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All Journal Jurnal Farmasi Sains dan Komunitas Jurnal Wiyata : Penelitian Sains dan Kesehatan Biosaintifika: Journal of Biology & Biology Education Jurnal Ilmiah Cendekia Eksakta Bubungan Tinggi: Jurnal Pengabdian Masyarakat Jurnal Abdidas Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal DiMas (Jurnal Pengabdian Kepada Masyarakat) Ruang Cendekia : Jurnal Pengabdian Kepada Masyarakat International Journal of Public Health Excellence (IJPHE) Media Farmasi Indonesia Jurnal Farmasi Sains dan Praktis Open Community Service Journal Indonesian Journal of Community Services Cel Pena Dimas: Jurnal Pengabdian Masyarakat Sabangka Abdimas Jurnal Pengabdian Masyarakat Sabangka Setawar Abdimas Biosaintifika: Journal of Biology & Biology Education Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Christina Astutiningsih
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Utilization of Milk Waste and Rosemary as Enviromentally Friendly Soap in Samirono, Getasan, Semarang Palupi, Dwi Hadi Setya; Astutiningsih, Christina; Rohmah, Syifaur; Suskawati, Ida; Susilowati, Novy Dwi
Indonesian Journal of Community Services Cel Vol. 3 No. 3 (2024): Indonesian Journal of Community Services Cel
Publisher : Research and Social Study Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70110/ijcsc.v3i3.74

Abstract

Fresh cow’s milk has weaknesses, namely it is easily perishable and its shelf life tends to be short. Processing fresh cow’s milk into product is one of the efforts to extend the shelf life of cow’s milk. One of the products that can be made from fresh milk is soap. The ingredients used in making soap are quite simple and widely available in the market at relatively cheap prices. Rosemary can be used as an additive in manufacture of cow’s milk soap. The target of making envirometally friendly soap is directed at people who have dairy cows. The goal to be achieved is to increase the value of cow’s comodity and increase entrepreurship by producing and marketing enviromentally friendly soap and being able to solve the problem of relatively short milk shelf life. This service is divided into several stages. At this stage, a training process was carried out on making soap from fresh cow’s milk waste and marketing methods for the product. It is hoped that milk that can be consumed again can be processed into soap using active ingredients from rosemary, so that the soap produced can increase added value both economically and for the environment. The results of this community service is solid soap using raw materials from milk waste and rosmeray. This community service activity was received with great enthusiasm by the participants who took part in the training on how to make cow's milk soap. There is a significant difference (p<0.05) in the results of the pretest and posttest questionnaires, indicating an increase in understanding of the material presented in this community service activity. This activity has been successfully implemented.
PENENTUAN FENOLIK TOTAL, FLAVONOID TOTAL, AKTIVITAS ANTIOKSIDAN DAN NILAI SPF FRAKSI BUAH OKRA (Abelmoschus esculentus L.) Astutiningsih, Christina; Anggraeny, Ebta Narasukma
CENDEKIA EKSAKTA Vol. 8 No. 1 (2023)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/ce.v8i1.8260

Abstract

Buah okra banyak dikonsumsi sebagai sayur dan diperkirakan dapat dimanfaatkan dalam produk kosmetik. Karena adanya komponen golongan fenolik, yaitu senyawa antioksidan dan senyawa pelindung, buah okra diyakini dapat mengurangi peningkatan radikal bebas yang dihasilkan oleh paparan sinar matahari. Penelitian ini bertujuan untuk memfraksinasi buah okra, mengkaji kandungan total fenolik dan flavonoidnya, serta menguji aktivitas antioksidan dan perlindungan sinar matahari dari fraksi buah okra. Dalam penelitian ini, ekstraksi etanol dilanjutkan dengan remaserasi dan fraksinasi dengan n-heksana, etil asetat, dan air. Pengujian potensi sebagai tabir surya ditentukan berdasarkan metode perhitungan nilai SPF, nilai persen transmitan eritema dan nilai persen transmitan pigmentasi. Hasil analisis menunjukkan fraksi etil asetat memiliki kandungan fenolik dan flavonoid terbesar yaitu 251, 0116 mgGAE/g dan 127,6178 mgQE/g. Nilai IC50 juga menunjukkan konsentrasi paling kecil yaitu 40,2254 ppm. Fraksi etil asetat pada konsentrasi 100ppm memberikan nilai SPF 8,5973; 200ppm 49,7069 dan 400ppm sebesar 77,4765 yang menunjukkan fraksi etil asetat mampu memberikan perlindungan ultra. Persen transmisi pigmentasi (Tp) 100ppm adalah 0,3441; 200ppm sebesar 0,1447 dan 400ppm sebesar 0,1113 serta persen transmisi eritema (Te) 100ppm sebesar 0,3407; 200ppm sebesar 0,1436 dan 400ppm sebesar 0,1102 menunjukkan kemampuan fraksi etil asetat sebagai sunblock.Kata kunci: Buah Okra, antioksidan, tabir surya, fraksi
Inovasi Lilin Aromaterapi Sereh (Cympogon citratus) dan Lemon (Citrus lemon) sebagai Antinyamuk di Kelurahan Karangayu, Semarang Astutiningsih, Christina; Salsabila, Livia; Amelia, Sevy; Istiana, Tiara Aulia; Lestari, Amanda Wahyu; Ayuningtyas, Fannia Sekar; Setyaningsih, Wiwin; Anggarini, Naya
Open Community Service Journal Vol. 4 No. 1 (2025): Open Community Service Journal
Publisher : Research and Social Study Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33292/ocsj.v4i1.114

Abstract

Demam Berdarah Dengue (DBD) adalah penyakit menular yang disebabkan oleh virus Dengue yang disebarkan oleh vektor nyamuk Aedes aegypti dan Aedes albopictus. Pencegahan penyakit tersebut dapat dengan menghindari gigitan nyamuk pembawa virus. Diketahui beberapa bahan alamiah seperti lemon dan sereh, mempunyai khasiat sebagai pengusir nyamuk. Zat tersebut akan lebih efektif apabila dibuat sebagai lilin aromaterapi. Tujuan pengabdian ini untuk peningkatan pengetahuan tentang demam berdarah dan skill pembuatan lilin aroamterapi kepada ibu-ibu PKK Anjasmoro Tengah, Karangayu, Semarang tentang produksi lilin aromaterapi yang dapat digunakan sebagai antinyamuk. Pelaksanaan pengabdian dilakukan dengan metode ceramah yang sebelumnya diawali dengan pre-test, diskusi interaktif, demonstrasi dan praktik langsung untuk meningkatkan kapasitas dan kreativitas masyarakat, bagian akhir dari kegiatan dilakukan post-test. Kegiatan pre-test dan post-test dilakukan untuk mengetahui tingkat pemahaman peserta. Hasil menunjukkan adanya peningkatan pengetahuan tentang demam berdarah dan pembuatan lilin aromaterapi dari peserta berdasarkan hasil pre-hanya memiliki pengetahuan sekitar 20% dapat meningkat sampai lebih dari 75% berarti kegiatan yang dilakukan mendapat tanggapan positif.
Quantification of Bioactives and Bioactivities in Different Parts of Abelmoschus esculentus  Astutiningsih, Christina; Suharsanti, Ririn; Ismail, Wan Ismahanisa; Sufiyanto, Mohammad Imam; Minah, Faidliyah Nilna; Firmiaty, Sri
Biosaintifika: Journal of Biology & Biology Education Vol. 17 No. 2 (2025): August 2025
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v17i2.24073

Abstract

The presence of natural antioxidants in medicinal plants plays a crucial role in inhibiting the detrimental effects of oxidative stress. The aim of this research is to explore more deeply all parts of A. esculenta L from flowers, fruits, seeds, leaves, and stems for the levels of compounds and antioxidant and enzyme inhibitor activities. The flowers demonstrated the highest TPC with 173.15942 ± 6.5083 mg GAE/g. The stems exhibited the lowest TPC value at 69.1967 ± 2.8408 mg GAE/g. The flowers also showed TFC value of 83.157 ± 2.021 mg QE/g while the stems displayed the lowest with 36.7240 ± 1.337 mg QE/g. IC50 value that the flowers possessed the highest antioxidant activity with 22.6539 ± 1.6452 mg/mL, whereas the stems displayed a slightly lower. In terms of the inhibitor of a-amylase activity, the flowers had an IC50 value of 102.4885 ± 11.4370 mg/mL whereas the stems had a lower. The highest IC50 value of the a-glucosidase inhibitor was 76.95 ± 12.0888 mg/mL in the flowers, and the lowest was in the stems. The highest IC50 of pancreatic lipase inhibitor was 109.5943 ± 9.7391 mg/mL in the flowers, and the lowest was in the stems. This study show that there is a relationship between the high content of total phenolic and total flavonoids on antioxidants, antidiabetic and antilipase activities.
Potential of Flavonoid Isolate from Okra Fruit (Abelmoschus esculentus L.) as Antidiabetic and Antilipase Agent In Vitro and In Silico Astutiningsih, Christina; Meri , Meri
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 12 No. 1 (2025): March
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v12i1.6053

Abstract

Obesity, which is currently a global issue that contributes to a number of diseases, including diabetes and coronary heart disease. This study set out to isolate and identify the flavonoid compounds from okra fruit that demonstrate the ability to inhibit alpha glucosidase and pancreatic lipase. Okra fruit powder was extracted using ethanol at a concentration of 80% following fractination with n-hexane, ethyl acetate, and aquadest. TLC preparation was used to isolate flavonoid from fraction ethyl acetate. Flavonoids that were succesfully isolated were quercetin compounds. The IC50 value of quercetin was found to be 47.9763 micrograms/mL. This was greater than IC50 acarbose as a positive control at a concentration of 33.8169 micrograms/mL, which showed its ability as an inhibitor -glucosidase was smaller. Quercetin acted as pancreatic lipase inhibitors, albeit weaker than the positive control Orlistat, which at the same concentration could inhibit 68% of pancreatic lipase activity, while quercetin could only inhibit 50%. Using molecular docking in silico testing, quercetin compounds were shown to have a stronger bond than the positive control. Similar to positive control, quercetin compounds could interact with receptors with amino acids residues GLU 277 (glutamic acid) and ASP 352 (aspartic acid), amino acids crucial in determining enzyme activity. Conversely, in the silico tests for  pancreatic lipase inhibition, Orlistat  displayed an exceedingly strong bond than quercetin compounds. Despite this, quercetin compounds also showed interaction between resceptors with amino acids residues MET 123 (Methionine) and ALA 51 (Alanine), amino acids that determine enzyme activity (catalytic site of enzyme)
Co-Authors A. Ariani Hesti Wulan A. Barry Anggoro Adilah Athtahirah Adli Ponco Wicaksono Adzra Fernanda Dini Agus Suprijono Amelia, Sevy Anggarini, Naya Anggie, Erlyn Juanita Anggraeny, Ebta Narasukma Anis Nurhayati Anjas Ninda Kirani Atikah Darumas Putri Ayuningtyas, Fannia Sekar Bayu Tri Murti Calsy Fauzia Nurhadian Dwi Hadi Setya Palupi Ebta Narasukma Anggraeni Ebta, Ebta Narasukma Anggraeni Eko Sutrisno Etty Sulistyowati Faidliyah Nilna Minah Feb Rukmini Firmiaty, Sri Frida Nuzulia Hajar Nurma Wachidah Himawan Hindratna Indah Sulistyarini Ismail, Wan Ismahanisa Istiana, Tiara Aulia Jayawarsa, A.A. Ketut Kristantri, Rika Sebtiana Leenawaty Limantara Lestari, Amanda Wahyu Listyani Listyani Maria Caecilia Nanny Setiawati Melani Paulina Maya Ocsari Meri , Meri Murtasih MUTMAINAH Nadia, Lailatun Nanik Wijayati Nur Patria Tjahjani Ocky K. Radjasa Ocky K. Radjasa Rahmawati Salsa Dinurrosifa Ratih Octaviani Riani, Elfa Rika Septiana Ririn Suharsanti Ririn Suharsanti, Ririn Rohmah, Syifaur Salsabila, Livia Sekarwati, Anisa Selamat Muliadi Setyaningsih, Wiwin Sri Suratiningsih Sri Wahyuni Sufiyanto, Mohammad Imam suryaningsih Susilowati, Novy Dwi Suskawati, Ida Wahyuning Setyani Wulan Kartika Sari Zulfa, Salsabila Rizqi