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All Journal Jurnal Sosialisasi: Jurnal Hasil Pemikiran, Penelitian dan Pengembangan Keilmuan Sosiologi Pendidikan Indonesian Journal of Cancer Chemoprevention Equilibrium: Jurnal Pendidikan Pharmascience Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Jurnal Ilmiah Cendekia Eksakta Jurnal Dedikasi Pinisi Business Administration Review Daengku: Journal of Humanities and Social Sciences Innovation Jurnal Ilmiah Bakti Farmasi Social Landscape Journal Media Farmasi Indonesia Pinisi Journal of Sociology Education Review AML/CFT Journal The Journal of Anti Money Laundering and Countering the Financing of Terrorism Jurnal Pengabdian Masyarakat Ininnawa: Jurnal Pengabdian Masyarakat Borneo Journal of Pharmacy Paramacitra : Jurnal Pengabdian Masyarakat DISCOURSE : Indonesian Journal of Social Studies and Education EDUSOS: Jurnal Edukasi dan Ilmu Sosial
Ibrahim Arifin
Fakultas Farmasi, Universitas Wahid Hasyim
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences Other

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Journal : Pharmascience

 1 
Efek Hepatoprotektor Ekstrak Etanol Daun Kenikir (Cosmos caudatus Kunth.) Pada Tikus Yang Diinduksi Doksorubisin Junvidya Heroweti; Ibrahim Arifin; Nurul Arlin Hidayati; Rizki Suciantika
Jurnal Pharmascience Vol 6, No 2 (2019): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v6i2.7348

Abstract

ABSTRAK Doksorubisin adalah agen kemoterapi yang mempunyai efek samping hepatotoksik dengan cara pembentukan radikal bebas. Daun kenikir (Cosmos caudatus Kunth.) memiliki potensi untuk mencegah efek hepatotoksik akibat penggunaan doksorubisin. Penelitian bertujian untuk membuktikan potensi Ekstrak Etanol Daun Kenikir (EEDK) sebagai hepatoprotektor pada tikus yang diinduksi doksorubisin. Penelitian ini merupakan penelitian eksperimental menggunakan randomized matched post only control group design. Sebanyak 25 ekor tikus galur wistar dibagi menjadi 5 kelompok secara acak. Kelompok I, control normal diberi asupan aquadest, kelompok II kontrol hepatotoksik diberikan doksorubisin dosis 5 mg/KgBB. Kelompok III, IV dan V merupakan kelompok perlakuan EEDK dengan dosis berturut-turut 250,500, dan 1000 mg/kgBB dengan doksorubisin dosis 5 mg/kgBB. Pemberian doksorubisin dilakukan pada hari ke-1, ke-5,ke-9 dan hari ke-13 secara intraperitonial (ip) dan pemberian EEDK dilakukan 1 kali sehari selama 14 hari secara peroral (po). SEluruh hewan uji diambil darahnya pada hari ke-15. Kadar SGOT dan SGPT dievaluasi untuk melihat adanya kerusakan hati. Data kadar SGOT dianalisis dengan one way anova, sedangkan data kadar SGPT dianalisis menggunakan Kruskall-wallis. Hasil penelitian menunjukkan bahwa doksorubisin dapat menyebabkan hepatotoksik ditandai dengan peningkatan kadar SGOT dan SGPT. Ekstrak etanol daun kenikir mampu memberikan efek hepatoprotektor yang signifikan (p≤0,05) pada tikus yang diinduksi doksorubisin ditunjukkan dengan penurunan kadar SGOT dan SGPT. Kata Kunci: doksorubisin, daun kenikir, hepatoprotektor, SGOT, SGPT  ABSTRACT Doxorubicin is a chemotherapeutic agent has hepatotoxic side effects through the formation of free radicals. Marigold leaves (Cosmos caudatus Kunth.) has the potential to prevent hepatotoxic effects caused by the use of doxorubicin. This study aims to prove the potential of Ethanol Extract of Marigold Leaves (EEDK) as a hepatoprotector in doxorubicin-induced rats. This study was an experimental study with a randomized matched post test only control group design. 25 wistar male rats were divided into 5 groups randomly. Group I as normal control was given aquadest intake, group II as hepatotoxic control was given doxorubicin dose 5 mg/Kg BW, group III, IV and V was EEDK treatment group dose 250, 500 and 1000 mg/Kg BW and doxorubicin dose 5 mg/Kg BW. Doxorubicin was given on day 1, 5, 9 and 13intraperitoneal (i.p) and EEDK was given once a day for 14 days orally (p.o). All blood samples were taken on the 15th day. SGOT and SGPT levels were evaluated to see liver damage. SGOT level data were analyzed statistically by One Way Anova, while SGPT level data were analyzed using Kruskall-Wallis. The results showed that doxorubicin-induced hepatotoxity characterized by increased SGOT and SGPT levels. Ethanol extract of marigold leaves can provide hepatoprotector effect significantly (p≤0.05) in doxorubicin-induced rats indicate by decreased SGOT and SGPT levels. Keywords: doxorubicin, marigold leaves, hepatoprotector, SGOT, SGPT
Efek Sitotoksik Ekstrak Etanolik Ocimum basilicum, L. Pada Sel Kanker Payudara Devi Nisa Hidayati; Ibrahim Arifin; Fatimatuz Zahroh; Lina Wahyuni
Jurnal Pharmascience Vol 6, No 2 (2019): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v6i2.7353

Abstract

ABSTRAK Pengobatan kanker menggunakan bahan alam terus dikembangkan. Salah satu tanaman yang memiliki efek sitotoksik Ocimum basilicum, L. tujuan penelitian ini adalah mengetahui aktivitas sitotoksik dari ekstrak etanol Ocimum basilicum (EEOB) terhadap sel kanker payudara T47D dan MCF7. Ocimum basilicum diekstraksi menggunakan metode maserasi dengan pelarut etanol 70%. Pengujian aktivitas sitotoksik menggunakan metode MTT assay dengan  seri konsentrasi EEOB 1000; 500; 250; 125; 62.5; 31,25 µg/mL. Hasil uji aktivitas sitotoksik EEOB memperlihatkan nilai IC50 pada sel T47D dan MCF-7 sebesar 399.86 µg/ml dan 387.76 µg/ml. Kata Kunci—Sitotoksik, Ocinum basilicum L., T47D, MCF-7  ABSTRACT             Cancer treatment using natural ingredients continues to be developed. One of the plants that is proven to have cytotoxic activity is basil leaves (Ocimum basilicum, L.). This study aims to determine the cytotoxic activity of ethanol extract of basil leaves (EEBL) on T47D and MCF-7 breast cancer cells. Basil leaves were extracted using maceration  with ethanol 70%. The cytotoxic test was perfomed using MTT assay with various EEBL concentrations: 1000; 500; 250; 125; 62.5; 31,25 µg/mL. The results showed that IC50 of cytotoxic activity in T47D and MCF-7 was 399.86 µg/ml and 387.76 µg/ml respectively. Keywords—Cytotoxic, Ocinum basilicum L., T47D, MCF-7
Co-Authors . Anindyajati ., Muhammad Syukur A. Octamaya Tenri Awaru Abdul Rahman Adam Hermawan Agustang, Andi Dodi May Putra Ahmad Fudhail  Majid Ahmad, M Ridwan Said Ahmad, M. Ridwan Said Akbar, Muh. Akmal, Muh Ikramullah Aksayanti Al Faris, Risman Alimuddin, Ardawati Andi Ima Kesuma Anindyajati Anindyajati Anis Fauzia Arifin, Jamaluddin Arsyada, Muhammad Farih Aslinda, Andi Awaru, Andi Octamaya Tenri Ayu Shabrina Bahri bahri Cahyaning Gita Rizkita Devi Nisa Hidayati Dewi Hastuti Diki, Hendrawan Edy Meiyanto Edy Meiyanto Eka Wahyuni Nurul Qori'ah Endah Subekti Ernawati Syahruddin Kaseng Fachrian, Ahmad Maulana Farikha Maharani Fatimatuz Zahroh Fatimatuz Zahroh Firdaus W Suhaeb Hasni Hasni Heroweti, Junvidya Hidayati, Nurul Arlin HUSNA, ASMA'UL Ilham Saputra Jamilah Jamilah Jayadi, Abd Asathin Bardan Jumadi Jumadi Kabur, Savio Ricardus Khibran, Muh Fauzan Khoirul Anwar Lina Wahyuni Lina Wahyuni Mubarak, M. Alwi Muddiin, Muhammad Imaa Muhammad Nur Muhammad Syukur Musdalifah Musdalifah Mustahar AM, Muh. Abid Muthi Ikawati Mutiani Mutiani Mutmainnah M., Ulfah N, Muh Ilham Nirwana NUR FADILAH Nur Hidayah Nurfadilla, Rizki Nurmagfira Nurul Arlin Hidayati Pratama, S.Si., M.Si., Mario Pratiwi, Nevy Ramadhan S, Muhammad Syahrul Rijal, Muh. Rizaldi Syam , Muh Rizki Suciantika Sadriani, Andi Safitri, Nurafia Sari Haryanti Sari Haryanti Seppa, Yusi Irensi Sri Wahyuni Taufik, Parham Tiara Nur’aini Umi Any Tiyas Wati Zainal Arifin Zainal, Henni Zulfafasya, Nisrina Zulkifli Arifin