 94.2%. These findings suggest that the STEAM-based practicum guide is both feasible and effective as an instructional tool, offering meaningful and engaging learning experiences in chemistry laboratories. The study contributes to the advancement of innovative practicum materials and supports the implementation of STEAM principles in science education.
Assessing various administration strategies for dsRNA vaccine delivery: a concise review of VP15-WSSV research progress in tiger shrimp Penaeus monodon Parenrengi, Andi; Lante, Samuel; Suryati, Emma; Rosmiati, Rosmiati; Sulaeman, Sulaeman; Herlinah, Herlinah; Andriani, Yosie
Jurnal Ilmiah Perikanan dan Kelautan Vol. 17 No. 3 (2025): JURNAL ILMIAH PERIKANAN DAN KELAUTAN
Publisher : Faculty of Fisheries and Marine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jipk.v17i3.73580

Abstract

Graphical Abstract     Highlight Research 1. The dsRNA application should correspond to the developmental stages of shrimp2. Immersion method was commonly used for larvae for handling many individuals3. Injection technique effectively delivered dsRNA to cells but was unsuitable for large-scale4. Oral administration of pellet-enriched dsRNA was applicable to apply on shrimp larvae, juveniles, and broodstocks     Abstract RNAi technology offers a novel powerful approach to silence gene expression by introducing double-stranded RNA (dsRNA) into the cell to degrade the mRNA at the post-transcriptional stage. An administration method of dsRNA delivery is one of the main considerations in applying the dsRNA vaccine for controlling pathogen infections. This mini-review was focused on the evaluation of three different methods (immersion, injection, and oral administration) of VP15-dsRNA vaccine delivery to the tiger shrimp post-WSSV challenge test. The immersion method was generally applied for the larval stage of tiger shrimp and seemed to be a simple technique for a large number of individuals in a small tank. The VP15-dsRNA application by immersion improved the survival of tiger shrimp larvae by 3.9% compared to the control groups. The injection technique was an effective way to deliver dsRNA to the cell, but it is difficult to apply in a large number of individuals or populations. The injection of VP15-dsRNA increased significantly the survival rate, proPO, and THC of tiger shrimp. A higher survival rate (75%) was exhibited in tiger shrimp injected with in vivo and in vitro VP15-dsRNA than in the control. Oral administration by pellet-enriched VP15-dsRNA was a useful way for larvae, juveniles, and broodstocks, but it has limitations since the pellet leaches into the water. The application of the VP15-dsRNA vaccine on the feed significantly enhanced the 26.7% higher survival rate compared to the control. The higher survival was also supported by a higher number of THC. The three VP15-dsRNA delivery methods provide potential approaches to increase tiger shrimp resistance to control pathogen infection
Isolation of Endophytic Pseudomonas Strains from Papaya Leaves and Their Extracellular Enzyme Production and Antioxidant Profile Sarjono, Purbowatiningrum Ria; Choirunnisa, Nur Fadilla; Triwijayanti, Yunita; Salsabila, Salsabila; Asy’ari, Mukhammad; Ngadiwiyana, Ngadiwiyana; Ismiyarto, Ismiyarto; Prasetya, Nor Basid Adiwibowo; Andriani, Yosie
Jurnal Kimia Valensi Vol. 11 No. 1 (2025): Jurnal Kimia VALENSI
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i1.40921

Abstract

Endophytic bacteria, symbiotic microorganisms residing in plant tissues, produce bioactive compounds similar to host plants, such as antioxidants. These antioxidants are crucial in combating free radicals linked to degenerative diseases. This study isolates and characterizes two endophytic bacterial strains from papaya leaves, exploring their enzymatic and antioxidant activities. Two isolates of endophytic bacteria from papaya leaves were obtained, F1-A and F1-B. F1-A endophytic bacteria are types of monobacilli, Gram-positive bacteria. F1-B endophytic bacteria are types of Bacilli. Using 16S rRNA analysis, both isolates were predicted to belong to the Pseudomonas bacterial strain. Research on optimizing their growth under various temperatures and pH conditions showed that both isolates grow best at 37°C. F1-B provides a better opportunity as a source of industrial enzymes because it can excrete amylase, urease, cellulose, and protease enzymes compared to F1-A, which can only produce amylase and protease enzymes. Nevertheless, F1-A can act as a potent antioxidant with an IC50 of 34.18 ppm compared to F1-B, which has an IC50 value of 292.31 ppm. The IC50 value of the F1-A isolate was not much different from the IC50 of quercetin, which was 12.50 ppm. The ability of F1-A as an antioxidant is also influenced by the results of phytochemical screening, which can contain more secondary metabolites than F1-B. These results highlight the potential of Pseudomonas strains as sources of industrial enzymes and natural antioxidants, warranting further investigation.
Co-Authors Afrizal Mayub Agustiningtias, Wardah Izzati Aisyah, Siti Zanuba Andi Parenrengi Asy’ari, Mukhammad Ayu, Inna Puspa Bashari, Muhammad Hasan Beginer Subhan BHAKTI KARYADI Choirunnisa, Nur Fadilla Dewi Handayani Dondy Arafat Efahmi, Efahmi Elfahmi Elfahmi, Elfahmi Emma Suryati Herlinah Herlinah Hermansyah Amir, Hermansyah Ismiyarto Ismitarto Jasnizat Saidin Mai Efdi Masyerli, Scify Bilqis Nawafi Mohamad Gazali Nebuchadnezzar Akbar NEVIATY PUTRI ZAMANI Ngadiwiyana M.Si. S.Si. Ni Kadek Dita Cahyani, Ni Kadek Dita Nor Basid Adiwibawa Prasetya Noraznawati Ismail Novriyandi Hanif Nurhamidah Nurhamidah Purbowatiningrum Ria Sarjono Riezky Maya Probosari Rosmiati Rosmiati Salsabila, Salsabila Samuel Lante, Samuel Sani, Lalu M. Iqbal Sulaeman Sulaeman Sutarno Sutarno Syafrizayanti, Syafrizayanti Triwijayanti, Yunita Untung Kurnia Agung, Mochamad Yahya, Rodhiyah Zahrani , Arifah